AU2021101824A4

AU2021101824A4 - Zhuang Medicine Compound Moxa Stick for Treating Ankylosing Spondylitis and Preparation Method Thereof

Info

Publication number: AU2021101824A4
Application number: AU2021101824A
Authority: AU
Inventors: Jianwen Xu
Original assignee: First Affiliated Hospital of Guangxi Medical University
Current assignee: First Affiliated Hospital of Guangxi Medical University
Priority date: 2021-04-09
Filing date: 2021-04-09
Publication date: 2021-05-27
Anticipated expiration: 2029-04-09

Abstract

A Zhuang medicine compound moxa stick for treating ankylosing spondylitis and a preparation method thereof are disclosed in the invention. The moxa stick is a columnar structure and composed of a filler and a roll paper for packaging the filler. Wherein, the fillers comprise the following raw materials of moxa, Premnafulva Craib., Calophyllum membranaceum Gardn. et Champ, Ramulus cinnamomi, Moghania philippinensis, Schefflera arboricola Hayata., Ardisia gigantifolia Stapf., Caulis pipers futokadsurae, Illicium difengpi and Caulis Phyllanthi Reticulati. The moxa stick of the invention is prepared based on Zhuang medicine theory, and the combination of various drugs can give full play to the maximum efficacy in treating ankylosing spondylitis, with small toxic and side effects, low cost, treatment on the symptoms and the causes and reasonable prescription. Specifically, Premna fulva, Calophyllum membranaceum and Moghania philippinensis can strengthen waist and bone, promote blood circulation and dredge collaterals; Schefflera arboricola, Ardisia gigantifolia, Caulis pipers futokadsurae, Illicium difengpi and Caulis Phyllanthi Reticulati can dispel wind and dampness as well disperse blood stasis and swelling: and Ramulus cinnamomi can expands the surrounding blood vessels, enhances the circulation of body surface, promotes the secretion of sweat glands, thus increases the distribution of heat, and promotes all drugs to enter the blood circulation through the skin better.

Description

Zhuang Medicine Compound Moxa Stick for Treating Ankylosing Spondylitis and

Preparation Method Thereof

TECHNICAL FIELD

The invention relates to a moxa stick for acupuncture and moxibustion belonging to

Zhuang compound medicines, and particularly describes a Zhuang medicine compound

moxa stick for treating ankylosing spondylitis and a preparation method thereof.

BACKGROUND

Ankylosing spondylitis refers to a common chronic progressive osteoarthropathy in

clinic, which mainly affects the axial skeleton and leads to severe pain and disability. At

present, the pathogenesis of ankylosing spondylitis has not been fully clarified. The

simple western medicine treatment has poor effect, and most of them are oral drugs, with

significant side effects after long-term application.

Ankylosing spondylitis belongs to the category of gout in Zhuang medicine, with slow,

long and recrudescent proceeding of pathological changes. Besides, it often involves the

spinous process, sacroiliac joint and hip joint. The Zhuang medicine believes that its

pathogenesis is congenital deficiency or acquired loss of nourishment, and then

pathogenic toxins such as wind, cold, and dampness swoop into the bones and muscles to

block the blood network and nervous network, causing the upper qi, lower qi and middle

qi to fail to synchronize and disease occurs.

Moxibustion therapy, as one of the common external therapies in Zhuang medicine, has

been widely used for the treatment of various diseases caused by the invasion of

pathogenic toxins such as wind, cold, and dampness and the blockage of blood network

and nervous network. There are many reports about the application of the traditional moxibustion therapy to the treatment of ankylosing spondylitis, but most of them use

Folium Artemisiae Argyi alone. However, there has not been a report of a suitable

compound moxa stick based on the theory of Zhuang medicine to treat ankylosing

spondylitis, which can improve the improve treatment effect.

SUMMARY

The purpose of the present invention is to provide a Zhuang medicine compound moxa

stick with significant curative effect, safety, reliability, no toxic side effects, and broad

clinical application prospects for the treatment of ankylosing spondylitis, and further

provides a preparation method thereof, so as to solve the above-mentioned problems

raised in the background.

In order to achieve the above objectives, the present invention provides the following

technical solutions.

The Zhuang medicine compound moxa stick for treating ankylosing spondylitis has a

columnar moxa stick and is composed of a filler and a roll paper for packaging the filler.

Wherein, the filler is prepared from the following parts by weight of raw materials of

200300 parts of moxa, 10~15 parts of Premnafulva Craib., 10~15 parts of Calophyllum

membranaceum Gardn. et Champ, 10-15 parts of Ramulus cinnamomi, 4-6 parts of

Moghaniaphilippinensis, 4-6 parts of Schefflera arboricolaHayata., 4-6 parts of Ardisia

gigantifolia Stapf., 4-6 parts of Caulispipersfutokadsurae, 4-6 parts of Illicium difengpi

and 4-6 parts of Caulis PhyllanthiReticulati.

