AU2023214024A1 - Expression cassettes for treating epilepsy and neuropathic pain - Google Patents

Expression cassettes for treating epilepsy and neuropathic pain Download PDF

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Publication number
AU2023214024A1
AU2023214024A1 AU2023214024A AU2023214024A AU2023214024A1 AU 2023214024 A1 AU2023214024 A1 AU 2023214024A1 AU 2023214024 A AU2023214024 A AU 2023214024A AU 2023214024 A AU2023214024 A AU 2023214024A AU 2023214024 A1 AU2023214024 A1 AU 2023214024A1
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seq
identity
polynucleotide sequence
sequence
nucleic acid
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AU2023214024A
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Annahita KERAVALA
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Trames Bio Inc
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Trames Bio Inc
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N2750/14011—Parvoviridae
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    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14151—Methods of production or purification of viral material
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    • C12N2830/00—Vector systems having a special element relevant for transcription
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    • C12N2830/00—Vector systems having a special element relevant for transcription
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/48—Vector systems having a special element relevant for transcription regulating transport or export of RNA, e.g. RRE, PRE, WPRE, CTE
    • C—CHEMISTRY; METALLURGY
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal

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  • Animal Behavior & Ethology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2023214024A 2022-01-31 2023-01-31 Expression cassettes for treating epilepsy and neuropathic pain Pending AU2023214024A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202263304960P 2022-01-31 2022-01-31
US63/304,960 2022-01-31
US202263312480P 2022-02-22 2022-02-22
US63/312,480 2022-02-22
PCT/US2023/061702 WO2023147604A2 (en) 2022-01-31 2023-01-31 Expression cassettes for treating epilepsy and neuropathic pain

Publications (1)

Publication Number Publication Date
AU2023214024A1 true AU2023214024A1 (en) 2024-08-01

Family

ID=87472551

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2023214024A Pending AU2023214024A1 (en) 2022-01-31 2023-01-31 Expression cassettes for treating epilepsy and neuropathic pain

Country Status (10)

Country Link
US (1) US20250090689A1 (https=)
EP (1) EP4473120A2 (https=)
JP (1) JP2025504060A (https=)
KR (1) KR20240158883A (https=)
CN (1) CN119343455A (https=)
AU (1) AU2023214024A1 (https=)
CA (1) CA3250143A1 (https=)
IL (1) IL314298A (https=)
MX (1) MX2024009350A (https=)
WO (1) WO2023147604A2 (https=)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2007029712A1 (ja) * 2005-09-08 2009-03-19 財団法人阪大微生物病研究会 リンパ球系・血球系細胞へ遺伝子導入するためのプロモーターおよびその利用方法
CN110546257B (zh) * 2017-03-17 2024-03-01 阿德夫拉姆生物技术股份有限公司 用于增强基因表达的组合物和方法

Also Published As

Publication number Publication date
EP4473120A2 (en) 2024-12-11
CN119343455A (zh) 2025-01-21
KR20240158883A (ko) 2024-11-05
WO2023147604A3 (en) 2024-01-04
CA3250143A1 (en) 2023-08-03
US20250090689A1 (en) 2025-03-20
JP2025504060A (ja) 2025-02-06
IL314298A (en) 2024-09-01
WO2023147604A2 (en) 2023-08-03
MX2024009350A (es) 2024-11-08

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