AU2022251843B2 - <i>A PI3K-DELTA INHIBITOR FOR USE IN TREATMENT REGIMENS</i> - Google Patents
<i>A PI3K-DELTA INHIBITOR FOR USE IN TREATMENT REGIMENS</i>Info
- Publication number
- AU2022251843B2 AU2022251843B2 AU2022251843A AU2022251843A AU2022251843B2 AU 2022251843 B2 AU2022251843 B2 AU 2022251843B2 AU 2022251843 A AU2022251843 A AU 2022251843A AU 2022251843 A AU2022251843 A AU 2022251843A AU 2022251843 B2 AU2022251843 B2 AU 2022251843B2
- Authority
- AU
- Australia
- Prior art keywords
- salt
- compound
- formula
- cancer
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/485—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Inorganic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicinal Preparation (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB2104416.9A GB202104416D0 (en) | 2021-03-29 | 2021-03-29 | Treatment reginmens |
| GB2104416.9 | 2021-03-29 | ||
| GBGB2117511.2A GB202117511D0 (en) | 2021-12-03 | 2021-12-03 | Treatment regimens |
| GB2117511.2 | 2021-12-03 | ||
| PCT/EP2022/058283 WO2022207646A1 (en) | 2021-03-29 | 2022-03-29 | A pi3k-delta inhibitor for use in treatment regimens |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2022251843A1 AU2022251843A1 (en) | 2023-10-05 |
| AU2022251843B2 true AU2022251843B2 (en) | 2026-04-09 |
Family
ID=81388915
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2022251843A Active AU2022251843B2 (en) | 2021-03-29 | 2022-03-29 | <i>A PI3K-DELTA INHIBITOR FOR USE IN TREATMENT REGIMENS</i> |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US12605389B2 (https=) |
| EP (1) | EP4313058B1 (https=) |
| JP (1) | JP7839803B2 (https=) |
| AU (1) | AU2022251843B2 (https=) |
| CA (1) | CA3212731A1 (https=) |
| DK (1) | DK4313058T3 (https=) |
| ES (1) | ES3031295T3 (https=) |
| FI (1) | FI4313058T3 (https=) |
| HR (1) | HRP20250516T1 (https=) |
| HU (1) | HUE071610T2 (https=) |
| LT (1) | LT4313058T (https=) |
| MX (1) | MX2023011442A (https=) |
| PL (1) | PL4313058T3 (https=) |
| PT (1) | PT4313058T (https=) |
| RS (1) | RS66754B1 (https=) |
| SI (1) | SI4313058T1 (https=) |
| WO (1) | WO2022207646A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2026510567A (ja) * | 2023-03-03 | 2026-04-08 | アイオンクチュラ・ソシエテ・アノニム | 血液悪性腫瘍の治療におけるロギノリシブ及びｂｃｌ－２阻害剤の組み合わせ |
| AU2024231699A1 (en) * | 2023-03-03 | 2025-09-11 | Ionctura Sa | Combination of roginolisib and hdac inhibitor in the treatment of haematological malignancy |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011058149A1 (en) * | 2009-11-13 | 2011-05-19 | Merck Serono S.A. | Tricyclic pyrazol amine derivatives |
| WO2014121901A1 (en) * | 2013-02-07 | 2014-08-14 | Merck Patent Gmbh | Polymorphic forms |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9986723B2 (en) | 2014-10-22 | 2018-06-05 | The Board Of Regents Of The University Of Texas System | Screen and use of therapeutics for pancreatic ductal adenocarcinoma |
| GB201502020D0 (en) | 2015-02-06 | 2015-03-25 | Cancer Rec Tech Ltd | Autotaxin inhibitory compounds |
| EP3610264A1 (en) | 2017-04-13 | 2020-02-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the diagnosis and treatment of pancreatic ductal adenocarcinoma |
-
2022
- 2022-03-29 WO PCT/EP2022/058283 patent/WO2022207646A1/en not_active Ceased
- 2022-03-29 CA CA3212731A patent/CA3212731A1/en active Pending
- 2022-03-29 AU AU2022251843A patent/AU2022251843B2/en active Active
- 2022-03-29 MX MX2023011442A patent/MX2023011442A/es unknown
- 2022-03-29 HR HRP20250516TT patent/HRP20250516T1/hr unknown
- 2022-03-29 PT PT227192663T patent/PT4313058T/pt unknown
- 2022-03-29 EP EP22719266.3A patent/EP4313058B1/en active Active
- 2022-03-29 DK DK22719266.3T patent/DK4313058T3/da active
- 2022-03-29 HU HUE22719266A patent/HUE071610T2/hu unknown
- 2022-03-29 SI SI202230137T patent/SI4313058T1/sl unknown
- 2022-03-29 FI FIEP22719266.3T patent/FI4313058T3/fi active
- 2022-03-29 PL PL22719266.3T patent/PL4313058T3/pl unknown
- 2022-03-29 LT LTEPPCT/EP2022/058283T patent/LT4313058T/lt unknown
- 2022-03-29 ES ES22719266T patent/ES3031295T3/es active Active
- 2022-03-29 JP JP2023560623A patent/JP7839803B2/ja active Active
- 2022-03-29 US US18/271,196 patent/US12605389B2/en active Active
- 2022-03-29 RS RS20250390A patent/RS66754B1/sr unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011058149A1 (en) * | 2009-11-13 | 2011-05-19 | Merck Serono S.A. | Tricyclic pyrazol amine derivatives |
| WO2014121901A1 (en) * | 2013-02-07 | 2014-08-14 | Merck Patent Gmbh | Polymorphic forms |
Non-Patent Citations (1)
| Title |
|---|
| MACQUEEN AMY R., VITICCHIE GIUDITTA, NIEWOLA KAROLINA, FINOTELLO FRANCESCA, POWLEY IAN, SHAH PRITOM, VAN DER VEEN LARS, LAHN MICHA: "Abstract 666: A novel, highly selective PI3Kδ inhibitor for the treatment of solid malignancies that express high levels of target protein as assessed by immunohistochemistry", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR), vol. 80, no. 16_Supplement, 15 August 2020 (2020-08-15), pages 666 - 666, XP055941409, ISSN: 0008-5472, DOI: 10.1158/1538-7445.AM2020-666 * |
Also Published As
| Publication number | Publication date |
|---|---|
| PT4313058T (pt) | 2025-06-02 |
| AU2022251843A1 (en) | 2023-10-05 |
| LT4313058T (lt) | 2025-05-26 |
| US20240058351A1 (en) | 2024-02-22 |
| RS66754B1 (sr) | 2025-05-30 |
| WO2022207646A1 (en) | 2022-10-06 |
| JP2024518685A (ja) | 2024-05-02 |
| US12605389B2 (en) | 2026-04-21 |
| PL4313058T3 (pl) | 2025-06-23 |
| HUE071610T2 (hu) | 2025-09-28 |
| EP4313058A1 (en) | 2024-02-07 |
| ES3031295T3 (en) | 2025-07-07 |
| CA3212731A1 (en) | 2022-10-06 |
| SI4313058T1 (sl) | 2025-07-31 |
| EP4313058B1 (en) | 2025-03-05 |
| FI4313058T3 (fi) | 2025-04-30 |
| MX2023011442A (es) | 2023-10-18 |
| JP7839803B2 (ja) | 2026-04-02 |
| HRP20250516T1 (hr) | 2025-06-20 |
| DK4313058T3 (da) | 2025-05-12 |
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