AU2022298911A1 - Wound covering, for increasing the no concentration in wounds - Google Patents
Wound covering, for increasing the no concentration in wounds Download PDFInfo
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- AU2022298911A1 AU2022298911A1 AU2022298911A AU2022298911A AU2022298911A1 AU 2022298911 A1 AU2022298911 A1 AU 2022298911A1 AU 2022298911 A AU2022298911 A AU 2022298911A AU 2022298911 A AU2022298911 A AU 2022298911A AU 2022298911 A1 AU2022298911 A1 AU 2022298911A1
- Authority
- AU
- Australia
- Prior art keywords
- wound
- carbides
- minerals
- synthetic fibres
- wound dressing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010052428 Wound Diseases 0.000 title description 74
- 208000027418 Wounds and injury Diseases 0.000 title description 74
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims description 45
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 16
- 239000011707 mineral Substances 0.000 claims description 16
- 229920002994 synthetic fiber Polymers 0.000 claims description 16
- 239000000463 material Substances 0.000 claims description 15
- 150000001247 metal acetylides Chemical class 0.000 claims description 15
- 229920000297 Rayon Polymers 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 12
- 229920002334 Spandex Polymers 0.000 claims description 9
- 229920002678 cellulose Polymers 0.000 claims description 9
- 239000001913 cellulose Substances 0.000 claims description 9
- 229920000728 polyester Polymers 0.000 claims description 8
- 239000004698 Polyethylene Substances 0.000 claims description 7
- 239000000853 adhesive Substances 0.000 claims description 7
- 229920000642 polymer Polymers 0.000 claims description 7
- 239000004743 Polypropylene Substances 0.000 claims description 6
- 230000001070 adhesive effect Effects 0.000 claims description 6
- 239000002245 particle Substances 0.000 claims description 6
- 239000004759 spandex Substances 0.000 claims description 6
- 239000004814 polyurethane Substances 0.000 claims description 5
- 239000004952 Polyamide Substances 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 229920002647 polyamide Polymers 0.000 claims description 4
- 239000005020 polyethylene terephthalate Substances 0.000 claims description 4
- 239000004677 Nylon Substances 0.000 claims description 3
- 150000001242 acetic acid derivatives Chemical class 0.000 claims description 3
- 150000001252 acrylic acid derivatives Chemical class 0.000 claims description 3
- 229920001778 nylon Polymers 0.000 claims description 3
- 239000002964 rayon Substances 0.000 claims description 3
- 235000017166 Bambusa arundinacea Nutrition 0.000 claims description 2
- 235000017491 Bambusa tulda Nutrition 0.000 claims description 2
- 235000015334 Phyllostachys viridis Nutrition 0.000 claims description 2
- 239000011425 bamboo Substances 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
- 235000010469 Glycine max Nutrition 0.000 claims 1
- 244000068988 Glycine max Species 0.000 claims 1
- 244000082204 Phyllostachys viridis Species 0.000 claims 1
- 229910052681 coesite Inorganic materials 0.000 claims 1
- 229910052906 cristobalite Inorganic materials 0.000 claims 1
- 239000000377 silicon dioxide Substances 0.000 claims 1
- 235000012239 silicon dioxide Nutrition 0.000 claims 1
- 229910052682 stishovite Inorganic materials 0.000 claims 1
- 229910052905 tridymite Inorganic materials 0.000 claims 1
- 239000002023 wood Substances 0.000 claims 1
- 239000010410 layer Substances 0.000 description 18
- 230000029663 wound healing Effects 0.000 description 12
- 239000012876 carrier material Substances 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 8
- 230000008569 process Effects 0.000 description 8
- 239000013543 active substance Substances 0.000 description 7
- -1 polyethylene Polymers 0.000 description 7
- 230000000845 anti-microbial effect Effects 0.000 description 6
- 239000002759 woven fabric Substances 0.000 description 5
- 229920000742 Cotton Polymers 0.000 description 4
- MCMNRKCIXSYSNV-UHFFFAOYSA-N Zirconium dioxide Chemical compound O=[Zr]=O MCMNRKCIXSYSNV-UHFFFAOYSA-N 0.000 description 4
- 239000004745 nonwoven fabric Substances 0.000 description 4
- 239000011505 plaster Substances 0.000 description 4
- 229920000747 poly(lactic acid) Polymers 0.000 description 4
- 229920000573 polyethylene Polymers 0.000 description 4
- 230000005855 radiation Effects 0.000 description 4
- 230000017531 blood circulation Effects 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000005670 electromagnetic radiation Effects 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 239000005014 poly(hydroxyalkanoate) Substances 0.000 description 2
- 229920000139 polyethylene terephthalate Polymers 0.000 description 2
