AU2018318425A1 - Methods of treatment of osteoarthritis with transdermal cannabidiol gel - Google Patents
Methods of treatment of osteoarthritis with transdermal cannabidiol gel Download PDFInfo
- Publication number
- AU2018318425A1 AU2018318425A1 AU2018318425A AU2018318425A AU2018318425A1 AU 2018318425 A1 AU2018318425 A1 AU 2018318425A1 AU 2018318425 A AU2018318425 A AU 2018318425A AU 2018318425 A AU2018318425 A AU 2018318425A AU 2018318425 A1 AU2018318425 A1 AU 2018318425A1
- Authority
- AU
- Australia
- Prior art keywords
- cbd
- pain
- cannabidiol
- patients
- osteoarthritis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- QHMBSVQNZZTUGM-ZWKOTPCHSA-N cannabidiol Chemical compound OC1=CC(CCCCC)=CC(O)=C1[C@H]1[C@H](C(C)=C)CCC(C)=C1 QHMBSVQNZZTUGM-ZWKOTPCHSA-N 0.000 title claims abstract description 137
- QHMBSVQNZZTUGM-UHFFFAOYSA-N Trans-Cannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1C1C(C(C)=C)CCC(C)=C1 QHMBSVQNZZTUGM-UHFFFAOYSA-N 0.000 title claims abstract description 135
- 229950011318 cannabidiol Drugs 0.000 title claims abstract description 133
- ZTGXAWYVTLUPDT-UHFFFAOYSA-N cannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1C1C(C(C)=C)CC=C(C)C1 ZTGXAWYVTLUPDT-UHFFFAOYSA-N 0.000 title claims abstract description 133
- PCXRACLQFPRCBB-ZWKOTPCHSA-N dihydrocannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1[C@H]1[C@H](C(C)C)CCC(C)=C1 PCXRACLQFPRCBB-ZWKOTPCHSA-N 0.000 title claims abstract description 133
- 238000000034 method Methods 0.000 title claims abstract description 32
- 201000008482 osteoarthritis Diseases 0.000 title claims abstract description 28
- 238000011282 treatment Methods 0.000 title description 31
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- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 11
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- -1 250 mg daily Chemical compound 0.000 description 2
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- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- QMMJWQMCMRUYTG-UHFFFAOYSA-N 1,2,4,5-tetrachloro-3-(trifluoromethyl)benzene Chemical compound FC(F)(F)C1=C(Cl)C(Cl)=CC(Cl)=C1Cl QMMJWQMCMRUYTG-UHFFFAOYSA-N 0.000 description 1
- SBASXUCJHJRPEV-UHFFFAOYSA-N 2-(2-methoxyethoxy)ethanol Chemical compound COCCOCCO SBASXUCJHJRPEV-UHFFFAOYSA-N 0.000 description 1
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- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
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- 101000871151 Homo sapiens G-protein coupled receptor 55 Proteins 0.000 description 1
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- 206010027940 Mood altered Diseases 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
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- 150000001346 alkyl aryl ethers Chemical class 0.000 description 1
- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
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- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 description 1
- 229940031578 diisopropyl adipate Drugs 0.000 description 1
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- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 1
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- XYIBRDXRRQCHLP-UHFFFAOYSA-N ethyl acetoacetate Chemical compound CCOC(=O)CC(C)=O XYIBRDXRRQCHLP-UHFFFAOYSA-N 0.000 description 1
- LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 1
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- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
