AU2021100694A4

AU2021100694A4 - Display Light Source Module, Display Screen and Their Application for Promoting the Growth and Repairing of Retinal Cells and Optic Neure

Info

Publication number: AU2021100694A4
Application number: AU2021100694A
Authority: AU
Inventors: Yingchao BAO; Lei Chen; Peng Cheng; Huanfa Jiang; Zhengxuan JIANG; Gang Yao; Guifang ZHENG
Original assignee: Qingdao Leimv Biotechnology Co Ltd; Anhui Medical University; Hefei University of Technology
Current assignee: Qingdao Leimv Biotechnology Co Ltd; Anhui Medical University; Hefei University of Technology
Priority date: 2021-02-04
Filing date: 2021-02-04
Publication date: 2021-04-22
Anticipated expiration: 2029-02-04

Abstract

This invention involves the display light source module, display screen and their application for promoting the growth and repairing of retinal cells and optic neure, including: Emission spectrum wavelength, including the light source of visible light with a wavelength of 400-700 nm and far-red light with a wavelength of 650-900 nm. With the application of this invention, the light source in light source module can emit the far-red light with a wavelength of 650-900 nm to promote repairing of damaged retinal cells and the growth of apoptotic retinal cells and optic neure. This invention is a solution to the failed repairing of impaired retinal cells and optic neure in the existing techniques. As a solution for developing visual health LCD TV and display, the technical scheme in this invention can reduce the impairment of human vision health due to LCD TV with LED backlight and other electronic display screens which use LED active or passive lighting as light source. -1/6 (a) 100 -E- G1 -- G2 -A- G3 80 -y-G4 -4-G5 -4- G6 60 -1- G8 --*- G9 - - G1800 =450 nm 40- -e G11 * 2 -|-G12 3 X- G13 20 -)K G14 - G15 --G16 0 660 660 700 7k0 800 860 Wavelength Fig. 1 (b) .700 0.035- -- HeLa cell absorption spectrum - Far-red light LED 600 S0.030 0.025 500 0.020- 30 COE 0.015- -300I~ CnC 0.010. -20C'__ -0 600 650 700 750 800 850 900 Wavelengt, nm h Fig. 2

Description

-1/6

(a) 100 -E- G1 -- G2 -A- G3 80 -y-G4 -4-G5 -4- G6 60 -1- G8 --*- G9 - - G1800 =450 nm 40- -e G11

* 2 -|-G12 3 X- G13 20 -)K G14 - G15 --G16 0 660 660 700 7k0 800 860 Wavelength

Fig. 1

(b) .700 0.035- -- HeLa cell absorption spectrum - Far-red light LED 600 S0.030 0.025 500

0.020- COE 30 0.015- -300I~ CnC 0.010. -20C'__ -0

600 650 700 750 800 850 900 Wavelengt, nm h

Fig. 2

Display Light Source Module, Display Screen and Their Application for

Promoting the Growth and Repairing of Retinal Cells and Optic Neure

Technical Field

This invention involves a display light source module and particularly, the display

light source module, display screen and their application for promoting the growth and

repairing of retinal cells and optic neure.

Background

Ever since the internet + era, we have enjoyed the great convenience in daily life

and significant improvement of living quality benefited from the news and information

transmitted by smart phones, vehicle display screens, LCD TVs and large display

screens. The LCD, which has the highest number of users and market share at

present among all kinds of electronic screens, needs the backlight due to the liquid

crystal's failure in active luminescence. The previous LCD, which takes the cold

cathode ray tube as backlight, is gradually replaced by LED (light emitting diode) due

to the high voltage and energy consumption of cold cathode ray tube. Featured by

high efficiency, low consumption, solid encapsulation, long life, high reliability, small

size and good shock resistance, LED applies to manufacturing of lightweight and thin

products, bringing new light source to LCD and further promoting the convenience

and thinning of LED. The LED is fully used in the LCD at present.

The existing techniques are focused on reducing the impairment of retinal cells

and optic neure due to electronic screen, which means they cannot repair the

impaired retinal cells and optic neure at all.

Summary

As a solution to technical problem, this invention is to provide the display light

source module, display screen and their application for promoting the growth and

repairing of retinal cells and optic neure, and repairing the impaired retinal cells and

optic neure.

