AU2022294860A1 - Idh mutant inhibitor and use thereof - Google Patents

Idh mutant inhibitor and use thereof Download PDF

Info

Publication number
AU2022294860A1
AU2022294860A1 AU2022294860A AU2022294860A AU2022294860A1 AU 2022294860 A1 AU2022294860 A1 AU 2022294860A1 AU 2022294860 A AU2022294860 A AU 2022294860A AU 2022294860 A AU2022294860 A AU 2022294860A AU 2022294860 A1 AU2022294860 A1 AU 2022294860A1
Authority
AU
Australia
Prior art keywords
compound
general formula
pharmaceutically acceptable
acceptable salt
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
AU2022294860A
Other languages
English (en)
Inventor
Houxing Fan
Lihui QIAN
Yuli Xie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wigen Biomedicine Technology Shanghai Co Ltd
Original Assignee
Wigen Biomedicine Technology Shanghai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wigen Biomedicine Technology Shanghai Co Ltd filed Critical Wigen Biomedicine Technology Shanghai Co Ltd
Publication of AU2022294860A1 publication Critical patent/AU2022294860A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2022294860A 2021-06-15 2022-06-15 Idh mutant inhibitor and use thereof Pending AU2022294860A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN202110661394.5 2021-06-15
CN202110661394 2021-06-15
PCT/CN2022/099018 WO2022262784A1 (zh) 2021-06-15 2022-06-15 Idh突变体抑制剂及其用途

Publications (1)

Publication Number Publication Date
AU2022294860A1 true AU2022294860A1 (en) 2024-01-25

Family

ID=84526875

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2022294860A Pending AU2022294860A1 (en) 2021-06-15 2022-06-15 Idh mutant inhibitor and use thereof

Country Status (10)

Country Link
US (1) US20240208978A1 (https=)
EP (1) EP4356914A4 (https=)
JP (1) JP2024524933A (https=)
KR (1) KR20240021774A (https=)
CN (1) CN117460512A (https=)
AU (1) AU2022294860A1 (https=)
BR (1) BR112023024454A2 (https=)
CA (1) CA3217608A1 (https=)
MX (1) MX2023013664A (https=)
WO (1) WO2022262784A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2026035776A1 (en) * 2024-08-05 2026-02-12 Frontier Medicines Corporation Pi3k-alpha binding compounds and uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012184205A (ja) * 2011-03-08 2012-09-27 Dainippon Sumitomo Pharma Co Ltd ２−アミノ置換８−オキソジヒドロプリン誘導体
PL2900675T3 (pl) * 2012-09-28 2019-08-30 Takeda Pharmaceutical Company Limited Sposób wytwarzania pochodnej tienopirymidyny
JP6387360B2 (ja) * 2013-03-14 2018-09-05 ノバルティス アーゲー 変異ｉｄｈの阻害薬としての３−ピリミジン−４−イル−オキサゾリジン−２−オン
MA46064B1 (fr) * 2014-09-19 2020-04-30 Forma Therapeutics Inc Dérivés de pyridin-2-(1h)-one-quinolinone en tant qu'inhibiteurs d'isocitrate déshydrogénase
US9624175B2 (en) * 2015-04-21 2017-04-18 Forma Therapeutics, Inc. Fused-bicyclic aryl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors
ES2764523T3 (es) * 2015-07-27 2020-06-03 Lilly Co Eli Compuestos de 7-feniletilamino-4H-pirimido[4,5-D][1,3]oxazin-2-ona y su uso como inhibidores de IDH1 mutantes
CN109311863B (zh) 2016-06-06 2021-10-29 伊莱利利公司 突变型idh1抑制剂
CN107556366B (zh) * 2016-06-30 2025-02-07 上海海和药物研究开发股份有限公司 具有突变型异柠檬酸脱氢酶抑制活性的化合物、其制备方法及用途
KR102232614B1 (ko) * 2016-07-21 2021-03-29 난징 산홈 팔마세우티칼 컴퍼니 리미티드 이소시트레이트 탈수소효소 억제제의 화학적 화합물 및 이의 적용
ES2941631T3 (es) 2016-12-16 2023-05-24 Lilly Co Eli Compuestos de Pirido[4,3-d][1,3]oxazin-2-ona como inhibidores de IDH1 e IDH2 mutantes
CN110872297B (zh) * 2018-09-04 2023-02-14 上海再极医药科技有限公司 氨基嘧啶并五元杂环化合物、其中间体、制备方法、药物组合物及应用
WO2020141439A1 (en) * 2018-12-31 2020-07-09 Integral Biosciences Private Limited Heterocyclic compounds as mutant idh inhibitors

Also Published As

Publication number Publication date
KR20240021774A (ko) 2024-02-19
JP2024524933A (ja) 2024-07-09
CN117460512A (zh) 2024-01-26
WO2022262784A1 (zh) 2022-12-22
US20240208978A1 (en) 2024-06-27
CA3217608A1 (en) 2022-12-22
EP4356914A1 (en) 2024-04-24
MX2023013664A (es) 2024-01-08
BR112023024454A2 (pt) 2024-02-06
EP4356914A4 (en) 2025-01-08

Similar Documents

Publication Publication Date Title
JP7773987B2 (ja) スピロ環含有キナゾリン化合物
CA3213029A1 (en) Parp inhibitor containing piperazine structure, preparation method therefor and pharmaceutical use thereof
AU2020350745A1 (en) Fused pyridone compound, and preparation method therefor and use thereof
CA3227336A1 (en) Naphthyridine derivative as atr inhibitor and method for preparing same
CN114901661A (zh) 新型K-Ras G12C抑制剂
EP4495113A1 (en) Kif18a inhibitor
CN115315427B (zh) Hpk1抑制剂及其制备方法和用途
JP2024540511A (ja) Ｅｇｆｒタンパク質分解用化合物及びその使用
JP7796674B2 (ja) Ｗｅｅ－１阻害剤としてのピラゾロ［３，４－ｄ］ピリミジン－３－オン誘導体
CN113045570A (zh) 含螺环的喹唑啉化合物
AU2022294860A1 (en) Idh mutant inhibitor and use thereof
IL312179A (en) A compound containing pyridyl
RU2860311C2 (ru) Ингибитор мутанта idh и его применение
CN115768775B (zh) Idh突变体抑制剂及其用途
CN117986269A (zh) 喜树碱衍生物及其制备方法和应用
US12577250B2 (en) 1,2,4-triazolone derivative as DHODH inhibitor, and preparation method therefor and use thereof
CN113582988B (zh) 吡啶并环类化合物及其医药用途
EP4488263A2 (en) Phenylurea derivative and pharmaceutical use thereof
CN116249702B (zh) 用作dhodh抑制剂的1,2,4-三唑酮衍生物
EP4488267A1 (en) Histamine h3 receptor antagonist and medical use thereof
HK40121805A (en) Histamine h3 receptor antagonist and medical use thereof
EP4332104A1 (en) Fused ring compound as wee-1 inhibitor, and preparation method therefor and use thereof
US20240308992A1 (en) Drak2 inhibitor, and preparation method therefor and use thereof
HK40111379A (en) Pyridyl-containing compound
HK40009163A (en) Magl inhibitors