AU2019267680C1 - Methods and compositions for the treatment of hepatitis b infection - Google Patents

Methods and compositions for the treatment of hepatitis b infection Download PDF

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Publication number
AU2019267680C1
AU2019267680C1 AU2019267680A AU2019267680A AU2019267680C1 AU 2019267680 C1 AU2019267680 C1 AU 2019267680C1 AU 2019267680 A AU2019267680 A AU 2019267680A AU 2019267680 A AU2019267680 A AU 2019267680A AU 2019267680 C1 AU2019267680 C1 AU 2019267680C1
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AU
Australia
Prior art keywords
hbsag
bnp
seq
loop
antigenic epitope
Prior art date
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AU2019267680A
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English (en)
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AU2019267680B2 (en
AU2019267680A1 (en
Inventor
Ronald FARQUHAR
Stephen Locarnini
Hans Netter
Renae WALSH
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Melbourne Health
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Melbourne Health
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Publication date
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Publication of AU2019267680A1 publication Critical patent/AU2019267680A1/en
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Publication of AU2019267680B2 publication Critical patent/AU2019267680B2/en
Assigned to MELBOURNE HEALTH reassignment MELBOURNE HEALTH Request for Assignment Assignors: Clearb Therapeutics Ltd., MELBOURNE HEALTH
Priority to AU2024227453A priority Critical patent/AU2024227453A1/en
Publication of AU2019267680C1 publication Critical patent/AU2019267680C1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • A61K39/292—Serum hepatitis virus, hepatitis B virus, e.g. Australia antigen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10123—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10171—Demonstrated in vivo effect

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
AU2019267680A 2018-05-10 2019-05-09 Methods and compositions for the treatment of hepatitis b infection Active AU2019267680C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2024227453A AU2024227453A1 (en) 2018-05-10 2024-10-18 Methods and compositions for the treatment of hepatitis b infection

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862669663P 2018-05-10 2018-05-10
US62/669,663 2018-05-10
PCT/US2019/031483 WO2019217654A1 (en) 2018-05-10 2019-05-09 Methods and compositions for the treatment of hepatitis b infection

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2024227453A Division AU2024227453A1 (en) 2018-05-10 2024-10-18 Methods and compositions for the treatment of hepatitis b infection

Publications (3)

Publication Number Publication Date
AU2019267680A1 AU2019267680A1 (en) 2020-11-26
AU2019267680B2 AU2019267680B2 (en) 2024-07-25
AU2019267680C1 true AU2019267680C1 (en) 2025-02-27

Family

ID=68466904

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2019267680A Active AU2019267680C1 (en) 2018-05-10 2019-05-09 Methods and compositions for the treatment of hepatitis b infection
AU2024227453A Pending AU2024227453A1 (en) 2018-05-10 2024-10-18 Methods and compositions for the treatment of hepatitis b infection

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2024227453A Pending AU2024227453A1 (en) 2018-05-10 2024-10-18 Methods and compositions for the treatment of hepatitis b infection

Country Status (10)

Country Link
US (4) US11773141B2 (https=)
EP (2) EP3810625B1 (https=)
JP (2) JP2021522864A (https=)
KR (2) KR20250027279A (https=)
CN (3) CN120571006A (https=)
AU (2) AU2019267680C1 (https=)
CA (1) CA3099726A1 (https=)
ES (1) ES2985391T3 (https=)
PL (1) PL3810625T3 (https=)
WO (1) WO2019217654A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025244940A1 (en) * 2024-05-21 2025-11-27 Clearb Therapeutics Ltd. Methods and compositions for mrna- and dna-based treatment of hepatitis b infection

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599231A (en) * 1984-03-09 1986-07-08 Scripps Clinic And Research Foundation Synthetic hepatitis B virus vaccine including both T cell and B cell determinants
US20040146529A1 (en) * 1999-11-24 2004-07-29 Chiron Corporation HBV/HCV virus-like particle
EP2292642A1 (en) * 2003-06-10 2011-03-09 Opal Therapeutics Pty Ltd Immunomodulating compositions, uses therefor and processes for their production
WO2017060504A1 (en) * 2015-10-07 2017-04-13 Humabs Biomed Sa Antibodies that potently neutralize hepatitis b virus and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPQ912000A0 (en) 2000-07-31 2000-08-24 Crown In The Right Of The Queensland Department Of Health, The Improved virus like particles
CN100381463C (zh) * 2002-09-18 2008-04-16 中国人民解放军免疫学研究所 用于生产治疗用乙型肝炎疫苗或药物的免疫原及其制备方法和用途
AU2015259470A1 (en) * 2014-05-16 2016-11-10 Yale University Virus like vesicles (VLVs) based vaccines to prevent or treat chronic hepatitis B virus (HBV) infection

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599231A (en) * 1984-03-09 1986-07-08 Scripps Clinic And Research Foundation Synthetic hepatitis B virus vaccine including both T cell and B cell determinants
US20040146529A1 (en) * 1999-11-24 2004-07-29 Chiron Corporation HBV/HCV virus-like particle
EP2292642A1 (en) * 2003-06-10 2011-03-09 Opal Therapeutics Pty Ltd Immunomodulating compositions, uses therefor and processes for their production
WO2017060504A1 (en) * 2015-10-07 2017-04-13 Humabs Biomed Sa Antibodies that potently neutralize hepatitis b virus and uses thereof

Also Published As

Publication number Publication date
EP3810625A1 (en) 2021-04-28
JP2024105291A (ja) 2024-08-06
CN119113097A (zh) 2024-12-13
ES2985391T3 (es) 2024-11-05
AU2019267680B2 (en) 2024-07-25
KR20250027279A (ko) 2025-02-25
AU2019267680A1 (en) 2020-11-26
EP3810625B1 (en) 2024-05-22
EP3810625A4 (en) 2022-05-11
WO2019217654A1 (en) 2019-11-14
US12202862B2 (en) 2025-01-21
US11773141B2 (en) 2023-10-03
US20250333450A1 (en) 2025-10-30
KR20210010872A (ko) 2021-01-28
JP2021522864A (ja) 2021-09-02
EP4389222A2 (en) 2024-06-26
CN112513063A (zh) 2021-03-16
EP4389222A3 (en) 2024-08-28
CA3099726A1 (en) 2019-11-14
CN120571006A (zh) 2025-09-02
US20220002349A1 (en) 2022-01-06
US20250145669A1 (en) 2025-05-08
AU2024227453A1 (en) 2024-11-21
US20240150412A1 (en) 2024-05-09
PL3810625T3 (pl) 2025-03-03

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Legal Events

Date Code Title Description
PC1 Assignment before grant (sect. 113)

Owner name: MELBOURNE HEALTH

Free format text: FORMER APPLICANT(S): CLEARB THERAPEUTICS LTD.; MELBOURNE HEALTH

DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 05 NOV 2024

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT FILED 05 NOV 2024

FGA Letters patent sealed or granted (standard patent)