AU2020241429A1 - Peptidomimetic macrocycles and uses thereof - Google Patents

Peptidomimetic macrocycles and uses thereof Download PDF

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Publication number
AU2020241429A1
AU2020241429A1 AU2020241429A AU2020241429A AU2020241429A1 AU 2020241429 A1 AU2020241429 A1 AU 2020241429A1 AU 2020241429 A AU2020241429 A AU 2020241429A AU 2020241429 A AU2020241429 A AU 2020241429A AU 2020241429 A1 AU2020241429 A1 AU 2020241429A1
Authority
AU
Australia
Prior art keywords
day
peptidomimetic macrocycle
days
hours
administered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2020241429A
Other languages
English (en)
Inventor
David Allen Annis
Luis Carvajal
Vojislav Vukovic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rein Therapeutics Inc
Original Assignee
Aileron Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aileron Therapeutics Inc filed Critical Aileron Therapeutics Inc
Publication of AU2020241429A1 publication Critical patent/AU2020241429A1/en
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
AU2020241429A 2019-03-15 2020-03-13 Peptidomimetic macrocycles and uses thereof Abandoned AU2020241429A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962819195P 2019-03-15 2019-03-15
US62/819,195 2019-03-15
US201962926018P 2019-10-25 2019-10-25
US62/926,018 2019-10-25
PCT/US2020/022682 WO2020190742A1 (en) 2019-03-15 2020-03-13 Peptidomimetic macrocycles and uses thereof

Publications (1)

Publication Number Publication Date
AU2020241429A1 true AU2020241429A1 (en) 2021-10-07

Family

ID=72424829

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2020241429A Abandoned AU2020241429A1 (en) 2019-03-15 2020-03-13 Peptidomimetic macrocycles and uses thereof

Country Status (7)

Country Link
US (1) US20200289609A1 (enExample)
EP (1) EP3938051A4 (enExample)
JP (1) JP2022525416A (enExample)
CN (1) CN114173878A (enExample)
AU (1) AU2020241429A1 (enExample)
CA (1) CA3132993A1 (enExample)
WO (1) WO2020190742A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113880766B (zh) * 2020-07-04 2023-10-31 成都先导药物开发股份有限公司 一种免疫调节剂
WO2023096947A1 (en) * 2021-11-29 2023-06-01 Merck Sharp & Dohme Llc C-terminal extended p53 activator crosslinked peptidomimetic macrocycles against mdm2/mdmx
JP2024546110A (ja) * 2021-12-10 2024-12-17 メルク・シャープ・アンド・ドーム・エルエルシー Ｐ５３ペプチド模倣大環状分子

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104474529A (zh) * 2008-02-08 2015-04-01 爱勒让治疗公司 治疗性的拟肽大环化合物
KR102104762B1 (ko) * 2010-08-13 2020-04-24 에일러론 테라퓨틱스 인코포레이티드 펩티도미메틱 거대고리
RU2642299C2 (ru) * 2012-02-15 2018-01-24 Эйлерон Терапьютикс, Инк. P53 пептидомиметические макроциклы
CN107106642B (zh) * 2014-09-24 2021-02-26 艾瑞朗医疗公司 拟肽大环化合物及其制剂
JP2018516844A (ja) * 2015-03-20 2018-06-28 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． ペプチド模倣大環状分子およびその使用
CA2996685A1 (en) * 2015-09-03 2017-03-09 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
WO2017205786A1 (en) * 2016-05-27 2017-11-30 Aileron Therapeutics, Inc. Cell permeable peptidomimetic macrocycles
CN110891588A (zh) * 2017-05-11 2020-03-17 艾瑞朗医疗公司 拟肽大环化合物及其用途
WO2020023502A1 (en) * 2018-07-23 2020-01-30 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof

Also Published As

Publication number Publication date
CN114173878A (zh) 2022-03-11
WO2020190742A1 (en) 2020-09-24
EP3938051A1 (en) 2022-01-19
JP2022525416A (ja) 2022-05-13
CA3132993A1 (en) 2020-09-24
EP3938051A4 (en) 2022-12-07
US20200289609A1 (en) 2020-09-17

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Legal Events

Date Code Title Description
MK1 Application lapsed section 142(2)(a) - no request for examination in relevant period