AU2019100542A4 - Infant lactoferrin-modulated milk powder and preparation method thereof - Google Patents
Infant lactoferrin-modulated milk powder and preparation method thereof Download PDFInfo
- Publication number
- AU2019100542A4 AU2019100542A4 AU2019100542A AU2019100542A AU2019100542A4 AU 2019100542 A4 AU2019100542 A4 AU 2019100542A4 AU 2019100542 A AU2019100542 A AU 2019100542A AU 2019100542 A AU2019100542 A AU 2019100542A AU 2019100542 A4 AU2019100542 A4 AU 2019100542A4
- Authority
- AU
- Australia
- Prior art keywords
- parts
- lactoferrin
- milk powder
- vitamin
- infant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000843 powder Substances 0.000 title claims abstract description 79
- 235000013336 milk Nutrition 0.000 title claims abstract description 27
- 210000004080 milk Anatomy 0.000 title claims abstract description 27
- 239000008267 milk Substances 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 108010063045 Lactoferrin Proteins 0.000 claims abstract description 60
- 102000010445 Lactoferrin Human genes 0.000 claims abstract description 60
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 claims abstract description 60
- 235000021242 lactoferrin Nutrition 0.000 claims abstract description 60
- 229940078795 lactoferrin Drugs 0.000 claims abstract description 60
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims abstract description 26
- 239000000203 mixture Substances 0.000 claims abstract description 21
- 239000002773 nucleotide Substances 0.000 claims abstract description 19
- 125000003729 nucleotide group Chemical group 0.000 claims abstract description 19
- 235000013406 prebiotics Nutrition 0.000 claims abstract description 19
- 239000006041 probiotic Substances 0.000 claims abstract description 19
- 235000018291 probiotics Nutrition 0.000 claims abstract description 19
- 239000011573 trace mineral Substances 0.000 claims abstract description 19
- 235000013619 trace mineral Nutrition 0.000 claims abstract description 19
- 235000018102 proteins Nutrition 0.000 claims abstract description 18
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 18
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 18
- PHIQHXFUZVPYII-ZCFIWIBFSA-O (R)-carnitinium Chemical compound C[N+](C)(C)C[C@H](O)CC(O)=O PHIQHXFUZVPYII-ZCFIWIBFSA-O 0.000 claims abstract description 13
- 239000001763 2-hydroxyethyl(trimethyl)azanium Substances 0.000 claims abstract description 13
- 235000019743 Choline chloride Nutrition 0.000 claims abstract description 13
- 108010001441 Phosphopeptides Proteins 0.000 claims abstract description 13
- 102000007544 Whey Proteins Human genes 0.000 claims abstract description 13
- 108010046377 Whey Proteins Proteins 0.000 claims abstract description 13
- 229960004203 carnitine Drugs 0.000 claims abstract description 13
- 239000005018 casein Substances 0.000 claims abstract description 13
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims abstract description 13
- 235000021240 caseins Nutrition 0.000 claims abstract description 13
- SGMZJAMFUVOLNK-UHFFFAOYSA-M choline chloride Chemical compound [Cl-].C[N+](C)(C)CCO SGMZJAMFUVOLNK-UHFFFAOYSA-M 0.000 claims abstract description 13
- 229960003178 choline chloride Drugs 0.000 claims abstract description 13
- 229960003080 taurine Drugs 0.000 claims abstract description 13
- 235000008939 whole milk Nutrition 0.000 claims abstract description 13
- 241000894006 Bacteria Species 0.000 claims abstract description 5
- 239000003995 emulsifying agent Substances 0.000 claims description 24
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 15
- -1 multivitamins Substances 0.000 claims description 13
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 12
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 claims description 12
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 12
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 12
- DLRVVLDZNNYCBX-UHFFFAOYSA-N Polydextrose Polymers OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(O)O1 DLRVVLDZNNYCBX-UHFFFAOYSA-N 0.000 claims description 12
- DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 claims description 12
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 12
- 229920000591 gum Polymers 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 12
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 12
- 239000002002 slurry Substances 0.000 claims description 12
- 235000021119 whey protein Nutrition 0.000 claims description 12
- 229910052742 iron Inorganic materials 0.000 claims description 8
- UHDGCWIWMRVCDJ-UHFFFAOYSA-N 1-beta-D-Xylofuranosyl-NH-Cytosine Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(CO)O1 UHDGCWIWMRVCDJ-UHFFFAOYSA-N 0.000 claims description 6
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 6
- UPJKSWLLCONYMW-UHFFFAOYSA-N 5'-Adenosine monophosphate Natural products COc1cc(O)c(C(=O)C)c(OC2OC(COC3OC(C)C(O)C(O)C3O)C(O)C(O)C2O)c1 UPJKSWLLCONYMW-UHFFFAOYSA-N 0.000 claims description 6
- 241000901050 Bifidobacterium animalis subsp. lactis Species 0.000 claims description 6
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 6
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 claims description 6
- UDMBCSSLTHHNCD-UHFFFAOYSA-N Coenzym Q(11) Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(O)=O)C(O)C1O UDMBCSSLTHHNCD-UHFFFAOYSA-N 0.000 claims description 6
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 6
- UHDGCWIWMRVCDJ-PSQAKQOGSA-N Cytidine Natural products O=C1N=C(N)C=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-PSQAKQOGSA-N 0.000 claims description 6
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 6
- 229930010555 Inosine Natural products 0.000 claims description 6
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 claims description 6
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 6
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 6
- 241001311547 Patina Species 0.000 claims description 6
- 229920001100 Polydextrose Polymers 0.000 claims description 6
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 6
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims description 6
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 6
- 229930003779 Vitamin B12 Natural products 0.000 claims description 6
- 229930003268 Vitamin C Natural products 0.000 claims description 6
- 229930003316 Vitamin D Natural products 0.000 claims description 6
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 6
- 229930003427 Vitamin E Natural products 0.000 claims description 6
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 6
- UDMBCSSLTHHNCD-KQYNXXCUSA-N adenosine 5'-monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O UDMBCSSLTHHNCD-KQYNXXCUSA-N 0.000 claims description 6
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 6
