AU2021263795A1 - Aerosol composition and method for sanitisation - Google Patents
Aerosol composition and method for sanitisation Download PDFInfo
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- AU2021263795A1 AU2021263795A1 AU2021263795A AU2021263795A AU2021263795A1 AU 2021263795 A1 AU2021263795 A1 AU 2021263795A1 AU 2021263795 A AU2021263795 A AU 2021263795A AU 2021263795 A AU2021263795 A AU 2021263795A AU 2021263795 A1 AU2021263795 A1 AU 2021263795A1
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- 239000000203 mixture Substances 0.000 title claims abstract description 99
- 239000000443 aerosol Substances 0.000 title claims abstract description 37
- 238000000034 method Methods 0.000 title claims description 11
- 239000003380 propellant Substances 0.000 claims abstract description 62
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 57
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 36
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims abstract description 34
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 33
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000004615 ingredient Substances 0.000 claims abstract description 16
- 239000003906 humectant Substances 0.000 claims abstract description 13
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000003205 fragrance Substances 0.000 claims description 8
- 238000009835 boiling Methods 0.000 claims description 3
- 230000000813 microbial effect Effects 0.000 claims description 3
- 238000002560 therapeutic procedure Methods 0.000 claims description 3
- 229940041677 topical spray Drugs 0.000 claims description 3
- NNPPMTNAJDCUHE-UHFFFAOYSA-N isobutane Chemical compound CC(C)C NNPPMTNAJDCUHE-UHFFFAOYSA-N 0.000 description 16
- 241000282414 Homo sapiens Species 0.000 description 10
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 10
- 239000011347 resin Substances 0.000 description 10
- 229920005989 resin Polymers 0.000 description 10
- 241000894006 Bacteria Species 0.000 description 9
- 239000001282 iso-butane Substances 0.000 description 8
- 229920002312 polyamide-imide Polymers 0.000 description 7
- 239000007921 spray Substances 0.000 description 7
- 239000004962 Polyamide-imide Substances 0.000 description 6
- 239000004411 aluminium Substances 0.000 description 6
- 229910052782 aluminium Inorganic materials 0.000 description 6
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 6
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 230000001225 therapeutic effect Effects 0.000 description 6
- 239000000463 material Substances 0.000 description 5
- 239000001294 propane Substances 0.000 description 5
- 230000000845 anti-microbial effect Effects 0.000 description 4
- 239000000645 desinfectant Substances 0.000 description 4
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 4
- 210000003491 skin Anatomy 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 239000005028 tinplate Substances 0.000 description 4
- 241000588724 Escherichia coli Species 0.000 description 3
- 230000002421 anti-septic effect Effects 0.000 description 3
- 239000004599 antimicrobial Substances 0.000 description 3
- 238000005260 corrosion Methods 0.000 description 3
- 230000007797 corrosion Effects 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 239000004922 lacquer Substances 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- -1 poly(ethylene terephthalate) Polymers 0.000 description 3
- 239000000344 soap Substances 0.000 description 3
- 230000000699 topical effect Effects 0.000 description 3
- 239000004593 Epoxy Substances 0.000 description 2
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 description 2
- 206010040904 Skin odour abnormal Diseases 0.000 description 2
- 229910000831 Steel Inorganic materials 0.000 description 2
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000001166 anti-perspirative effect Effects 0.000 description 2
- 239000003213 antiperspirant Substances 0.000 description 2
- 229940064004 antiseptic throat preparations Drugs 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000001273 butane Substances 0.000 description 2
- 239000002738 chelating agent Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000011928 denatured alcohol Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 239000008266 hair spray Substances 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- QWTDNUCVQCZILF-UHFFFAOYSA-N isopentane Chemical compound CCC(C)C QWTDNUCVQCZILF-UHFFFAOYSA-N 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 239000002304 perfume Substances 0.000 description 2
- 229920000139 polyethylene terephthalate Polymers 0.000 description 2
- 239000005020 polyethylene terephthalate Substances 0.000 description 2
- 239000010959 steel Substances 0.000 description 2
- 150000005846 sugar alcohols Polymers 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- NPNPZTNLOVBDOC-UHFFFAOYSA-N 1,1-difluoroethane Chemical compound CC(F)F NPNPZTNLOVBDOC-UHFFFAOYSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000191963 Staphylococcus epidermidis Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- PRPAGESBURMWTI-UHFFFAOYSA-N [C].[F] Chemical compound [C].[F] PRPAGESBURMWTI-UHFFFAOYSA-N 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000002998 adhesive polymer Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000008365 aqueous carrier Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000001332 colony forming effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- AFABGHUZZDYHJO-UHFFFAOYSA-N dimethyl butane Natural products CCCC(C)C AFABGHUZZDYHJO-UHFFFAOYSA-N 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 239000003822 epoxy resin Substances 0.000 description 1
