AU2018335788B2 - Methods and compositions for the treatment of epidermolysis bullosa - Google Patents

Methods and compositions for the treatment of epidermolysis bullosa Download PDF

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Publication number
AU2018335788B2
AU2018335788B2 AU2018335788A AU2018335788A AU2018335788B2 AU 2018335788 B2 AU2018335788 B2 AU 2018335788B2 AU 2018335788 A AU2018335788 A AU 2018335788A AU 2018335788 A AU2018335788 A AU 2018335788A AU 2018335788 B2 AU2018335788 B2 AU 2018335788B2
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AU
Australia
Prior art keywords
fluid
microvesicles
cells
cell
isolated
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AU2018335788A
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AU2018335788A1 (en
Inventor
Evangelos V. BADIAVAS
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University of Miami
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University of Miami
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Priority claimed from US15/712,294 external-priority patent/US20180104186A1/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5063Compounds of unknown constitution, e.g. material from plants or animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Botany (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Physical Water Treatments (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2018335788A 2017-09-22 2018-09-21 Methods and compositions for the treatment of epidermolysis bullosa Active AU2018335788B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15/712,294 US20180104186A1 (en) 2013-03-13 2017-09-22 Methods and compositions for the treatment of epidermolysis bullosa
US15/712,294 2017-09-22
PCT/US2018/052213 WO2019060719A1 (fr) 2017-09-22 2018-09-21 Méthodes et compositions pour le traitement d'une épidermolyse bulleuse

Publications (2)

Publication Number Publication Date
AU2018335788A1 AU2018335788A1 (en) 2020-03-19
AU2018335788B2 true AU2018335788B2 (en) 2024-08-15

Family

ID=65810503

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2018335788A Active AU2018335788B2 (en) 2017-09-22 2018-09-21 Methods and compositions for the treatment of epidermolysis bullosa

Country Status (9)

Country Link
EP (1) EP3684336A4 (fr)
JP (1) JP7525396B2 (fr)
CN (1) CN111182890A (fr)
AU (1) AU2018335788B2 (fr)
CA (1) CA3076610A1 (fr)
EA (1) EA202090814A1 (fr)
IL (1) IL273407A (fr)
MX (2) MX2020002777A (fr)
WO (1) WO2019060719A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10640464B2 (en) 2011-01-03 2020-05-05 The William M. Yarbrough Foundation Use of isothiocyanate functional surfactants as Nrf2 inducers to treat epidermolysis bullosa simplex and related diseases
KR102125567B1 (ko) 2019-07-02 2020-06-22 한양대학교 에리카산학협력단 식물 엑소좀의 대량 생산 방법
AU2020459825A1 (en) * 2020-07-22 2023-03-16 Osaka University Therapeutic agent for dystrophic epidermolysis bullosa
KR20230074475A (ko) * 2020-08-21 2023-05-30 더 유니버시티 오브 마이애미 골수-유래 중간엽 줄기 세포로부터의 미세소포를 사용한 치료의 조성물 및 방법
EP3971440B1 (fr) 2020-09-21 2023-12-27 Brembo S.p.A. Bande de freinage d'un disque de frein à disque et disque de frein à disque
CA3228644A1 (fr) * 2021-08-12 2023-02-16 Onconova Therapeutics, Inc. Methodes et compositions pour traiter le cancer
US20230114217A1 (en) * 2021-10-12 2023-04-13 Eliksa Therapeutics, Inc. Methods of treating epidermolysis bullosa with cell-free amniotic fluid compositions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2972193T3 (pl) 2013-03-13 2020-08-24 University Of Miami Sposób izolacji i oczyszczania mikropącherzyków z supernatantów hodowli komórkowej i płynów biologicznych
WO2015038075A1 (fr) 2013-09-16 2015-03-19 Agency For Science, Technology And Research Procédé
US20170173113A1 (en) * 2014-03-13 2017-06-22 Research Institute At Nationwide Children's Hospital Methods of delivering heparin binding epidermal growth factor using stem cell generated exosomes
WO2016172598A1 (fr) * 2015-04-22 2016-10-27 The Broad Institute Inc. Exosomes et leurs utilisations
WO2017123022A1 (fr) 2016-01-12 2017-07-20 주식회사 강스템바이오텍 Exosome dérivé de cellules souches contenant une quantité importante de facteurs de croissance
EP3402489B1 (fr) * 2016-01-15 2021-06-09 Orbsen Therapeutics Limited Compositions d'exosomes à base de sdc2 et leurs procédés d'isolement et d'utilisation

Also Published As

Publication number Publication date
MX2020002777A (es) 2020-09-17
KR20200088799A (ko) 2020-07-23
CN111182890A (zh) 2020-05-19
EA202090814A1 (ru) 2020-08-07
AU2018335788A1 (en) 2020-03-19
EP3684336A1 (fr) 2020-07-29
EP3684336A4 (fr) 2021-06-02
MX2022015753A (es) 2023-01-19
WO2019060719A1 (fr) 2019-03-28
IL273407A (en) 2020-05-31
CA3076610A1 (fr) 2019-03-28
JP7525396B2 (ja) 2024-07-30
JP2020534344A (ja) 2020-11-26

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