AU2019100542A4 - Infant lactoferrin-modulated milk powder and preparation method thereof - Google Patents
Infant lactoferrin-modulated milk powder and preparation method thereof Download PDFInfo
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- AU2019100542A4 AU2019100542A4 AU2019100542A AU2019100542A AU2019100542A4 AU 2019100542 A4 AU2019100542 A4 AU 2019100542A4 AU 2019100542 A AU2019100542 A AU 2019100542A AU 2019100542 A AU2019100542 A AU 2019100542A AU 2019100542 A4 AU2019100542 A4 AU 2019100542A4
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- lactoferrin
- milk powder
- vitamin
- infant
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- 239000000843 powder Substances 0.000 title claims abstract description 79
- 235000013336 milk Nutrition 0.000 title claims abstract description 27
- 210000004080 milk Anatomy 0.000 title claims abstract description 27
- 239000008267 milk Substances 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 108010063045 Lactoferrin Proteins 0.000 claims abstract description 60
- 102000010445 Lactoferrin Human genes 0.000 claims abstract description 60
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 claims abstract description 60
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Classifications
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- A—HUMAN NECESSITIES
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- A23C21/00—Whey; Whey preparations
- A23C21/06—Mixtures of whey with milk products or milk components
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/1526—Amino acids; Peptides; Protein hydrolysates; Nucleic acids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/1528—Fatty acids; Mono- or diglycerides; Petroleum jelly; Paraffine; Phospholipids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/158—Milk preparations; Milk powder or milk powder preparations containing additives containing vitamins or antibiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Dairy Products (AREA)
Abstract
The invention relates to the technical field of baby food, in particular to a preparation method of baby lactoferrin-modulated milk powder, which comprises, according to the parts by mass, 1000 parts of instant whole milk powder, 3.5-5 parts of lactoferrin, whey. 25-40 parts of protein powder, 5-12 parts of probiotics, 4-8 parts of prebiotics, 0.1-0.5 parts of taurine, 0.1-0.5 parts of casein phosphopeptide, 0.3-0.5 parts of DHA, 0.5-0.8 parts of ARA 0.1 to 0.5 parts of complex trace elements, 0.1 to 0.3 parts of multivitamins, 0.1 to 0.2 parts of choline chloride, 0.1 to 0.2 parts of carnitine, and 0.02 to 0.05 parts of a mixture of nucleotides. The invention mixes lactoferrin and various nutrients to stabilize intestinal colonies of infants, and in order to reduce the consumption and destruction of lactoferrin by bacteria in tissues and organs, the lactoferrin is encapsulated and protected. The action, slow release, improves the bioavailability of lactoferrin in the infant, fully absorbs, and enhances the health care effect of lactoferrin.
Description
DESCRIPTION
2019100542 21 May 2019
Infant lactoferrin-modulated milk powder and preparation method thereof
Field
The invention relates to the technical field of baby food, in particular to a preparation method of baby lactoferrin-modulated milk powder.
Background
Lactoferrin is a multifunctional active glycoprotein that has been receiving much attention. Lactoferrin, also known as lactoferrin, is found mainly in various exudates of mammals such as milk, tears or saliva. In the past ten years, extensive research has been carried out on biological functions. The proven biological functions are involved in iron metabolism, which can improve the bioavailability of intestinal cells to iron and reduce the stimulating effect of iron ions on the gastrointestinal tract. It has certain inhibition and killing effects on gastrointestinal harmful bacteria such as Escherichia coli and Helicobacter pylori; it promotes the growth of bifidobacteria and regulates the intestinal flora. However, due to the consumption and destruction of lactoferrin in intestinal bacteria, the function of lactoferrin is weakened, especially the intestinal colony of infants is unstable, absorption is slow, resulting in a large amount of lactoferrin loss, the effect of lactoferrin not obvious.
Summary
The object of the present invention is to overcome the shortcomings and deficiencies of the prior art, and to provide a baby lactoferrin-modulated milk powder, which can maximize the function of lactoferrin and improve the health care effect of lactoferrin.