- 239000005007 epoxy-phenolic resin Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000008233 hard water Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000000077 insect repellent Substances 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004324 lymphatic system Anatomy 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000003641 microbiacidal effect Effects 0.000 description 1
- 229940124561 microbicide Drugs 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- QYSGYZVSCZSLHT-UHFFFAOYSA-N octafluoropropane Chemical compound FC(F)(F)C(F)(F)C(F)(F)F QYSGYZVSCZSLHT-UHFFFAOYSA-N 0.000 description 1
- 239000000668 oral spray Substances 0.000 description 1
- 229940041678 oral spray Drugs 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 229920000647 polyepoxide Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/22—Phase substances, e.g. smokes, aerosols or sprayed or atomised substances
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- General Health & Medical Sciences (AREA)
- Environmental Sciences (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Steroid Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Disclosed is an aerosol composition for use as a sanitiser comprising: a) 60 wt% to 80 wt% ethanol, propanol, isopropanol or a mixture thereof; b) 10 wt% to 40 wt% propellant; and, c) 1 wt% to 10 wt% water,wherein said composition comprises 0.1 wt% to 2 wt% humectant selected from propylene glycol, dipropylene glycol or glycerol and wherein ratio of base: propellant is 70: 30 to 80: 20 parts by weight, where said base comprises every ingredient other than said propellant.
Description
AEROSOL COMPOSITION AND METHOD FOR SANITISATION
Field of Invention
This invention relates to aerosol compositions for sanitising or disinfecting animate as well as inanimate surfaces.
Background
Sanitisers, sometimes called disinfectants, antiseptics or antimicrobials are compositions that are applied to living tissues, e.g. skin, to reduce the possibility of infection. Sanitisers are generally used to denote compositions that provide instantaneous kill of microbes on topical surfaces of animal or human body while disinfectants are generally used for the killing germs on non-living surfaces. Sanitisers often involve use of alcohol-based microbicides. These are used by applying a few drops of the solution on to the topical surface e.g. the hands and then rubbed together. During rubbing, the alcohol and other antimicrobial substances spread on the desired surface causing the antimicrobial action. Parallelly, the alcohol evaporates leaving the surface disinfected without the need for rinsing it with water and subsequent drying as is necessary in the case of soap or other handwash products. Sanitisers are useful in hospitals, clinics, nursing homes and other healthcare places where doctors, nurses and other healthcare workers need to disinfect their hands, often several times an hour, as they attend to one patient after another to minimize the spread of diseases through contact. These are distinguished from antibiotics by the latter's ability to be transported through the lymphatic system to destroy bacteria within the body.
Human skin, i.e. the epidermis generally harbours several different microorganisms in concentrations exceeding millions or even billions of colony forming units (cfu) per square centimetre (cm2). Some microorganisms are harmless, but there are also various pathogenic species present, such as E. coli or S. aureus and a variety of viruses. Also, other unwanted bacteria may also inhabit the skin, such as S. epidermidis, which is generally non-pathogenic, but is believed to cause an unpleasant body odour.
Similarly, hand hygiene has continued to be an important practice advocated for preventing the spread of many diseases. A variety of cleansing and sanitising products
are available for such purpose including soap bars, liquid soaps, alcohol-based sanitising sprays, gels and tissues.
Surfaces can be broadly distinguished based on the fact whether they belong to a living organism or a non-living thing. Animate surfaces are surfaces of a living organism, especially human beings. On the other hand, inanimate surfaces are of non-living things such as table-tops, chairs, cupboards, tiles and the like.
High-touch surfaces are those that are handled frequently throughout the day by numerous people. These inanimate surfaces include doorknobs, light switches, phones, sink faucets, and toys. High-touch surfaces can become contaminated by direct contact with bodily fluids or through indirect contact with other contaminated objects, such as inadequately cleaned rags and sponges or improperly washed hands. Pathogens can continue to stay on such and other animate surfaces if they are not properly sanitised or disinfected. For example, certain viruses and bacteria are known to survive at least for many hours.
