AU2020210884A1 - Systems and methods for modulating CRISPR activity - Google Patents
Systems and methods for modulating CRISPR activity Download PDFInfo
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- AU2020210884A1 AU2020210884A1 AU2020210884A AU2020210884A AU2020210884A1 AU 2020210884 A1 AU2020210884 A1 AU 2020210884A1 AU 2020210884 A AU2020210884 A AU 2020210884A AU 2020210884 A AU2020210884 A AU 2020210884A AU 2020210884 A1 AU2020210884 A1 AU 2020210884A1
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- polynucleotide
- crispr
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- C12N2310/30—Chemical structure
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| US20150376586A1 (en) * | 2014-06-25 | 2015-12-31 | Caribou Biosciences, Inc. | RNA Modification to Engineer Cas9 Activity |
| WO2016022866A1 (en) | 2014-08-07 | 2016-02-11 | Agilent Technologies, Inc. | Cis-blocked guide rna |
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| WO2016094874A1 (en) * | 2014-12-12 | 2016-06-16 | The Broad Institute Inc. | Escorted and functionalized guides for crispr-cas systems |
| US9650617B2 (en) * | 2015-01-28 | 2017-05-16 | Pioneer Hi-Bred International. Inc. | CRISPR hybrid DNA/RNA polynucleotides and methods of use |
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| CN109072224B (zh) * | 2016-01-30 | 2022-07-15 | 株式会社博纳克 | 人工单导rna及其用途 |
| US20200291369A1 (en) | 2016-03-11 | 2020-09-17 | Erasmus University Medical Center Rotterdam | Improved CRISPR-Cas9 Genome Editing Tool |
| EP3219799A1 (en) * | 2016-03-17 | 2017-09-20 | IMBA-Institut für Molekulare Biotechnologie GmbH | Conditional crispr sgrna expression |
| CN109415729B (zh) | 2016-04-21 | 2022-12-09 | 生命技术公司 | 具有降低毒性的基因编辑试剂 |
| WO2017217768A1 (ko) * | 2016-06-15 | 2017-12-21 | 주식회사 툴젠 | 온타겟 및 오프타겟의 다중 타겟 시스템을 이용하는, 표적 특이적 유전자 가위 스크리닝 방법 및 이의 용도 |
| EP3638789A4 (en) * | 2017-06-12 | 2021-03-10 | California Institute of Technology | CONDITIONAL GUIDE RNAS |
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