Another object of the present invention is to provide a method for preparing the infant lactoferrin-modulated milk powder.
i
2019100542 21 May 2019
The specific technical solution is:
An infant lactoferrin-modulated milk powder is composed of the following substances according to the mass fraction, 1000 parts of instant whole milk powder, 3.5-5 parts of lactoferrin, 25-40 parts of whey protein powder, and probiotics 5-12 4 parts, prebiotics 4 to 8 parts, taurine 0.1 to 0.5 parts, casein phosphopeptide 0.1 to 0.5 parts, DHA 0.3 to 0.5 parts, ARA 0.5 to 0.8 parts, complex trace elements 0.1 to 0.5 parts, multivitamin 0.1 to 0.3 parts, 0.1-0.2 parts of choline chloride, 0.1-0.2 parts of carnitine, and 0.02-0.05 parts of a mixture of nucleotides.
Wherein, the probiotics include Bifidobacterium lactis and Lactobacillus rhamnosus, mixed according to a mass ratio of 1:1-5. Prebiotics include oligofructose, galactooligosaccharide, and polydextrose, mixed according to a mass ratio of 1:1-2:2-4. The nucleotide mixture comprises 5' inosine monosodium, 5' adenosine monophosphate, 5' uridine disodium, 5' cytidine disodium, 5' guanylate disodium according to mass ratio 1 :0.5-1:0.5-1:2-3:0.5-1.
The composite trace elements, including calcium, manganese, potassium, iron, zinc, copper, iodine and selenium, mixed according to the mass ratio of :
100:0.4-1:60-85:80-120:60-90:8-13:0.5 -1.5: 0.2-0.5.
The multivitamins, including vitamin A, vitamin D, vitamin E, vitamin KI, vitamin Bl, vitamin B6, vitamin B12, niacin, folic acid, pantothenic acid, vitamin C, biotin, mixed according to the mass ratio of:
100:15-22: 0.2-0.5:2-5:20-40:15-30:0.02-0.08:200-250:3-6:12-17:20005000:0.4-1.
The lactoferrin powder is a palatate lactoferrin.
The preparation method of the infant lactoferrin-modulated milk powder comprises the following steps:
(1) weighing each raw material according to the above weight parts;
(2) The lactoferrin powder and the whey protein powder are uniformly mixed, and then baked in an oven at a temperature of 65-80 ° C for 10-15 min; then
2019100542 21 May 2019 taken out and cooled to room temperature. The mixed protein powder is obtained; more preferably, the mixing is carried out while baking, and the three-axis multi-directional mixing process is adopted; the mixing part belongs to the cleaning operation, and the workshop personnel and equipment must have strict sanitary disinfection measures. The production environment must have constant parameter requirements, such as temperature, humidity, air pressure, and cleanliness.
After this process, lactoferrin and whey protein isolate work together, the charge is cross-linked at a certain temperature, and the whey protein is wrapped outside the lactoferrin, which further ensures that lactoferrin will not be transported in the future. Excessive loss in use, but the disadvantage is that some whey protein isolate will be lost, so the use of whey protein isolate in the present invention is about 50% higher than the normal use amount, which is the reason, but much cheaper whey protein isolate. The price is only a few tenths of the lactoferrin, and the lactoferrin is very beneficial to the health and immunity of the baby. Therefore, an important invention of the present invention is to adopt the method of selling the car and protecting the handsome.
(3) Then the cooled mixed protein powder and instant whole milk powder, probiotics, prebiotics, taurine, casein phosphopeptide, DHA, ARA, complex trace elements, multivitamins, choline chloride, carnitine After the mixture of nucleotides is evenly mixed, it is packaged.
The lactoferrin described herein is a palatate lactoferrin, and the preparation method comprises the following steps:
(1) dissolving the emulsifier and the edible gum in water to obtain a slurry; the emulsifier and water are used in an amount of 20 to 50 mg of emulsifier per 1 ml of water;
(2) The slurry is sprayed on the outer surface of the main lactoferrin powder, and spray-dried to obtain a patina lactoferrin.