- DRTQHJPVMGBUCF-PSQAKQOGSA-N beta-L-uridine Natural products O[C@H]1[C@@H](O)[C@H](CO)O[C@@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-PSQAKQOGSA-N 0.000 claims description 6
- 229940009289 bifidobacterium lactis Drugs 0.000 claims description 6
- 235000020958 biotin Nutrition 0.000 claims description 6
- 239000011616 biotin Substances 0.000 claims description 6
- 229960002685 biotin Drugs 0.000 claims description 6
- 229910052791 calcium Inorganic materials 0.000 claims description 6
- 239000011575 calcium Substances 0.000 claims description 6
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims description 6
- 239000002131 composite material Substances 0.000 claims description 6
- 229910052802 copper Inorganic materials 0.000 claims description 6
- 239000010949 copper Substances 0.000 claims description 6
- UHDGCWIWMRVCDJ-ZAKLUEHWSA-N cytidine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-ZAKLUEHWSA-N 0.000 claims description 6
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 6
- 239000000194 fatty acid Substances 0.000 claims description 6
- 229930195729 fatty acid Natural products 0.000 claims description 6
- 229960000304 folic acid Drugs 0.000 claims description 6
- 235000019152 folic acid Nutrition 0.000 claims description 6
- 239000011724 folic acid Substances 0.000 claims description 6
- 235000021255 galacto-oligosaccharides Nutrition 0.000 claims description 6
- 150000003271 galactooligosaccharides Chemical class 0.000 claims description 6
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 6
- RQFCJASXJCIDSX-UUOKFMHZSA-N guanosine 5'-monophosphate Chemical compound C1=2NC(N)=NC(=O)C=2N=CN1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O RQFCJASXJCIDSX-UUOKFMHZSA-N 0.000 claims description 6
- 229960003786 inosine Drugs 0.000 claims description 6
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 claims description 6
- 229960003512 nicotinic acid Drugs 0.000 claims description 6
- 235000001968 nicotinic acid Nutrition 0.000 claims description 6
- 239000011664 nicotinic acid Substances 0.000 claims description 6
- 229940055726 pantothenic acid Drugs 0.000 claims description 6
- 235000019161 pantothenic acid Nutrition 0.000 claims description 6
- 239000011713 pantothenic acid Substances 0.000 claims description 6
- 235000013856 polydextrose Nutrition 0.000 claims description 6
- 239000001259 polydextrose Substances 0.000 claims description 6
- 229940035035 polydextrose Drugs 0.000 claims description 6
- 239000011591 potassium Substances 0.000 claims description 6
- 229910052700 potassium Inorganic materials 0.000 claims description 6
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 239000011669 selenium Substances 0.000 claims description 6
- 229910052711 selenium Inorganic materials 0.000 claims description 6
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims description 6
- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 claims description 6
- 229940045145 uridine Drugs 0.000 claims description 6
- 229940088594 vitamin Drugs 0.000 claims description 6
- 229930003231 vitamin Natural products 0.000 claims description 6
- 235000013343 vitamin Nutrition 0.000 claims description 6
- 239000011782 vitamin Substances 0.000 claims description 6
- 235000019155 vitamin A Nutrition 0.000 claims description 6
- 239000011719 vitamin A Substances 0.000 claims description 6
- 235000019163 vitamin B12 Nutrition 0.000 claims description 6
- 239000011715 vitamin B12 Substances 0.000 claims description 6
- 235000019158 vitamin B6 Nutrition 0.000 claims description 6
- 239000011726 vitamin B6 Substances 0.000 claims description 6
- 235000019154 vitamin C Nutrition 0.000 claims description 6
- 239000011718 vitamin C Substances 0.000 claims description 6
- 235000019166 vitamin D Nutrition 0.000 claims description 6
- 239000011710 vitamin D Substances 0.000 claims description 6
- 150000003710 vitamin D derivatives Chemical class 0.000 claims description 6
- 235000019165 vitamin E Nutrition 0.000 claims description 6
- 229940046009 vitamin E Drugs 0.000 claims description 6
- 239000011709 vitamin E Substances 0.000 claims description 6
- 229940045997 vitamin a Drugs 0.000 claims description 6
- 229940011671 vitamin b6 Drugs 0.000 claims description 6
- 229940046008 vitamin d Drugs 0.000 claims description 6
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 6
- 238000005303 weighing Methods 0.000 claims description 6
- 239000011701 zinc Substances 0.000 claims description 6
- 229910052725 zinc Inorganic materials 0.000 claims description 6
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 claims description 5
- 241000218588 Lactobacillus rhamnosus Species 0.000 claims description 5
- DNISEZBAYYIQFB-PHDIDXHHSA-N (2r,3r)-2,3-diacetyloxybutanedioic acid Chemical compound CC(=O)O[C@@H](C(O)=O)[C@H](C(O)=O)OC(C)=O DNISEZBAYYIQFB-PHDIDXHHSA-N 0.000 claims description 4
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 4
- 229910052740 iodine Inorganic materials 0.000 claims description 4
- 239000011630 iodine Substances 0.000 claims description 4
- 229920001353 Dextrin Polymers 0.000 claims description 3
- 239000004375 Dextrin Substances 0.000 claims description 3
- 229920002752 Konjac Polymers 0.000 claims description 3
- 229930006000 Sucrose Natural products 0.000 claims description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 3
- 235000019425 dextrin Nutrition 0.000 claims description 3
- 239000000252 konjac Substances 0.000 claims description 3
- 235000019823 konjac gum Nutrition 0.000 claims description 3
- 239000001814 pectin Substances 0.000 claims description 3
- 229920001277 pectin Polymers 0.000 claims description 3
- 235000010987 pectin Nutrition 0.000 claims description 3
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 3
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 3
- 239000005720 sucrose Substances 0.000 claims description 3
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 2
- 229920001817 Agar Polymers 0.000 claims description 2
- 108010010803 Gelatin Proteins 0.000 claims description 2
- 229920002148 Gellan gum Polymers 0.000 claims description 2
- 229920002907 Guar gum Polymers 0.000 claims description 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 2
- 229920000881 Modified starch Polymers 0.000 claims description 2
- 239000004368 Modified starch Substances 0.000 claims description 2
- 239000008272 agar Substances 0.000 claims description 2
- 235000010419 agar Nutrition 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 239000008273 gelatin Substances 0.000 claims description 2
- 229920000159 gelatin Polymers 0.000 claims description 2
- 235000019322 gelatine Nutrition 0.000 claims description 2