This invention solves the technical problems above through the following

technical means:

This invention involves the display light source module, display screen and their

application for promoting the growth and repairing of retinal cells and optic neure,

comprising:

Emission spectrum wavelength, including the light source with a wavelength of

650-900 nm.

With the application of this invention, the light source in light source module can

emit the far-red light with a wavelength of 650-900 nm to promote repairing of

damaged retinal cells and the growth of apoptotic retinal cells and optic neure. So, this

invention can repair the impaired retinal cells and optic neure compared with the

existing techniques.

Optionally, the light source above comprises of: The far-red light LED used in

array combination to emit and white light LED to emit visible light, wherein,

The far-red light LED is encapsulated with blue-light LED with coating material,

wherein, the emission spectrum of blue-light LED has wavelength peak range of

450-470 nm; the coating material includes: Red light fluorescent material; the

emission spectrum of red light fluorescent material has the wavelength range of

650-900 nm.

Optionally, the control process of light source module includes:

Control the far-red light LED of emission infrared spectrum to give out light

according to the preset luminescence period, wherein the luminescence period is 5-60

min;

and/or,

Control the continuous illumination of white light LED of emitted visible light.

Optionally, the light source module also includes: Backlight; the white light LED of

light source is arranged at the outer side of the first lateral side of backlight while the

far-red light LED of light source is at the outer side of the second lateral side of

backlight, wherein, both of the first and the second side have the common port.

Optionally, the light source module also includes: Backlight; the white light LED

and far-red light LED are arranged in planar array at interval; the planar array is

arranged at the backside of backlight.

Optionally, the light source module comprises of several LEDs which launch

visible light and far-red light and the backlight, wherein, the preparation process of

LED that launches visible light and far-red light includes:

Mix the fluorescent powder and transparent silicone evenly at the preset

proportion to get the coating material; wherein, the fluorescent powder includes:

Infrared fluorescent powder, red light fluorescent powder and green light fluorescent

powder; the red light fluorescent powder includes: One type or combination of

K2TiF:Mn 4 +, K2TiF:Mn 4 + or K2 (Si, Ti)F:Mn 4 +; the green light fluorescent powder

includes: One type or combination of p-SIALON:Eu 2 + or Lu3GaO12:Ce 3 +.

Perform vacuum mixing and defoaming to the coating materials and cover them

on LED chip evenly to get the LED which launches visible light and far-red light;

wherein, the emission spectrum of blue-light LED has the wavelength peak range of

450-470 nm;

The light source module includes: Backlight; the planar array, which is composed

of LED that launches visible light and far-red light in light source, is arranged at the

backside of backlight.

Optionally, the infrared light fluorescent material includes:

One type or combination of YA13B4012:Cr 3 *, (YGd)3(AI,Ga)5O12:Cr3 *,

(Y,Gd)3(AI,Sc)5O12:Cr 3 *, (YGd)3(Ga,Sc)O12:Cr 3*, K3AIF6:Cr 3 +, Y3(AI,Sc)5O12:Cr3 +,

Mg4Nb2O9:Cr 3 ' and LiScSi206:Cr 3 *;

The red light fluorescent material includes:

One type or combination of K2TiF:Mn 4 +, K2TiF:Mn 4 + or K2 (Si, Ti)F6: Mn 4 +;

The green light fluorescent powder includes: One type or combination of

P-SIALON: Eu 2 + or Lu3GaO12:Ce 3*.

Optionally, the coating materials also include:

2 The CaAl1.2Sio.N3:Eu which accounts for 1-10% of total mass of red light

fluorescent powder.

Optionally, this invention also involves the display for promoting the growth and

repairing of retinal cells and optic neure; the display comprises of several arrays of

pixels, each of which is formed by encapsulating any light source, red light LED and

green light LED of Claim 1-10.

Merits of this invention:

(1) This invention is a solution to the failed repairing of impaired retinal cells and

optic neure in the existing techniques.

(2) The LED light source disclosed in this invention can alleviate the impairment

to vision health of human eyes due to LCD TV or other display screens which use

LED active or passive lighting as light source; besides, it can promote the repairing

and regeneration of retinal cells and optic neure, improve the vision and eye health.

(3) In this invention, the far-red light LED and the existing white light LED are

integrated for operating, or the far-red light fluorescent powder, green light fluorescent

powder and red light fluorescent powder are coated on the blue light LED to get the

white light LED which supports far-red light emission function; so, this invention not

only spreads the display image, but also supports biological regulation of eye cells

and neuron, extends the application of display in terms of vision health and

photobiomodulation and realizes new functions by integrating the techniques.