2019100542 21 May 2019
Wherein, the emulsifier is one of monostearyl fatty acid ester, polyglycerol ester, sucrose fatty acid ester, monoglyceride succinate, mono-diglyceride, sodium carboxymethyl cellulose, monoglyceride diacetyl tartaric acid Mixed with or in combination; the edible gum is modified starch, gellan gum, konjac gum, dextrin, carrageenan, xanthan gum, pectin, microcrystalline cellulose, propylene glycol alginate, gelatin, agar, hedgehog One or more of soybean gum, guar gum, and sodium alginate.
The present invention has the following advantages and effects over the prior art:
The invention mixes lactoferrin and various nutrients to stabilize intestinal colonies of infants, and in order to reduce the consumption and destruction of lactoferrin by bacteria in tissues and organs, the lactoferrin is encapsulated and protected. The action, slow release, improves the bioavailability of lactoferrin in the infant, fully absorbs, and enhances the health care effect of lactoferrin.
Embodiments
The present invention will be further described in detail below with reference to the embodiments, but the embodiments of the present invention are not limited thereto.
Embodiment 1
A baby lactoferrin-modulated milk powder consisting of the following substances in mass parts: 1000 parts of instant whole milk powder, 3.5 parts of lactoferrin, 22.3 parts of whey protein powder, 6.2 parts of probiotics, and prebiotics 5.1 , 0.24 parts of taurine, 0.33 parts of casein phosphopeptide, 0.51 parts of DHA, 0.64 parts of ARA, 0.58 parts of complex trace elements, 0.12 parts of multivitamin, 0.14 parts of choline chloride, 0.18 parts of carnitine, mixture of nucleotides 0.02 parts.
Wherein, the probiotics include Bifidobacterium lactis, Lactobacillus
2019100542 21 May 2019 rhamnosus, mixed at a mass ratio of 1:2. Prebiotics include oligofructose, galactooligosaccharide, and poly dextrose, mixed at a mass ratio of 1:1:3. The nucleotide mixture comprises 5' inosine monosodium, 5' adenosine monophosphate, 5' uridine disodium, 5' cytidine disodium, 5' guanylate disodium according to mass ratio 1 :0.5:0.5:2.5:0.6. The composite trace elements, including calcium, manganese, potassium, iron, zinc, copper, iodine and selenium, are mixed according to a mass ratio of 100:0.82:64:94:75:9:0.8:0.3. The multivitamins, including vitamin A, vitamin D, vitamin E, vitamin KI, vitamin Bl, vitamin B6, vitamin B12, niacin, folic acid, pantothenic acid, vitamin C, biotin, mixed according to a mass ratio of 100:20:0.3: 3.5:32:26:0.04:220:3.5:14:2000:0.58.
The preparation method of the infant lactoferrin-modulated milk powder comprises the following steps:
(1) dissolving the emulsifier and the edible gum in water to obtain a slurry; the emulsifier and water are used in an amount of 20 mg of emulsifier/1 ml of water; the emulsifier is a mono-hard fatty acid ester; For konjac gum.
(2) The slurry is sprayed on the outer surface of the main lactoferrin powder, and spray-dried to obtain a patina lactoferrin.
(3) weighing each raw material according to the above weight parts;
(4) The lactoferrin powder and the clear separated protein powder are uniformly mixed, and then baked in an oven, the baking temperature is 80 ° C, the time is 10 min; then taken out and cooled to room temperature to obtain a mixed protein powder; Adopting a three-axis multi-directional mixing process;
(5) Then the cooled mixed protein powder and instant whole milk powder, probiotics, prebiotics, taurine, casein phosphopeptides, DHA, ARA, complex trace elements, multivitamins, choline chloride, carnitine After the mixture of nucleotides is evenly mixed, it is packaged.