- 229920000903 polyhydroxyalkanoate Polymers 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 229920002635 polyurethane Polymers 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 241000588626 Acinetobacter baumannii Species 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 241001330002 Bambuseae Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000282414 Homo sapiens Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 241000588747 Klebsiella pneumoniae Species 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 description 1
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 229910010413 TiO 2 Inorganic materials 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000012790 adhesive layer Substances 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 238000000137 annealing Methods 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000003490 calendering Methods 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000003851 corona treatment Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- ZRALSGWEFCBTJO-UHFFFAOYSA-N guanidine group Chemical group NC(=N)N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000004922 lacquer Substances 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 229940127554 medical product Drugs 0.000 description 1
- 229960003085 meticillin Drugs 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 238000009832 plasma treatment Methods 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920006264 polyurethane film Polymers 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 238000006479 redox reaction Methods 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
Description
Wound covering, for increasing the nitric oxide concentration in wounds
The present invention discloses a wound covering and a method for increasing the nitric oxide concentration in a wound by means of a wound covering that contains fibres in which a percentage of particulate minerals and/or carbides is embedded.
Plasters are medical products that are applied to a wound and close the wound. The main purpose of a plaster is to prevent dirt and bacteria from entering the body, as well as to support the natural wound healing process.
A wound covering, commonly called a plaster, conventionally consists of a carrier that carries a wound dressing that forms the wound contact layer. The carrier is usually attached to the surface of the body via an applied skin-compatible adhesive, wherein the wound contact layer comes to lie over the wound to be covered. It is likewise possible to configure the wound covering to not be self-adhesive and to affix it on/over the wound by means of bandages.
The wound contact layer is usually the part of a wound covering that interacts with the wound. It is the part (surface area) of the wound dressing that faces the wound. Its function is to prevent, for example, fibres from the wound dressing from entering the wound or the carrier from sticking to the wound. The wound contact layer can consist of different materials, however polyethylene, polylactide, viscose nonwoven fabrics are conventionally used.
Due to the direct exchange with the body, it is advantageous if the wound contact layer has a high biocompatibility, as this avoids possible additional inflammatory processes and allergic reactions, resulting in a better wound healing process.
There are numerous terms for biocompatibility. In the context of the present invention, biocompatibility means: The ability of a material to perform its intended function (in this case, to aid the wound healing process) without causing undesirable local or systemic effects. The biocompatibility of a material depends not only on its intrinsic material properties (hydrophilicity, charge, mechanical properties, etc.), but rather also on the environment (site of use) and desired function. One possible way to improve the biocompatibility of a material is to change its surface.
Antimicrobial active agents have been known to persons skilled in the art for a long time. Basically, all substances above a certain concentration have a cell-damaging effect and thus also an antimicrobial effect against microbes (for example, bacteria, fungi). Antimicrobial active agents are characterized by the fact that the cell-damaging effect against microbes is greater than against the cells of a higher organism (human, mammal, fish, etc.).
A substance of great interest for wound healing, which not only promotes wound healing but also has antimicrobial properties, is nitric oxide (NO).
Nitric oxide is therefore known to contribute positively to wound healing through several mechanisms of action: - nitric oxide promotes angiogenesis: the blood vessels are their new formation is promoted. - nitric oxide has an anti-inflammatory effect: the immune system is stimulated. - nitric oxide has an antimicrobial effect: for example, against Pseudomonas aeruginosa, Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae and Staphylococcus aureus (including Methicillin-resistant Staphylococcus aureus (MRSA) species).