- 235000011852 gelatine desserts Nutrition 0.000 claims description 2
- 235000010492 gellan gum Nutrition 0.000 claims description 2
- 239000000216 gellan gum Substances 0.000 claims description 2
- 235000010417 guar gum Nutrition 0.000 claims description 2
- 239000000665 guar gum Substances 0.000 claims description 2
- 229960002154 guar gum Drugs 0.000 claims description 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 2
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 2
- 235000019426 modified starch Nutrition 0.000 claims description 2
- 229960000292 pectin Drugs 0.000 claims description 2
- 229920000223 polyglycerol Polymers 0.000 claims description 2
- 235000010413 sodium alginate Nutrition 0.000 claims description 2
- 239000000661 sodium alginate Substances 0.000 claims description 2
- 229940005550 sodium alginate Drugs 0.000 claims description 2
- 229920001285 xanthan gum Polymers 0.000 claims description 2
- 235000010493 xanthan gum Nutrition 0.000 claims description 2
- 239000000230 xanthan gum Substances 0.000 claims description 2
- 229940082509 xanthan gum Drugs 0.000 claims description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- 241000102542 Kara Species 0.000 claims 1
- 229920000161 Locust bean gum Polymers 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 125000005456 glyceride group Chemical group 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 235000010420 locust bean gum Nutrition 0.000 claims 1
- 239000000711 locust bean gum Substances 0.000 claims 1
- 230000000529 probiotic effect Effects 0.000 claims 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 claims 1
- 229940095050 propylene Drugs 0.000 claims 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims 1
- 239000001384 succinic acid Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 11
- 230000000968 intestinal effect Effects 0.000 abstract description 6
- 230000036541 health Effects 0.000 abstract description 4
- 235000008452 baby food Nutrition 0.000 abstract description 3
- 230000006378 damage Effects 0.000 abstract description 3
- 230000009471 action Effects 0.000 abstract description 2
- 235000015097 nutrients Nutrition 0.000 abstract description 2
- 210000000056 organ Anatomy 0.000 abstract description 2
- 239000005862 Whey Substances 0.000 abstract 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 6
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 241000699670 Mus sp. Species 0.000 description 4
- 238000010171 animal model Methods 0.000 description 4
- 210000000628 antibody-producing cell Anatomy 0.000 description 4
- 241000287828 Gallus gallus Species 0.000 description 3
- 210000003743 erythrocyte Anatomy 0.000 description 3
- 230000036039 immunity Effects 0.000 description 3
- 230000000242 pagocytic effect Effects 0.000 description 3
- 210000003024 peritoneal macrophage Anatomy 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 2
- HDSBZMRLPLPFLQ-UHFFFAOYSA-N Propylene glycol alginate Chemical compound OC1C(O)C(OC)OC(C(O)=O)C1OC1C(O)C(O)C(C)C(C(=O)OCC(C)O)O1 HDSBZMRLPLPFLQ-UHFFFAOYSA-N 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000008827 biological function Effects 0.000 description 2
- 235000010418 carrageenan Nutrition 0.000 description 2
- 239000000679 carrageenan Substances 0.000 description 2
- 229920001525 carrageenan Polymers 0.000 description 2
- 229940113118 carrageenan Drugs 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 2
- 235000010409 propane-1,2-diol alginate Nutrition 0.000 description 2
- 239000000770 propane-1,2-diol alginate Substances 0.000 description 2
- 230000009278 visceral effect Effects 0.000 description 2
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 2
- 241000186000 Bifidobacterium Species 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 244000060234 Gmelina philippensis Species 0.000 description 1
- 241000590002 Helicobacter pylori Species 0.000 description 1
- 101710154606 Hemagglutinin Proteins 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- 241000186660 Lactobacillus Species 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 101710093908 Outer capsid protein VP4 Proteins 0.000 description 1
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 1
- 206010057249 Phagocytosis Diseases 0.000 description 1
- 101710176177 Protein A56 Proteins 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000003749 cleanliness Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 235000013350 formula milk Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 230000035931 haemagglutination Effects 0.000 description 1
- 229940037467 helicobacter pylori Drugs 0.000 description 1
- 239000000185 hemagglutinin Substances 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000010438 iron metabolism Effects 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 229940039696 lactobacillus Drugs 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 244000005706 microflora Species 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000008782 phagocytosis Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 210000001138 tear Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C21/00—Whey; Whey preparations
- A23C21/06—Mixtures of whey with milk products or milk components
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/1526—Amino acids; Peptides; Protein hydrolysates; Nucleic acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/1528—Fatty acids; Mono- or diglycerides; Petroleum jelly; Paraffine; Phospholipids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/158—Milk preparations; Milk powder or milk powder preparations containing additives containing vitamins or antibiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Dairy Products (AREA)
Abstract
The invention relates to the technical field of baby food, in particular to a preparation method of baby lactoferrin-modulated milk powder, which comprises, according to the parts by mass, 1000 parts of instant whole milk powder, 3.5-5 parts of lactoferrin, whey. 25-40 parts of protein powder, 5-12 parts of probiotics, 4-8 parts of prebiotics, 0.1-0.5 parts of taurine, 0.1-0.5 parts of casein phosphopeptide, 0.3-0.5 parts of DHA, 0.5-0.8 parts of ARA 0.1 to 0.5 parts of complex trace elements, 0.1 to 0.3 parts of multivitamins, 0.1 to 0.2 parts of choline chloride, 0.1 to 0.2 parts of carnitine, and 0.02 to 0.05 parts of a mixture of nucleotides. The invention mixes lactoferrin and various nutrients to stabilize intestinal colonies of infants, and in order to reduce the consumption and destruction of lactoferrin by bacteria in tissues and organs, the lactoferrin is encapsulated and protected. The action, slow release, improves the bioavailability of lactoferrin in the infant, fully absorbs, and enhances the health care effect of lactoferrin.