As one further scheme of the invention, the filler is further prepared from the following

parts by weight of raw materials of 200 parts of moxa, 10 parts of Premnafulva Craib.,

parts of Calophyllum membranaceum Gardn. et Champ, 10 parts of Ramulus cinnamomi, 4 parts of Moghaniaphilippinensis, 4 parts of Schefflera arboricolaHayata.,

4 parts of Ardisia gigantifolia Stapf., 4 parts of Caulispipersfutokadsurae,4 parts of

Illicium difengpi and 4 parts of Caulis PhyllanthiReticulati.

As one further scheme of the invention, the filler is optionally prepared from the

following parts by weight of raw materials of 250 parts of moxa, 12 parts of Premna

fulva Craib., 12 parts of Calophyllum membranaceum Gardn. et Champ, 12 parts of

Ramulus cinnamomi, 5 parts of Moghania philippinensis, 5 parts of

Schefflera arboricolaHayata., 5 parts of Ardisia gigantifolia Stapf., 5 parts of

Caulis pipersfutokadsurae, 5 parts of Illicium difengpi and 5 parts of Caulis Phyllanthi

Reticulati.

As one further scheme of the invention, the filler is preferably prepared from the

following parts by weight of raw materials of 300 parts of moxa, 15 parts of Premna

fulva Craib., 15 parts of Calophyllum membranaceum Gardn. et Champ, 15 parts of

Ramulus cinnamomi, 6 parts of Moghania philippinensis, 6 parts of

Schefflera arboricolaHayata., 6 parts of Ardisia gigantifolia Stapf., 6 parts of

Caulis pipersfutokadsurae, 6 parts of Illicium difengpi and 6 parts of Caulis Phyllanthi

Reticulati.

The preparation method of the Zhuang medicine compound moxa stick for treating

ankylosing spondylitis includes the following steps of grinding Premna fulva Craib.,

Calophyllum membranaceum, Ramulus cinnamomi, Moghania philippinensis,

Schefflera arboricolaHayata., Ardisia gigantifolia Stapf., Caulispipersfutokadsurae,

Illicium difengpi and Caulis Phyllanthi Reticulati. into fine powder, sieving the powder

with a 100-mesh sieve and uniformly mixing; then paving the roll paper, uniformly spreading the moxa and the medicine powder on the paper and rolling the paper tightly like a firecracker; and finally, applying egg white outside, pasting a layer of roll paper again with leaving 3cm blank paper at both ends and rolling tightly.

Pharmacological analysis

Premnafulva Craib, belonging to Premna of Verbenaceae, is pungent in taste, slightly

sweet in flavour and neutral in nature. It can strengthen waist and bone, promote blood

circulation and remove blood stasis and eliminate stagnation to stop pain. Further, it is

mainly used for lumbago, sprain, rheumatic arthritis, rheumatoid arthritis, edema,

carbuncle and bum due to hot liquid or fire.

Calophyllum membranaceum Gardn.et Champ. has slightly bitter taste and mild nature. It

can dispel wind-damp, strengthen muscles and bones, activate blood and relieve pain.

Further, it is mainly used for rheumatism joint pain, lumbago and leg pain, falling injury,

jaundice hepatitis, irregular menstruation and dysmenorrhea.

Ramulus cinnamomic is the dry twig of Cinnamomum cassia Presl, pungent, sweet and

warm in nature. It has the effect of sweating and releasing muscle, warming and

activating meridian, helping Yang and promoting Qi transformation, eliminating cold to

stop pain. It is mainly used for arthralgia, common cold due to wind-cold, epigastric

crymodynia, blood cold, amenorrhea, phlegm, edema, palpitation and renal mass disease.

Moghaniaphilippinensisis the root of FlemingiaphilippinensisMerr.et Rolfe. It is sweet,

astringent and neutral nature. It has the effect of dispelling wind and eliminating

dampness, relaxing tendons and activating collaterals, strengthening tendons and bones,

diminishing inflammation and relieving pain. It is mainly used for the treatment of

rheumatism, bone pain, lumbar pain, fatigue, dizziness, weakness of limbs, indigestion and loss of appetite.

Schefflera arboricolaHayata is pungent, slightly bitter and warm in nature. It has the

effect of dispelling wind and relieving pain, promoting blood circulation and

detumescence, and mainly treats rheumatic arthralgia, headache, toothache, epigastric

pain, dysmenorrhea, postpartum abdominal pain, swelling and pain of injuries, fracture,

sore.

