AU2022328401A1 - Gene editing systems comprising an rna guide targeting stathmin 2 (stmn2) and uses thereof - Google Patents
Gene editing systems comprising an rna guide targeting stathmin 2 (stmn2) and uses thereof Download PDFInfo
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- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C12N15/86—Viral vectors
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0684—Cells of the urinary tract or kidneys
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
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- C12N2800/00—Nucleic acids vectors
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163231784P | 2021-08-11 | 2021-08-11 | |
| US63/231,784 | 2021-08-11 | ||
| US202263322002P | 2022-03-21 | 2022-03-21 | |
| US63/322,002 | 2022-03-21 | ||
| PCT/US2022/040042 WO2023018858A1 (en) | 2021-08-11 | 2022-08-11 | Gene editing systems comprising an rna guide targeting stathmin 2 (stmn2) and uses thereof |
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| AU2022328401A1 true AU2022328401A1 (en) | 2024-02-22 |
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| Application Number | Title | Priority Date | Filing Date |
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| AU2022328401A Pending AU2022328401A1 (en) | 2021-08-11 | 2022-08-11 | Gene editing systems comprising an rna guide targeting stathmin 2 (stmn2) and uses thereof |
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|---|---|
| US (2) | US20230203539A1 (https=) |
| EP (1) | EP4384618A1 (https=) |
| JP (1) | JP2024529108A (https=) |
| KR (1) | KR20240052763A (https=) |
| AU (1) | AU2022328401A1 (https=) |
| CA (1) | CA3228487A1 (https=) |
| CO (1) | CO2024002315A2 (https=) |
| IL (1) | IL310616A (https=) |
| MX (1) | MX2024001878A (https=) |
| WO (1) | WO2023018858A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023205844A1 (en) * | 2022-04-26 | 2023-11-02 | Peter Maccallum Cancer Institute | Nucleic acids and uses thereof |
| KR20250151430A (ko) * | 2023-02-15 | 2025-10-21 | 아버 바이오테크놀로지스, 인크. | 스타스민 2(stmn2) 전사체에서 비정상적인 스플라이싱을 억제하는 유전자 편집 방법 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019178427A1 (en) | 2018-03-14 | 2019-09-19 | Arbor Biotechnologies, Inc. | Novel crispr dna targeting enzymes and systems |
| CA3126918A1 (en) * | 2019-01-14 | 2020-07-23 | President And Fellows Of Harvard College | Methods and compositions for restoring stmn2 levels |
| EP3976010A4 (en) * | 2019-06-03 | 2023-08-02 | Quralis Corporation | Oligonucleotides and methods of use for treating neurological diseases |
| CN121380024A (zh) | 2020-03-31 | 2026-01-23 | 阿伯生物技术公司 | 包含Cas12i2变体多肽的组合物及其用途 |
| CN115851665B (zh) * | 2021-05-27 | 2025-01-24 | 中国科学院动物研究所 | 工程化的Cas12i核酸酶及其效应蛋白以及用途 |
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2022
- 2022-08-11 US US17/885,876 patent/US20230203539A1/en not_active Abandoned
- 2022-08-11 CA CA3228487A patent/CA3228487A1/en active Pending
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- 2022-08-11 KR KR1020247007547A patent/KR20240052763A/ko active Pending
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- 2022-08-11 WO PCT/US2022/040042 patent/WO2023018858A1/en not_active Ceased
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2024
- 2024-02-27 CO CONC2024/0002315A patent/CO2024002315A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA3228487A1 (en) | 2023-02-16 |
| JP2024529108A (ja) | 2024-08-01 |
| CO2024002315A2 (es) | 2024-03-07 |
| WO2023018858A1 (en) | 2023-02-16 |
| US20250127924A1 (en) | 2025-04-24 |
| MX2024001878A (es) | 2024-02-29 |
| IL310616A (en) | 2024-04-01 |
| US20230203539A1 (en) | 2023-06-29 |
| KR20240052763A (ko) | 2024-04-23 |
| EP4384618A1 (en) | 2024-06-19 |
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