AU2023216479A1 - Methods and compositions for generating human induced mesenchymal stem cells - Google Patents

Methods and compositions for generating human induced mesenchymal stem cells Download PDF

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Publication number
AU2023216479A1
AU2023216479A1 AU2023216479A AU2023216479A AU2023216479A1 AU 2023216479 A1 AU2023216479 A1 AU 2023216479A1 AU 2023216479 A AU2023216479 A AU 2023216479A AU 2023216479 A AU2023216479 A AU 2023216479A AU 2023216479 A1 AU2023216479 A1 AU 2023216479A1
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culture media
pathway agonist
cells
media
concentration
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Kenneth R. Chien
Ran YANG
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Smartcella Solutions AB
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Smartcella Solutions AB
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N5/0602—Vertebrate cells
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    • C12N5/0662—Stem cells
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    • C12N5/0602—Vertebrate cells
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    • C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
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    • C12N5/0602—Vertebrate cells
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    • C12N5/0655—Chondrocytes; Cartilage
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
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    • C12N2500/00—Specific components of cell culture medium
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/105—Insulin-like growth factors [IGF]
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    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases [EC 2.]
    • C12N2501/727—Kinases (EC 2.7.)
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue

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  • Wood Science & Technology (AREA)
  • Rheumatology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2023216479A 2022-02-07 2023-02-06 Methods and compositions for generating human induced mesenchymal stem cells Pending AU2023216479A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263307368P 2022-02-07 2022-02-07
US63/307,368 2022-02-07
PCT/IB2023/000071 WO2023148556A1 (en) 2022-02-07 2023-02-06 Methods and compositions for generating human induced mesenchymal stem cells

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AU2023216479A1 true AU2023216479A1 (en) 2024-07-25

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US (1) US20230257714A1 (https=)
EP (1) EP4476327A1 (https=)
JP (1) JP2025504204A (https=)
KR (1) KR20240141307A (https=)
AU (1) AU2023216479A1 (https=)
CA (1) CA3243344A1 (https=)
IL (1) IL314150A (https=)
WO (1) WO2023148556A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2026017857A1 (en) 2024-07-18 2026-01-22 Smartcella Solutions Ab Treatment of osteoarthritis and/or rheumatoid arthritis with pro-chondrogenic and/or chondrocyte protective factors
WO2026017864A1 (en) 2024-07-18 2026-01-22 Smartcella Solutions Ab Treatment of osteoarthritis and/or rheumatoid arthritis with pro-chondrogenic and/or chondrocyte protective factors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20130112028A (ko) * 2010-06-17 2013-10-11 스템알디, 인크. 무혈청 합성 세포배양 배지
SI2785359T1 (sl) * 2011-11-30 2018-11-30 Astellas Institute For Regenerative Medicine Mezenhimske stromalne celice in uporabe povezane z njimi
US11180733B2 (en) * 2016-07-04 2021-11-23 Agency For Science, Technology And Research Method of generating mesenchymal stem cells and uses thereof
KR20190040477A (ko) * 2017-10-10 2019-04-18 건국대학교 글로컬산학협력단 미분화 전능성 줄기세포의 선택적 제거방법
CN111826348B (zh) * 2020-06-12 2023-04-14 云南东森生物科技有限公司 一种人诱导性多能干细胞来源的间充质干细胞体外高效制备方法和应用
EP4168535A4 (en) * 2020-06-23 2024-10-09 Accellta Ltd. MEDIA AND METHODS FOR PRODUCING MESENCHYMAL STEM CELLS
CN111849885B (zh) * 2020-08-04 2022-07-01 浙江大学 一种人胚胎干细胞诱导分化成间充质干细胞的方法

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IL314150A (en) 2024-09-01
WO2023148556A1 (en) 2023-08-10
CA3243344A1 (en) 2023-08-10
EP4476327A1 (en) 2024-12-18
JP2025504204A (ja) 2025-02-06
US20230257714A1 (en) 2023-08-17
KR20240141307A (ko) 2024-09-26

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