AU2021208027B2 - Substituted triazinones as thyroid hormone receptor agonists - Google Patents
Substituted triazinones as thyroid hormone receptor agonistsInfo
- Publication number
- AU2021208027B2 AU2021208027B2 AU2021208027A AU2021208027A AU2021208027B2 AU 2021208027 B2 AU2021208027 B2 AU 2021208027B2 AU 2021208027 A AU2021208027 A AU 2021208027A AU 2021208027 A AU2021208027 A AU 2021208027A AU 2021208027 B2 AU2021208027 B2 AU 2021208027B2
- Authority
- AU
- Australia
- Prior art keywords
- dichloro
- phenoxy
- dioxo
- triazin
- difluoromethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2020/071741 | 2020-01-13 | ||
| CN2020071741 | 2020-01-13 | ||
| CNPCT/CN2020/107757 | 2020-08-07 | ||
| CN2020107757 | 2020-08-07 | ||
| PCT/CN2021/071381 WO2021143706A1 (en) | 2020-01-13 | 2021-01-13 | Substituted triazinones as thyroid hormone receptor agonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2021208027A1 AU2021208027A1 (en) | 2022-07-28 |
| AU2021208027B2 true AU2021208027B2 (en) | 2025-10-16 |
Family
ID=74418122
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2021208027A Active AU2021208027B2 (en) | 2020-01-13 | 2021-01-13 | Substituted triazinones as thyroid hormone receptor agonists |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US11780825B2 (https=) |
| EP (1) | EP4090652A1 (https=) |
| JP (1) | JP7728265B2 (https=) |
| KR (1) | KR20220128383A (https=) |
| CN (1) | CN115244037B (https=) |
| AU (1) | AU2021208027B2 (https=) |
| IL (1) | IL294494A (https=) |
| MX (1) | MX2022008626A (https=) |
| WO (1) | WO2021143706A1 (https=) |
| ZA (1) | ZA202207541B (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GEP20247637B (en) | 2019-05-08 | 2024-06-25 | Aligos Therapeutics Inc | Modulators of thr-b and methods of use thereof |
| EP4090652A1 (en) | 2020-01-13 | 2022-11-23 | Eccogene (Shanghai) Co., Ltd. | Substituted triazinones as thyroid hormone receptor agonists |
| JP7813730B2 (ja) | 2020-06-17 | 2026-02-13 | オートバーン セラピューティクス，インク． | 甲状腺様作用剤 |
| WO2021257851A1 (en) | 2020-06-17 | 2021-12-23 | Autobahn Therapeutics, Inc. | Thyromimetics |
| EP4240730A1 (en) | 2020-11-06 | 2023-09-13 | Aligos Therapeutics, Inc. | 2-pyridones as thyroid hormone receptor modulators |
| CN114685450A (zh) * | 2020-12-30 | 2022-07-01 | 昆药集团股份有限公司 | 2-吡啶酮类衍生物及其制备方法和在医药上的应用 |
| CN117624069A (zh) * | 2022-08-19 | 2024-03-01 | 凯思凯迪（上海）医药科技有限公司 | 一种多环类甲状腺激素β受体激动剂及其用途 |
| CN118146123A (zh) * | 2024-02-04 | 2024-06-07 | 河北鼎泰制药有限公司 | 一种盐酸安罗替尼中间体的合成方法 |
| WO2026067791A1 (en) * | 2024-09-30 | 2026-04-02 | Ascletis Pharma (China) Co., Limited | 2-phenyl-1,2,4-triazine-3,5(2h,4h)-dione derivatives as thr-beta agonist or modulators for the treatment of obesity |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1088819A2 (en) * | 1999-09-30 | 2001-04-04 | Pfizer Products Inc. | 6-azauracil derivatives as thyroid receptor ligands |
| JP2012106996A (ja) * | 2010-10-19 | 2012-06-07 | Mitsubishi Tanabe Pharma Corp | 新規甲状腺ホルモンβ受容体作動薬 |
