AU2022394985A1 - Novel ionizable lipids and lipid nanoparticles and methods of using the same - Google Patents

Novel ionizable lipids and lipid nanoparticles and methods of using the same Download PDF

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AU2022394985A1
AU2022394985A1 AU2022394985A AU2022394985A AU2022394985A1 AU 2022394985 A1 AU2022394985 A1 AU 2022394985A1 AU 2022394985 A AU2022394985 A AU 2022394985A AU 2022394985 A AU2022394985 A AU 2022394985A AU 2022394985 A1 AU2022394985 A1 AU 2022394985A1
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lipid
compound
mol
branched
mmol
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Arijit ADHIKARI
Sanmit ADHIKARI
Alessandra Bartolozzi
Roman Bogorad
Roman Erdmann
Alaina HOWE
Siddharth Patel
John Proudfoot
Dominick SALERNO
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Sail Biomedicines Inc
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Sail Biomedicines Inc
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    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/16—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by carboxyl groups
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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AU2022394985A 2021-11-16 2022-11-16 Novel ionizable lipids and lipid nanoparticles and methods of using the same Pending AU2022394985A1 (en)

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JP7543259B2 (ja) 2018-10-18 2024-09-02 アクイタス セラピューティクス インコーポレイテッド 活性剤の脂質ナノ粒子送達のための脂質
WO2022016070A1 (en) 2020-07-16 2022-01-20 Acuitas Therapeutics, Inc. Cationic lipids for use in lipid nanoparticles
US12311033B2 (en) 2023-05-31 2025-05-27 Capstan Therapeutics, Inc. Lipid nanoparticle formulations and compositions
AU2024305510A1 (en) * 2023-06-16 2026-01-08 Acuitas Therapeutics, Inc. Amide containing lipids
CN117185942B (zh) * 2023-07-04 2025-09-12 清华大学 一种可用于靶向肺部递送广谱中和抗体的脂质纳米颗粒及其制备方法与应用
WO2025042786A1 (en) 2023-08-18 2025-02-27 Flagship Pioneering Innovations Vi, Llc Compositions comprising circular polyribonucleotides and uses thereof
WO2025143118A1 (ja) * 2023-12-27 2025-07-03 アステラス製薬株式会社 脊髄損傷の治療用医薬組成物及び脊髄損傷の非ヒト霊長類動物モデルの作製方法
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