AU2019243179A1 - Use of exosomes for targeted delivery of therapeutic agents - Google Patents
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- AU2019243179A1 AU2019243179A1 AU2019243179A AU2019243179A AU2019243179A1 AU 2019243179 A1 AU2019243179 A1 AU 2019243179A1 AU 2019243179 A AU2019243179 A AU 2019243179A AU 2019243179 A AU2019243179 A AU 2019243179A AU 2019243179 A1 AU2019243179 A1 AU 2019243179A1
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- GBABOYUKABKIAF-IELIFDKJSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-IELIFDKJSA-N 0.000 description 1
- 229960002066 vinorelbine Drugs 0.000 description 1
- CILBMBUYJCWATM-PYGJLNRPSA-N vinorelbine ditartrate Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.OC(=O)[C@H](O)[C@@H](O)C(O)=O.C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC CILBMBUYJCWATM-PYGJLNRPSA-N 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 230000036642 wellbeing Effects 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229940053867 xeloda Drugs 0.000 description 1
- 229940055760 yervoy Drugs 0.000 description 1
- 229950009268 zinostatin Drugs 0.000 description 1
- 229960000641 zorubicin Drugs 0.000 description 1
- FBTUMDXHSRTGRV-ALTNURHMSA-N zorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(\C)=N\NC(=O)C=1C=CC=CC=1)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 FBTUMDXHSRTGRV-ALTNURHMSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862649057P | 2018-03-28 | 2018-03-28 | |
US62/649,057 | 2018-03-28 | ||
PCT/US2019/024603 WO2019191444A1 (fr) | 2018-03-28 | 2019-03-28 | Utilisation d'exosomes pour l'administration ciblée d'agents thérapeutiques |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2019243179A1 true AU2019243179A1 (en) | 2020-11-12 |
Family
ID=68060505
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2019243179A Pending AU2019243179A1 (en) | 2018-03-28 | 2019-03-28 | Use of exosomes for targeted delivery of therapeutic agents |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP3773747A4 (fr) |
JP (1) | JP2021519296A (fr) |
KR (1) | KR20200136978A (fr) |
CN (1) | CN112533643A (fr) |
AU (1) | AU2019243179A1 (fr) |
CA (1) | CA3095136A1 (fr) |
WO (1) | WO2019191444A1 (fr) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
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IT201900007785A1 (it) * | 2019-05-31 | 2020-12-01 | Univ Degli Studi Milano | Vescicole extracellulari per veicolare farmaci terapeutici o diagnostici |
KR20220124170A (ko) * | 2019-12-05 | 2022-09-13 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 간 섬유증 및 섬유증 관련 기타 질환에 대한 엑소좀 기반 치료요법 |
WO2021119552A1 (fr) * | 2019-12-13 | 2021-06-17 | Lawrence Livermore National Security, Llc | Compositions de vésicule à nanotubes et utilisations associées |
CN117860902B (zh) * | 2021-11-17 | 2024-07-16 | 中国人民解放军空军军医大学 | 一种前列腺癌分子靶向系统及其构建方法和应用 |
CN114774471A (zh) * | 2022-05-10 | 2022-07-22 | 厦门星际诺康细胞科技有限公司 | 一种呈现il27稳转细胞及其构建方法、呈现il27工程化外泌体及其制备方法和应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7473678B2 (en) * | 2004-10-14 | 2009-01-06 | Biomimetic Therapeutics, Inc. | Platelet-derived growth factor compositions and methods of use thereof |
US9085778B2 (en) * | 2006-05-03 | 2015-07-21 | VL27, Inc. | Exosome transfer of nucleic acids to cells |
GB201121069D0 (en) * | 2011-12-07 | 2012-01-18 | Isis Innovation | Delivery system |
WO2014076137A1 (fr) * | 2012-11-13 | 2014-05-22 | Lötvall Jan | Administration d'un agent thérapeutique |
CA2877847A1 (fr) * | 2012-11-29 | 2014-06-05 | Yeda Research And Development Co. Ltd. | Methodes de prevention d'une metastase tumorale, de traitement et de pronostic du cancer, et d'identification d'agents susceptibles de constituer des inhibiteurs de metastase |
DK3076949T3 (da) * | 2013-12-04 | 2019-11-25 | Univ Texas | Fremgangsmåde til isolering af kræftcelle-afledte eksosomer |
EP3307890A1 (fr) * | 2015-06-10 | 2018-04-18 | Board of Regents, The University of Texas System | Utilisation d'exosomes pour le traitement de maladies |
AU2016381513A1 (en) * | 2015-12-30 | 2018-07-19 | The Regents Of The University Of California | Methods for enhanced production and isolation of cell-derived vesicles |
TWI601741B (zh) * | 2016-07-11 | 2017-10-11 | 財團法人國家衛生研究院 | 利用前列腺素受體ep4-拮抗劑誘導幹細胞製造含有高囊泡含物之外泌體囊泡的方法及其應用 |
-
2019
- 2019-03-28 CA CA3095136A patent/CA3095136A1/fr active Pending
- 2019-03-28 CN CN201980034058.9A patent/CN112533643A/zh active Pending
- 2019-03-28 JP JP2020551798A patent/JP2021519296A/ja active Pending
- 2019-03-28 AU AU2019243179A patent/AU2019243179A1/en active Pending
- 2019-03-28 WO PCT/US2019/024603 patent/WO2019191444A1/fr unknown
- 2019-03-28 EP EP19776678.5A patent/EP3773747A4/fr active Pending
- 2019-03-28 KR KR1020207030993A patent/KR20200136978A/ko unknown
Also Published As
Publication number | Publication date |
---|---|
CN112533643A (zh) | 2021-03-19 |
WO2019191444A1 (fr) | 2019-10-03 |
JP2021519296A (ja) | 2021-08-10 |
KR20200136978A (ko) | 2020-12-08 |
EP3773747A1 (fr) | 2021-02-17 |
CA3095136A1 (fr) | 2019-10-03 |
EP3773747A4 (fr) | 2022-02-23 |
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