W02006/050776 A1 (Unilever) discloses antiperspirant aerosol product in which the antiperspirant active is dissolved in water, the resulting aqueous solution is emulsified in an oily continuous phase, and the oil-in-water emulsion composition is packaged in a dispensing device comprising a particular selection of lacquered components.
US6299862 B (Tom Barrow, 2001) discloses delivery of a sanitiser to a personal use surface, such as a toilet seat surface. The sanitiser has a dispensing unit for delivery of the sanitiser as an aerosol spray, leaving only the sanitiser in pure form on the seat surface. This results in quick drying of the surface in 12 to 15 seconds. It is disclosed that the ratio of alcohol:propellant at 70:30 combination is optimal for ensuring that only pure alcohol is delivered to the seat surface. Further it is disclosed that 85:15 proportion of isobutane:propane, as propellant, provides for optimum surface contact i.e. the composition does not disappear into the atmosphere but permits the wetting of the surface with pure alcohol. The composition is anhydrous.
US2004259951 A1 (Unilever) discloses anti-microbial composition including aerosols, comprising at least 25% C1 to C4 monohydric alcohol carrier fluid, an iron (III) chelator having an iron (III) binding constant of 1023 or greater; a solubility promoter selected from the group consisting of: water; an organic amine; a polyhydric alcohol or derivative thereof; a volatile propellant having fluorine-carbon or oxygen-carbon bonds; any combination of (a) to (d). The transitional metal chelator serves as an active anti microbial, whilst the carrier fluid-solubility promoter mixture enables the formation of a stable composition. Preferred compositions are homogeneous solutions.
EP0180483 A2 (Rutland, 1985) discloses fine dispersion spray and emulsion as an oral spray or a mouthrinse with water and comprising a potable mono-, di- or polyhydric alcohol or mixture thereof as non-aqueous carrier base, and a substantially water- insoluble surfactant such as lecithin, the agent being in the form of a stable solution or suspension which, when released from pressure and mixed with air or water, forms an unstable aerosol or hydrosol respectively which then achieves a more stable state by coating out on a surface, such as teeth or gums to loosen plaque and reduce adhesive forces.
GB1595649 A (National Starch, 1981) discloses that shelf life and metal container corrosion of hair spray resin formulations can be addressed by addition of small amounts of water to the hair spray resin and it also improves the stability. Addition of water improves the color stability of the polymer solution of the aerosol container.
JP03176417 (San El Chem, 1991) discloses a mouth spray aerosol where the propellant forms 5 to 95 wt%.
US5565193 A (Procter & Gamble) discloses hair styling compositions including aerosol comprising silicone grafted adhesive polymer, 0.5 to 15% C10-C14 branched chain hydrocarbons a polar solvent phase such as water, alcohols, comprising 80 to 98.9% of the composition. The compositions also comprise 10% to 60% propellant.
An aerosol can contains one fluid that boils well below room temperature (called the propellant) and one that boils at a much higher temperature (called the product, also
referred to as forming part of the “base”). The product is the substance intended for topical application, such as a fragrance or room-freshener or an insect repellent. The propellant is the means of getting the product out of the can. Both fluids are stored in a sealed metal can.
Generally aerosol compositions are fragranced (i.e. perfumed) and contain a denatured alcohol, usually ethanol, a propellant, which may be a blend of short-chain hydrocarbons, and water.
Summary of the Invention
We have now unexpectedly determined that certain aerosol compositions can be used to sanitise animate as well as inanimate surfaces, primarily animate surfaces such as human hands.
In accordance with a first aspect of the invention is disclosed an aerosol composition for use as a sanitiser, comprising: a) 60 wt% to 80 wt% ethanol, propanol, isopropanol or a mixture thereof; b) 15 wt% to 35 wt% propellant; and, c) 1 wt% to 10 wt% water, wherein said composition comprises 0.1 wt% to 2 wt% humectant selected from propylene glycol, dipropylene glycol or glycerol and wherein ratio of base: propellant is 70: 30 to 80: 20 parts by weight, where said base comprises every ingredient other than said propellant.
In accordance with a second aspect of the invention is disclosed a non-therapeutic method of sanitising an animate or inanimate surface, comprising a step of topical spray application of an aerosol composition comprising: a) 60 wt% to 80 wt% ethanol, propanol, isopropanol or a mixture thereof; b) 15 wt% to 35wt% propellant; and, c) 1 wt% to 10 wt% water, wherein said composition comprises 0.1 wt% to 2 wt% humectant selected from propylene glycol, dipropylene glycol or glycerol and wherein ratio of base: propellant is 70: 30 to 80: 20 parts by weight, where said base comprises every ingredient other than said propellant.