Brief Description of the Figures

Fig. 1 is the luminescence spectrogram of 16 samples provided in example 1 of

this invention;

Fig. 2 is the luminescence spectrogram of encapsulated far-red light LED of 16

samples numbered G6 provided in example 1 of this invention;

Fig. 3 is the luminescence spectrogram of blue light LED chip and green light

LED chip of contrast test in example 1 of this invention;

Fig. 4 is the luminescence spectrogram of the blue light LED and green light LED

which integrate far-red light LED respectively in example 1 of this invention;

Fig. 5 is the schematic diagram for retinal section of mouse under irradiation of

blue light LED and green light LED in contrast test of this invention 1.

Fig. 6 is the schematic diagram for retinal section of mouse under irradiation of

blue light LED and green light LED which integrate far-red light LED respectively in

this invention 1.

Fig. 7 is the luminescence spectrogram of blue light LED in example 2 of this

invention;

Fig. 8 is the luminescence spectrogram of 16 samples under 450 nm motivations in example 2 of this invention;

Fig. 9 is the luminescence spectrogram of 16 samples under 620 nm motivations

in example 2 of this invention;

Fig. 10 is the contrast diagram for luminescence spectrogram of far-red light LED

encapsulated in example 2 and absorption spectrum of HeLa cell in this invention;

Fig. 11 is the luminescence spectrogram of 16 samples under 450 nm

motivations in example 3 of this invention;

Fig. 12 is the contrast diagram for luminescence spectrogram of far-red light LED

encapsulated in example 3 and absorption spectrum of HeLa cell in this invention;

Description of the Invention

To solve the problems in the existing techniques, this invention involves the

display light source module, display screen and their application for promoting the

growth and repairing of retinal cells and optic neure, including: The light source with

emission spectrum wavelength including 650-900 nm.

Specifically, the light source above comprises of: The far-red light LED used in

array combination toemit and white light LED to emit visible light, wherein

wherein, the emission spectrum of blue-light LED has wavelength peak range of

450-470 nm; the coating material includes: Red light fluorescent material; the

emission spectrum of red light fluorescent material has the wavelength range of

650-900 nm. The white light LED is realized by the blue light LED chip with peak

emission wavelength of about 450 nm and matched with green and red fluorescent

powder. The detailed realization process is not introduced here, or the white light LED

can be realized by the existing white light LED.

In actual applications, perform vacuum mixing and defoaming to far-red light

fluorescent powder in silicone and then cover it on the blue light LED evenly.

Specifically, the control process of light source module includes:

Control the far-red light LED of emission infrared spectrum to give out light

min; and/or, control the continuous illumination of white light LED of emitted visible

light.

Specifically, the light source module also includes: Backlight; the white light LED

of light source is arranged at the outer side of the first lateral side of backlight while

the far-red light LED of light source is at the outer side of the second lateral side of

backlight, wherein, both of the first and the second side have the common port.

arranged at the backside of backlight.

Specifically, the light source comprises of several LEDs which can launch visible

light and far-red light, wherein, the manufacturing process of LED includes:

Mix the fluorescent powder and transparent silicone evenly at the preset

powder;

Perform vacuum mixing and defoaming to the coating materials and cover them

450-470 nm;

Specifically, the light source module includes: Backlight; the planar array, which is composed of LED that launches visible light and far-red light in light source, is arranged at the backside of backlight.

Specifically, the infrared light fluorescent material includes: One type or

combination of YA13B4012:Cr 3+, (YGd)3(AI,Ga)5O12:Cr 3 +, (YGd)3(AI,Sc)5O12:Cr 3 +,

(Y,Gd)3(Ga,Sc)O12:Cr3 +, K3AIF6:Cr 3+, Y3(AI,Sc)5O12:Cr 3+, Mg4Nb2O9:Cr 3' and

LiScSi206:Cr 3+; the red fluorescent material includes: One type or combination of

K2TiF:Mn 4 +, K2TiF:Mn 4 + or K2(Si,Ti)F:Mn 4 +; the green fluorescent material includes:

One type or combination of p-SIALON:Eu 2+or Lu3GaO12:Ce 3 *.

