AU2021297245A1 - Methods for diagnosing respiratory pathogens and predicting covid-19 related outcomes - Google Patents

Methods for diagnosing respiratory pathogens and predicting covid-19 related outcomes Download PDF

Info

Publication number
AU2021297245A1
AU2021297245A1 AU2021297245A AU2021297245A AU2021297245A1 AU 2021297245 A1 AU2021297245 A1 AU 2021297245A1 AU 2021297245 A AU2021297245 A AU 2021297245A AU 2021297245 A AU2021297245 A AU 2021297245A AU 2021297245 A1 AU2021297245 A1 AU 2021297245A1
Authority
AU
Australia
Prior art keywords
methylation
subject
hla
infection
classifier
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
AU2021297245A
Other languages
English (en)
Inventor
Bret BARNES
Kathleen Barnes
Christopher GIGNOUX
Rasika MATHIAS
Paul Norman
Brett Peterson
Rishi Porecha
Alem TAYE
Ivana YANG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Colorado Colorado Springs
Illumina Software Inc
Original Assignee
University of Colorado System
University of Colorado Colorado Springs
Illumina Software Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Colorado System, University of Colorado Colorado Springs, Illumina Software Inc filed Critical University of Colorado System
Publication of AU2021297245A1 publication Critical patent/AU2021297245A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
AU2021297245A 2020-06-23 2021-06-23 Methods for diagnosing respiratory pathogens and predicting covid-19 related outcomes Pending AU2021297245A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063042669P 2020-06-23 2020-06-23
US63/042,669 2020-06-23
PCT/US2021/038763 WO2021262894A1 (en) 2020-06-23 2021-06-23 Methods for diagnosing respiratory pathogens and predicting covid-19 related outcomes

Publications (1)

Publication Number Publication Date
AU2021297245A1 true AU2021297245A1 (en) 2023-02-02

Family

ID=79281779

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2021297245A Pending AU2021297245A1 (en) 2020-06-23 2021-06-23 Methods for diagnosing respiratory pathogens and predicting covid-19 related outcomes

Country Status (10)

Country Link
US (1) US20240093318A1 (enExample)
EP (1) EP4168593A4 (enExample)
JP (1) JP2023532444A (enExample)
KR (1) KR20230038486A (enExample)
CN (1) CN116096920A (enExample)
AU (1) AU2021297245A1 (enExample)
BR (1) BR112022026509A2 (enExample)
CA (1) CA3184128A1 (enExample)
MX (1) MX2023000105A (enExample)
WO (1) WO2021262894A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4308017A4 (en) * 2021-03-18 2025-02-12 The Board of Trustees of the Leland Stanford Junior University Systems and methods to generate a surgical risk score and uses thereof
EP4303326A1 (fr) * 2022-07-06 2024-01-10 Biomérieux Determination du risque de deces d'un sujet infecte par un virus respiratoire par mesure du niveau d'expression du gene oas2
WO2024008955A1 (en) * 2022-07-08 2024-01-11 Age Labs As Method of screening for severe covid-19 susceptibility
EP4484575A1 (de) * 2023-06-30 2025-01-01 Cerascreen GmbH Markersequenzen zur diagnose und therapiesteuerung von patienten mit testosteron-defizienz