In accordance with a third aspect of the invention is disclosed the non-therapeutic use of an aerosol composition comprising: a) 60 wt% to 80 wt% ethanol, propanol, isopropanol or a mixture thereof; b) 15 wt% to 35 wt% propellant; and, c) 1 wt% to 10 wt% water, wherein said composition comprises 0.1 wt% to 2 wt% humectant selected from propylene glycol, dipropylene glycol or glycerol and wherein ratio of base: propellant is 70: 30 to 80: 20 parts by weight, where said base comprises every ingredient other than said propellant, for sanitising an animate or an inanimate surface.
Herein, all amounts, percentages and ratios are by weight, unless otherwise indicated. In addition, all percentages are by weight of the total composition.
Herein, all amounts, percentages and ratios are to be understood as prefixed by the word “about”.
Herein, “propellant” means a gas capable of being liquefied by compression and having a boiling point of less than 10°C and preferably less than 0°C.
Herein, any material, ratio or weight indicated as “preferred” is to be understood as preferably used in combination within any other material, ratio or weight indicated as “preferred”.
Herein, the word “comprising” and “comprised of’, etc., should be understood as meaning that other components/features could also be present; i.e. the listed steps or options need not be exhaustive.
Detailed Description
The invention relates to an aerosol composition for use as a sanitiser comprising: a) 60 wt% to 80 wt% ethanol, propanol, isopropanol or a mixture thereof; b) 15 wt% to 35 wt% propellant; and,
c) 1 wt% to 10 wt% water, wherein said composition comprises 0.1 wt% to 2 wt% humectant selected from propylene glycol, dipropylene glycol or glycerol and wherein ratio of base: propellant is 70: 30 to 80: 20 parts by weight, where said base comprises every ingredient other than said propellant.
The composition requires the presence of a propellant which is a volatile ingredient. A volatile propellant serves to pressurise the composition within a dispensing device and to enhance spray formation when the composition is released from the dispensing device via a spray nozzle. When a volatile propellant is present the benefit of the invention is particularly relevant - corrosion resistance being particularly important in a pressurised system.
It is preferred that the propellant is at least one of difluoroethane, propane, butane or isobutane or combinations thereof. More preferred are those volatile propellants that are gases at standard temperature and pressure, but are present in the composition in a liquefied state prior to release from a suitable dispensing device. It is preferred that boiling point of the propellant is less 0°C.
The composition comprises 15 wt% to 30 wt% propellant. While the propellant may be entirely just one of the propellants named hereinbefore, it is preferred that at least 40 parts by weight of the propellant is n-butane. Preferably 40 to 50 parts by weight of the propellant is n-butane. It is more preferred that the propellant further comprises at least one of isobutane and propane. It is even more preferred that the propellant comprises n- butane, isobutane and propane where at least 40 parts by weight of the propellant is n- butane. Other suitable ingredients include pentane and isopentane and mixtures of two or more thereof. Other preferred propellants are isobutane, isobutane/isopropane, isobutane/propane and mixtures of isopropane, isobutane and butane.
The aerosol composition comprises 60 wt% to 80 wt% ethanol, propanol, isopropanol or a mixture thereof. More preferably the composition comprises 60 wt% to 75 wt% ethanol, propanol, isopropanol or a mixture thereof. Further preferably in the 60 wt% to 80 wt% ethanol, propanol, isopropanol or mixture thereof, at least 80 parts by weight is ethanol. The alcohol is preferably either pure alcohol or denatured alcohol. More preferably the
alcohol is entirely ethanol, further preferably specially denatured (SD) ethanol which contains a denaturing agent like t-butyl alcohol.
Alternatively, the composition comprises 65 wt% to as high as 95 wt%, preferably 60 to 80 wt% ethanol, propanol, isopropanol or a mixture thereof.
The composition comprises 0.1 wt% to 2 wt% humectant selected from propylene glycol, dipropylene glycol or glycerol. More preferably the humectant is propylene glycol. The humectant may aid in countering the drying effects of the 60 wt% to 80 wt% ethanol, propanol, isopropanol or a mixture thereof when the composition is applied to the human skin, in particular the hands.