Embodiment 2
A baby lactoferrin-modulated milk powder consisting of the following
2019100542 21 May 2019 substances in mass parts: 1000 parts of instant whole milk powder, 4.6 parts of lactoferrin, 32 parts of whey protein powder, 7.5 parts of probiotics, 6.8 parts of prebiotics 0.63 parts of taurine, 0.24 parts of casein phosphopeptide, 0.38 parts of DHA, 0.68 parts of ARA, 0.35 parts of complex trace elements, 0.15 parts of multivitamin, 0.12 parts of choline chloride, 0.18 parts of carnitine, 0.03 mixture of nucleotides Share.
Wherein, the probiotics include Bifidobacterium lactis, Lactobacillus rhamnosus, mixed at a mass ratio of 1:4. Prebiotics include oligofructose, galactooligosaccharide, and polydextrose, which are mixed at a mass ratio of 1:2:2. The nucleotide mixture comprises 5' inosine monosodium, 5' adenosine monophosphate, 5' uridine disodium, 5' cytidine disodium, 5' guanylate disodium according to mass ratio 1 :0.8:0.5:3:0.7. The composite trace elements, including calcium, manganese, potassium, iron, zinc, copper, iodine and selenium, are mixed according to a mass ratio of 100:0.9:65:115:85:11:1.2:0.3. The multivitamins, including vitamin A, vitamin D, vitamin E, vitamin KI, vitamin Bl, vitamin B6, vitamin B12, niacin, folic acid, pantothenic acid, vitamin C, biotin, mixed according to the mass ratio of 100:18:0.2: 4:35:27:0.05:200:5:15:3000:0.4.
The preparation method of the infant lactoferrin-modulated milk powder comprises the following steps:
(1) dissolving the emulsifier and the edible gum in water to obtain a slurry; the emulsifier and water are used in an amount of 35 mg of emulsifier per 1 ml of water; the emulsifier is sodium carboxymethylcellulose; The glue is pectin.
(2) The slurry is sprayed on the outer surface of the main lactoferrin powder, and spray-dried to obtain a patina lactoferrin.
(3) weighing each raw material according to the above weight parts;
(4) The lactoferrin powder and the clear protein powder are uniformly mixed, and then baked in an oven, the baking temperature is 75 ° C, the time is 10 min; then taken out and cooled to room temperature to obtain a mixed protein powder;
2019100542 21 May 2019 (5) Then the cooled mixed protein powder and instant whole milk powder, probiotics, prebiotics, taurine, casein phosphopeptides, DHA, ARA, complex trace elements, multivitamins, choline chloride, carnitine After the mixture of nucleotides is evenly mixed, it is packaged.
Embodiment 3
A baby lactoferrin-modulated milk powder consisting of the following substances in mass parts: 1000 parts of instant whole milk powder, 3.8 parts of lactoferrin, 26 parts of whey protein powder, 10.3 parts of probiotics, 6.7 parts of prebiotics 0.34 parts of taurine, 0.35 parts of casein phosphopeptide, 0.38 parts of DHA, 0.75 parts of ARA, 0.46 parts of complex trace elements, 0.24 parts of multivitamins, 0.16 parts of choline chloride, 0.13 parts of carnitine, 0.03 mixture of nucleotides Share.
Wherein, the probiotics include Bifidobacterium lactis, Lactobacillus rhamnosus, mixed at a mass ratio of 1:4. Prebiotics include oligofructose, galactooligosaccharide, and poly dextrose, mixed at a mass ratio of 1:1:3. The nucleotide mixture comprises 5' inosine monosodium, 5' adenosine monophosphate, 5' uridine disodium, 5' cytidine disodium, 5' guanylate disodium according to mass ratio 1 :0.7:0.81:3:0.5. The composite trace elements, including calcium, manganese, potassium, iron, zinc, copper, iodine, selenium, are mixed according to a mass ratio of 100:0.54:75:100:85:10:1.5:0.5. The multivitamins, including vitamin A, vitamin D, vitamin E, vitamin KI, vitamin Bl, vitamin B6, vitamin B12, niacin, folic acid, pantothenic acid, vitamin C, biotin, mixed according to the mass ratio of 100:18:0.03: 3:30:25:0.07:210:5:15:4000:0.6.