By increasing nitric oxide production in the wound, blood circulation to the wound is also increased, which increases the oxygen content of the wound and effectively accelerates wound healing (Reference: https://doi.orq/10.1016/s0076-6879(05)96048-5, https://doi.orq/10.1038/s41598-017-11567-5 and https://doi.org/10.1016/j.niox.2009.10.006)
Plaster systems that release nitric oxide and thereby contribute to wound healing are already known from W02014188174A. Herein, the plaster system releases nitric oxide formed by redox reactions into the wound, resulting in a costly and complex product construction.
Natural minerals and carbides are known to reflect, to absorb, to emit electromagnetic radiation, to lead to interaction of wavelengths (shifting, amplification, extinction of wavelengths) as well as to polarization. Particularly preferred are minerals and carbides in the form of particles because they exhibit a particularly high surface energy. Particularly interesting is the shape and size of the particles, as these can effectively influence the effectiveness, for example, through the anisotropic influence of the particle shape.
Among the best known naturally occurring minerals are SiC, Si 2, CaC 2, TiO 2 , ZrO2 as well as A12 0 3 .
It is the task of the invention to provide a cost-effective wound covering that can increase the nitric oxide content in the wound by utilizing ambient radiation, in particular light and body heat.
The task is solved by means of a wound covering comprising - a carrier layer, - a wound dressing which is fixed on the carrier layer and which forms the wound contact layer with its free surface, - wherein the wound dressing has a content of synthetic fibres, - wherein a percentage of particulate minerals and/or carbides is embedded in the synthetic fibres, - wherein the fibres consist 90 - 99% by weight, based on the total weight of the synthetic fibres, of a polymer or mixtures of polymers from the group consisting of acrylates, acetates, elastanes (in particular, lycra, spandex), polyesters, polyamides (in particular, nylon), viscose (in particular, rayon), PU, PE, PET, PP, cellulose or semi-cellulose materials, - wherein the content of minerals and/or carbides is 1 - 10% by weight based on the total weight of the synthetic fibres, and - wherein the maximum particle size of the minerals and/or carbides is less than 1.5 mm, and - optionally an adhesive applied to the carrier layer for fixing the wound dressing to the carrier and/or fixing the wound covering to the skin.
The present invention offers the advantage that the heat of one's own body is used to increase nitric oxide production within the wound.
Traditionally, nitric oxide is produced enzymatically in wounds by macrophages and fibroblasts. In this process, nitric oxide can be produced from the guanidine group in arginine in an oxidative process. An alternative to this biologically internal process is the production of nitric oxide by radiation. For this purpose, nitrite-rich compounds are photolytically converted to nitric oxide on the skin. This too is a natural process and can be produced by UV-A radiation, nevertheless exposing wounds to UV can be counterproductive as it can often lead to scarring.
To circumvent this problem and at the same time to take advantage of the beneficial properties of nitric oxide, wound coverings according to the invention can be used to promote the self production of nitric oxide in the covered wound.
For this purpose, wound coverings according to the invention can be used, which wound coverings comprise a content of fibres that enable the absorption and reflection of electromagnetic radiation. Such fibres are known from WO 2020150493 Al. As a result, the UV-A rays are converted into other wavelengths and replaced by wavelengths in the NIR or FIR range, which promote the nitric oxide production of one's own body.
In another embodiment of the invention, the wound covering used in a wound dressing according to the invention is doped with minerals and/or carbides, in particular with SiC, Si 2 , CaC 2 , Ti 2
, ZrO2 and/or A12 0 3 , by embedding them in the intermediate spaces of the wound dressing, in the form of a lacquer layer that was applied to the wound dressing, or by incorporating them into the respective material of the wound contact layer.
A subject matter of a further invention is a method for increasing the nitric oxide concentration in a wound by means of a wound covering comprising: - a carrier layer, - a wound dressing which is fixed on the carrier layer and forms the wound contact layer with its free surface, - wherein the wound dressing comprises a content of SiC, Si 2 , CaC 2 , Ti 2 , ZrO 2
and/or A1 2 0 3 , and - optionally, an adhesive applied to the carrier layer. wherein the wound is covered with the wound covering.