It is preferred that the composition comprises 4 to 8 wt % water. Alternatively, the water content may be 1 to 15 wt%, preferably 1 to 12 wt% and more preferably 1 to 10 wt%.
Further preferably the aerosol composition is devoid of fragrance ingredients. A fragrance (also referred to as perfume) is typically composed of multiple different accords or notes and may be selected as desired. The presence of a fragrance usually enhances the treating of body odour, whether by a masking effect or otherwise. The fragrance may be in the form of a free (non-encapsulated) fragrance or it may be encapsulated in one of the multiple encapsulating materials used for this purpose. Useful components of the fragrance include materials of both natural and synthetic origin. They include single compounds and mixtures. Specific examples of such components may be found in the current literature, e.g., in Fenaroli's Handbook of Flavour Ingredients, 1975, CRC Press; Synthetic Food Adjuncts, 1947 by M. B. Jacobs, edited by Van Nostrand; or Perfume and Flavour and Chemicals by S. Arctander 1969, Montclair, N.J. (USA). These substances are well known to the person skilled in the art of perfuming and/or aromatizing consumer products, i.e. , of imparting an odour to a consumer product that is traditionally perfumed, or of modifying the odour of the consumer product.
The ratio of base: propellant is 70: 30 to 80: 20 parts by weight, where said base comprises every ingredient other than said propellant.
In accordance with the invention is disclosed an aerosol composition for use as a sanitiser. More preferably the use is as a hand sanitiser.
Preferably there is a reduction in the number of microbes present on the hands. It is further preferred that the reduction is due to microbial kill. Further preferably at least 99.9 % of the microbes are killed. It is yet further preferred that the said microbes are bacteria. More preferably the bacteria include Gram-positive and Gram-negative bacteria, where said Gram-positive bacteria include S. aureus and said Gram-negative bacteria include E. coli.
In accordance with a fourth aspect of the invention is disclosed a non-therapeutic method of sanitising an animate or inanimate surface, comprising a step of topical spray application of an aerosol composition comprising: a) 60 wt% to 80 wt% ethanol, propanol, isopropanol or a mixture thereof; b) 15 wt% to 35 wt% propellant; and, c) 1 wt% to 10 wt% water, wherein said composition comprises 0.1 wt% to 2 wt% humectant selected from propylene glycol, dipropylene glycol or glycerol and wherein ratio of base: propellant is 70: 30 to 80: 20 parts by weight, where said base comprises every ingredient other than said propellant.
The method is for an animate surface and is non-therapeutic in nature. The most preferred animate surface is human hands, although other surfaces may also be sanitised.
Alternatively, the method is for an animate surface and is therapeutic in nature. In this case it is preferred that the animate surface is human hands.
When the method is for an inanimate surface, preferably the inanimate surface is toilet seat, although the present invention may serve to sanitise any other inanimate surface that is amenable to be so sanitised.
In accordance with a further aspect of the invention is disclosed non-therapeutic use of an aerosol composition comprising:
a) 60 wt% to 80 wt% ethanol, propanol, isopropanol or a mixture thereof; b) 15 wt% to 35 wt% propellant; and, c) 1 wt% to 10 wt% water, for sanitising an animate or an inanimate surface, wherein said composition comprises 0.1 wt% to 2 wt% humectant selected from propylene glycol, dipropylene glycol or glycerol and wherein ratio of base: propellant is 70: 30 to 80: 20 parts by weight, where said base comprises every ingredient other than said propellant.
The use is for an animate surface and is non-therapeutic in nature. Preferably the animate surface is human hands. Alternatively, the use is for an animate surface and is therapeutic in nature. In such cases it is preferred that the animate surface is human hands. When the use is for an inanimate surface, it is preferred that the inanimate surface is toilet seat, although the present invention may serve to sanitise any other inanimate surface that is amenable to be so sanitised.
Preferably the container-dispenser is made of aluminium or tinplate or steel. Numerous lacquers are available for the protection of aluminium or tinplate can bodies and mounting cups. Examples of such lacquers include epoxyphenolic resin (also called epon-phenolic and often abbreviated to “epoxy” or “EPON”); poly(ethylene terephthalate) (PET); polypropylene; organosol (also called EP-Vinyl or Micoflex); and polyamide imide resin (also called PAM or PAI). Preferably the resin is polyamide-imide.
