AU2021102458A4 - Compound preparation and method for inhibiting growth of mycotoxin in milk container - Google Patents
Compound preparation and method for inhibiting growth of mycotoxin in milk container Download PDFInfo
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- 235000013336 milk Nutrition 0.000 title claims abstract description 62
- 239000008267 milk Substances 0.000 title claims abstract description 62
- 210000004080 milk Anatomy 0.000 title claims abstract description 62
- 238000002360 preparation method Methods 0.000 title claims abstract description 35
- 231100000678 Mycotoxin Toxicity 0.000 title claims abstract description 33
- 239000002636 mycotoxin Substances 0.000 title claims abstract description 33
- 150000001875 compounds Chemical class 0.000 title claims abstract description 29
- 230000002401 inhibitory effect Effects 0.000 title claims abstract description 22
- 238000000034 method Methods 0.000 title description 12
- 241000628997 Flos Species 0.000 claims abstract description 28
- 240000002234 Allium sativum Species 0.000 claims abstract description 14
- 240000005343 Azadirachta indica Species 0.000 claims abstract description 14
- 241001474374 Blennius Species 0.000 claims abstract description 14
- 235000013500 Melia azadirachta Nutrition 0.000 claims abstract description 14
- 235000004611 garlic Nutrition 0.000 claims abstract description 14
- 235000012054 meals Nutrition 0.000 claims abstract description 14
- 239000002994 raw material Substances 0.000 claims abstract description 8
- 238000001035 drying Methods 0.000 claims description 10
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- 229940079593 drug Drugs 0.000 description 12
- 230000000694 effects Effects 0.000 description 9
- 238000002474 experimental method Methods 0.000 description 8
- 239000002108 aflatoxin M1 Substances 0.000 description 6
- 229930073161 aflatoxin M1 Natural products 0.000 description 6
- MJBWDEQAUQTVKK-IAGOWNOFSA-N aflatoxin M1 Chemical compound C=1([C@]2(O)C=CO[C@@H]2OC=1C=C(C1=2)OC)C=2OC(=O)C2=C1CCC2=O MJBWDEQAUQTVKK-IAGOWNOFSA-N 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 238000001514 detection method Methods 0.000 description 5
- 235000020185 raw untreated milk Nutrition 0.000 description 5
- 238000009991 scouring Methods 0.000 description 5
- 229930195730 Aflatoxin Natural products 0.000 description 4
- XWIYFDMXXLINPU-UHFFFAOYSA-N Aflatoxin G Chemical compound O=C1OCCC2=C1C(=O)OC1=C2C(OC)=CC2=C1C1C=COC1O2 XWIYFDMXXLINPU-UHFFFAOYSA-N 0.000 description 4
- 239000005409 aflatoxin Substances 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 229940126680 traditional chinese medicines Drugs 0.000 description 4
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- 239000003112 inhibitor Substances 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 235000020247 cow milk Nutrition 0.000 description 2
- 235000013365 dairy product Nutrition 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
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- 238000004659 sterilization and disinfection Methods 0.000 description 2
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- 231100000331 toxic Toxicity 0.000 description 2
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- 239000005878 Azadirachtin Substances 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- VEHPJKVTJQSSKL-UHFFFAOYSA-N azadirachtin Natural products O1C2(C)C(C3(C=COC3O3)O)CC3C21C1(C)C(O)C(OCC2(OC(C)=O)C(CC3OC(=O)C(C)=CC)OC(C)=O)C2C32COC(C(=O)OC)(O)C12 VEHPJKVTJQSSKL-UHFFFAOYSA-N 0.000 description 1
- FTNJWQUOZFUQQJ-IRYYUVNJSA-N azadirachtin A Natural products C([C@@H]([C@]1(C=CO[C@H]1O1)O)[C@]2(C)O3)[C@H]1[C@]23[C@]1(C)[C@H](O)[C@H](OC[C@@]2([C@@H](C[C@@H]3OC(=O)C(\C)=C/C)OC(C)=O)C(=O)OC)[C@@H]2[C@]32CO[C@@](C(=O)OC)(O)[C@@H]12 FTNJWQUOZFUQQJ-IRYYUVNJSA-N 0.000 description 1
