AU2022431253A1 - Serpin peptides and methods of using the same - Google Patents

Serpin peptides and methods of using the same Download PDF

Info

Publication number
AU2022431253A1
AU2022431253A1 AU2022431253A AU2022431253A AU2022431253A1 AU 2022431253 A1 AU2022431253 A1 AU 2022431253A1 AU 2022431253 A AU2022431253 A AU 2022431253A AU 2022431253 A AU2022431253 A AU 2022431253A AU 2022431253 A1 AU2022431253 A1 AU 2022431253A1
Authority
AU
Australia
Prior art keywords
seq
peptide
serpin
disease
serpin peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
AU2022431253A
Other languages
English (en)
Inventor
Dana AUSTIN
Cohava Gelber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SERPIN PHARMA LLC
Original Assignee
SERPIN PHARMA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SERPIN PHARMA LLC filed Critical SERPIN PHARMA LLC
Publication of AU2022431253A1 publication Critical patent/AU2022431253A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
AU2022431253A 2022-01-05 2022-12-30 Serpin peptides and methods of using the same Pending AU2022431253A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263266444P 2022-01-05 2022-01-05
US63/266,444 2022-01-05
PCT/US2022/082669 WO2023133078A2 (en) 2022-01-05 2022-12-30 Serpin peptides and methods of using the same

Publications (1)

Publication Number Publication Date
AU2022431253A1 true AU2022431253A1 (en) 2024-07-25

Family

ID=87074167

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2022431253A Pending AU2022431253A1 (en) 2022-01-05 2022-12-30 Serpin peptides and methods of using the same

Country Status (8)

Country Link
US (2) US20250161419A1 (https=)
EP (1) EP4460322A4 (https=)
JP (1) JP2025503607A (https=)
CN (1) CN118804758A (https=)
AU (1) AU2022431253A1 (https=)
CA (1) CA3247129A1 (https=)
IL (1) IL314135A (https=)
WO (1) WO2023133078A2 (https=)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017040287A1 (en) * 2015-08-28 2017-03-09 Serpin Pharma, Llc Methods for treatment of diseases
WO2017123401A1 (en) * 2016-01-13 2017-07-20 Children's Hospital Medical Center Compositions and methods for treating allergic inflammatory conditions
EP3773727A4 (en) * 2018-04-09 2022-05-04 Yale University BIFUNCTIONAL SMALL MOLECULES TO TARGETING THE SELECTIVE DEGRADATION OF CIRCULATING PROTEINS
KR20220099963A (ko) * 2019-10-10 2022-07-14 예일 유니버시티 세포 수용체를 통한 분자 분해제로서의 조작된 항체
US20210162029A1 (en) * 2019-11-04 2021-06-03 Azitra Inc Compositions and methods for treatment or prevention of skin diseases and disorders with lekti
EP4003391A4 (en) * 2020-07-06 2023-02-22 Serpin Pharma, LLC PEPTIDES AND METHODS OF USE THEREOF
AU2022222778A1 (en) * 2021-02-22 2023-08-31 Yale University Targeted bifunctional degraders and methods using same

Also Published As

Publication number Publication date
US20230406906A1 (en) 2023-12-21
WO2023133078A2 (en) 2023-07-13
CA3247129A1 (en) 2023-07-13
EP4460322A2 (en) 2024-11-13
US20250161419A1 (en) 2025-05-22
IL314135A (en) 2024-09-01
JP2025503607A (ja) 2025-02-04
CN118804758A (zh) 2024-10-18
EP4460322A4 (en) 2026-02-25
WO2023133078A3 (en) 2023-08-17

Similar Documents

Publication Publication Date Title
Liu et al. Oxymatrine attenuates bleomycin-induced pulmonary fibrosis in mice via the inhibition of inducible nitric oxide synthase expression and the TGF-β/Smad signaling pathway
US20240261364A1 (en) Peptides and methods of using the same
Elsherbiny et al. ABT-702, an adenosine kinase inhibitor, attenuates inflammation in diabetic retinopathy
Wu et al. Recombinant adiponectin peptide promotes neuronal survival after intracerebral haemorrhage by suppressing mitochondrial and ATF4‐CHOP apoptosis pathways in diabetic mice via Smad3 signalling inhibition
Chen et al. Carbon monoxide ameliorates acetaminophen‐induced liver injury by increasing hepatic HO‐1 and Parkin expression
US20210008177A1 (en) Elapidae neurotoxin enhances opioid analgesic effect and inhibits opioid induced hyperalgesia and tolerance
Tamai et al. Caveolae in mesangial cells and caveolin expression in mesangial proliferative glomerulonephritis
Chen et al. Asiatic acid alleviates cisplatin-induced renal fibrosis in tumor-bearing mice by improving the TFEB-mediated autophagy-lysosome pathway
Yang et al. Resolvin D2 activates anti-inflammatory microglia via restoring autophagy flux and alleviate neuropathic pain following spinal cord injury in rats
Yang et al. Effect of Acer tegmentosum bark on atopic dermatitis-like skin lesions in NC/Nga mice
Lin et al. Peroxisome proliferator-activator receptor γ and psoriasis, molecular and cellular biochemistry
EP3257520B1 (en) Ostreolysin for use in the treatment of steatohepatitis
US20190216901A1 (en) Acth prophylactic treatment of renal disorders
Cao et al. Intracellular and extracellular Cyclophilin a promote cardiac fibrosis through TGF-β signaling in response to angiotensin Ⅱ
US20250161419A1 (en) Serpin peptides and methods of using the same
EP3967705A1 (en) Rvg derived peptides
Campo et al. High-molecular weight hyaluronan reduced renal PKC activation in genetically diabetic mice
US20230405070A1 (en) Plectranthus amboinicus extract for use in inhibiting immune responses
HK40118659A (zh) Serpin肽及其使用方法
US20250353898A1 (en) Serpin peptide derivatives and methods of using the same
Lee et al. Protective Effect of Delta-Like 1 Homolog against muscular atrophy in a mouse model
HK40121727A (zh) Serpin肽衍生物及其使用方法
WO2016011133A1 (en) A peptide therapy to counteract insulin resistance and type 2 diabetes
Chen et al. Etomidate protects against homocysteine-induced blood-brain barrier disruption via upregulation of Krüppel-like factor 2
KR102115557B1 (ko) 폐 섬유증의 예방 또는 치료용 약학적 조성물