The aluminium or tinplate can may also be lacquered on its outside; however, it is its internal surface that is coated with preferably a polyamide-imide resin. The resin is applied to the internal surface of the can by methods known in the art. The layer is preferably of thickness from 1 to 50 microns at all points on the internal surface of the can.
It is preferred that the aerosol composition is packed in said container-dispenser at a vapor pressure of 30 to 50 psi, at 20°C.
The mounting cup used with the present invention serves to close off the can body at its top, typically at a narrowed or ‘necked’ section of the body. The bottom of the mounting
cup may come into contact with the composition contained within the body of the can.
The mounting cup typically has a valve present in a hole in its centre. In use, opening of the valve allows the aerosol composition to leave the can body via a nozzle and thereby produce a spray.
The mounting cup may be lacquered on its top side; however, it is its bottom side that is more frequently in contact with the composition and it is this side that is also preferably protected by an polyamide-imide resin. The resin is a layer of material applied to the bottom surface of the mounting cup by methods known in the art. The layer is preferably of thickness from 1 to 500 microns at all points on the internal surface of the mounting cup, the high maximum being due to the difficulty of applying lacquer to the mounting cup because of its highly contoured surface. The average thickness of the layer is preferably from 1 to 50 microns and may be measured by making 10 or more measurements at random positions on the bottom side of the mounting cup.
In order to further enhance corrosion resistance, it is preferred that the mounting cup, like the can body, is made from aluminium or tinplate or steel. For the same reason, it also preferred that the mounting cup is coated on its top side with epoxy or polyamide-imide resin, as well as on its bottom side.
The invention will now be explained with the help of exemplary non-limiting examples.
Examples
Example 1
The aerosol composition of Table 1, in accordance with the invention, was packaged in a standard 75 ml, container-dispenser made of aluminium. The aerosol composition detailed in Table 1 was prepared and filled by a method known in the art. The container- dispenser had a can, valve cup and dispensing means. Internal surfaces of the can and valve cup were coated with polyamide-imide resin.
Table 1
Note: the base: propellant ratio was 83: 17 parts by weight and in one case the composition of the propellant was as in column A of Table 2 below. In the other example it was as in column B.
Table 2
Example 2
The aerosol composition of Table 3, in accordance with the invention, was packaged in a standard 75 ml, container-dispenser made of aluminium. The aerosol composition detailed in Table 3 was prepared and filled by a method known in the art. The container- dispenser had a can, valve cup and dispensing means. Internal surfaces of the can and valve cup were coated with an epoxy resin but the valve was devoid of a vapour phase tap (VPT).
Table 3
Note: the base: propellant ratio was 75: 25 parts by weight and in one case the composition of the propellant was as in column A of Table 4 below. In the other example it was as in column B.
Table 4
Evaluation of efficacy:
Samples of the composition of Table 3 (with propellant [A] of Table 4) evaluated in accordance with the principles outlined in BS EN 1276:2009 (modified) under the following test conditions.
BS EN 1276 is a European Standard which specifies a test method and the minimum requirements for bactericidal activity of chemical disinfectant and antiseptic products that form a homogeneous, physically stable preparation when diluted with hard water or - in the case of ready-to-use products - with water. It is a Quantitative suspension test for the evaluation of bactericidal activity of chemical disinfectants and antiseptics used in food, industrial, domestic and institutional areas.
Product Concentration: Neat as supplied (80%) Contact Time: 30 seconds
Organic Challenge: 0.3% bovine albumin (Dirty Conditions) Temperature: Ambient (22°C)
Test Organisms: Staphylococcus aureus #255 ATCC 6538 Escherichia coli #256 ATCC 8739
Results are summarised in Table 5.
Table 5
The term "log reduction" as used herein means a 10-fold or 90 percent reduction in the number of viable microorganisms. By "2 log" reduction it is meant that the number of viable bacteria is reduced by 9.9 percent. By "4 log" reduction it is meant that the number of viable bacteria is reduced by 99.99 percent.
The data in Table 5 indicates that the composition of the invention brings about significant reduction in the number of microbes due to microbial kill. More than 99.9 % of said microbes are killed because the log-reduction is more than 5. Therefore, the composition is useful to sanitise a variety of surfaces, primarily human hands.
Claims (13)
1. An aerosol composition for use as a sanitiser comprising: a) 60 wt% to 80 wt% ethanol, propanol, isopropanol or a mixture thereof; b) 15 wt% to 35 wt% propellant; and, c) 1 wt% to 10 wt% water, wherein said composition comprises 0.1 wt% to 2 wt% humectant selected from propylene glycol, dipropylene glycol or glycerol and wherein ratio of base: propellant is 70: 30 to 80: 20 parts by weight, where said base comprises every ingredient other than said propellant.