The preparation method of the infant lactoferrin-modulated milk powder comprises the following steps:
(1) dissolving the emulsifier and the edible gum in water to obtain a slurry; the emulsifier and water are used in an amount of 35 mg of emulsifier per 1 ml of water; and the emulsifier is sucrose fatty acid ester and diacetyl tartaric acid
2019100542 21 May 2019 monoglyceride Mix one to one; the edible gum is carrageenan and dextrin mixed one to one.
(2) The slurry is sprayed on the outer surface of the main lactoferrin powder, and spray-dried to obtain a patina lactoferrin.
(3) weighing each raw material according to the above weight parts;
(4) The lactoferrin powder and the clear protein powder are uniformly mixed, and then baked in an oven, the baking temperature is 65 ° C, the time is 10 min; then taken out and cooled to room temperature to obtain a mixed protein powder;
(5) Then the cooled mixed protein powder and instant whole milk powder, probiotics, prebiotics, taurine, casein phosphopeptides, DHA, ARA, complex trace elements, multivitamins, choline chloride, carnitine After the mixture of nucleotides is evenly mixed, it is packaged.
Embodiment 4
A baby lactoferrin-prepared milk powder consisting of the following substances in mass parts: 1000 parts of instant whole milk powder, 4.3 parts of lactoferrin, 34 parts of whey protein powder, 8.4 parts of probiotics, 5.6 parts of prebiotics 0.46 parts of taurine, 0.23 parts of casein phosphopeptide, 0.43 parts of DHA, 0.64 parts of ARA, 0.27 parts of complex trace elements, 0.16 parts of multivitamins, 0.14 parts of choline chloride, 0.16 parts of carnitine, 0.045 mixture of nucleotides Share.
Wherein, the probiotics include Bifidobacterium lactis, Lactobacillus rhamnosus, mixed at a mass ratio of 1:2. Prebiotics include oligofructose, galactooligosaccharide, and polydextrose, which are mixed at a mass ratio of 1:2:2. The nucleotide mixture comprises 5' inosine monosodium, 5' adenosine monophosphate, 5' uridine disodium, 5' cytidine disodium, 5' guanylate disodium according to mass ratio 1 : 0.6:0.8:2.5:0.6. The composite trace elements, including calcium, manganese, potassium, iron, zinc, copper, iodine, selenium, are mixed according to a mass ratio of 100:1:72:114:75:11:1.4:0.2. The multivitamins,
2019100542 21 May 2019 including vitamin A, vitamin D, vitamin E, vitamin KI, vitamin Bl, vitamin B6, vitamin B12, niacin, folic acid, pantothenic acid, vitamin C, biotin, mixed according to the mass ratio of 100:22:0.5: 2:40:15:0.08:200:3:12:5000:0.4.
The preparation method of the infant lactoferrin-modulated milk powder comprises the following steps:
(1) dissolving the emulsifier and the edible gum in water to obtain a slurry; the emulsifier and water are used in an amount of 25 mg of emulsifier per 1 ml of water; the emulsifier is diacetyl tartaric acid monoglyceride; The gum is propylene glycol alginate.
(2) The slurry is sprayed on the outer surface of the main lactoferrin powder, and spray-dried to obtain a patina lactoferrin.
(3) weighing each raw material according to the above weight parts;
(4) The lactoferrin powder and the clear protein powder are uniformly mixed, and then baked in an oven, the baking temperature is 65 ° C, the time is 15 min; and then taken out and cooled to room temperature to obtain a mixed protein powder;
(5) Then the cooled mixed protein powder and instant whole milk powder, probiotics, prebiotics, taurine, casein phosphopeptides, DHA, ARA, complex trace elements, multivitamins, choline chloride, carnitine After the mixture of nucleotides is evenly mixed, it is packaged.
Lactoferrin has various biological activities such as antibacterial, anti-oxidation and anti-cancer. Adding lactoferrin to infant formula or baby food can help infants resist microorganisms such as E. coli, reduce common diseases such as diarrhea caused by viruses, and improve their immunity. The formulation of this patent application is more beneficial to the immune and nervous systems and promotes the growth of visceral mature and healthy visceral microflora.
