AU2022307875B2 - Crystalline forms of (s, e)-4-(dimethylamino)-n-(3-(4-(2-hydroxy-1-phenylethylamino)-6-phenylfuro[2,3-d]pyrimidin-5-yl)phenyl)but-2-enamide free base - Google Patents

Crystalline forms of (s, e)-4-(dimethylamino)-n-(3-(4-(2-hydroxy-1-phenylethylamino)-6-phenylfuro[2,3-d]pyrimidin-5-yl)phenyl)but-2-enamide free base Download PDF

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Publication number
AU2022307875B2
AU2022307875B2 AU2022307875A AU2022307875A AU2022307875B2 AU 2022307875 B2 AU2022307875 B2 AU 2022307875B2 AU 2022307875 A AU2022307875 A AU 2022307875A AU 2022307875 A AU2022307875 A AU 2022307875A AU 2022307875 B2 AU2022307875 B2 AU 2022307875B2
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crystalline form
abt
peak
free base
pharmaceutical composition
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AU2022307875A1 (en
Inventor
Sue-Ming Chang
Hsing-Pang Hsieh
Tsu-An Hsu
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Anbogen Therapeutics Inc
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Anbogen Therapeutics Inc
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Assigned to ANBOGEN THERAPEUTICS, INC. reassignment ANBOGEN THERAPEUTICS, INC. Request for Assignment Assignors: SHIH, CHUAN
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2022307875A 2021-07-06 2022-07-06 Crystalline forms of (s, e)-4-(dimethylamino)-n-(3-(4-(2-hydroxy-1-phenylethylamino)-6-phenylfuro[2,3-d]pyrimidin-5-yl)phenyl)but-2-enamide free base Active AU2022307875B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163218504P 2021-07-06 2021-07-06
US63/218,504 2021-07-06
PCT/US2022/036260 WO2023283269A1 (en) 2021-07-06 2022-07-06 Crystalline forms of (s, e)-4-(dimethylamino)-n-(3-(4-(2-hydroxy-1-phenylethylamino)-6-phenylfuro[2,3-d]pyrimidin-5-yl)phenyl)but-2-enamide free base

Publications (2)

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AU2022307875A1 AU2022307875A1 (en) 2023-11-02
AU2022307875B2 true AU2022307875B2 (en) 2024-08-01

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AU2022307875A Active AU2022307875B2 (en) 2021-07-06 2022-07-06 Crystalline forms of (s, e)-4-(dimethylamino)-n-(3-(4-(2-hydroxy-1-phenylethylamino)-6-phenylfuro[2,3-d]pyrimidin-5-yl)phenyl)but-2-enamide free base

Country Status (12)

Country Link
US (2) US12240858B2 (enExample)
EP (1) EP4330259A4 (enExample)
JP (1) JP7565118B2 (enExample)
KR (1) KR102783648B1 (enExample)
CN (1) CN116916922B (enExample)
AU (1) AU2022307875B2 (enExample)
BR (1) BR112023024853A2 (enExample)
CA (1) CA3217088A1 (enExample)
IL (1) IL308946B2 (enExample)
MX (1) MX2023013093A (enExample)
TW (1) TWI809967B (enExample)
WO (1) WO2023283269A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
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TWI906763B (zh) * 2024-02-05 2025-12-01 財團法人國家衛生研究院 表皮生長因子受體抑制劑

Family Cites Families (2)

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Publication number Priority date Publication date Assignee Title
US8507502B2 (en) * 2008-11-10 2013-08-13 National Health Research Institutes Fused bicyclic and tricyclic pyrimidine compounds as tyrosine kinase inhibitors
KR101301533B1 (ko) * 2010-02-09 2013-09-04 한미사이언스 주식회사 암세포 성장 억제 효과를 갖는 신규 피리미딘 유도체

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TW202309041A (zh) 2023-03-01
JP2024514995A (ja) 2024-04-04
US12240858B2 (en) 2025-03-04
IL308946A (en) 2024-01-01
KR102783648B1 (ko) 2025-03-18
IL308946B2 (en) 2026-01-01
CA3217088A1 (en) 2023-01-12
BR112023024853A2 (pt) 2024-02-15
CN116916922A (zh) 2023-10-20
TWI809967B (zh) 2023-07-21
WO2023283269A1 (en) 2023-01-12
AU2022307875A1 (en) 2023-11-02
CN116916922B (zh) 2026-01-02
US20230021909A1 (en) 2023-01-26
EP4330259A4 (en) 2024-10-09
KR20230118963A (ko) 2023-08-14
EP4330259A1 (en) 2024-03-06
JP7565118B2 (ja) 2024-10-10
IL308946B1 (en) 2025-09-01
US20240368175A1 (en) 2024-11-07
MX2023013093A (es) 2024-04-09

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Legal Events

Date Code Title Description
DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE INVENTION TITLE TO READ CRYSTALLINE FORMS OF (S, E)-4-(DIMETHYLAMINO)-N-(3-(4-(2-HYDROXY-1-PHENYLETHYLAMINO)-6-PHENYLFURO(2,3-D)PYRIMIDIN-5-YL)PHENYL)BUT-2-ENAMIDE FREE BASE

PC1 Assignment before grant (sect. 113)

Owner name: ANBOGEN THERAPEUTICS, INC.

Free format text: FORMER APPLICANT(S): SHIH, CHUAN

FGA Letters patent sealed or granted (standard patent)