AU2806789A - Renin inhibiting peptides that contain amino and hydroxy dicarboxylic acids - Google Patents

Renin inhibiting peptides that contain amino and hydroxy dicarboxylic acids

Info

Publication number
AU2806789A
AU2806789A AU28067/89A AU2806789A AU2806789A AU 2806789 A AU2806789 A AU 2806789A AU 28067/89 A AU28067/89 A AU 28067/89A AU 2806789 A AU2806789 A AU 2806789A AU 2806789 A AU2806789 A AU 2806789A
Authority
AU
Australia
Prior art keywords
dicarboxylic acids
contain amino
inhibiting peptides
renin inhibiting
hydroxy dicarboxylic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU28067/89A
Other versions
AU617740C (en
Inventor
Suvit Thaisrivongs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of AU2806789A publication Critical patent/AU2806789A/en
Application granted granted Critical
Publication of AU617740C publication Critical patent/AU617740C/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU28067/89A 1987-11-16 1988-10-11 Renin inhibiting peptides that contain amino and hydroxy dicarboxylic acids Ceased AU617740C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12127087A 1987-11-16 1987-11-16
US121270 1987-11-16

Publications (2)

Publication Number Publication Date
AU2806789A true AU2806789A (en) 1989-06-14
AU617740C AU617740C (en) 1992-10-01

Family

ID=

Also Published As

Publication number Publication date
DK119590D0 (en) 1990-05-14
JPH03500886A (en) 1991-02-28
EP0394311A1 (en) 1990-10-31
WO1989004833A1 (en) 1989-06-01
FI902422A0 (en) 1990-05-15
DK119590A (en) 1990-05-14

Similar Documents

Publication Publication Date Title
US5654451B1 (en) Amino acids and peptides having modified c-terminals and modified n-terminals
AU3193489A (en) Renin inhibitors containing alpha-heteroatom amino acids
GB2282066B (en) Salts of peptides with carboxy-terminated polyesters
IL114910A0 (en) Snthetic excitatory amino acids
AU9065891A (en) Novel renin inhibiting peptides
GB9325558D0 (en) Percaboxylic acids
AU556832B2 (en) Chromogenic amino acid esters and peptide esters
AU4042585A (en) Substituted alpha amino acids
HU9500412D0 (en) Amino acid derivative
AU4517289A (en) Trialkylsilyl esters of amino acids and their use in the synthesis of peptides
AU7254891A (en) Renin inhibiting peptides having an alpha-heteroatom amino acid at the p3 position
AU2806789A (en) Renin inhibiting peptides that contain amino and hydroxy dicarboxylic acids
AU4834890A (en) Renin inhibitors containing c-terminal dihydroxy amides
GB8511710D0 (en) N-benzyloxycarbonyl amino acids
AU4665289A (en) N-alkylation of n-alpha-boc-protected amino acids
GB8806571D0 (en) Supports for proteins & amino acids
AU7085398A (en) Process for esterification of amino acids and peptides
AU2492492A (en) Protein preparation containing the essential amino acids
GB2316073B (en) Alkylation of amino acids
ZA89480B (en) Renin inhibitors containing alpha-heteroatom amino acids
AU1942488A (en) Use of amino acids for the preparation of a beverage
ZA86961B (en) Peptide derivatives which inhibit renin and acid proteases
IL118659A (en) Unnatural amino acids
NZ235284A (en) Amino diacid esters and their preparation
IE842086L (en) Cyclopropane amino acids and peptides