Description
DESCRIPTION
2019100542 21 May 2019
Infant lactoferrin-modulated milk powder and preparation method thereof
Field
The invention relates to the technical field of baby food, in particular to a preparation method of baby lactoferrin-modulated milk powder.
Background
Lactoferrin is a multifunctional active glycoprotein that has been receiving much attention. Lactoferrin, also known as lactoferrin, is found mainly in various exudates of mammals such as milk, tears or saliva. In the past ten years, extensive research has been carried out on biological functions. The proven biological functions are involved in iron metabolism, which can improve the bioavailability of intestinal cells to iron and reduce the stimulating effect of iron ions on the gastrointestinal tract. It has certain inhibition and killing effects on gastrointestinal harmful bacteria such as Escherichia coli and Helicobacter pylori; it promotes the growth of bifidobacteria and regulates the intestinal flora. However, due to the consumption and destruction of lactoferrin in intestinal bacteria, the function of lactoferrin is weakened, especially the intestinal colony of infants is unstable, absorption is slow, resulting in a large amount of lactoferrin loss, the effect of lactoferrin not obvious.
Summary
The object of the present invention is to overcome the shortcomings and deficiencies of the prior art, and to provide a baby lactoferrin-modulated milk powder, which can maximize the function of lactoferrin and improve the health care effect of lactoferrin.
Another object of the present invention is to provide a method for preparing the infant lactoferrin-modulated milk powder.
i
2019100542 21 May 2019
The specific technical solution is:
An infant lactoferrin-modulated milk powder is composed of the following substances according to the mass fraction, 1000 parts of instant whole milk powder, 3.5-5 parts of lactoferrin, 25-40 parts of whey protein powder, and probiotics 5-12 4 parts, prebiotics 4 to 8 parts, taurine 0.1 to 0.5 parts, casein phosphopeptide 0.1 to 0.5 parts, DHA 0.3 to 0.5 parts, ARA 0.5 to 0.8 parts, complex trace elements 0.1 to 0.5 parts, multivitamin 0.1 to 0.3 parts, 0.1-0.2 parts of choline chloride, 0.1-0.2 parts of carnitine, and 0.02-0.05 parts of a mixture of nucleotides.
Wherein, the probiotics include Bifidobacterium lactis and Lactobacillus rhamnosus, mixed according to a mass ratio of 1:1-5. Prebiotics include oligofructose, galactooligosaccharide, and polydextrose, mixed according to a mass ratio of 1:1-2:2-4. The nucleotide mixture comprises 5' inosine monosodium, 5' adenosine monophosphate, 5' uridine disodium, 5' cytidine disodium, 5' guanylate disodium according to mass ratio 1 :0.5-1:0.5-1:2-3:0.5-1.
The composite trace elements, including calcium, manganese, potassium, iron, zinc, copper, iodine and selenium, mixed according to the mass ratio of :
100:0.4-1:60-85:80-120:60-90:8-13:0.5 -1.5: 0.2-0.5.
The multivitamins, including vitamin A, vitamin D, vitamin E, vitamin KI, vitamin Bl, vitamin B6, vitamin B12, niacin, folic acid, pantothenic acid, vitamin C, biotin, mixed according to the mass ratio of:
100:15-22: 0.2-0.5:2-5:20-40:15-30:0.02-0.08:200-250:3-6:12-17:20005000:0.4-1.
The lactoferrin powder is a palatate lactoferrin.
The preparation method of the infant lactoferrin-modulated milk powder comprises the following steps:
(1) weighing each raw material according to the above weight parts;
(2) The lactoferrin powder and the whey protein powder are uniformly mixed, and then baked in an oven at a temperature of 65-80 ° C for 10-15 min; then
2019100542 21 May 2019 taken out and cooled to room temperature. The mixed protein powder is obtained; more preferably, the mixing is carried out while baking, and the three-axis multi-directional mixing process is adopted; the mixing part belongs to the cleaning operation, and the workshop personnel and equipment must have strict sanitary disinfection measures. The production environment must have constant parameter requirements, such as temperature, humidity, air pressure, and cleanliness.
After this process, lactoferrin and whey protein isolate work together, the charge is cross-linked at a certain temperature, and the whey protein is wrapped outside the lactoferrin, which further ensures that lactoferrin will not be transported in the future. Excessive loss in use, but the disadvantage is that some whey protein isolate will be lost, so the use of whey protein isolate in the present invention is about 50% higher than the normal use amount, which is the reason, but much cheaper whey protein isolate. The price is only a few tenths of the lactoferrin, and the lactoferrin is very beneficial to the health and immunity of the baby. Therefore, an important invention of the present invention is to adopt the method of selling the car and protecting the handsome.
(3) Then the cooled mixed protein powder and instant whole milk powder, probiotics, prebiotics, taurine, casein phosphopeptide, DHA, ARA, complex trace elements, multivitamins, choline chloride, carnitine After the mixture of nucleotides is evenly mixed, it is packaged.