- FTNJWQUOZFUQQJ-NDAWSKJSSA-N azadirachtin A Chemical compound C([C@@H]([C@]1(C=CO[C@H]1O1)O)[C@]2(C)O3)[C@H]1[C@]23[C@]1(C)[C@H](O)[C@H](OC[C@@]2([C@@H](C[C@@H]3OC(=O)C(\C)=C\C)OC(C)=O)C(=O)OC)[C@@H]2[C@]32CO[C@@](C(=O)OC)(O)[C@@H]12 FTNJWQUOZFUQQJ-NDAWSKJSSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C3/00—Preservation of milk or milk preparations
- A23C3/08—Preservation of milk or milk preparations by addition of preservatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/23—Solid substances, e.g. granules, powders, blocks, tablets
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/20—Targets to be treated
- A61L2202/23—Containers, e.g. vials, bottles, syringes, mail
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A compound preparation for inhibiting growth of the mycotoxin in the milk container provided by the
present invention is as follows: the compound preparation is prepared from the following raw materials in
parts by weight: 0.8-1.2 parts of garlic, 0.2-0.3 part of Flos caryophylli, 1.5-2.5 parts of Flos chrysanthemi indici,
0.3-0.7 part of Azadirachta Indica A., 0.8-1.2 parts of Herba taraxaci, 0.2-0.3 part of seaweed meal and 0.8-1.2
parts of Herba artemisiaescopariae.
Description
Description
Technical Field
The present invention relates to a production safety method for milk in a farm, in particular to a compound preparation and a method for inhibiting growth of mycotoxin in a milk container.
Background
Milk has become a necessity of life. However, mycotoxin has become one of main quality safety risk factors of the milk and threatened the human health severely. A large number of milk containers need to be employed in the milk production process. The milk containers are cleaned with clear water generally in the site because they are recycled, which is easy to produce the mycotoxin in the milk containers and then pollute milk products. However, the mycotoxin cannot be degraded by using whether pasteurization or high temperature sterilization in the milk processing process, which harms human bodies to a certain degree. At present, countries with developed dairy industry have already actively monitored the milk polluted by the mycotoxin, and an enzyme linked immunosorbent assay, serving as a milk rapid detection method, has already been widely applied to analysis and detection of the mycotoxin. However, there is no good method for realizing the inhibition of the mycotoxin in each production link. As a farm production link, growth of the mycotoxin caused by residual milk in the milk containers is an important pollution link. The existing milk container scouring mode is as follows: the milk containers (including milk containers on milk tankers) should be cleaned once immediately every day when being empty. When the milk containers are incompletely cleaned, cow milk may be polluted severely, bacteria can also grow even at a low temperature, and thus the quality of the cow milk is poor. When the milk
Description
containers are cleaned, water at a temperature of 15-45°C is used, and manual scrubbing is a relatively complete cleaning method. All parts in each milk container is scrubbed. Milk pumps, milk tubes and valves need to be cleaned with the clear water once after each use and should be scoured and cleaned twice per week. Particularly, it should be noted that parts including outlet valves, stirrers, tank covers and tank corners need to be scoured, and it needs to ensure that a cleaning agent is in contact with all the parts in each container for at least 2 min. The problems of the above method are as follows: manual cleaning has the possibility of missing scrubbing, the employed warm water cannot completely clean the interior of each valve, and the stirrers, the tank covers and the tank corners are difficult in complete cleaning, which may cause a cleaning dead angle and then cause growth of the mycotoxin.