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4751180A (en) 1985-03-28 1988-06-14 Chiron Corporation Expression using fused genes providing for protein product
US4935233A (en) 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
US8114414B2 (en) 1994-11-08 2012-02-14 The Trustees Of The University Of Pennsylvania Compositions and methods for treatment of cervical cancer
EP2298900A1 (en) 1996-09-17 2011-03-23 Novartis Vaccines and Diagnostics, Inc. Compositions and methods for treating intracellular diseases
US6099848A (en) 1997-11-18 2000-08-08 The Trustees Of The University Of Pennsylvania Immunogenic compositions comprising DAL/DAT double-mutant, auxotrophic, attenuated strains of Listeria and their methods of use
GB9726555D0 (en) 1997-12-16 1998-02-11 Smithkline Beecham Plc Vaccine
WO2001041782A2 (en) 1999-12-09 2001-06-14 Chiron Corporation Method for administering a cytokine to the central nervous system and the lymphatic system
US6855320B2 (en) 2000-03-29 2005-02-15 The Trustees Of The University Of Pennsylvania Fusion of non-hemolytic, truncated form of listeriolysin O to antigens to enhance immunogenicity
AU2001255196A1 (en) 2000-03-29 2001-10-08 The Trustees Of The University Of Pennsylvania Compositions and methods for enhancing immunogenicity of antigens
WO2002002807A2 (en) * 2000-06-30 2002-01-10 Epigenomics Ag Diagnosis of diseases associated with cell signalling
US8771702B2 (en) 2001-03-26 2014-07-08 The Trustees Of The University Of Pennsylvania Non-hemolytic LLO fusion proteins and methods of utilizing same
US7794728B2 (en) 2002-05-29 2010-09-14 The Regents Of The University Of California Attenuated Listeria spp. and methods for using the same
US8337861B2 (en) 2003-01-09 2012-12-25 The Trustees Of The University Of Pennsylvania Compositions, methods and kits for enhancing the immunogenicity of a bacterial vaccine vector
KR101192652B1 (ko) 2003-02-06 2012-10-19 앤저 테라퓨틱스 인코퍼레이티드 비포식 세포로의 침투가 약화된 리스테리아, 리스테리아를 포함하는 백신, 및 그것의 사용방법
US7935804B2 (en) 2006-03-01 2011-05-03 Aduro Biotech Engineered Listeria and methods of use thereof
US7665238B2 (en) 2006-04-03 2010-02-23 S.C. Johnson & Son, Inc. Air freshener with holder
CN101755044B (zh) 2007-05-18 2014-06-11 米迪缪尼有限公司 通过冻干泡沫保存生物活性材料
JP5985397B2 (ja) 2009-11-11 2016-09-06 アドバクシス インコーポレイテッド 組換えリステリア株およびそれを含む免疫原性組成物
EP2521797A4 (en) * 2010-01-04 2013-07-10 Lineagen Inc DNA METHYLATION BIOMARKER FOR LUNG FUNCTION
AU2013266968B2 (en) 2012-05-25 2017-06-29 Emmanuelle CHARPENTIER Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
SG10201700916SA (en) 2012-12-27 2017-03-30 Aduro Biotech Inc Signal peptide fusion partners facilitating listerial expression of antigenic sequences and methods of preparation and use thereof
CA2955612C (en) 2014-07-18 2022-05-17 Advaxis, Inc. Combination of a pd-1 antagonist and a listeria-based vaccine for treating prostate cancer
EP3169355A4 (en) 2014-07-18 2018-07-25 Advaxis, Inc. Listeria-based immunogenic compositions for eliciting anti-tumor responses
MA41218A (fr) 2014-12-19 2017-10-24 Advaxis Inc Combinaison de vaccin à base de listeria comportant des anticorps anti-ox40 ou anti-gitr
BR112019018272A2 (pt) * 2017-03-02 2020-07-28 Youhealth Oncotech, Limited marcadores metilação para diagnosticar hepatocelular carcinoma e câncer
MA47821A (fr) * 2017-03-10 2020-01-15 Self Screen Bv Classificateur de méthylation pour la détection de cancers invasifs induits par le hpv, de cancers gynécologiques et anogénitaux non induits par le hpv et de leurs lésions précurseurs de haut grade

Also Published As

Publication number Publication date
US20240093318A1 (en) 2024-03-21
MX2023000105A (es) 2023-04-25
EP4168593A1 (en) 2023-04-26
WO2021262894A1 (en) 2021-12-30
JP2023532444A (ja) 2023-07-28
EP4168593A4 (en) 2024-11-27
KR20230038486A (ko) 2023-03-20
CN116096920A (zh) 2023-05-09
BR112022026509A2 (pt) 2023-03-07
CA3184128A1 (en) 2021-12-30

Similar Documents

Publication Publication Date Title
US20240093318A1 (en) Method for diagnosing respiratory pathogens and predicting covid-19 related outcomes
US20240282449A1 (en) Methods and systems for machine learning analysis of inflammatory skin diseases
US20210139987A1 (en) Methods, computer-readable media, and systems for assessing samples and wounds, predicting whether a wound will heal, and monitoring effectiveness of a treatment
US20220399116A1 (en) Systems and methods for assessing a bacterial or viral status of a sample
WO2015035367A1 (en) Methods and systems for analysis of organ transplantation
US20220246242A1 (en) Methods of assessing risk of developing a severe response to coronavirus infection
US20230340601A1 (en) Transcriptome Analysis For Treating Inflammation
US20160194709A1 (en) DIAGNOSTIC METHOD FOR PREDICTING RESPONSE TO TNFalpha INHIBITOR
CN109477145A (zh) 炎症性肠病的生物标志物
Higham et al. Increased mast cell activation in eosinophilic chronic obstructive pulmonary disease
Duffy Understanding immune variation for improved translational medicine
US20250391505A1 (en) Methods and Systems for Machine Learning Analysis of Lupus Nephritis
Souquette et al. Integrated drivers of basal and acute immunity in diverse human populations
US20220205042A1 (en) Molecular Signatures for Distinguishing Liver Transplant Rejections or Injuries
CN106119406B (zh) 多发性肉芽肿血管炎及微小动脉炎的基因分型诊断试剂盒及使用方法
EP4413164A1 (en) Screening method for rheumatoid arthritis
EP3825418A2 (en) Molecular signatures for distinguishing liver transplant rejections or injuries
US20260117297A1 (en) Longitudinal Gene Expression Analysis of Inflammatory Skin Diseases
US11104951B2 (en) Molecular signatures for distinguishing liver transplant rejections or injuries
Deng et al. A novel Bayesian framework for harmonizing information across tissues and studies to increase cell type deconvolution accuracy
Cathomas et al. Two distinct immunopathological profiles in autopsy lungs of COVID-19
Vivas et al. Prediction of autoimmune diseases: From bench to bedside
Gray What the X chromosome can teach us about the immune system and autoimmunity
Okada et al. POS0312 ENDOGENEOUS HUMAN HERPESVIRUS 6B INTEGRATED IN HUMAN GENOME SEQUENCE ASSOCIATES WITH AFFECTION AND SEVERITY OF SYSTEMIC LUPUS ERYTHEMATOSUS
Reynolds et al. Mapping interindividual dynamics of innate immune response at single-cell resolution