The lactoferrin described herein is a palatate lactoferrin, and the preparation method comprises the following steps:
(1) dissolving the emulsifier and the edible gum in water to obtain a slurry; the emulsifier and water are used in an amount of 20 to 50 mg of emulsifier per 1 ml of water;
(2) The slurry is sprayed on the outer surface of the main lactoferrin powder, and spray-dried to obtain a patina lactoferrin.
2019100542 21 May 2019
Wherein, the emulsifier is one of monostearyl fatty acid ester, polyglycerol ester, sucrose fatty acid ester, monoglyceride succinate, mono-diglyceride, sodium carboxymethyl cellulose, monoglyceride diacetyl tartaric acid Mixed with or in combination; the edible gum is modified starch, gellan gum, konjac gum, dextrin, carrageenan, xanthan gum, pectin, microcrystalline cellulose, propylene glycol alginate, gelatin, agar, hedgehog One or more of soybean gum, guar gum, and sodium alginate.
The present invention has the following advantages and effects over the prior art:
The invention mixes lactoferrin and various nutrients to stabilize intestinal colonies of infants, and in order to reduce the consumption and destruction of lactoferrin by bacteria in tissues and organs, the lactoferrin is encapsulated and protected. The action, slow release, improves the bioavailability of lactoferrin in the infant, fully absorbs, and enhances the health care effect of lactoferrin.
Embodiments
The present invention will be further described in detail below with reference to the embodiments, but the embodiments of the present invention are not limited thereto.
Embodiment 1
A baby lactoferrin-modulated milk powder consisting of the following substances in mass parts: 1000 parts of instant whole milk powder, 3.5 parts of lactoferrin, 22.3 parts of whey protein powder, 6.2 parts of probiotics, and prebiotics 5.1 , 0.24 parts of taurine, 0.33 parts of casein phosphopeptide, 0.51 parts of DHA, 0.64 parts of ARA, 0.58 parts of complex trace elements, 0.12 parts of multivitamin, 0.14 parts of choline chloride, 0.18 parts of carnitine, mixture of nucleotides 0.02 parts.
Wherein, the probiotics include Bifidobacterium lactis, Lactobacillus
2019100542 21 May 2019 rhamnosus, mixed at a mass ratio of 1:2. Prebiotics include oligofructose, galactooligosaccharide, and poly dextrose, mixed at a mass ratio of 1:1:3. The nucleotide mixture comprises 5' inosine monosodium, 5' adenosine monophosphate, 5' uridine disodium, 5' cytidine disodium, 5' guanylate disodium according to mass ratio 1 :0.5:0.5:2.5:0.6. The composite trace elements, including calcium, manganese, potassium, iron, zinc, copper, iodine and selenium, are mixed according to a mass ratio of 100:0.82:64:94:75:9:0.8:0.3. The multivitamins, including vitamin A, vitamin D, vitamin E, vitamin KI, vitamin Bl, vitamin B6, vitamin B12, niacin, folic acid, pantothenic acid, vitamin C, biotin, mixed according to a mass ratio of 100:20:0.3: 3.5:32:26:0.04:220:3.5:14:2000:0.58.
The preparation method of the infant lactoferrin-modulated milk powder comprises the following steps:
(1) dissolving the emulsifier and the edible gum in water to obtain a slurry; the emulsifier and water are used in an amount of 20 mg of emulsifier/1 ml of water; the emulsifier is a mono-hard fatty acid ester; For konjac gum.
(2) The slurry is sprayed on the outer surface of the main lactoferrin powder, and spray-dried to obtain a patina lactoferrin.
(3) weighing each raw material according to the above weight parts;
(4) The lactoferrin powder and the clear separated protein powder are uniformly mixed, and then baked in an oven, the baking temperature is 80 ° C, the time is 10 min; then taken out and cooled to room temperature to obtain a mixed protein powder; Adopting a three-axis multi-directional mixing process;
(5) Then the cooled mixed protein powder and instant whole milk powder, probiotics, prebiotics, taurine, casein phosphopeptides, DHA, ARA, complex trace elements, multivitamins, choline chloride, carnitine After the mixture of nucleotides is evenly mixed, it is packaged.
Embodiment 2
A baby lactoferrin-modulated milk powder consisting of the following
2019100542 21 May 2019 substances in mass parts: 1000 parts of instant whole milk powder, 4.6 parts of lactoferrin, 32 parts of whey protein powder, 7.5 parts of probiotics, 6.8 parts of prebiotics 0.63 parts of taurine, 0.24 parts of casein phosphopeptide, 0.38 parts of DHA, 0.68 parts of ARA, 0.35 parts of complex trace elements, 0.15 parts of multivitamin, 0.12 parts of choline chloride, 0.18 parts of carnitine, 0.03 mixture of nucleotides Share.
Wherein, the probiotics include Bifidobacterium lactis, Lactobacillus rhamnosus, mixed at a mass ratio of 1:4. Prebiotics include oligofructose, galactooligosaccharide, and polydextrose, which are mixed at a mass ratio of 1:2:2. The nucleotide mixture comprises 5' inosine monosodium, 5' adenosine monophosphate, 5' uridine disodium, 5' cytidine disodium, 5' guanylate disodium according to mass ratio 1 :0.8:0.5:3:0.7. The composite trace elements, including calcium, manganese, potassium, iron, zinc, copper, iodine and selenium, are mixed according to a mass ratio of 100:0.9:65:115:85:11:1.2:0.3. The multivitamins, including vitamin A, vitamin D, vitamin E, vitamin KI, vitamin Bl, vitamin B6, vitamin B12, niacin, folic acid, pantothenic acid, vitamin C, biotin, mixed according to the mass ratio of 100:18:0.2: 4:35:27:0.05:200:5:15:3000:0.4.