All of Y3(AI,Sc)5O12:Cr 3+, YA13B4012:Cr 3 +, Mg4Nb29:Cr 3 ' and LiScSi206:Cr 3 ' are

the existing fluorescent powders, wherein, Y3(AI,Sc)5O12:Cr 3 +, YA13B4012:Cr 3 +,

Mg4Nb2O9:Cr 3 *, and LiScSi206:Cr3 * are the abbreviations of

Y3[(Alo.75Sco.25)o.92Cro.o8]501, Y(Alo.96Cro.o4)3(BO3)4, (Mgo.97Cro.o3)4Nb2O8.98 and

Li(Sco.96Cro.4)Si2O6 respectively.

Specifically, the far-red light device can be hardly detected by human eyes after

being turned on due to weak response of human eyes to the far-red light. For easy

identification, the coating material also includes: The CaA1.2Sio.8N3:Eu 2 + which

accounts for 1-10% of total massof red light fluorescent powder. Besides,the red light

launched by CaA1.2Sio.8N3:Eu2 + can improve cell DNA activity to certain level.

On one hand, this invention provides the application of display light source

module, which is designed for promoting the growth and repairing of retinal cells and

optic neure, in the treatment of eye diseases.

On the other hand, this invention also involves the display for promoting the

growth and repairing of retinal cells and optic neure; the display comprises of several

arrays of pixels, each of which is formed by encapsulating any light source, red light

LED and green light LED of any item above.

Example 1

1) Evenly mix the silicones which are modeled Y550A and Y500B respectively

and produced by Jiangxi Leader Technology Co., Ltd. at the ratio of 1:1 to get the

transparent silicones.

2) Table 1 shows the chemical formula and synthesis conditions of far-red light

fluorescent material (Y1-xGdx)3[(Gal-tSct)1-zCrz]5012; produce 16 types of

(Y,Gd)3(Ga,Sc)5O12:Cr fluorescent powders according to the chemical formula in

Table 1, as shown in Table 1:

Table 1

Sample No. Chemical Formula Synthesis Condition G1 Y3(Gao.94Cro.o6)5012 Calcination for 4h at 1,350°C

3) Mix the (YGd)3(Ga,Sc)5O12:Cr 3 *fluorescent powders with the silicones at the

ratio of 1:1; apply vacuum mixing and defoaming to the fluorescent powders and

silicones by using the MT-1000 vacuum defoaming machine produced by Shenzhen

Marath Technology Co., Ltd. Titrate the mixture of fluorescent powders and

transparent silicones, which are defoamed using the Type D-260 dispenser produced

by Shenzhen Axxo Automation Technology Co., Ltd., onto the Type 5730 blue light

LED chip produced by APT Electronics Co., Ltd.; transfer the LED holder, as well as

the LED chip with silicon, into the Type DZF-6020 vacuum oven produced by

Shanghai Boxun Medical Biological Instrument Corp. Apply solidification for 4h at

vacuum condition at 150°C to get the far-red light LED bead.

4) Light up the far-red light LED bead and test the emission spectrum of far-red

light LED bead by using the USB4000 fiber optic spectrometer produced by Ocean

Optics, INC. Fig. 1 is the luminescence spectrogram of 16 samples provided in

example 1 of this invention. As shown in Fig. 1, the emission wavelength of the 16 fluorescent powder samples motivated by 450 nm is 675-850 nm and the sample numbered G6 has the highest luminescence. Fig. 2 is the luminescence spectrogram of encapsulated far-red light LED of 16 samples numbered G6 provided in example 1 of this invention and shows the emission spectrum of far-red light LED encapsulated by sample numbered G6 and driven by 300mA current. This device generates the broad band spectrum comprising multiple peaks, with peak emission wavelength of

715-756 nm and emission wavelength range of 675-850 nm. Fig. 2 also shows the

absorption spectrum of HeLa cell. By comparing the emission spectrum of LED

far-red light device and HeLa, Fig. 2 shows that far-red light LED encapsulated by

(Y,Gd)3(Ga,Sc)5012:Cr fluorescent powder can be matched with the absorption

spectrum of HeLa, in order to better perform biological regulation.