Summary A purpose of the present invention is to provide a compound preparation and a method for inhibiting growth of mycotoxin in a milk container with respect to the above defects in the prior art, which may lower growth of the mycotoxin, reduce the mycotoxin in raw milk and then improve the quality and the safety of the raw milk. The technical solution of the compound preparation for inhibiting growth of the mycotoxin in the milk container provided by the present invention is as follows: the compound preparation is prepared from the following raw materials in parts by weight: 0.8-1.2 parts of garlic, 0.2-0.3 part of Flos caryophylli, 1.5-2.5 parts of Flos chrysanthemi indici, 0.3-0.7 part of Azadirachta Indica A., 0.8-1.2 parts of Herba taraxaci, 0.2-0.3 part of seaweed meal and 0.8-1.2 parts of Herba artemisiaescopariae. Preferably, the compound preparation is prepared from the following raw materials in parts by weight: 1 part of garlic, 0.25 part of Flos caryophylli, 2 parts
Description
of Flos chrysanthemi indici, 0.5 part of Azadirachta Indica A., 1 part of Herba taraxaci, 0.25 part of seaweed meal and 0.5 part of Herba artemisiaescopariae. A preparation method of the compound preparation for inhibiting growth of the mycotoxin in the milk container provided by the present invention comprises the following steps: (1) coarsely crushing the Flos caryophylli, the Flos chrysanthemi indici, the Azadirachta Indica A., the Herba taraxaci and the Herba artemisiae scopariae according to the above ratio; (2) drying a mixture obtained in the step (1); (3) drying and crushing the garlic to obtain garlic powder; (4) mixing the garlic powder with the dried mixture in the step (2), and then conducting crushing; (5) uniformly mixing the seaweed meal with the mixture in the step (4); (6) drying a mixture obtained in the step (5) to obtain the compound preparation for inhibiting growth of the mycotoxin in the milk container. The present invention has the beneficial effects that: (1) In a preparation process of the present invention, a method of uniform mixing in batch and drying in batch is employed, so that effective components of traditional Chinese medicines are kept to the maximum degree, and the curative effect is improved; (2) In composition of a drug and determination of a ratio of the present invention, a formula and a ratio thereof are obtained by screening through a great number of tests, that is, 1 part of garlic, 0.25 part of Flos caryophylli, 2 parts of Flos chrysanthemi indici, 0.5 part of Azadirachta Indica A., 1 part of Herba taraxaci, 0.25 part of seaweed meal and 0.5 part of Herba artemisiae scopariae, which are not described in the prior art and are optimal in effect; (3) The conventional technical biases are overcome, and a formula is innovated by carefully selecting traditional Chinese medicines with definite effect, such as the garlic, the Flos chrysanthemi indici and the Azadirachta Indica A., and mixing the above traditional Chinese medicines with the seaweed meal;
Description
(4) After the milk container is scoured, the quality of the milk is not affected although there are less residues; resistance of people can even be improved; and a taste of the milk can also be improved with fragrance of the Flos chrysanthemi indici. In addition, the garlic in the present invention contains rich proteins, oligosaccharide, polysaccharides, fats, minerals and the like, has the efficacy of resisting tumors and pathogenic microorganisms, preventing and controlling cardiovascular diseases and the like, can exert the effects of preventing diseases and protecting health after being taken for a long time, is a common clinical medicine and is mainly used for broad-spectrum bacterium resistance, sterilization, inflammation reduction and the like. The Flos caryophylli is warm in nature, is acrid in taste, distributes to spleen, stomach, lung or kidney channels, contains clove oil, has the characteristics of a preservative and a fungicide and may further aid digestion. The Flos chrysanthemi indici is bitter and little cool in nature, is acrid in taste and has the efficacy of dispelling wind and heat, dispersing swelling and removing toxicity. Azadirachtin extracted from the Azadirachta Indica A. can prevent biosynthesis of the mycotoxin and is a broad-spectrum, efficient, low-toxicity and easily degradable insecticide without residues, as recognized around the world. The Herba taraxaci is bitter and cool in nature, is sweet in taste and has the efficacy of clearing away heat and toxic materials, dispersing swelling and removing stasis. The seaweed meal contains the polysaccharide, is capable of boosting immunity and has the anticancer activity. The Herba artemisiae scopariae is rich in vitamins as well as multi-trace elements and more than 20 kinds of amino acids necessary for a human body and has a good health care function. The above seven traditional Chinese medicines are combined to use and collectively exert the efficacy of clearing away heat and toxic materials, inhibiting the mycotoxin and enhancing the organism resistivity. For the compound preparation of the present invention, common Chinese herbal medicines are reasonably formulated and utilized, the drug availability is improved after partial extraction, and the dosage is reduced; and repeated test
Description
results in the milk container of a farm in the later period show that the compound preparation has relatively good effect of inhibiting growth of the mycotoxin and has the effect of obviously improving the taste of the milk.