The preparation method of the infant lactoferrin-modulated milk powder comprises the following steps:
(1) dissolving the emulsifier and the edible gum in water to obtain a slurry; the emulsifier and water are used in an amount of 35 mg of emulsifier per 1 ml of water; the emulsifier is sodium carboxymethylcellulose; The glue is pectin.
(2) The slurry is sprayed on the outer surface of the main lactoferrin powder, and spray-dried to obtain a patina lactoferrin.
(3) weighing each raw material according to the above weight parts;
(4) The lactoferrin powder and the clear protein powder are uniformly mixed, and then baked in an oven, the baking temperature is 75 ° C, the time is 10 min; then taken out and cooled to room temperature to obtain a mixed protein powder;
2019100542 21 May 2019 (5) Then the cooled mixed protein powder and instant whole milk powder, probiotics, prebiotics, taurine, casein phosphopeptides, DHA, ARA, complex trace elements, multivitamins, choline chloride, carnitine After the mixture of nucleotides is evenly mixed, it is packaged.
Embodiment 3
A baby lactoferrin-modulated milk powder consisting of the following substances in mass parts: 1000 parts of instant whole milk powder, 3.8 parts of lactoferrin, 26 parts of whey protein powder, 10.3 parts of probiotics, 6.7 parts of prebiotics 0.34 parts of taurine, 0.35 parts of casein phosphopeptide, 0.38 parts of DHA, 0.75 parts of ARA, 0.46 parts of complex trace elements, 0.24 parts of multivitamins, 0.16 parts of choline chloride, 0.13 parts of carnitine, 0.03 mixture of nucleotides Share.
Wherein, the probiotics include Bifidobacterium lactis, Lactobacillus rhamnosus, mixed at a mass ratio of 1:4. Prebiotics include oligofructose, galactooligosaccharide, and poly dextrose, mixed at a mass ratio of 1:1:3. The nucleotide mixture comprises 5' inosine monosodium, 5' adenosine monophosphate, 5' uridine disodium, 5' cytidine disodium, 5' guanylate disodium according to mass ratio 1 :0.7:0.81:3:0.5. The composite trace elements, including calcium, manganese, potassium, iron, zinc, copper, iodine, selenium, are mixed according to a mass ratio of 100:0.54:75:100:85:10:1.5:0.5. The multivitamins, including vitamin A, vitamin D, vitamin E, vitamin KI, vitamin Bl, vitamin B6, vitamin B12, niacin, folic acid, pantothenic acid, vitamin C, biotin, mixed according to the mass ratio of 100:18:0.03: 3:30:25:0.07:210:5:15:4000:0.6.
The preparation method of the infant lactoferrin-modulated milk powder comprises the following steps:
(1) dissolving the emulsifier and the edible gum in water to obtain a slurry; the emulsifier and water are used in an amount of 35 mg of emulsifier per 1 ml of water; and the emulsifier is sucrose fatty acid ester and diacetyl tartaric acid
2019100542 21 May 2019 monoglyceride Mix one to one; the edible gum is carrageenan and dextrin mixed one to one.
(2) The slurry is sprayed on the outer surface of the main lactoferrin powder, and spray-dried to obtain a patina lactoferrin.
(3) weighing each raw material according to the above weight parts;
(4) The lactoferrin powder and the clear protein powder are uniformly mixed, and then baked in an oven, the baking temperature is 65 ° C, the time is 10 min; then taken out and cooled to room temperature to obtain a mixed protein powder;
(5) Then the cooled mixed protein powder and instant whole milk powder, probiotics, prebiotics, taurine, casein phosphopeptides, DHA, ARA, complex trace elements, multivitamins, choline chloride, carnitine After the mixture of nucleotides is evenly mixed, it is packaged.
Embodiment 4
A baby lactoferrin-prepared milk powder consisting of the following substances in mass parts: 1000 parts of instant whole milk powder, 4.3 parts of lactoferrin, 34 parts of whey protein powder, 8.4 parts of probiotics, 5.6 parts of prebiotics 0.46 parts of taurine, 0.23 parts of casein phosphopeptide, 0.43 parts of DHA, 0.64 parts of ARA, 0.27 parts of complex trace elements, 0.16 parts of multivitamins, 0.14 parts of choline chloride, 0.16 parts of carnitine, 0.045 mixture of nucleotides Share.
Wherein, the probiotics include Bifidobacterium lactis, Lactobacillus rhamnosus, mixed at a mass ratio of 1:2. Prebiotics include oligofructose, galactooligosaccharide, and polydextrose, which are mixed at a mass ratio of 1:2:2. The nucleotide mixture comprises 5' inosine monosodium, 5' adenosine monophosphate, 5' uridine disodium, 5' cytidine disodium, 5' guanylate disodium according to mass ratio 1 : 0.6:0.8:2.5:0.6. The composite trace elements, including calcium, manganese, potassium, iron, zinc, copper, iodine, selenium, are mixed according to a mass ratio of 100:1:72:114:75:11:1.4:0.2. The multivitamins,
2019100542 21 May 2019 including vitamin A, vitamin D, vitamin E, vitamin KI, vitamin Bl, vitamin B6, vitamin B12, niacin, folic acid, pantothenic acid, vitamin C, biotin, mixed according to the mass ratio of 100:22:0.5: 2:40:15:0.08:200:3:12:5000:0.4.
The preparation method of the infant lactoferrin-modulated milk powder comprises the following steps:
(1) dissolving the emulsifier and the edible gum in water to obtain a slurry; the emulsifier and water are used in an amount of 25 mg of emulsifier per 1 ml of water; the emulsifier is diacetyl tartaric acid monoglyceride; The gum is propylene glycol alginate.
(2) The slurry is sprayed on the outer surface of the main lactoferrin powder, and spray-dried to obtain a patina lactoferrin.
