AU2023204806A1 - Designing biomolecule sequence variants with pre-specified attributes - Google Patents

Designing biomolecule sequence variants with pre-specified attributes Download PDF

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Publication number
AU2023204806A1
AU2023204806A1 AU2023204806A AU2023204806A AU2023204806A1 AU 2023204806 A1 AU2023204806 A1 AU 2023204806A1 AU 2023204806 A AU2023204806 A AU 2023204806A AU 2023204806 A AU2023204806 A AU 2023204806A AU 2023204806 A1 AU2023204806 A1 AU 2023204806A1
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Australia
Prior art keywords
antibody
training
sequence variants
model
computing system
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Pending
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AU2023204806A
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English (en)
Inventor
Joshua MEIER
Goran Rakocevic
Ariel Schwartz
Roberto SPREAFICO
Nebojsa Tijanic
Matthew WEINSTOCK
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Absci Corp
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Absci Corp
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Publication of AU2023204806A1 publication Critical patent/AU2023204806A1/en
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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/30—Detection of binding sites or motifs
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/02—Neural networks
    • G06N3/08—Learning methods
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis

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  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Theoretical Computer Science (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Evolutionary Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Data Mining & Analysis (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Evolutionary Computation (AREA)
  • Artificial Intelligence (AREA)
  • Software Systems (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Databases & Information Systems (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Bioethics (AREA)
  • Mathematical Physics (AREA)
  • Biomedical Technology (AREA)
  • Computational Linguistics (AREA)
  • General Physics & Mathematics (AREA)
  • Computing Systems (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Machine Translation (AREA)
AU2023204806A 2022-01-07 2023-01-05 Designing biomolecule sequence variants with pre-specified attributes Pending AU2023204806A1 (en)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US202263297679P 2022-01-07 2022-01-07
US63/297,679 2022-01-07
US202263320067P 2022-03-15 2022-03-15
US63/320,067 2022-03-15
US202263338433P 2022-05-04 2022-05-04
US202263338398P 2022-05-04 2022-05-04
US63/338,433 2022-05-04
US63/338,398 2022-05-04
US202263339450P 2022-05-07 2022-05-07
US63/339,450 2022-05-07
US202263398222P 2022-08-15 2022-08-15
US63/398,222 2022-08-15
US18/046,849 US20230268026A1 (en) 2022-01-07 2022-10-14 Designing biomolecule sequence variants with pre-specified attributes
US18/046,849 2022-10-14
PCT/US2023/060167 WO2023133462A1 (en) 2022-01-07 2023-01-05 Designing biomolecule sequence variants with pre-specified attributes

Publications (1)

Publication Number Publication Date
AU2023204806A1 true AU2023204806A1 (en) 2024-07-25

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AU2023204806A Pending AU2023204806A1 (en) 2022-01-07 2023-01-05 Designing biomolecule sequence variants with pre-specified attributes

Country Status (9)

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US (1) US20230268026A1 (https=)
EP (1) EP4460827A1 (https=)
JP (1) JP2025504384A (https=)
KR (1) KR20240141868A (https=)
AU (1) AU2023204806A1 (https=)
CA (1) CA3247366A1 (https=)
IL (1) IL313957A (https=)
MX (1) MX2024008515A (https=)
WO (1) WO2023133462A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12282941B2 (en) * 2022-06-30 2025-04-22 Constant Contact, Inc. Email subject line generation method
CN115747089A (zh) * 2022-07-06 2023-03-07 河南省巴饲福微生物技术研究院 一种生产谷胱甘肽的重组酿酒酵母菌及其构建方法
US20240047006A1 (en) * 2022-07-07 2024-02-08 Lurong Pan Artificial intelligence system and method for designing protein sequences
WO2025058962A1 (en) * 2023-09-11 2025-03-20 Absci Corporation High-throughput methods for kinetic characterization, quantifying and optimizing antibodies and antibody fragments expression in bacteria
CN117079716B (zh) * 2023-09-13 2024-04-05 江苏运动健康研究院 一种基于基因检测的肿瘤用药方案的深度学习预测方法
CN116994654B (zh) * 2023-09-27 2023-12-29 北京立康生命科技有限公司 一种用于鉴定与mhc-i/hla-i类结合及tcr识别肽段的方法、设备及存储介质
US20250109209A1 (en) 2023-10-03 2025-04-03 Absci Corporation Tl1a associated antibody compositions and methods of use
WO2025122885A1 (en) 2023-12-08 2025-06-12 Absci Corporation Anti-her2 associated antibody compositions designed by artificial intelligence and methods of use
WO2025144700A1 (en) 2023-12-27 2025-07-03 Absci Corporation Nanobody library screening using bacterial surface display
WO2025155628A1 (en) * 2024-01-16 2025-07-24 The Regents Of The University Of California Interpretable deep learning predicts chemoresistance
WO2025170869A1 (en) * 2024-02-06 2025-08-14 Aikium Inc. Multi-objective designed molecules and generation thereof
US20250279158A1 (en) * 2024-02-29 2025-09-04 Lurong Pan Computer-assisted method and system for evaluating and modifying immunogenicity of protein sequences using a protein large language model
WO2025255259A1 (en) * 2024-06-06 2025-12-11 Generate Biomedicines, Inc. Machine learning-guided generation of cross-reactive neutralizing antigen binding molecules against viral proteins
WO2026019845A1 (en) * 2024-07-16 2026-01-22 Hepta Bio, Inc. Generalizable transformer for disease state classification from liquid biopsies

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8178338B2 (en) 2005-07-01 2012-05-15 The Regents Of The University Of California Inducible expression vectors and methods of use thereof
CN107119095B (zh) 2008-01-03 2022-07-05 康乃尔研究基金会有限公司 原核生物中的糖基化蛋白表达
WO2017106583A1 (en) 2015-12-15 2017-06-22 Absci, Llc Cytoplasmic expression system
US20150353940A1 (en) 2013-08-05 2015-12-10 Absci, Llc Vectors for use in an inducible coexpression system
EP3924971A1 (en) 2019-02-11 2021-12-22 Flagship Pioneering Innovations VI, LLC Machine learning guided polypeptide analysis
WO2020208555A1 (en) * 2019-04-09 2020-10-15 Eth Zurich Systems and methods to classify antibodies
EP4008006A1 (en) 2019-08-02 2022-06-08 Flagship Pioneering Innovations VI, LLC Machine learning guided polypeptide design
MX2022008801A (es) 2020-01-15 2022-11-07 Absci Corp Enriquecimiento de células específico de la actividad.
JP2023513578A (ja) 2020-02-11 2023-03-31 アブサイ コーポレーション 近接アッセイ

Also Published As

Publication number Publication date
US20230268026A1 (en) 2023-08-24
WO2023133462A1 (en) 2023-07-13
IL313957A (en) 2024-08-01
CA3247366A1 (en) 2023-07-13
KR20240141868A (ko) 2024-09-27
JP2025504384A (ja) 2025-02-12
EP4460827A1 (en) 2024-11-13
MX2024008515A (es) 2024-08-27

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