AU2021206008A1 - Engineered Leishmania cells - Google Patents

Engineered Leishmania cells Download PDF

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Publication number
AU2021206008A1
AU2021206008A1 AU2021206008A AU2021206008A AU2021206008A1 AU 2021206008 A1 AU2021206008 A1 AU 2021206008A1 AU 2021206008 A AU2021206008 A AU 2021206008A AU 2021206008 A AU2021206008 A AU 2021206008A AU 2021206008 A1 AU2021206008 A1 AU 2021206008A1
Authority
AU
Australia
Prior art keywords
nucleotides
homologous
dna fragments
homologous region
leishmania
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
AU2021206008A
Other languages
English (en)
Inventor
Amirreza Faridmoayer
Rainer FOLLADOR
Anke Judith HARSMAN
Manuela Mally
Fabio SERVENTI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Limmatech Biologics AG
Original Assignee
Limmatech Biologics AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Limmatech Biologics AG filed Critical Limmatech Biologics AG
Publication of AU2021206008A1 publication Critical patent/AU2021206008A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/10—Protozoa; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2021206008A 2020-01-07 2021-01-07 Engineered Leishmania cells Pending AU2021206008A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062958088P 2020-01-07 2020-01-07
US62/958,088 2020-01-07
PCT/EP2021/050173 WO2021140144A1 (en) 2020-01-07 2021-01-07 Engineered leishmania cells

Publications (1)

Publication Number Publication Date
AU2021206008A1 true AU2021206008A1 (en) 2022-07-28

Family

ID=74194706

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2021206008A Pending AU2021206008A1 (en) 2020-01-07 2021-01-07 Engineered Leishmania cells

Country Status (6)

Country Link
US (1) US20230048847A1 (https=)
EP (1) EP4087912A1 (https=)
JP (1) JP7720307B2 (https=)
AU (1) AU2021206008A1 (https=)
CA (1) CA3166728A1 (https=)
WO (1) WO2021140144A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20240145084A (ko) 2017-06-30 2024-10-04 림마테크 바이오로직스 아게 조작되고 완전-기능 맞춤 당단백질
JP2024513755A (ja) 2021-03-23 2024-03-27 グリコエラ アーゲー マンノース３グリカン媒介タンパク質分解
WO2022200390A2 (en) 2021-03-23 2022-09-29 Glycoera Ag Glycan-mediated protein degradation
WO2024068753A1 (en) 2022-09-28 2024-04-04 Glycoera Ag Glycan-mediated protein degradation
US20260055211A1 (en) 2023-01-05 2026-02-26 Glycoera Ag Glycoengineered polypeptides targeting anti-neutrophil autoantibodies and uses thereof
WO2024147113A1 (en) 2023-01-05 2024-07-11 Glycoera Ag Glycoengineered polypeptides targeting anti-podocyte autoantibodies and uses thereof
JP2026501773A (ja) 2023-01-05 2026-01-16 グリコエラ アーゲー 免疫グロブリンａを標的とする糖鎖改変ポリペプチド及びそれを含む複合体
WO2024218743A1 (en) 2023-04-21 2024-10-24 Glycoera Ag Multi-functional molecules comprising glycans and uses thereof
WO2025215516A1 (en) 2024-04-08 2025-10-16 Glycoera Ag Glycoengineered polypeptides targeting igg4 autoantibodies and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69133557D1 (de) * 1990-08-29 2007-03-15 Pharming Intellectual Pty Bv Homologe rekombination in säugetier-zellen
US7351578B2 (en) * 1999-12-10 2008-04-01 Invitrogen Corp. Use of multiple recombination sites with unique specificity in recombinational cloning
US20010010928A1 (en) * 1999-03-26 2001-08-02 Stephen M. Beverley Protozoan expression system
WO2001032896A1 (en) * 1999-11-05 2001-05-10 Jena Bioscience Gmbh Protein expression systems for non-pathogenic <i>kinetoplastidae</i>
WO2002090556A1 (en) * 2001-05-08 2002-11-14 Jena Bioscience Gmbh Method for targeted homologous gene replacement in kinetoplastidae
KR20140048929A (ko) * 2011-06-21 2014-04-24 에비아제닉스 에스.에이. 물질대사적 발달의 방법
US11293033B2 (en) * 2016-05-18 2022-04-05 Amyris, Inc. Compositions and methods for genomic integration of nucleic acids into exogenous landing pads
KR20240145084A (ko) 2017-06-30 2024-10-04 림마테크 바이오로직스 아게 조작되고 완전-기능 맞춤 당단백질
WO2019234021A1 (en) * 2018-06-04 2019-12-12 Limmatech Biologics Ag Glycoengineered monoclonal antibody

Also Published As

Publication number Publication date
US20230048847A1 (en) 2023-02-16
EP4087912A1 (en) 2022-11-16
CA3166728A1 (en) 2021-07-15
JP7720307B2 (ja) 2025-08-07
WO2021140144A1 (en) 2021-07-15
JP2023509734A (ja) 2023-03-09

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