| WO2020169069A1 (en) * | 2019-02-21 | 2020-08-27 | Nanjing Ruijie Pharma Co., Ltd. | Novel compounds and their uses as thyroid hormone receptor agonists |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| DK1262177T3 (da) | 2001-05-31 | 2006-11-20 | Pfizer Prod Inc | Medicinsk brug af thyromimetiske forbindelser til behandling af hårtab og kompositioner |
| PL1919878T3 (pl) | 2005-07-21 | 2011-03-31 | Hoffmann La Roche | Pochodne pirydazynonu jako agoniści receptora hormonu tarczycy |
| US8076334B2 (en) | 2007-09-20 | 2011-12-13 | Hoffmann-La Roche Inc. | Prodrugs of thyroid hormone analogs |
| TWI534144B (zh) | 2009-04-20 | 2016-05-21 | 田邊三菱製藥股份有限公司 | 甲狀腺荷爾蒙β受體作動藥 |
| CN109574995B (zh) | 2018-01-23 | 2020-07-24 | 深圳市塔吉瑞生物医药有限公司 | 取代的哒嗪酮化合物 |
| CN111801324B (zh) | 2018-06-12 | 2021-10-22 | 四川海思科制药有限公司 | 甲状腺激素受体激动剂及其用途 |
| EP4090652A1 (en) | 2020-01-13 | 2022-11-23 | Eccogene (Shanghai) Co., Ltd. | Substituted triazinones as thyroid hormone receptor agonists |
| JP7813730B2 (ja) * | 2020-06-17 | 2026-02-13 | オートバーン セラピューティクス，インク． | 甲状腺様作用剤 |
-
2021
- 2021-01-13 EP EP21702359.7A patent/EP4090652A1/en active Pending
- 2021-01-13 CN CN202180019696.0A patent/CN115244037B/zh active Active
- 2021-01-13 KR KR1020227027435A patent/KR20220128383A/ko active Pending
- 2021-01-13 AU AU2021208027A patent/AU2021208027B2/en active Active
- 2021-01-13 WO PCT/CN2021/071381 patent/WO2021143706A1/en not_active Ceased
- 2021-01-13 MX MX2022008626A patent/MX2022008626A/es unknown
- 2021-01-13 US US17/147,538 patent/US11780825B2/en active Active
- 2021-01-13 IL IL294494A patent/IL294494A/en unknown
- 2021-01-13 JP JP2022542655A patent/JP7728265B2/ja active Active
-
2022
- 2022-07-07 ZA ZA2022/07541A patent/ZA202207541B/en unknown
-
2023
- 2023-08-11 US US18/448,277 patent/US12291518B2/en active Active
-
2025
- 2025-03-03 US US19/068,129 patent/US20250320197A1/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1088819A2 (en) * | 1999-09-30 | 2001-04-04 | Pfizer Products Inc. | 6-azauracil derivatives as thyroid receptor ligands |
| JP2012106996A (ja) * | 2010-10-19 | 2012-06-07 | Mitsubishi Tanabe Pharma Corp | 新規甲状腺ホルモンβ受容体作動薬 |
| WO2020169069A1 (en) * | 2019-02-21 | 2020-08-27 | Nanjing Ruijie Pharma Co., Ltd. | Novel compounds and their uses as thyroid hormone receptor agonists |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2023510835A (ja) | 2023-03-15 |
| EP4090652A1 (en) | 2022-11-23 |
| CA3164404A1 (en) | 2021-07-22 |
| US12291518B2 (en) | 2025-05-06 |
| JP7728265B2 (ja) | 2025-08-22 |
| US20240190846A1 (en) | 2024-06-13 |
| US20250320197A1 (en) | 2025-10-16 |
| AU2021208027A1 (en) | 2022-07-28 |
| ZA202207541B (en) | 2024-12-18 |
| US20210230146A1 (en) | 2021-07-29 |
| IL294494A (en) | 2022-09-01 |
| KR20220128383A (ko) | 2022-09-20 |
| WO2021143706A1 (en) | 2021-07-22 |
| CN115244037B (zh) | 2024-10-25 |
| US11780825B2 (en) | 2023-10-10 |
| CN115244037A (zh) | 2022-10-25 |
| MX2022008626A (es) | 2022-08-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC1 | Assignment before grant (sect. 113) |
Owner name: ECCOGENE INC. Free format text: FORMER APPLICANT(S): ECCOGENE (SHANGHAI) CO., LTD. |
|
| FGA | Letters patent sealed or granted (standard patent) |