Ardisia gigantifolia Stapf is pungent, bitter and warm in nature. It has the effect of

dispelling wind and activating blood circulation, strengthening muscles and bones,

dispersing blood stasis and detumescence. It is mainly used for rheumatoid arthritis pain,

muscle and bone pain, swelling and pain of injuries, postpartum paralysis, hemiplegia and

chronic ulcer.

Caulis pipersfutokadsurae is the dried cane of Piperkadsura (Choisy)Ohwi. It is pungent,

bitter and slightly warm-natured. It has the effect of dispelling rheumatism, dredging

meridians and collaterals, and stopping arthralgia. It is mainly used to treat arthralgia due

to wind cold and dampness, limb pain, tendon contracture, and stiff flexion and extension.

Illicium difengpi K.I.B.et K.I.M. is slightly pungent, astringent and warm-natured. It has

the effect of dispelling wind and removing dampness, promoting qi circulation to relieve

pain. It is mainly responsible for rheumatic arthralgia and low back pain due to fatigue.

Caulis Phyllanthi Reticulati. is the stem of Phyllanthus reticulatus

Poir.var.glaberMuell.~Age.

It is light and astringent in taste and mild in nature. It has the effect of dispelling wind

and

activating blood circulation, dispersing blood stasis and detumescence; it is mainly used for rheumatic arthralgia and traumatic injury.

Compared with the existing technology, the invention has the following advantages.

The moxa stick of the invention is prepared based on Zhuang medicine theory, and the

combination of various drugs can give full play to the maximum efficacy in treating

ankylosing spondylitis, with small toxic and side effects, low cost, and reasonable

prescription. Specifically, Premna fulva, Calophyllum membranaceum and Moghania

philippinensis can strengthen waist and bone, promote blood circulation and dredge

collaterals; Schefflera arboricola, Ardisia gigantifolia, Caulispipersfutokadsurae,

Illicium difengpi and Caulis Phyllanthi Reticulati can dispel wind and dampness as well

disperse blood stasis and swelling: and Ramulus cinnamomi can expands the surrounding

blood vessels, enhances the circulation of body surface, promotes the secretion of sweat

glands, thus increases the distribution of heat, and promotes all drugs to enter the blood

circulation through the skin better.

DESCRIPTION OF THE INVENTION

The technical scheme of the patent is further described in detail below in connection with

specific embodiments.

Embodiment 1

Wherein, the filler is prepared from the following parts by weight of raw materials of 200

parts of moxa, 10 parts of Premnafulva Craib., 10 parts of Calophyllum membranaceum

Gardn. et Champ, 10parts of Ramulus cinnamomi, 4 parts of Moghania philippinensis, 4 parts of Schefflera arboricolaHayata., 4 parts of Ardisia gigantifolia Stapf., 4 parts of

Caulispipersfutokadsurae, 4 parts of Illicium difengpi and 4 parts of Caulis Phyllanthi

Reticulati.

Embodiment 2

Wherein, the filler is prepared from the following parts by weight of raw materials of 250

parts of moxa, 12 parts of Premnafulva Craib., 12 parts of Calophyllum membranaceum

Gardn. et Champ, 12 parts of Ramulus cinnamomi, 5 parts of Moghaniaphilippinensis, 5

parts of Schefflera arboricolaHayata., 5 parts of Ardisia gigantifolia Stapf., 5 parts of

Caulispipersfutokadsurae, 5 parts of Illicium difengpi and 5 parts of Caulis Phyllanthi

Reticulati.

Embodiment 3

Wherein, the filler is prepared from the following parts by weight of raw materials of 300

parts of moxa, 15 parts of Premnafulva Craib., 15 parts of Calophyllum membranaceum

Gardn. et Champ, 15 parts of Ramulus cinnamomi, 6 parts of Moghaniaphilippinensis, 6

parts of Schefflera arboricolaHayata., 6 parts of Ardisia gigantifolia Stapf., 6 parts of

Caulispipersfutokadsurae, 6 parts of Illicium difengpi and 6 parts of Caulis Phyllanthi

Reticulati.

