AU2023256547A1 - Istaroxime-containing intravenous formulation for the treatment of pre-cardiogenic shock and cardiogenic shock - Google Patents
Istaroxime-containing intravenous formulation for the treatment of pre-cardiogenic shock and cardiogenic shock Download PDFInfo
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- AU2023256547A1 AU2023256547A1 AU2023256547A AU2023256547A AU2023256547A1 AU 2023256547 A1 AU2023256547 A1 AU 2023256547A1 AU 2023256547 A AU2023256547 A AU 2023256547A AU 2023256547 A AU2023256547 A AU 2023256547A AU 2023256547 A1 AU2023256547 A1 AU 2023256547A1
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- istaroxime
- cardiogenic shock
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
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- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
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| US202263332909P | 2022-04-20 | 2022-04-20 | |
| US63/332,909 | 2022-04-20 | ||
| PCT/US2023/018998 WO2023205183A1 (en) | 2022-04-20 | 2023-04-18 | Istaroxime-containing intravenous formulation for the treatment of pre-cardiogenic shock and cardiogenic shock |
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| AU2023256547A1 true AU2023256547A1 (en) | 2024-11-28 |
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| JP (1) | JP2025513337A (https=) |
| KR (1) | KR20250005343A (https=) |
| CN (1) | CN119156218A (https=) |
| AU (1) | AU2023256547A1 (https=) |
| CA (1) | CA3248625A1 (https=) |
| IL (1) | IL316164A (https=) |
| MX (1) | MX2024012948A (https=) |
| WO (1) | WO2023205183A1 (https=) |
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| WO2025128432A1 (en) * | 2023-12-11 | 2025-06-19 | Windtree Therapeutics, Inc. | Istaroxime and metabolite derivatives thereof for reducing the risk of acute myocardial arrhythmia |
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| US4534899A (en) | 1981-07-20 | 1985-08-13 | Lipid Specialties, Inc. | Synthetic phospholipid compounds |
| US5846743A (en) | 1995-02-22 | 1998-12-08 | Brigham And Women's Hospital, Inc. | Polyphoshoinositide binding peptides for intracellular drug delivery |
| US6007839A (en) | 1996-02-16 | 1999-12-28 | The Liposome Company, Inc. | Preparation of pharmaceutical compositions containing etherlipid-containing multiple lipid liposomes |
| US5874268A (en) | 1996-09-23 | 1999-02-23 | Duke University | Method of introducing exogenous compounds into cells by electroporation and apparatus for same |
| US6063400A (en) | 1997-07-02 | 2000-05-16 | Sdg, Inc. | Targeted liposomal constructs for diagnostic and therapeutic uses |
| SE9704076D0 (sv) | 1997-11-06 | 1997-11-06 | Holdingbolaget Vid Goeteborgs | Method for permeabilisation of cell structures and use thereof |
| US6589503B1 (en) | 1998-06-20 | 2003-07-08 | Washington University | Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy |
| US20040151766A1 (en) | 2003-01-30 | 2004-08-05 | Monahan Sean D. | Protein and peptide delivery to mammalian cells in vitro |
| WO2005063156A1 (en) | 2003-12-22 | 2005-07-14 | Shear/Kershman Laboratories, Inc. | Oral peptide delivery system with improved bioavailability |
| JP3903061B2 (ja) | 2003-12-24 | 2007-04-11 | 株式会社Ｌｔｔバイオファーマ | 薬物を含有するナノ粒子およびその製造方法、ならびに当該ナノ粒子からなる非経口投与用製剤 |
| WO2006014035A1 (en) | 2004-08-06 | 2006-02-09 | Biospectrum, Inc. | Multiple layered liposome and preparation method thereof |
| WO2006044986A1 (en) | 2004-10-18 | 2006-04-27 | Nitto Denko Corporation | Intracellular peptide delivery |
| CN101267805A (zh) | 2005-07-27 | 2008-09-17 | 普洛体维生物治疗公司 | 制造脂质体的系统和方法 |
| CN103315968B (zh) | 2013-06-26 | 2015-04-01 | 中国生命药物治疗有限公司 | 一种注射用粉针剂及其制备方法 |
| MX2021010483A (es) | 2019-03-05 | 2021-10-01 | Windtree Therapeutics Inc | Formulacion intravenosa que contiene istaroxima para el tratamiento de insuficiencia cardiaca aguda (ahf). |
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- 2023-04-18 CN CN202380035206.5A patent/CN119156218A/zh active Pending
- 2023-04-18 AU AU2023256547A patent/AU2023256547A1/en active Pending
- 2023-04-18 EP EP23723312.7A patent/EP4511040A1/en active Pending
- 2023-04-18 JP JP2024561787A patent/JP2025513337A/ja active Pending
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- 2023-04-18 KR KR1020247038640A patent/KR20250005343A/ko active Pending
- 2023-04-18 WO PCT/US2023/018998 patent/WO2023205183A1/en not_active Ceased
- 2023-04-18 CA CA3248625A patent/CA3248625A1/en active Pending
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2024
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2025513337A (ja) | 2025-04-24 |
| IL316164A (en) | 2024-12-01 |
| MX2024012948A (es) | 2024-11-08 |
| WO2023205183A1 (en) | 2023-10-26 |
| EP4511040A1 (en) | 2025-02-26 |
| CA3248625A1 (en) | 2023-10-26 |
| CN119156218A (zh) | 2024-12-17 |
| KR20250005343A (ko) | 2025-01-09 |
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