The following experiments are carried out to verify the effect.
The first is an enhanced immunity test. A sample prepared in Example 1 was
2019100542 21 May 2019 used as an experimental example, and a skim milk powder containing an equal amount of lactoferrin was used as a comparative example according to Example 1.
The experimental animals were selected from mice with a mass of 18-22 g, 54 male and female, and were randomly divided into three groups. Each group was randomly divided into three groups for testing.
According to the food intake of the test mice, the maximum dose was designed to be 10 g/d, fed directly, and fed continuously for 30 days.
The MTT method was used to induce the transformation of mouse spleen lymphocytes induced by ConA; the hemagglutinin assay was performed by hemagglutination method; the antibody-producing cells were detected by Jerne modified slide method; and the mouse peritoneal macrophages phagocytized chicken red blood cells were tested by semi-in vivo method.
The experimental results are shown in the following table:
Table 1 Effect of sample group on serum blood lysin anti-volume number in mice
| dose | Number of experimental animals | Optical density difference |
| Experimental example | 6 | 224.10±10.54 |
| Comparative example | 6 | 186.02±10.26 |
It can be seen from Table 1 that the experimental example has an obvious effect of increasing the blood solubilization anti-volume number compared with the mouse of the comparative example.
Table 2 Effect of sample on mouse antibody-producing cells
| dose | Number of experimental animals | Antibody-producing cell number (106) |
| Experimental example | 6 | 324.84±43.21 |
| Comparative example | 6 | 214.37±50.34 |
From Table 2, it can be seen that the experimental example has an effect of increasing the number of antibody-producing cells as compared with the mouse of io
Table 3 Effect of sample group on the ability of mouse peritoneal macrophages to phagocytose chicken red blood cells
2019100542 21 May 2019 the comparative example.
| dose | Number of experimental animals | Percentage of phagocytosis (%) | Phagocytic index |
| Experimental example | 6 | 34.10±4.21 | 1.15±0.12 |
| Comparative example | 6 | 28.12±3.43 | 1.02±0.11 |
It can be seen from Table 3 that the peritoneal macrophages have superior phagocytic phagocytic index to chicken red blood cells compared with the control mice.
The above is only one embodiment of the present invention, and the description thereof is more specific and detailed, but is not to be construed as limiting the scope of the invention. It should be noted that a number of variations and modifications may be made by those skilled in the art without departing from the spirit and scope of the invention.
Claims (3)
- 2019100542 21 May 20191. A baby lactoferrin-modulated milk powder characterized by comprising1000 parts of instant whole milk powder, 3.5 to 5 parts of lactoferrin, and 25 to 40 parts of whey protein powder in parts by mass, 5 to 12 parts of probiotics, 4 to 8 parts of prebiotics, 0.1 to 0.5 parts of taurine, 0.1 to 0.5 parts of casein phosphopeptide, 0.3 to 0.5 parts of DHA, 0.5 to 0.8 parts of ARA, and 0.1 to 0.5 of complex trace elements; a multivitamin of 0.1 to 0.3 parts, a choline chloride of 0.1 to 0.2 parts, a carnitine of 0.1 to 0.2 parts, and a nucleotide mixture of 0.02 to 0.05 parts.2. The infant lactoferrin-modulated milk powder according to claim 1, wherein the probiotic bacteria include bifidobacterium lactis and lactobacillus rhamnosus, and are mixed at a mass ratio of 1:1 to 5.3. The infant lactoferrin-modulated milk powder according to claim 1, wherein the prebiotic comprises oligofructose, galactooligosaccharide and polydextrose, mixed according to a mass ratio of 1:1 to 2: 2-4.4. The infant lactoferrin-modulated milk powder according to claim 1, wherein the nucleotide mixture comprises 5' inosine disodium, 5' adenosine monophosphate, 5' uridine Acid disodium, 5' cytidine disodium, and 5' guanylate disodium according to the mass ratio of 1:0.5-1:0.5-1: 2-3:0.5-1.5. The infant lactoferrin-modulated milk powder according to claim 1, wherein the composite trace elements include calcium, manganese, potassium, iron, zinc, copper, iodine and selenium according to a mass ratio. 