The preparation method of the Zhuang medicine compound moxa stick for treating

ankylosing spondylitis in Embodiments 1-3 includes the following steps of grinding

Premna fulva Craib., Calophyllum membranaceum Gardn. et Champ, Ramulus

cinnamomi, Moghania philippinensis, Schefflera arboricolaHayata., Ardisia

gigantifolia Stapf., Caulis pipersfutokadsurae, Illicium difengpi and Caulis Phyllanthi

Reticulati. into fine powder, sieving the powder with a 100-mesh sieve and uniformly

mixing; then paving the roll paper, uniformly spreading the moxa and the medicine

powder on the paper and rolling the paper tightly like a firecracker; and finally, applying

egg white outside, pasting a layer of roll paper again with leaving 3cm blank paper at

both ends and rolling tightly

Curative effect judgment

1. Case selection

patients with ankylosing spondylitis were selected as the treatment group using the

Zhuang medicine compound moxa stick of the invention, aged from 16 to 52 years, with

an average of 27.3 years.

2. Therapeutic schedule

Fifty patients were treated with the Zhuang medicine compound moxa stick, and the

moxibustion was carried out once a day. Specifically, the single hole moxibustion box

was used for fumigating moxibustion for 15-20min each time, until the skin flushed. In

the process of moxibustion, people should pay attention to the feeling of the patients so as

to adjust the distance between the fire source and the skin and timely flick the ashes to

avoid scalding the patients. After use, the moxa stick should be placed in the fire bottle to

avoid fire. After moxibustion, patients should be advised to avoid cold and humidity,

regulate emotion, and eat less fat, sweet, thick and cold and spicy food.

3. Evaluation criteria of curative effect

Clinically relieved: Back pain disappeared without stiffness and limited activity; and

erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were normal.

Remarkably effective: The pain of the back and waist disappeared basically, with

occasional stiffness and limited movement. ESR and CRP were normal or close to normal.

Effective: The clinical symptoms and signs such as lumbar and back pain were improved

to a certain extent and ESR and CRP were improved as well.

Ineffective: The clinical symptoms and signs such as lumbar and back pain were not

improved, and the ESR and CPR were not improved.

4. Result

cases were clinically relieved, 21 cases were remarkably effective, 10 cases were

effective, 4 cases were ineffective, and the total effective rate was 92%.

Here are three typical cases.

(1) Patient Li, female, 20 years old, from Bobai, Guangxi

The patient was diagnosed because of repeated pain in the waist, buttock and hip, rigidity

of lumbar plate, limited activity for 4 years and aggravation for 3 weeks. There was

diagnostic information of pale face, thin body, bad neck rotation, hard to bend down,

slightly swollen knee joint. Moreover, the tongue coating was white and greasy, and the

pulse is smooth. Pelvic X-ray anteroposterior and lateral film showed that sacroiliac joint

was blurred, consistent with the change signs of AS and HLA-B27 was positive, ESR

was 46 mm/h and CRP was 38mg/L. According to the medical history, physical signs and

imaging examination, ankylosing spondylitis was diagnosed. After 10 days of

moxibustion treatment, the waist hip pain was slightly improved, the lumbar plate

stiffness was slightly relieved, the neck and waist activities were slightly better, and the shortness of breath and fatigue were alleviated. After 6 weeks of treatment, the symptoms and signs were further improved, ESR and CRP were normal. Furthermore, there was no recurrence after half a year of follow-up.

(2) Patient Zhang, male, 27 years old, from Yizhou, Guangxi

The patient had recurrent lumbosacral pain for more than 4 years, which aggravated for 1

month. There was diagnostic information of waist and hip joint pain and limited activity

with aggravation in cold day, walking inconvenience, cold hands and feet, sleepy and

weak. Besides, tongue was light red, tongue coating was thin and slightly yellow, pulse

was heavy. CT scan of sacroiliac joint showed that bilateral sacroiliac joint surface was

blurred, joint space narrowed, and partial fusion was seen. HLA-B27 was positive, ESR

was 29mm/h and CRP was 76mg/L. According to the medical history, physical signs and

imaging examination, it was diagnosed as ankylosing spondylitis. Moxibustion was used

for treatment. After one week, morning stiffness, pain in waist and hip were reduced, and

hands and feet became warmer. After 5 weeks of continuous treatment, symptoms and

signs were improved further, ESR and CRP were almost normal. Moreover, there was no

recurrence in half a year follow-up.

(3) Patient Feng, male, 38 years old, from Nanning, Guangxi

The patient had been diagnosed with recurrent lumbago and backache for more than 10

years. There was diagnostic information of limited movement of spine in all directions,

pain on both hips caused by gentle pressure, limited movement of both hips in all

directions, dark tongue, thin white tongue coating and smooth pulse. The X-ray film of

sacroiliac joint showed destruction and partial fusion of bilateral sacroiliac joints, and the

lumbar spine showed bamboo-like changes; HLA-B27 was positive, ESR was 58mm/h, and CRP was 23mg/L. According to the medical history, physical signs and imaging examination, ankylosing spondylitis was diagnosed, and moxibustion treatment of the invention could reduce the pain of low back and slightly improve the activity of spine and hip joint after 2 weeks. After 5 weeks of treatment, the back pain disappeared, the movement of spine and hip joint was slightly limited. Further, ESR and CRP were improved.