(3) weighing each raw material according to the above weight parts;
(4) The lactoferrin powder and the clear protein powder are uniformly mixed, and then baked in an oven, the baking temperature is 65 ° C, the time is 15 min; and then taken out and cooled to room temperature to obtain a mixed protein powder;
(5) Then the cooled mixed protein powder and instant whole milk powder, probiotics, prebiotics, taurine, casein phosphopeptides, DHA, ARA, complex trace elements, multivitamins, choline chloride, carnitine After the mixture of nucleotides is evenly mixed, it is packaged.
Lactoferrin has various biological activities such as antibacterial, anti-oxidation and anti-cancer. Adding lactoferrin to infant formula or baby food can help infants resist microorganisms such as E. coli, reduce common diseases such as diarrhea caused by viruses, and improve their immunity. The formulation of this patent application is more beneficial to the immune and nervous systems and promotes the growth of visceral mature and healthy visceral microflora.
The following experiments are carried out to verify the effect.
The first is an enhanced immunity test. A sample prepared in Example 1 was
2019100542 21 May 2019 used as an experimental example, and a skim milk powder containing an equal amount of lactoferrin was used as a comparative example according to Example 1.
The experimental animals were selected from mice with a mass of 18-22 g, 54 male and female, and were randomly divided into three groups. Each group was randomly divided into three groups for testing.
According to the food intake of the test mice, the maximum dose was designed to be 10 g/d, fed directly, and fed continuously for 30 days.
The MTT method was used to induce the transformation of mouse spleen lymphocytes induced by ConA; the hemagglutinin assay was performed by hemagglutination method; the antibody-producing cells were detected by Jerne modified slide method; and the mouse peritoneal macrophages phagocytized chicken red blood cells were tested by semi-in vivo method.
The experimental results are shown in the following table:
Table 1 Effect of sample group on serum blood lysin anti-volume number in mice
dose | Number of experimental animals | Optical density difference |
Experimental example | 6 | 224.10±10.54 |
Comparative example | 6 | 186.02±10.26 |
It can be seen from Table 1 that the experimental example has an obvious effect of increasing the blood solubilization anti-volume number compared with the mouse of the comparative example.
Table 2 Effect of sample on mouse antibody-producing cells
dose | Number of experimental animals | Antibody-producing cell number (106) |
Experimental example | 6 | 324.84±43.21 |
Comparative example | 6 | 214.37±50.34 |
From Table 2, it can be seen that the experimental example has an effect of increasing the number of antibody-producing cells as compared with the mouse of io
Table 3 Effect of sample group on the ability of mouse peritoneal macrophages to phagocytose chicken red blood cells
2019100542 21 May 2019 the comparative example.
dose | Number of experimental animals | Percentage of phagocytosis (%) | Phagocytic index |
Experimental example | 6 | 34.10±4.21 | 1.15±0.12 |
Comparative example | 6 | 28.12±3.43 | 1.02±0.11 |
It can be seen from Table 3 that the peritoneal macrophages have superior phagocytic phagocytic index to chicken red blood cells compared with the control mice.
The above is only one embodiment of the present invention, and the description thereof is more specific and detailed, but is not to be construed as limiting the scope of the invention. It should be noted that a number of variations and modifications may be made by those skilled in the art without departing from the spirit and scope of the invention.
Claims (3)
- 2019100542 21 May 20191. A baby lactoferrin-modulated milk powder characterized by comprising1000 parts of instant whole milk powder, 3.5 to 5 parts of lactoferrin, and 25 to 40 parts of whey protein powder in parts by mass, 5 to 12 parts of probiotics, 4 to 8 parts of prebiotics, 0.1 to 0.5 parts of taurine, 0.1 to 0.5 parts of casein phosphopeptide, 0.3 to 0.5 parts of DHA, 0.5 to 0.8 parts of ARA, and 0.1 to 0.5 of complex trace elements; a multivitamin of 0.1 to 0.3 parts, a choline chloride of 0.1 to 0.2 parts, a carnitine of 0.1 to 0.2 parts, and a nucleotide mixture of 0.02 to 0.05 parts.2. The infant lactoferrin-modulated milk powder according to claim 1, wherein the probiotic bacteria include bifidobacterium lactis and lactobacillus rhamnosus, and are mixed at a mass ratio of 1:1 to 5.3. The infant lactoferrin-modulated milk powder according to claim 1, wherein the prebiotic comprises oligofructose, galactooligosaccharide and polydextrose, mixed according to a mass ratio of 1:1 to 2: 2-4.4. The infant lactoferrin-modulated milk powder according to claim 1, wherein the nucleotide mixture comprises 5' inosine disodium, 5' adenosine monophosphate, 5' uridine Acid disodium, 5' cytidine disodium, and 5' guanylate disodium according to the mass ratio of 1:0.5-1:0.5-1: 2-3:0.5-1.5. The infant lactoferrin-modulated milk powder according to claim 1, wherein the composite trace elements include calcium, manganese, potassium, iron, zinc, copper, iodine and selenium according to a mass ratio. 100:0.4-1:60-85:80-120:60-90:8-13:0.5-1.5:0.2-0.5 mixed.6. The infant lactoferrin-modulated milk powder according to claim 1, wherein the multivitamin comprises vitamin A, vitamin D, vitamin E, vitamin KI, vitamin Bl, vitamin B6, and vitamin B12. , niacin, folic acid, pantothenic acid, vitamin C, biotin, mixed according to the mass ratio of 100: 15-22: 0.2-0.5: 2-5: 20-40:15-30: 0.02-0.08: 200-250:3-6 :12-17:i2019100542 21 May 20192000-5000: 0.4-1.7. The infant lactoferrin-modulated milk powder according to claim 1, wherein the lactoferrin powder is palatate lactoferrin.8. The method for preparing an infant lactoferrin-modulated milk powder according to any one of claims 1 to 7, comprising the steps of:(1) Weighing each raw material according to the above weight parts;