The wound dressing in a wound covering according to the invention preferably has a special wound contact layer,
- which is characterized by biodegradability and high biocompatibility and/or - comprises a wound contact layer with anti-inflammatory properties and/or - comprises a wound contact layer with bacteriostatic properties.
According to the invention, it is advantageous to use a carrier system that is both breathable and provides a semi-occlusive barrier for moist wound healing.
A wound dressing according to the invention which promotes wound healing causes a favourable environment for wound healing by physical processes, increases blood circulation to the wound environment, increases the oxygen content of the wound by the release or production of nitric oxide using (body) heat radiation.
The nitric oxide release within a wound ensures better blood circulation thereof whereby faster healing is favoured.
In principle, all rigid, flexible and elastic sheet materials made of synthetic and natural raw materials are suitable as carrier materials. Examples include textiles such as woven fabrics, knitted fabrics, scrim or nonwoven fabrics, as well as meshes, films, foams and laminates made from the afore-listed materials, as well as papers.
Preferably, the carrier material is a film, a woven fabric or a nonwoven fabric, particularly preferably with a thickness of between 20 pm and 200 pm, especially with a grammage of 20 to 200
In principle, both natural and synthetic carrier materials come under consideration. The carrier material is preferably selected from the group consisting of cotton, viscose, polypropylenes, polyesters, polyamides, PET, PVC, polyethylenes, polyurethanes, silicones and polylactic acids. The carrier material is preferably selected from the group consisting of cotton, viscose, polyesters, polyethylenes and polyurethanes. 2 g/m .
Particularly preferably, the carrier material is a polyurethane film, a polyethylene film, a polyester nonwoven, a woven fabric of viscose, polyester or cotton, or a woven fabric of any mixture of viscose, polyester and/or cotton.
The carrier material preferably has an adhesive layer that is permeable to air and water vapor, but is impermeable to water, and having a thickness of approximately 10 pm to 200 pm.
Carrier materials are preferably those that can be used in such a way after application of the adhesive that they meet the requirements for a functionally suitable skin overlay.
Preferably, these materials can be pre-treated or alternatively subsequently treated. Common pre treatments are plasma treatment or alternatively corona treatment and hydrophobic finishing; common post-treatments are calendering, annealing, laminating, die-cutting, capping and sterilization.
The wound dressing may comprise a substrate for absorbing wound exudate.
Suitable materials for wound dressings are viscose fibres, these viscose fibres can be cellulose, bamboo and similar materials. Other suitable polymers for the manufacture of wound dressings are PLA (polylactide), PHA (polyhydroxyalkanoate) as well as PP (polypropylene).
Different encapsulated active agents can also be incorporated into the wound dressings, wherein the active agents additionally promote wound healing. In particular, antimicrobial active agents, wound healing-promoting active agents and pain-relieving active agents are advantageous.
The synthetic fibres used in wound coverings according to the invention are preferably produced by common manufacturing methods (extrusion, spinning), for which purpose the main fibre material is dissolved in suitable ionic solvents and said solution is admixed with minerals and/or carbides. These resulting suspensions are spun or extruded, wherein the synthetic fibre to be used according to the invention is obtained.
These synthetic fibres can be processed into the wound dressing according to the invention as a woven fabric or a fibrous web (in particular, nonwoven fabric).
Claims (4)
- ClaimsWound covering comprising - a carrier layer, - a wound dressing which is fixed on the carrier layer and forms the wound contact layer with its free surface, - wherein the wound dressing has a content of synthetic fibres, - wherein a percentage of particulate minerals and/or carbides is embedded in the synthetic fibres, - wherein the fibres consist 90 - 99% by weight, based on the total weight of the synthetic fibres, of a polymer or mixtures of polymers from the group consisting of acrylates, acetates, elastanes (in particular, lycra, spandex), polyesters, polyamides (in particular, nylon), viscose (in particular, rayon), PU, PE, PET, PP, cellulose or semi-cellulose materials, - wherein the content of minerals and/or carbides is 1 - 10% by weight based on the total weight of the synthetic fibres, and - wherein the maximum particle size of the minerals and/or carbides is less than 1.5 mm, and - optionally an adhesive applied to the carrier layer for fixing the wound dressing to the carrier and/or fixing the wound covering to the skin.