5) Encapsulate the far-red light LED by using the Sample G6 prepared in Step 4),

and test by using the blue light LED and green light LED at the condition with and

without far-red light LED respectively; select and weigh the 200-220g SD male rats,

randomly divide them into 4 groups, wherein, perform blue light LED irradiation to the

1 st group, blue light LED and far-red light LED irradiation to the 2 nd group, green light

LED irradiation to the 3 rd group and perform green light irradiation LED and far-red

light LED irradiation to the 4 th group. Perform 4h illumination to the 4 groups of rats

each day under the same conditions, ensure normal daytime changes at the rest

period and continue the test for 4 weeks in succession. Once the illumination is done,

take the ocular retina of rat for HE dyeing and observe their changes.

Fig. 3 is the luminescence spectrogram of blue light LED chip and green light

LED chip of contrast test in example 1 of this invention; Fig. 4 is the luminescence

spectrogram of the blue light LED and green light LED which integrate far-red light

LED respectively in example 1 of this invention. As shown in Fig. 3 and Fig. 4, the luminescence spectrogram of both blue light LED and green light LED are located in the range of visible spectrum; the spectrum of Sample G6 is the infrared spectrum that integrates the blue light LED and green light LED of infrared light LED. Fig. 5 is the schematic diagram for retinal section of mouse under irradiation of blue light LED and green light LED in contrast test of this invention 1. Fig. 6 is the schematic diagram for retinal section of mouse under irradiation of blue light LED and green light LED which integrate far-red light LED respectively in this invention 1. As shown in Fig. 5 (a), the retinal cells are sparse; as shown in Fig. 5 (b), the INL (endothelial cell) density of rat retina can be increased by adding the far-red light and the impairment is repaired obviously; however, the repaired INL of rat is still sparse. As shown in Fig. 6 (a), the

INL density of rat retina can be increased by adding the far-red light and the

impairment is repaired obviously. By comparing the Fig. 5 (a) and Fig. 6 (a), the rat

retina has certain impairment under the green light irradiation, for the INL is sparse

and thinned under the green light irradiation, but the impairment is minor under the

irradiation of green light. By comparing Fig. 5 (b) and Fig. 6 (b), the inner/outer cells of

rat retina are more dense and developed, proving that far-red light has an active role

in promoting the repairing and regeneration of retinal cells.

The cell growth and apoptosis are fast, but the neuronal cells, once impaired, are

unable to have promoted repairing and growth except for photobiomodulation. The

photobiomodulation of cells via far-red light is among the effective methods.

It is worth noting that the processes, other than the synthesis conditions designed

by the invention applicant, can be realized through the existing processes and

parameters in the preparation process of far-red light fluorescent powder; besides, the

metallic oxides used by the applicant are purchased from Sinopharm Chemical

Reagent Co., Ltd.

Example 2

The fluorescent materials used in example 1 and 2 of this invention are different;

the fluorescent material used in example 2 is (Y1-xGdx)3[(A-tGat)1-zCrz]5O12, wherein

x!1, 05t!1, 0<xs0.1, which is called (YGd)3(AI,Ga)5O12:Cr 3+ in short.

Fig. 7 is the luminescence spectrogram of blue light LED in example 2 of this

invention; Fig. 8 is the luminescence spectrogram of 16 samples under 450 nm

motivations in example 2 of this invention; Fig. 9 is the luminescence spectrogram of

16 samples under 620 nm motivations in example 2 of this invention. As shown in Fig.

7-9, the components of fluorescent powder can be changed to control the emission

wavelength of fluorescent powder; the emission spectrum configuration of fluorescent

powder slightly varies when being motivated at different wavelengths; the sample

numbered A6 has the highest luminescence.

encapsulated in example 2 and absorption spectrum of HeLa cell in this invention; the

emission spectrum of far-red light LED encapsulated by No. A6 sample and driven by

mA current is shown in Fig. 10. Fig. 10 also shows the absorption spectrum of HeLa

cell. By comparing the emission spectrum of far-red light LED and HeLa cell

absorption spectrum in Fig. 10, the overlapped spectrum area of them proves that this

far-red light LED can satisfy the requirements of photobiomodulation

(T.I.Karu,eta.,IEEEJ.Sel.Top.QuantumElectron,2001,7,982).

Example 3

The far-red light fluorescent materials used in example 1 and 3 of this invention

are different; the fluorescent material used in example 3 is

(Y1-xGdx)3[(A 1-tSct)1-zCrz]12, wherein n0x!1, O!t1, 0<xs0.1, which is abbreviated as

(Y,Gd)3(AI,Sc)5012:Cr.