2. An aerosol composition for use as claimed in claim 1 wherein said composition is devoid of fragrance ingredients.
3. A composition for use as claimed in claim 1 or 2 wherein boiling point of said propellant is less 0°C.
4. A composition for use as claimed in any of claims 1 to 3 wherein the composition comprises 60 wt% to 75 wt% ethanol, propanol, isopropanol or a mixture thereof.
5. A composition for use as claimed in any of claims 1 to 4 wherein in said 60 wt% to 80 wt% ethanol, propanol, isopropanol or mixture thereof, at least 80 parts by weight is ethanol.
6. A composition for use as claimed in any of claims 1 to 5 wherein said composition comprises 4 to 8 wt % water.
7. An aerosol composition for use as claimed in any of claims 1 to 5 wherein said use is as a hand sanitiser.
8. An aerosol composition for use as claimed in claim 7 to sanitise hands due to reduction in the number of microbes present on the hands.
9. An aerosol composition for use as claimed in claim 8 wherein said reduction is due to microbial kill.
10. An aerosol composition for use as claimed in claim 9 wherein at least 99.9 % of said microbes are killed.
11. A non-therapeutic method of sanitising an animate or inanimate surface, comprising a step of topical spray application of an aerosol composition comprising: a) 60 wt% to 80 wt% ethanol, propanol, isopropanol or a mixture thereof; b) 15 wt% to 35 wt% propellant; and, c) 1 wt% to 10 wt% water wherein said composition comprises 0.1 wt% to 2 wt% humectant selected from propylene glycol, dipropylene glycol or glycerol and wherein ratio of base: propellant is 70: 30 to 80: 20 parts by weight, where said base comprises every ingredient other than said propellant.
12. A method as claimed in claim 11 wherein said method is for an animate surface.
13. Non-therapeutic use of an aerosol composition comprising: a) 60 wt% to 80 wt% ethanol, propanol, isopropanol or a mixture thereof; b) 10 wt% to 40 wt% propellant; and, c) 1 wt% to 10 wt% water, for sanitising an animate or an inanimate surface, wherein said composition comprises 0.1 wt% to 2 wt% humectant selected from propylene glycol, dipropylene glycol or glycerol and wherein ratio of base: propellant is 70: 30 to 80: 20 parts by weight, where said base comprises every ingredient other than said propellant.
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IN202021018491 | 2020-04-30 | ||
IN202021018491 | 2020-04-30 | ||
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EP20179886 | 2020-06-15 | ||
PCT/EP2021/060094 WO2021219422A1 (en) | 2020-04-30 | 2021-04-19 | Aerosol composition and method for sanitisation |
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AU2021263795A1 true AU2021263795A1 (en) | 2022-11-17 |
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BR (1) | BR112022020543A2 (en) |
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Publication number | Priority date | Publication date | Assignee | Title |
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GB1595649A (en) | 1978-05-25 | 1981-08-12 | Nat Starch Chem Corp | Aerosol hair spray compositions |
CA1245988A (en) | 1984-11-02 | 1988-12-06 | Richard H. Roydhouse | Oral fine dispersion sprays and emulsions |
JPH03176417A (en) * | 1989-12-05 | 1991-07-31 | San Ei Chem Ind Ltd | Mouth-refreshing agent |
JP3176417B2 (en) | 1992-04-02 | 2001-06-18 | 積水化学工業株式会社 | Dewatering press mold for cement mortar molding |
US5565193A (en) | 1993-08-05 | 1996-10-15 | Procter & Gamble | Hair styling compositions containing a silicone grafted polymer and low level of a volatile hydrocarbon solvent |
US6299862B1 (en) | 1999-09-02 | 2001-10-09 | Tom Barrow | Rapidly drying sanitizing aerosol compositions containing alcohols, isobutane and propane |
GB0001129D0 (en) | 2000-01-18 | 2000-03-08 | Unilever Plc | Anti-microbial aerosol compositions |
FR2877842B1 (en) | 2004-11-13 | 2008-12-12 | Unilever Nv Naamlooze Vennoots | ANTI-TRANSPIRANT AEROSOL PRODUCT |
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WO2021219422A1 (en) | 2021-11-04 |
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