AU2023254262A1 - Methods of classifying the differentiation state of cells and related compositions of differentiated cells - Google Patents

Methods of classifying the differentiation state of cells and related compositions of differentiated cells Download PDF

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Publication number
AU2023254262A1
AU2023254262A1 AU2023254262A AU2023254262A AU2023254262A1 AU 2023254262 A1 AU2023254262 A1 AU 2023254262A1 AU 2023254262 A AU2023254262 A AU 2023254262A AU 2023254262 A AU2023254262 A AU 2023254262A AU 2023254262 A1 AU2023254262 A1 AU 2023254262A1
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cells
differentiation state
genes
expression levels
differentiation
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Derren Barken
Jim MOSSMAN
Roy Williams
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Aspen Neuroscience Inc
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Aspen Neuroscience Inc
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    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0622—Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells
    • G—PHYSICS
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869—Interleukin
    • G—PHYSICS
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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    • C12N2533/00—Supports or coatings for cell culture, characterised by material
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    • C12N2533/52—Fibronectin; Laminin

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  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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AU2023254262A 2022-04-15 2023-04-14 Methods of classifying the differentiation state of cells and related compositions of differentiated cells Pending AU2023254262A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202263331783P 2022-04-15 2022-04-15
US63/331,783 2022-04-15
US202263353525P 2022-06-17 2022-06-17
US63/353,525 2022-06-17
PCT/US2023/065811 WO2023201361A1 (en) 2022-04-15 2023-04-14 Methods of classifying the differentiation state of cells and related compositions of differentiated cells

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US (1) US20230377685A1 (https=)
EP (1) EP4508645A1 (https=)
JP (1) JP2025512442A (https=)
KR (1) KR20250007548A (https=)
CN (1) CN119384700A (https=)
AU (1) AU2023254262A1 (https=)
CA (1) CA3250467A1 (https=)
IL (1) IL316055A (https=)
MX (1) MX2024012742A (https=)
WO (1) WO2023201361A1 (https=)

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JP2025512442A (ja) 2025-04-17
US20230377685A1 (en) 2023-11-23
IL316055A (en) 2024-11-01
KR20250007548A (ko) 2025-01-14
CA3250467A1 (en) 2023-10-19
EP4508645A1 (en) 2025-02-19
MX2024012742A (es) 2025-04-02
CN119384700A (zh) 2025-01-28
WO2023201361A1 (en) 2023-10-19

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