AU2022339044A1 - Dosage regime - Google Patents
Dosage regime Download PDFInfo
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- AU2022339044A1 AU2022339044A1 AU2022339044A AU2022339044A AU2022339044A1 AU 2022339044 A1 AU2022339044 A1 AU 2022339044A1 AU 2022339044 A AU2022339044 A AU 2022339044A AU 2022339044 A AU2022339044 A AU 2022339044A AU 2022339044 A1 AU2022339044 A1 AU 2022339044A1
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- Australia
- Prior art keywords
- peg3
- carboxy
- aib
- isoglu
- compound
- Prior art date
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- 208000008589 Obesity Diseases 0.000 claims abstract description 73
- 235000020824 obesity Nutrition 0.000 claims abstract description 52
- 230000000694 effects Effects 0.000 claims abstract description 50
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- TWSALRJGPBVBQU-PKQQPRCHSA-N glucagon-like peptide 2 Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(O)=O)[C@@H](C)CC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)CC)C1=CC=CC=C1 TWSALRJGPBVBQU-PKQQPRCHSA-N 0.000 claims abstract description 43
- 101800000221 Glucagon-like peptide 2 Proteins 0.000 claims abstract description 40
- 150000001875 compounds Chemical class 0.000 claims abstract description 40
- 229940125542 dual agonist Drugs 0.000 claims description 253
- 101100353123 Rattus norvegicus Ppp1r15a gene Proteins 0.000 claims description 149
- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 99
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- 208000012696 congenital leptin deficiency Diseases 0.000 claims description 16
- 208000020694 gallbladder disease Diseases 0.000 claims description 16
- 208000001022 morbid obesity Diseases 0.000 claims description 16
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 claims description 15
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- ASGMFNBUXDJWJJ-JLCFBVMHSA-N (1R,3R)-3-[[3-bromo-1-[4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl]pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N,1-dimethylcyclopentane-1-carboxamide Chemical compound BrC1=NN(C2=NC(=NC=C21)N[C@H]1C[C@@](CC1)(C(=O)NC)C)C1=CC=C(C=C1)C=1SC(=NN=1)C ASGMFNBUXDJWJJ-JLCFBVMHSA-N 0.000 claims description 2
- UAOUIVVJBYDFKD-XKCDOFEDSA-N (1R,9R,10S,11R,12R,15S,18S,21R)-10,11,21-trihydroxy-8,8-dimethyl-14-methylidene-4-(prop-2-enylamino)-20-oxa-5-thia-3-azahexacyclo[9.7.2.112,15.01,9.02,6.012,18]henicosa-2(6),3-dien-13-one Chemical compound C([C@@H]1[C@@H](O)[C@@]23C(C1=C)=O)C[C@H]2[C@]12C(N=C(NCC=C)S4)=C4CC(C)(C)[C@H]1[C@H](O)[C@]3(O)OC2 UAOUIVVJBYDFKD-XKCDOFEDSA-N 0.000 claims description 2
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Landscapes
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| US6451987B1 (en) | 1999-03-15 | 2002-09-17 | Novo Nordisk A/S | Ion exchange chromatography of proteins and peptides |
| EP1956000B1 (en) | 1999-03-17 | 2016-10-05 | Novo Nordisk A/S | Acylating agents useful for acylating peptides |
| AU2017371516C1 (en) | 2016-12-09 | 2021-09-02 | Zealand Pharma A/S | Acylated GLP-1/GLP-2 dual agonists |
| WO2018104558A1 (en) * | 2016-12-09 | 2018-06-14 | Zealand Pharma A/S | Acylated glp-1/glp-2 dual agonists |
| JP2020500890A (ja) * | 2016-12-09 | 2020-01-16 | ジーランド・ファーマ・ア／エス | Ｇｌｐ−１／ｇｌｐ−２二重アゴニスト |
| BR112021020941A2 (pt) | 2019-06-14 | 2021-12-21 | Zealand Pharma As | Composição farmacêutica parenteral isotônica, método para melhoria da estabilidade química da dita composição e uso de manitol |
| EP4126003A1 (en) * | 2020-03-30 | 2023-02-08 | Zealand Pharma A/S | Glp-1/glp-2 dual agonists |
| TW202241491A (zh) * | 2020-12-16 | 2022-11-01 | 丹麥商西蘭製藥公司 | Ｇｌｐ－１／ｇｌｐ－２雙重促效劑之醫藥組合物 |
| JP7809117B2 (ja) * | 2020-12-16 | 2026-01-30 | ジーランド ファーマ エー／エス | Ｇｌｐ－１／ｇｌｐ－２デュアルアゴニストの医薬組成物 |
| TW202241492A (zh) * | 2020-12-16 | 2022-11-01 | 丹麥商西蘭製藥公司 | Ｇｌｐ－１／ｇｌｐ－２雙重促效劑之醫藥組合物 |
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2022
- 2022-09-02 AU AU2022339044A patent/AU2022339044A1/en active Pending
- 2022-09-02 IL IL311166A patent/IL311166A/en unknown
- 2022-09-02 EP EP22805777.4A patent/EP4392054A1/en active Pending
- 2022-09-02 JP JP2024513893A patent/JP2024533153A/ja active Pending
- 2022-09-02 US US18/688,026 patent/US20250073311A1/en active Pending
- 2022-09-02 CA CA3228429A patent/CA3228429A1/en active Pending
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- 2022-09-02 TW TW111133296A patent/TW202315882A/zh unknown
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2024
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| WO2023031380A9 (en) | 2024-02-22 |
| US20250073311A1 (en) | 2025-03-06 |
| EP4392054A1 (en) | 2024-07-03 |
| JP2024533153A (ja) | 2024-09-12 |
| KR20240058121A (ko) | 2024-05-03 |
| TW202315882A (zh) | 2023-04-16 |
| IL311166A (en) | 2024-04-01 |
| WO2023031380A1 (en) | 2023-03-09 |
| CA3228429A1 (en) | 2023-03-09 |
| MX2024002600A (es) | 2024-03-22 |
| CL2024000647A1 (es) | 2024-09-13 |
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