Detailed Description
The preferred embodiments of the present invention are described below. It should be understood that the preferred embodiments described here are only used for illustrating and explaining the present invention, not for limiting the present invention. Embodiment 1: the technical solution of the compound preparation for inhibiting growth of the mycotoxin in the milk container provided by the present invention is as follows: the compound preparation is prepared from the following raw materials in parts by weight: 1 part of garlic, 0.25 part of Flos caryophylli, 2 parts of Flos chrysanthemi indici, 0.5 part of Azadirachta Indica A., 1 part of Herba taraxaci, 0.25 part of seaweed meal and 0.5 part of Herba artemisiae scopariae. A preparation method of the compound preparation for inhibiting growth of the mycotoxin in the milk container provided by the present invention comprises the following steps: (1) coarsely crushing the Flos caryophylli, the Flos chrysanthemi indici, the Azadirachta Indica A., the Herba taraxaci and the Herba artemisiae scopariae according to the above ratio; (2) drying a mixture obtained in the step (1); (3) drying and crushing the garlic to obtain garlic powder; (4) mixing the garlic powder with the dried mixture in the step (2), and then conducting crushing; (5) uniformly mixing the seaweed meal with the mixture in the step (4); (6) drying a mixture obtained in the step (5) to obtain the compound preparation for inhibiting growth of the mycotoxin in the milk container.
Description
Embodiment 2: the technical solution of the compound preparation for inhibiting growth of the mycotoxin in the milk container provided by the present invention is as follows: the compound preparation is prepared from the following raw materials in parts by weight: 0.8 part of garlic, 0.2 part of Flos caryophylli, 1.5 parts of Flos chrysanthemi indici, 0.3 part of Azadirachta Indica A., 0.8 part of Herba taraxaci, 0.2 part of seaweed meal and 0.8 part of Herba artemisiae scopariae. The preparation method refers to the method mentioned in embodiment 1. Embodiment 3: the technical solution of the compound preparation for inhibiting growth of the mycotoxin in the milk container provided by the present invention is as follows: the compound preparation is prepared from the following raw materials in parts by weight: 1.2 parts of garlic, 0.3 part of Flos caryophylli, 2.5 parts of Flos chrysanthemi indici, 0.7 part of Azadirachta Indica A., 1.2 parts of Herba taraxaci, 0.3 part of seaweed meal and 1.2 parts of Herba artemisiae scopariae. The preparation method refers to the method mentioned in embodiment 1. The present invention uses the compound preparation for inhibiting growth of the mycotoxin in the milk container prepared in the embodiment 1 to conduct pharmacodynamics study. 1. Experimental method In an experiment, 20 milk containers from 8 dairy farms were selected from a certain region, and randomized into 4 groups with 5 milk containers in each group, wherein one group was a control group, and the other three groups were experimental groups. Before the experiment, contents of aflatoxin samples M1 in the 20 milk containers were detected with high performance liquid chromatography (HPLC). The milk containers sent milk once a day. After milk sending, the control group contained raw milk according to a previously normal using mode and was scoured with clear water for 1-2 times after the raw milk was sent; and in the control group, the milk containers were scoured with the mycotoxin with
Description
concentrations of 1%, 2% and 5% every day respectively. The experiment lasted for 30 days. The experimental groups and treatment modes are shown in Table 1.
Table 1 Milk Container Grouping and Treatment Group Treatment Blank control Scouring with clear water for 1-2 times Drug with low dosage Scouring with 1% inhibitor once per week Drug with medium dosage Scouring with 2% inhibitor once per week Drug with high dosage Scouring with 5% inhibitor once per week
After administration, at the last day of each week, sampling was conducted from the milk containers randomly in each group for detecting the aflatoxin M1; and the raw milk was sampled, boiled and then tasted by 10 persons in blind each time. Result and analysis 2.1 Change in aflatoxin M1 The aflatoxin M1 was detected before the experiment was started. After 1 week, 2 weeks, 3 weeks and 4 weeks after administration, detection was conducted again, and results were obviously changed. After administration, the content of the aflatoxin M1 in each test group was obviously lowered. Although each detection value did not exceed 0.5 pg/kg specified by the state, the aflatoxin may accumulate in a human body if being taken continuously, so that presence of the aflatoxin should still be reduced to lower the risk. Through detection in a laboratory, the concentration of the aflatoxin of 2% for once a week for 2 weeks is the best. Specifically see Table 2.