- (2) Mixing the lactoferrin powder and the clear separated protein powder, placing them in an oven for baking, and then taking out and cooling to room temperature to obtain a mixed protein powder;
- (3) Then the cooled mixed protein powder and instant whole milk powder, probiotics, prebiotics, taurine, casein phosphopeptide, DHA, ARA, complex trace elements, multivitamins, choline chloride, carnitine After the mixture of nucleotides is evenly mixed, it is packaged.9. The method for preparing an infant lactoferrin-modulated milk powder according to claim 8, wherein the lactoferrin is a palatate lactoferrin, and the preparation method comprises the following steps:(1) dissolving the emulsifier and the edible gum in water to obtain a slurry; the emulsifier and water are used in an amount of 20 to 50 mg of emulsifier per 1 ml of water;(2) The slurry is sprayed on the outer surface of the main lactoferrin powder, and spray-dried to obtain a patina lactoferrin.10. The method for preparing an infant lactoferrin-modulated milk powder according to claim 9, wherein the emulsifier is a mono-stea fatty acid ester, a polyglycerol ester, a sucrose fatty acid ester, or a succinic acid single Mixing one or more of glyceride, mono-diglyceride, sodium carboxymethylcellulose, monoglyceride diacetyl tartaric acid; the edible gum is modified starch, gellan gum, konjac gum, dextrin, kara One or more of gum, xanthan gum, pectin, microcrystalline cellulose, propylene2019100542 21 May 2019 glycol alginate, gelatin, agar, locust bean gum, guar gum, and sodium alginate.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2019100542A AU2019100542A4 (en) | 2019-05-21 | 2019-05-21 | Infant lactoferrin-modulated milk powder and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2019100542A AU2019100542A4 (en) | 2019-05-21 | 2019-05-21 | Infant lactoferrin-modulated milk powder and preparation method thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2019100542A4 true AU2019100542A4 (en) | 2019-06-27 |
Family
ID=66998021
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2019100542A Active AU2019100542A4 (en) | 2019-05-21 | 2019-05-21 | Infant lactoferrin-modulated milk powder and preparation method thereof |
Country Status (1)
Country | Link |
---|---|
AU (1) | AU2019100542A4 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112493317A (en) * | 2020-11-26 | 2021-03-16 | 拉格比(广东)健康科技有限公司 | Composition containing lactoferrin and preparation method thereof |
CN113558105A (en) * | 2021-07-21 | 2021-10-29 | 澳新西特(厦门)营养品有限公司 | Formula milk powder containing lactoferrin and preparation method thereof |
CN114041503A (en) * | 2021-11-03 | 2022-02-15 | 重庆第二师范学院 | Probiotics activity maintaining method and application of probiotics activity maintaining method in solid lipid food |
-
2019
- 2019-05-21 AU AU2019100542A patent/AU2019100542A4/en active Active
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112493317A (en) * | 2020-11-26 | 2021-03-16 | 拉格比(广东)健康科技有限公司 | Composition containing lactoferrin and preparation method thereof |
CN113558105A (en) * | 2021-07-21 | 2021-10-29 | 澳新西特(厦门)营养品有限公司 | Formula milk powder containing lactoferrin and preparation method thereof |
CN113558105B (en) * | 2021-07-21 | 2023-10-24 | 澳新西特(厦门)营养品有限公司 | Production line for preparing lactoferrin-containing formula milk powder and preparation method thereof |
CN114041503A (en) * | 2021-11-03 | 2022-02-15 | 重庆第二师范学院 | Probiotics activity maintaining method and application of probiotics activity maintaining method in solid lipid food |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU2019100542A4 (en) | Infant lactoferrin-modulated milk powder and preparation method thereof | |
CN104869850B (en) | Extrusion nutrient powder with improved stability of emulsion and dispersiveness and preparation method thereof | |
ES2599478T3 (en) | Food Additive Composition | |
RU2491080C2 (en) | Diarrhoea risk reduction | |
BRPI0809622A2 (en) | PROBIOTICS FOR IMPROVEMENT OF GUT MICROBIOTA | |
CN103621633A (en) | Infant series yak milk formula milk powder and preparation method thereof | |
CN111227044B (en) | Dairy product, preparation method and medical application thereof | |
CN110115291A (en) | A kind of infant's lactoferrin modulation milk powder and preparation method thereof | |
ES2803175T3 (en) | Dietary supplement | |
US20190240268A1 (en) | Infection protective agent for infants | |
CN109069555A (en) | Towards neonatal for improving the composition of brain function | |
CN109288063A (en) | A kind of multi-joint Cernevit-12 and preparation method thereof being proliferated beneficial bacteria of intestinal tract | |
CN108450555A (en) | A kind of shield tooth infant's formula milk and preparation method thereof | |
US20190201459A1 (en) | Anti-allergic agent for infants | |
CN112244095A (en) | Milk powder for regulating immunity and preparation method thereof | |
CN110692741A (en) | Formula milk powder for promoting bone growth and preparation method thereof | |
CN111587923A (en) | An infant formula containing sialic acid and its preparation method | |
CN106306029A (en) | Portable full nutritional yoghurt for spaceflight, yoghurt sheet, and preparation method thereof | |
CN111202137A (en) | Formula milk powder for improving immunity of children and preparation method thereof | |
CN110810849A (en) | Composition for increasing bone mineral density and application thereof | |
CN116649420B (en) | Nutritional milk powder with effects of nourishing intelligence and promoting digestion and absorption, and its preparation method | |
CN107307083A (en) | A kind of oat taste milk probiotics companion and preparation method thereof | |
US20240156886A1 (en) | Gos pre-conditioning lactobacillus strains and gos in final formulation | |
CN111227046B (en) | Application of dairy product in improving infant intestinal SIgA level | |
Gotteland et al. | Functional food in child nutrition |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FGI | Letters patent sealed or granted (innovation patent) |