AU2021471586A1 - Oligonucleotide compositions and methods of use thereof - Google Patents

Oligonucleotide compositions and methods of use thereof Download PDF

Info

Publication number
AU2021471586A1
AU2021471586A1 AU2021471586A AU2021471586A AU2021471586A1 AU 2021471586 A1 AU2021471586 A1 AU 2021471586A1 AU 2021471586 A AU2021471586 A AU 2021471586A AU 2021471586 A AU2021471586 A AU 2021471586A AU 2021471586 A1 AU2021471586 A1 AU 2021471586A1
Authority
AU
Australia
Prior art keywords
oligonucleotide
rho
oligonucleotides
linkage
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
AU2021471586A
Other languages
English (en)
Inventor
Michael John Byrne
Lankai GUO
Andrew Guzior HOSS
Naoki Iwamoto
Chandra Vargeese
Vinod VATHIPADIEKAL
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wave Life Sciences Pte Ltd
Original Assignee
Wave Life Sciences Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wave Life Sciences Pte Ltd filed Critical Wave Life Sciences Pte Ltd
Publication of AU2021471586A1 publication Critical patent/AU2021471586A1/en
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/11Antisense
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/315Phosphorothioates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/34Spatial arrangement of the modifications
    • C12N2310/341Gapmers, i.e. of the type ===---===

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2021471586A 2021-10-27 2021-10-27 Oligonucleotide compositions and methods of use thereof Pending AU2021471586A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2021/056900 WO2023075766A1 (fr) 2021-10-27 2021-10-27 Compositions d'oligonucléotides et leurs méthodes d'utilisation

Publications (1)

Publication Number Publication Date
AU2021471586A1 true AU2021471586A1 (en) 2024-05-09

Family

ID=86158394

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2021471586A Pending AU2021471586A1 (en) 2021-10-27 2021-10-27 Oligonucleotide compositions and methods of use thereof

Country Status (3)

Country Link
AU (1) AU2021471586A1 (fr)
CA (1) CA3236136A1 (fr)
WO (1) WO2023075766A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018098264A1 (fr) 2016-11-23 2018-05-31 Wave Life Sciences Ltd. Compositions et procédés de synthèse de phosphoramidites et d'oligonucléotides

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11332733B2 (en) * 2018-02-12 2022-05-17 lonis Pharmaceuticals, Inc. Modified compounds and uses thereof
AU2020262485A1 (en) * 2019-04-25 2021-11-11 Wave Life Sciences Ltd. Oligonucleotide compositions and methods of use thereof
JP2022532169A (ja) * 2019-05-09 2022-07-13 ウェイブ ライフ サイエンシズ リミテッド オリゴヌクレオチド組成物及びその使用方法

Also Published As

Publication number Publication date
CA3236136A1 (fr) 2023-05-04
WO2023075766A1 (fr) 2023-05-04

Similar Documents

Publication Publication Date Title
US20230145795A1 (en) Oligonucleotide compositions and methods of use thereof
CA3137740A1 (fr) Compositions d'oligonucleotides et leurs procedes d'utilisation
US20220098585A1 (en) Oligonucleotide compositions and methods thereof
JP7422068B2 (ja) オリゴヌクレオチド組成物及びその方法
CA3139513A1 (fr) Compositions oligonucleotidiques et leurs procedes d'utilisation
CA3156176A1 (fr) Compositions oligonucleotidiques et leurs procedes d'utilisation
CA3154768A1 (fr) Compositions d'oligonucleotides et leurs procedes d'utilisation
JP2023515862A (ja) オリゴヌクレオチド組成物及びその方法
CA2989682A1 (fr) Compositions d'oligonucleotides et procedes associes
WO2023075766A1 (fr) Compositions d'oligonucléotides et leurs méthodes d'utilisation
WO2023076352A2 (fr) Compositions oligonucléotidiques et leurs procédés d'utilisation
WO2023049475A1 (fr) Compositions d'oligonucléotides et procédés associés
WO2024020188A2 (fr) Compositions d'oligonucléotides et méthodes associées
WO2023220087A1 (fr) Compositions d'oligonucléotides et procédés associés
WO2023049218A1 (fr) Compositions oligonuclétiques double brin et procédés s'y rapportant
TW202340464A (zh) 以ATN1 mRNA或pre-mRNA作為標的之反義寡核苷酸