Table 2 Content of Aflatoxin M1/(ng-kg')
Group One week Two weeks Three weeks Four weeks Blank control 46.05 50.77 67.99 89.08
Description
Drug with 39.34 40.45 30.09 30.00 dosage of 1% Drug with 20.99 16.06 0 0 dosage of 2% Drug with 18.42 0 0 0 dosage of 3%
2.2 Changes in taste and flavor after boiling In the whole experimental period, the milk in a low-dosage group, a medium-dosage group and a high-dosage group was considered to be fresh in taste and flavor after being boiled, so that the number of people for lowered milk odor is gradually increased, the number of people in the medium-dosage group is the most, and then the high-dosage group. Specifically see Table 3.
Table 3 Number of People (People) With Good Taste and Flavor of Milk in Each Group Every Week In Experimental Period Group One week Two weeks Three weeks Four weeks Blank control 10 12 11 11 Drug with 12 14 22 30 dosage of 1% Drug with 12 18 28 36 dosage of 2% Drug with 13 16 27 30 dosage of 5%
3 Discussion In this experiment, after the milk containers were scoured by the compound preparation, certain effects of inhibiting the contents of the aflatoxin M1 and improving the taste of the milk were exerted. However, a difference between
Description
groups in inhibition performance was not significant, while the inhibition performance was significantly better than that of a blank control group without administration after the experiment was ended. However, the taste of the milk in an administration group was significantly better than that in the blank control group. For the compound preparation of the present invention, common Chinese herbal medicines are reasonably formulated and utilized, the drug availability is improved after partial extraction, and the dosage is reduced. The results of repeated experiments in the milk container of the farm in the later period show that the compound preparation has a relatively good effect of inhibiting growth of the mycotoxin and the effect of obviously improving the taste of the milk. The above only describes part of preferred embodiments of the present invention. Those skilled in the art familiar with the field may use the described technical solution to modify the present invention or modify the described technical solution into an equivalent technical solution. Thus, any simple modification or equivalent replacement made according to the technical solution of the present invention belongs to the protection scope of the present invention.
Claims (3)
1. A compound preparation for inhibiting growth of mycotoxin in a milk container, which is prepared from the following raw materials in parts by weight: 0.8-1.2 parts of garlic, 0.2-0.3 part of Flos caryophylli, 1.5-2.5 parts of Flos chrysanthemi indici, 0.3-0.7 part of Azadirachta Indica A., 0.8-1.2 parts of Herba taraxaci, 0.2-0.3 part of seaweed meal and 0.8-1.2 parts of Herba artemisiae scopariae.
2. The compound preparation for inhibiting growth of mycotoxin in the milk container according to claim 1, which is prepared from the following raw materials in parts by weight: 1 part of garlic, 0.25 part of Flos caryophylli, 2 parts of Flos chrysanthemi indici, 0.5 part of Azadirachta Indica A., 1 part of Herba taraxaci, 0.25 part of seaweed meal and 0.5 part of Herba artemisiaescopariae.
3. A preparation method of the compound preparation for inhibiting growth of the mycotoxin in the milk container of claim 1 or 2, comprising the following steps: (1) coarsely crushing the Flos caryophylli, the Flos chrysanthemi indici, the Azadirachta Indica A., the Herba taraxaci and the Herba artemisiae scopariae according to the above ratio; (2) drying a mixture obtained in the step (1); (3) drying and crushing the garlic to obtain garlic powder; (4) mixing the garlic powder with the dried mixture in the step (2), and then conducting crushing; (5) uniformly mixing the seaweed meal with the mixture in the step (4); (6) drying a mixture obtained in the step (5) to obtain the compound preparation for inhibiting growth of the mycotoxin in the milk container.
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| AU2021102458A Ceased AU2021102458A4 (en) | 2021-05-11 | 2021-05-11 | Compound preparation and method for inhibiting growth of mycotoxin in milk container |
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2021
- 2021-05-11 AU AU2021102458A patent/AU2021102458A4/en not_active Ceased
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