100:0.4-1:60-85:80-120:60-90:8-13:0.5-1.5:0.2-0.5 mixed.6. The infant lactoferrin-modulated milk powder according to claim 1, wherein the multivitamin comprises vitamin A, vitamin D, vitamin E, vitamin KI, vitamin Bl, vitamin B6, and vitamin B12. , niacin, folic acid, pantothenic acid, vitamin C, biotin, mixed according to the mass ratio of 100: 15-22: 0.2-0.5: 2-5: 20-40:15-30: 0.02-0.08: 200-250:3-6 :12-17:i2019100542 21 May 20192000-5000: 0.4-1.7. The infant lactoferrin-modulated milk powder according to claim 1, wherein the lactoferrin powder is palatate lactoferrin.8. The method for preparing an infant lactoferrin-modulated milk powder according to any one of claims 1 to 7, comprising the steps of:(1) Weighing each raw material according to the above weight parts;
- (2) Mixing the lactoferrin powder and the clear separated protein powder, placing them in an oven for baking, and then taking out and cooling to room temperature to obtain a mixed protein powder;
- (3) Then the cooled mixed protein powder and instant whole milk powder, probiotics, prebiotics, taurine, casein phosphopeptide, DHA, ARA, complex trace elements, multivitamins, choline chloride, carnitine After the mixture of nucleotides is evenly mixed, it is packaged.9. The method for preparing an infant lactoferrin-modulated milk powder according to claim 8, wherein the lactoferrin is a palatate lactoferrin, and the preparation method comprises the following steps:(1) dissolving the emulsifier and the edible gum in water to obtain a slurry; the emulsifier and water are used in an amount of 20 to 50 mg of emulsifier per 1 ml of water;(2) The slurry is sprayed on the outer surface of the main lactoferrin powder, and spray-dried to obtain a patina lactoferrin.10. The method for preparing an infant lactoferrin-modulated milk powder according to claim 9, wherein the emulsifier is a mono-stea fatty acid ester, a polyglycerol ester, a sucrose fatty acid ester, or a succinic acid single Mixing one or more of glyceride, mono-diglyceride, sodium carboxymethylcellulose, monoglyceride diacetyl tartaric acid; the edible gum is modified starch, gellan gum, konjac gum, dextrin, kara One or more of gum, xanthan gum, pectin, microcrystalline cellulose, propylene2019100542 21 May 2019 glycol alginate, gelatin, agar, locust bean gum, guar gum, and sodium alginate.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112493317A (en) * | 2020-11-26 | 2021-03-16 | 拉格比(广东)健康科技有限公司 | Composition containing lactoferrin and preparation method thereof |
| CN113558105A (en) * | 2021-07-21 | 2021-10-29 | 澳新西特(厦门)营养品有限公司 | Formula milk powder containing lactoferrin and preparation method thereof |
| CN114041503A (en) * | 2021-11-03 | 2022-02-15 | 重庆第二师范学院 | Probiotics activity maintaining method and application of probiotics activity maintaining method in solid lipid food |
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2019
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112493317A (en) * | 2020-11-26 | 2021-03-16 | 拉格比(广东)健康科技有限公司 | Composition containing lactoferrin and preparation method thereof |
| CN113558105A (en) * | 2021-07-21 | 2021-10-29 | 澳新西特(厦门)营养品有限公司 | Formula milk powder containing lactoferrin and preparation method thereof |
| CN113558105B (en) * | 2021-07-21 | 2023-10-24 | 澳新西特(厦门)营养品有限公司 | Production line for preparing lactoferrin-containing formula milk powder and preparation method thereof |
| CN114041503A (en) * | 2021-11-03 | 2022-02-15 | 重庆第二师范学院 | Probiotics activity maintaining method and application of probiotics activity maintaining method in solid lipid food |
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