- 2. Method for increasing the nitric oxide concentration in a wound by means of a wound covering comprising: - a carrier layer, - a wound dressing which is fixed on the carrier layer and forms the wound contact layer with its free surface, - wherein the wound dressing has a content of synthetic fibres, - wherein a percentage of particulate minerals and/or carbides is embedded in the synthetic fibres, - wherein the fibres consist 90 - 99% by weight, based on the total weight of the synthetic fibres, of a polymer or mixtures of polymers from the group consisting of acrylates, acetates, elastanes (in particular, lycra, spandex), polyesters, polyamides (in particular, nylon), viscose (in particular, rayon), PU, PE, PET, PP, cellulose or semi-cellulose materials, - wherein the content of minerals and/or carbides is 1 - 10% by weight based on the total weight of the synthetic fibres, and - wherein the maximum particle size of the minerals and/or carbides is less than 1.5 mm, and - optionally an adhesive applied to the carrier layer for fixing the wound dressing to the carrier and/or fixing the wound covering to the skin, wherein the wound is covered by the wound covering.
- 3. Wound dressing according to claim 1 or method according to claim 2, characterized in that the cellulose or semi-cellulose of the synthetic fibres were produced from renewable raw materials, in particular bamboo, soya, wood or sugar.
- 4. Wound dressing according to at least one of the preceding claims, characterized in that the fibres comprise one or a plurality of natural, in particular minerals and/or carbides from the group SiC, SiO2, CaC 2, T0 2 , ZrO 2 as well as A1 2 03 .
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102021206439 | 2021-06-23 | ||
| DE102021206439.6 | 2021-06-23 | ||
| PCT/EP2022/057520 WO2022268368A1 (en) | 2021-06-23 | 2022-03-22 | Wound covering, for increasing the no concentration in wounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2022298911A1 true AU2022298911A1 (en) | 2023-09-28 |
Family
ID=81306740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2022298911A Pending AU2022298911A1 (en) | 2021-06-23 | 2022-03-22 | Wound covering, for increasing the no concentration in wounds |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP4359019A1 (en) |
| AU (1) | AU2022298911A1 (en) |
| DE (1) | DE112022003204A5 (en) |
| WO (2) | WO2022268368A1 (en) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1049941C (en) * | 1996-12-10 | 2000-03-01 | 珠海经济特区天年高科技国际企业公司 | Medical nonwoven fabrics contg. inorganic oxides composites powder |
| AU2003220481B2 (en) * | 2002-03-22 | 2007-11-22 | David D. Horinek | Polymeric fiber composition and method |
| FR2990855B1 (en) * | 2012-05-22 | 2014-05-30 | Rhodia Poliamida E Especialidades Ltda | USE OF A COMPOSITION CONTAINING A POLYMER AND MINERAL LOADS TO COMBAT SKIN AGING |
| ES2629283T3 (en) * | 2012-06-18 | 2017-08-08 | Rhodia Poliamida E Especialidades Ltda | Polymeric composition containing mineral fillers, to improve skin healing |
| GB201309091D0 (en) | 2013-05-20 | 2013-07-03 | Edixomed Ltd | Dressing system |
| WO2020150493A1 (en) | 2019-01-16 | 2020-07-23 | Hologenix, Llc | Cellulose and semi-cellulose based fibers and yarns embedded with mineral particles and methods of making the same |
-
2022
- 2022-03-22 WO PCT/EP2022/057520 patent/WO2022268368A1/en active Application Filing
- 2022-03-22 DE DE112022003204.9T patent/DE112022003204A5/en active Pending
- 2022-03-22 EP EP22716081.9A patent/EP4359019A1/en active Pending
- 2022-03-22 AU AU2022298911A patent/AU2022298911A1/en active Pending
- 2022-03-22 WO PCT/EP2022/057524 patent/WO2022268369A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| EP4359019A1 (en) | 2024-05-01 |
| DE112022003204A5 (en) | 2024-04-25 |
| WO2022268368A1 (en) | 2022-12-29 |
| WO2022268369A1 (en) | 2022-12-29 |
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