Fig. 11 is the luminescence spectrogram of 16 samples under 450 nm

motivations in example 3 of this invention; as shown in Fig. 11, the components of

fluorescent powder can be changed to control the emission wavelength of fluorescent

powder; the emission wavelength of the fluorescent powder is ranged 675-850 nm

and the sample numbered G6 has the highest luminescence. Fig. 12 is the contrast

diagram for luminescence spectrogram of far-red light LED encapsulated in example

3 and absorption spectrum of HeLa cell in this invention; as shown in Fig. 12, the

emission spectrum of this far-red light LED is a broad band spectrum comprising 2

peaks, wherein the emission wavelength of main peak is 758nm, while the

wavelength of secondary peak is 711 nm, and the emission wavelength is ranged

675-850 nm. By comparing with the absorption spectrum of HeLa cells, the emission

spectrum of this far-red light LED can better satisfy the requirements for vision health

of human eyes.

The examples above are to introduce the technological schemes of this invention,

instead of setting limitations; even if the invention is introduced in details by referring

to the examples above, the general technicians in this field should understand the

followings: It is allowed to modify the technical schemes in the examples above, or

replace the technical characteristics; however, such modifications or replacements

should not make the technical scheme separated from the idea and scope of technical

schemes in the examples.

Claims

Claims

1. Feature of display light source module, display screen and their application for

promoting the growth and repairing of retinal cells and optic neure and the module lies

in:

Emission spectrum wavelength, including the light source with a wavelength of

650-900 nm

2. The feature of the display light source module, display screen and their

application for promoting the growth and repairing of retinal cells and optic neure as

mentioned in Claim 1 is that the light sources include: the far-red light LED used in

array combination to emit and white light LED to emit visible light, wherein,

The far-red light LED is encapsulated with blue-light LED with coating material,

wherein, the emission spectrum of blue-light LED has wavelength peak range of

450-470 nm; the coating material includes: Red light fluorescent material; the

emission spectrum of red light fluorescent material has the wavelength range of

650-900 nm.

3. The feature of the display light source module, display screen and their

application for promoting the growth and repairing of retinal cells and optic neure as

mentioned in Claim 2 is that light sources and control processes of light source

module include:

Control the far-red light LED of emission infrared spectrum to give out light

according to the preset luminescence period, wherein the luminescence period is 5-60

min;

and/or

Control the continuous illumination of white light LED of emitted visible light.

4. The feature of the display light source module, display screen and their application for promoting the growth and repairing of retinal cells and optic neure as mentioned in Claim 2 is that the light source modules include backlight; the white light

LED of light source is arranged at the outer side of the first lateral side of backlight

while the far-red light LED of light source is at the outer side of the second lateral side

of backlight, wherein, both of the first and the second side have the common port.

5. The feature of the display light source module, display screen and their

application for promoting the growth and repairing of retinal cells and optic neure as

mentioned in Claim 2 is that light source modules include backlight; the white light

LED and far-red light LED are arranged in planar array at interval; the planar array is

arranged at the backside of backlight.

6. The feature of the display light source module, display screen and their

application for promoting the growth and repairing of retinal cells and optic neure as

mentioned in Claim 1 is that the light source module comprises of several LEDs which

launch visible light and far-red light and the backlight, wherein, the preparation

process of LED that launches visible light and far-red light includes:

Perform vacuum mixing and defoaming to the coating materials and cover them

on LED chip evenly to get the LED which launches visible light and far-red light;

wherein, the emission spectrum of blue-light LED has the wavelength peak range of

450-470 nm;

The light source module includes: Backlight; the planar array, which is composed

of LED that launches visible light and far-red light in light source, is arranged at the

backside of backlight.

7. The feature of any of display light source module, display screen and their

application for promoting the growth and repairing of retinal cells and optic neure as

mentioned in Claim 2-6 is that the infrared light fluorescent materials include:

One type or combination of YA13B4012:Cr 3 *, (YGd)3(AI,Ga)5O12:Cr3 *,

(Y,Gd)3(AI,Sc)5O12:Cr 3 *, (YGd)3(Ga,Sc)O12:Cr 3*, K3AIF6:Cr 3 +, Y3(AI,Sc)5O12:Cr3 +,

Mg4Nb2O9:Cr 3 ' and LiScSi206:Cr3 -.

