JP2022525416A - ペプチド模倣大環状分子およびその使用 - Google Patents

ペプチド模倣大環状分子およびその使用 Download PDF

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Publication number
JP2022525416A
JP2022525416A JP2021555813A JP2021555813A JP2022525416A JP 2022525416 A JP2022525416 A JP 2022525416A JP 2021555813 A JP2021555813 A JP 2021555813A JP 2021555813 A JP2021555813 A JP 2021555813A JP 2022525416 A JP2022525416 A JP 2022525416A
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macrocyclic molecule
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pharmaceutically active
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JP2022525416A5 (enExample
Inventor
ブコビッチ，ボイスラフ
カルバハル，ルイス
アニス，デビッド・アレン
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エイルロン セラピューティクス，インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
JP2021555813A 2019-03-15 2020-03-13 ペプチド模倣大環状分子およびその使用 Pending JP2022525416A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962819195P 2019-03-15 2019-03-15
US62/819,195 2019-03-15
US201962926018P 2019-10-25 2019-10-25
US62/926,018 2019-10-25
PCT/US2020/022682 WO2020190742A1 (en) 2019-03-15 2020-03-13 Peptidomimetic macrocycles and uses thereof

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JP2022525416A true JP2022525416A (ja) 2022-05-13
JP2022525416A5 JP2022525416A5 (enExample) 2023-03-20

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JP2021555813A Pending JP2022525416A (ja) 2019-03-15 2020-03-13 ペプチド模倣大環状分子およびその使用

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US (1) US20200289609A1 (enExample)
EP (1) EP3938051A4 (enExample)
JP (1) JP2022525416A (enExample)
CN (1) CN114173878A (enExample)
AU (1) AU2020241429A1 (enExample)
CA (1) CA3132993A1 (enExample)
WO (1) WO2020190742A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113880766B (zh) * 2020-07-04 2023-10-31 成都先导药物开发股份有限公司 一种免疫调节剂
WO2023096947A1 (en) * 2021-11-29 2023-06-01 Merck Sharp & Dohme Llc C-terminal extended p53 activator crosslinked peptidomimetic macrocycles against mdm2/mdmx
JP2024546110A (ja) * 2021-12-10 2024-12-17 メルク・シャープ・アンド・ドーム・エルエルシー Ｐ５３ペプチド模倣大環状分子

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018208954A2 (en) * 2017-05-11 2018-11-15 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104474529A (zh) * 2008-02-08 2015-04-01 爱勒让治疗公司 治疗性的拟肽大环化合物
KR102104762B1 (ko) * 2010-08-13 2020-04-24 에일러론 테라퓨틱스 인코포레이티드 펩티도미메틱 거대고리
RU2642299C2 (ru) * 2012-02-15 2018-01-24 Эйлерон Терапьютикс, Инк. P53 пептидомиметические макроциклы
CN107106642B (zh) * 2014-09-24 2021-02-26 艾瑞朗医疗公司 拟肽大环化合物及其制剂
JP2018516844A (ja) * 2015-03-20 2018-06-28 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． ペプチド模倣大環状分子およびその使用
CA2996685A1 (en) * 2015-09-03 2017-03-09 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
WO2017205786A1 (en) * 2016-05-27 2017-11-30 Aileron Therapeutics, Inc. Cell permeable peptidomimetic macrocycles
WO2020023502A1 (en) * 2018-07-23 2020-01-30 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018208954A2 (en) * 2017-05-11 2018-11-15 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof

Also Published As

Publication number Publication date
CN114173878A (zh) 2022-03-11
WO2020190742A1 (en) 2020-09-24
EP3938051A1 (en) 2022-01-19
AU2020241429A1 (en) 2021-10-07
CA3132993A1 (en) 2020-09-24
EP3938051A4 (en) 2022-12-07
US20200289609A1 (en) 2020-09-17

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