AU2021313472B2 - Methods and compositions for treating lung conditions - Google Patents

Methods and compositions for treating lung conditions

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Publication number
AU2021313472B2
AU2021313472B2 AU2021313472A AU2021313472A AU2021313472B2 AU 2021313472 B2 AU2021313472 B2 AU 2021313472B2 AU 2021313472 A AU2021313472 A AU 2021313472A AU 2021313472 A AU2021313472 A AU 2021313472A AU 2021313472 B2 AU2021313472 B2 AU 2021313472B2
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AU
Australia
Prior art keywords
exo
msc
mscs
ntfs
certain embodiments
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AU2021313472A
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English (en)
Other versions
AU2021313472A1 (en
Inventor
Revital ARICHA
Haggai KASPI
Ralph Kern
Chaim LEBOVITS
Yossef Levy
Jonathan SEMO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brainstorm Cell Therapeutics Ltd
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Brainstorm Cell Therapeutics Ltd
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Publication of AU2021313472A1 publication Critical patent/AU2021313472A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2021313472A 2020-07-20 2021-07-20 Methods and compositions for treating lung conditions Active AU2021313472B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063053780P 2020-07-20 2020-07-20
US63/053,780 2020-07-20
US202163133350P 2021-01-03 2021-01-03
US63/133,350 2021-01-03
PCT/IL2021/050885 WO2022018729A1 (en) 2020-07-20 2021-07-20 Methods and compositions for treating lung conditions

Publications (2)

Publication Number Publication Date
AU2021313472A1 AU2021313472A1 (en) 2023-02-23
AU2021313472B2 true AU2021313472B2 (en) 2025-10-16

Family

ID=77265158

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2021313472A Active AU2021313472B2 (en) 2020-07-20 2021-07-20 Methods and compositions for treating lung conditions

Country Status (7)

Country Link
US (1) US20230310507A1 (https=)
EP (1) EP4181935A1 (https=)
JP (2) JP7691488B2 (https=)
AU (1) AU2021313472B2 (https=)
CA (1) CA3189818A1 (https=)
IL (1) IL299997A (https=)
WO (1) WO2022018729A1 (https=)

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Publication number Priority date Publication date Assignee Title
JP2021526556A (ja) 2018-05-30 2021-10-07 ダイレクト バイオロジクス エルエルシー 成長因子および細胞外小胞を凍結または粉状にした、間葉系幹細胞（ｍｓｃ）の調製物を含む助剤、ならびにその使用方法
BR112021015549A2 (pt) 2019-02-07 2021-10-26 Direct Biologics Llc Método para tratar osteoartrite com uma combinação de exossomos de células tronco mesenquimais, células tronco mesenquimais sinoviais e andaimes
CA3146433A1 (en) 2019-07-18 2021-01-21 Direct Biologics Llc Preparations comprising mesenchymal stem cells and cannabinoids and methods of their use
CN113384597A (zh) * 2020-03-13 2021-09-14 西比曼生物科技（上海）有限公司 含人体细胞衍生的细胞膜外囊泡的雾化吸入制剂、制法及其应用
US12590310B2 (en) 2020-04-22 2026-03-31 Direct Biologics, Llc Methods and compositions for treating inflammatory conditions associated with infectious disease
EP4252761A4 (en) * 2020-11-26 2024-06-05 Samsung Life Public Welfare Foundation COMPOSITION FOR THE TREATMENT OF INFECTIOUS DISEASES, COMPRISING EXOSOMES DERIVED FROM THROMBIN-PROCESSED STEM CELLS
KR20240003167A (ko) * 2022-06-30 2024-01-08 주식회사 지씨셀 편도유래줄기세포를 유효성분으로 포함하는 감염성 폐 질환의 예방 또는 치료용 조성물
WO2024236603A1 (en) * 2023-05-18 2024-11-21 Khorakiwala Zahabiya Growth factor concentrate composition
CN116897887A (zh) * 2023-07-31 2023-10-20 湖南中医药大学 一种病毒性哮喘动物模型的构建方法
US12502407B2 (en) 2024-04-25 2025-12-23 Direct Biologics, Llc Treatment of fistula with bone marrow mesenchymal stem cell derived extracellular vesicles

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015016761A2 (en) * 2013-08-01 2015-02-05 Isletone Ab Mscs in the treatment of inflammatory pulmonary diseases
JP2015531594A (ja) * 2012-08-06 2015-11-05 ブレインストーム セル セラペウティクス リミテッド 神経栄養因子を分泌する間葉系幹細胞の作製方法

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US20080095749A1 (en) 2004-03-22 2008-04-24 Sudeepta Aggarwal Mesenchymal stem cells and uses therefor
CA2829586C (en) 2011-03-11 2021-03-02 Children's Medical Center Corporation Methods and compositions relating to mesenchymal stem cell exosomes
KR101843634B1 (ko) 2016-04-15 2018-03-30 사회복지법인 삼성생명공익재단 트롬빈 처리 줄기세포에서 유래된 엑소좀을 포함하는 만성폐질환 치료용 조성물
CA3072562A1 (en) * 2017-08-15 2019-02-21 Children's Medical Center Corporation Purified mesenchymal stem cell exosomes and uses thereof
GB2568255A (en) * 2017-11-08 2019-05-15 Evox Therapeutics Ltd Exosomes comprising RNA therapeutics
US12233092B2 (en) 2018-04-10 2025-02-25 Brainstorm Cell Therapeutics Ltd. MSC-NTF specific exosomes and use thereof
EP3813858B1 (en) * 2018-06-29 2023-11-01 North Carolina State University Therapeutic lung repair by inhalation of lung spheroid exosomes
BR112022017557A2 (pt) * 2020-03-05 2022-12-27 Mesoblast Int Sarl Método para tratar doenças pulmonares inflamatórias com o uso de células-tronco ou precursoras de linhagem mesenquimal
WO2021181399A1 (en) * 2020-03-12 2021-09-16 Exostem Biotec Ltd. Mesenchymal stromal cells and extracellular vesicles for treating viral infections, inflammation, and tissue fibrosis
CA3173216A1 (en) * 2020-04-03 2021-10-07 Silviu Itescu Method for treating hyperinflammation using mesenchymal lineage precursor or stem cells
EP4132479A1 (en) * 2020-04-07 2023-02-15 Ramot at Tel-Aviv University Ltd. Cannabidiol-containing compositions and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015531594A (ja) * 2012-08-06 2015-11-05 ブレインストーム セル セラペウティクス リミテッド 神経栄養因子を分泌する間葉系幹細胞の作製方法
WO2015016761A2 (en) * 2013-08-01 2015-02-05 Isletone Ab Mscs in the treatment of inflammatory pulmonary diseases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KHATRI MAHESH ET AL: "Mesenchymal stem cell-derived extracellular vesicles attenuate influenza virus-induced acute lung injury in a pig model", STEM CELL RESEARCH & THERAPY, 2018, vol. 9, no. 1, 13 pages. *

Also Published As

Publication number Publication date
JP2023534524A (ja) 2023-08-09
AU2021313472A1 (en) 2023-02-23
JP2025128209A (ja) 2025-09-02
CA3189818A1 (en) 2022-01-27
US20230310507A1 (en) 2023-10-05
WO2022018729A1 (en) 2022-01-27
JP7691488B2 (ja) 2025-06-11
EP4181935A1 (en) 2023-05-24
IL299997A (en) 2023-03-01

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