8. The feature of any of display light source module, display screen and their

application for promoting the growth and repairing of retinal cells and optic neure as

mentioned in Claims 7 is that the coating materials also include:

2 The CaAl1.2Sio.N3:Eu which accounts for 1-10% of total mass of red light

fluorescent powder.

9. Application of display light source module and display screen for promoting the

growth and repairing of retinal cells and optic neure and their application in treatment

of eye diseases in Claim 1-8.

10. The feature of the display light source module, display screen and their

application for promoting the growth and repairing of retinal cells and optic neure is

that the display screen comprises of several arrays of pixels, each of which is formed

by encapsulating any light source, red light LED and green light LED of Claim 1-8.

-1/6- 04 Feb 2021

(a) 100 G1 G2 G3 80 G4 G5 发光强度， a.u. G6 G7 60 2021100694

G8 G9 Light intensity

G10 ex=450 nm 40 G11 G12 G13 20 G14 G15 G16 0 600 650 700 750 800 850 波长， nm Wavelength

Fig. 1

(b) 700 0.035 HeLa HeLacell 细胞吸收 absorption 谱 spectrum Far-red 远红光LED light LED 600

a.u. 0.030 细胞吸收强度, a.u.

远红光LED发光强度, 500 Light intensity of Far-red 0.025 HeLa cell absorption

0.020 400 HeLaspectrum

0.015 300 light LED

0.010 200 0.005 100 0.000 0 600 650 700 750 800 850 900 波长， Wavelengt nm h Fig. 2

-2/6- 04 Feb 2021

(a) 蓝光 Blue LED light LED 600 Green light LED 发光强度, a.u. 绿光LED

400 Light intensity 2021100694

200

0

400 500 600 700 Wavelength 波长, nm Fig. 3

(b) Blue 蓝光 +远红 light + Far-red 光 light Green +远红绿光light 光 light + Far-red 600 发光强度, a.u.

400 Light intensity

200

0 400 500 600 700 800 900 波长, Wavelength nm Fig. 4

-3/6- 04 Feb 2021

LED blue light 2021100694

Without Far-red With Far-red Light Light

Fig. 5

LED green light

Without Far-red With Far-red Light Light

Fig. 6

(a) 100 蓝光芯片 Blue light chip a.u.

80 对发光强度，

60 Relative light 相intensity

40

20

0

400 500 600 700 800 波长， Wavelength nm

Fig. 7

-4/6- 04 Feb 2021

(b) G1 ex=455nm G2 600 G3 G4 500 a.u. G5 G6 400 G7 光强度， 2021100694

G8 G9 Relative light

300 intensity

G10 G11 发

200 G12 G13 G14 100 G15 G16 0 600 650 700 750 800 850 波长, Wavelength nm

Fig. 8

(d)0.035 80 HeLa HeLa cell细胞吸收spectrum absorption 谱 Far-red 远红光LED-2light LED-2

远红光LED发光强度, a.u. 0.030 胞吸收强度, a.u.

60 0.025 Light intensity of far-red LED HeLa cell absorption

0.020 40 intensity

0.015 HeLa细

0.010 20 0.005

0.000 0 600 650 700 750 800 850 900 波长， Wavelength nm

Fig. 9

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(c) G1 G2 G3 G4 300 G5 发光强度， a.u.

G6 G7 2021100694

G8 200 Light intensity

G9 G10 G11 G12 100 G13 G14 G15 G16 0 650 700 750 800 850 波长， Wavelength nm

Fig. 10

(a) S1 40 S2 S3 S4 30 S5 发光强度， a.u.

S6 S7 S8 20 S9 Light intensity

S10 S11 S12 10 S13 S14 S15 S16 0 600 650 700 750 800 850 Wavelength 波长， nm

Fig. 11

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(b) 100 0.035 HeLa HeLa 细absorption cell 胞吸收谱 spectrum Far-red光远红 light LEDLED-2

a.u. 0.030 80 a.u.

度, 0.025 强度,

光强LED 2021100694

intensity

60

far-red 0.020 细胞吸收

of 发 cell absorption

0.015 40

光LED intensity 0.010 HeLaHeLa

远红 20

Light 0.005

0.000 0 600 650 700 750 800 850 900 波长， Wavelength nm

Fig. 12