The moxibustion for ankylosing spondylitis is mainly applied to Dazhui, Shenzhu,

Zhiyang, Zhongshi, Yaoyangguan, Yaoshu and other Du channel acupoints. Besides,

scalding should be avoided during moxibustion.

ankylosing spondylitis, with small toxic and side effects, low cost, treatment on the

symptoms and the causes and reasonable prescription. Specifically, Premna fulva,

Calophyllum membranaceum and Moghania philippinensis can strengthen waist and

bone, promote blood circulation and dredge collaterals; Schefflera arboricola, Ardisia

gigantifolia, Caulis pipersfutokadsurae, Illicium difengpi and Caulis Phyllanthi

Reticulati can dispel wind and dampness as well disperse blood stasis and swelling: and

Ramulus cinnamomi can expands the surrounding blood vessels, enhances the circulation

of body surface, promotes the secretion of sweat glands, thus increases the distribution of

heat, and promotes all drugs to enter the blood circulation through the skin better.

The preferred embodiments of this patent have been described in detail above, but this

patent is not limited to the above embodiments, and various changes can be made within

the knowledge of ordinary technicians in this field without departing from the purpose.

Claims

THE CLAIMS DEFINING THE INVENTION ARE AS FOLLOWS:

1. A Zhuang medicine compound moxa stick for treating ankylosing spondylitis,

characterized in that the moxa stick is a columnar structure and composed of a filler and a

roll paper for packaging the filler. Wherein, the filler is prepared from the following parts

by weight of raw materials of 200-300 parts of moxa, 10-15 parts of Premna fulva

Craib., 10~15 parts of Calophyllum membranaceum Gardn. et Champ, 10~15 parts of

Ramulus cinnamomi, 4-6 parts of Moghania philippinensis, 4-6 parts of

Schefflera arboricolaHayata., 4-6 parts of Ardisia gigantifolia Stapf., 4-6 parts of

Caulis pipersfutokadsurae, 4-6 parts of Illicium difengpi and 4-6 parts of Caulis

PhyllanthiReticulati.

2. The Zhuang medicine compound moxa stick for treating ankylosing spondylitis as

stated in Claim 1, characterized in that the filler is further prepared from the following

parts of Calophyllum membranaceum Gardn. et Champ, 10 parts of Ramulus

cinnamomi, 4 parts of Moghaniaphilippinensis, 4 parts of Schefflera arboricolaHayata.,

Illicium difengpi and 4 parts of Caulis PhyllanthiReticulati.

3. The Zhuang medicine compound moxa stick for treating ankylosing spondylitis as

stated in Claim 1, characterized in that the filler is optionally prepared from the following

parts by weight of raw materials of 250 parts of moxa, 12 parts of Premnafulva Craib.,

12 parts of Calophyllum membranaceum Gardn. et Champ, 12 parts of Ramulus

cinnamomi, 5 parts of Moghaniaphilippinensis, 5 parts of Schefflera arboricolaHayata.,

parts of Ardisia gigantifolia Stapf., 5 parts of Caulispipersfutokadsurae,5 parts of

Illicium difengpi and 5 parts of Caulis PhyllanthiReticulati.

4. The Zhuang medicine compound moxa stick for treating ankylosing spondylitis as

parts by weight of raw materials of 300 parts of moxa, 15 parts of Premnafulva Craib.,

parts of Calophyllum membranaceum Gardn. et Champ, 15 parts of Ramulus

cinnamomi, 6 parts of Moghaniaphilippinensis, 6 parts of Schefflera arboricolaHayata.,

6 parts of Ardisia gigantifolia Stapf., 6 parts of Caulispipersfutokadsurae,6 parts of

Illicium difengpi and 6 parts of Caulis PhyllanthiReticulati.

5. A preparation method of the Zhuang medicine compound moxa stick for treating

ankylosing spondylitis as stated in any one of Claims 1-3, characterized by comprising

the following steps of grinding Premna fulva Craib., Calophyllum membranaceum

Gardn. et Champ, Ramulus cinnamomi, Moghania philippinensis,

with a 100-mesh sieve and uniformly mixing; then paving the roll paper, uniformly

spreading the moxa and the medicine powder on the paper and rolling the paper tightly

like a firecracker; and finally, applying egg white outside, pasting a layer of roll paper

again with leaving 3cm blank paper at both ends and rolling tightly.