AU2022266780A1 - Multimerization of binding molecules having an antibody constant region variant - Google Patents

Multimerization of binding molecules having an antibody constant region variant Download PDF

Info

Publication number
AU2022266780A1
AU2022266780A1 AU2022266780A AU2022266780A AU2022266780A1 AU 2022266780 A1 AU2022266780 A1 AU 2022266780A1 AU 2022266780 A AU2022266780 A AU 2022266780A AU 2022266780 A AU2022266780 A AU 2022266780A AU 2022266780 A1 AU2022266780 A1 AU 2022266780A1
Authority
AU
Australia
Prior art keywords
antigen
molecule
igg
human
region
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2022266780A
Other languages
English (en)
Other versions
AU2022266780A9 (en
Inventor
Rujin CHENG
Bin Fan
Simon HANSEN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NGM Biopharmaceuticals Inc
Original Assignee
NGM Biopharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NGM Biopharmaceuticals Inc filed Critical NGM Biopharmaceuticals Inc
Publication of AU2022266780A1 publication Critical patent/AU2022266780A1/en
Publication of AU2022266780A9 publication Critical patent/AU2022266780A9/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2022266780A 2021-04-28 2022-04-27 Multimerization of binding molecules having an antibody constant region variant Abandoned AU2022266780A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163180969P 2021-04-28 2021-04-28
US63/180,969 2021-04-28
PCT/US2022/026505 WO2022232246A1 (en) 2021-04-28 2022-04-27 Multimerization of binding molecules having an antibody constant region variant

Publications (2)

Publication Number Publication Date
AU2022266780A1 true AU2022266780A1 (en) 2023-11-09
AU2022266780A9 AU2022266780A9 (en) 2023-11-16

Family

ID=83847261

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2022266780A Abandoned AU2022266780A1 (en) 2021-04-28 2022-04-27 Multimerization of binding molecules having an antibody constant region variant

Country Status (7)

Country Link
US (1) US20240209116A1 (https=)
EP (1) EP4330277A4 (https=)
JP (1) JP2024516392A (https=)
CN (2) CN117255800A (https=)
AU (1) AU2022266780A1 (https=)
CA (1) CA3216755A1 (https=)
WO (1) WO2022232246A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4206226A4 (en) * 2020-08-31 2024-10-16 Medytox Inc. Anti-vegf hexameric antibody and composition comprising same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6509724B2 (ja) * 2012-04-20 2019-05-08 アプティーボ リサーチ アンド デベロップメント エルエルシー Ｃｄ３結合ポリペプチド
CN104736174B (zh) * 2012-07-06 2019-06-14 根马布私人有限公司 具有三重突变的二聚体蛋白质
JP2015524821A (ja) * 2012-08-02 2015-08-27 ジェイエヌ バイオサイエンシーズ エルエルシー システイン変異及びμ尾部を介して多量体化した抗体又は融合タンパク質
JP6685924B2 (ja) * 2014-04-11 2020-04-22 メディミューン，エルエルシー システイン操作抗体を含むコンジュゲート化合物
KR20180002653A (ko) * 2015-04-07 2018-01-08 제넨테크, 인크. 효능작용 활성을 갖는 항원 결합 복합체 및 사용 방법

Also Published As

Publication number Publication date
CN118359707A (zh) 2024-07-19
WO2022232246A1 (en) 2022-11-03
US20240209116A1 (en) 2024-06-27
AU2022266780A9 (en) 2023-11-16
EP4330277A1 (en) 2024-03-06
JP2024516392A (ja) 2024-04-15
CN117255800A (zh) 2023-12-19
EP4330277A4 (en) 2025-03-26
CA3216755A1 (en) 2022-11-03

Similar Documents

Publication Publication Date Title
AU2020414932B2 (en) Claudin18.2 binding moieties and uses thereof
US20180289802A1 (en) Formulations comprising pd-1 binding proteins and methods of making thereof
CA3186065A1 (en) Cd19 binding molecules and uses thereof
US20240182582A1 (en) Materials and methods for immune effector cells redirection
US20250230254A1 (en) Biosynthetic bioparatopic or bispecific binding molecules with enhanced effector functions
US20250011454A1 (en) Biosynthetic monovalent binding molecules with enhanced effector functions
US20240209116A1 (en) Multimerization of binding molecules having an antibody constant region variant
IL303610A (en) GUCY2C binding molecules and their uses
WO2023240067A2 (en) Multimerization of binding molecules having an antibody constant region variant and mutations that reduce effector functions
US20240218083A1 (en) Molecules with engineered antibody constant region variants
EP4294846A1 (en) Materials and methods for targeting regulatory t cells for enhancing immune surveillance
CN117545505A (zh) 具有工程化抗体恒定区变体的分子
EP4554969A1 (en) Material and methods for improved bioengineered pairing of antigen-binding variable regions
CN121909215A (zh) 抗acvr2b抗体及其用途

Legal Events

Date Code Title Description
SREP Specification republished