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- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/658—Medicinal preparations containing organic active ingredients o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2024205778A AU2024205778A1 (en) | 2017-08-14 | 2024-08-15 | Methods of treatment of osteoarthritis with transdermal cannabidiol gel |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762545468P | 2017-08-14 | 2017-08-14 | |
| US62/545,468 | 2017-08-14 | ||
| US201862661733P | 2018-04-24 | 2018-04-24 | |
| US62/661,733 | 2018-04-24 | ||
| PCT/IB2018/056090 WO2019034985A1 (en) | 2017-08-14 | 2018-08-13 | METHODS OF TREATING ARTHROSIS USING CANNABIDIOL TRANSDERMAL GEL |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2024205778A Division AU2024205778A1 (en) | 2017-08-14 | 2024-08-15 | Methods of treatment of osteoarthritis with transdermal cannabidiol gel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2018318425A1 true AU2018318425A1 (en) | 2020-02-27 |
Family
ID=65362584
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2018318425A Abandoned AU2018318425A1 (en) | 2017-08-14 | 2018-08-13 | Methods of treatment of osteoarthritis with transdermal cannabidiol gel |
| AU2024205778A Pending AU2024205778A1 (en) | 2017-08-14 | 2024-08-15 | Methods of treatment of osteoarthritis with transdermal cannabidiol gel |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2024205778A Pending AU2024205778A1 (en) | 2017-08-14 | 2024-08-15 | Methods of treatment of osteoarthritis with transdermal cannabidiol gel |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US20200170963A1 (zh) |
| EP (1) | EP3668500A4 (zh) |
| JP (2) | JP2020530857A (zh) |
| KR (1) | KR20200054171A (zh) |
| AU (2) | AU2018318425A1 (zh) |
| BR (1) | BR112020003025A2 (zh) |
| CA (1) | CA3072849A1 (zh) |
| IL (2) | IL301622A (zh) |
| JO (1) | JOP20200031A1 (zh) |
| MX (1) | MX2020001768A (zh) |
| WO (1) | WO2019034985A1 (zh) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12016829B2 (en) | 2019-10-11 | 2024-06-25 | Pike Therapeutics Inc. | Pharmaceutical composition and method for treating seizure disorders |
| CA3155181A1 (en) | 2019-10-14 | 2021-04-22 | Pike Therapeutics, Inc., 1219014 B.C. Ltd. | Transdermal delivery of cannabidiol |
| IL299399A (en) * | 2020-06-29 | 2023-02-01 | Zynerba Pharmaceuticals Inc | Treatment of fragile X syndrome with cannabidiol |
| MX2023011948A (es) * | 2021-04-12 | 2023-10-17 | Pike Therapeutics Inc | Entrega transdermica de cannabidiol:. |
| EP4098254A1 (en) * | 2021-06-04 | 2022-12-07 | Assistance Publique, Hopitaux De Paris | Cannabidiol for use in the treatment of pain resulting from an indoleamine 2,3-dioxygenase-1 (ido1) related disease |
| WO2024085581A1 (ko) * | 2022-10-17 | 2024-04-25 | (주)인벤티지랩 | 염증성 질환의 치료 또는 예방을 위한 서방형 주사용 조성물 및 이의 제조 방법 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9807639D0 (en) * | 1998-04-14 | 1998-06-10 | Kennedy Rheumatology Inst | Anti-inflammatory agents |
| US8449908B2 (en) * | 2000-12-22 | 2013-05-28 | Alltranz, Llc | Transdermal delivery of cannabidiol |
| GB2414933B (en) * | 2004-06-08 | 2009-07-15 | Gw Pharma Ltd | Cannabinoid compositions for the treatment of disease and/or symptoms in arthritis |
| AU2006249552B2 (en) * | 2005-05-25 | 2012-08-16 | Calosyn Pharma, Inc. | Method and composition for treating osteoarthritis |
| US20090247619A1 (en) * | 2008-03-06 | 2009-10-01 | University Of Kentucky | Cannabinoid-Containing Compositions and Methods for Their Use |
| CN106397591A (zh) * | 2008-12-22 | 2017-02-15 | 墨尔本大学 | 骨关节炎治疗 |
| MX2011011514A (es) * | 2009-04-28 | 2011-11-18 | Alltranz Inc | Formulaciones de canabidiol y metodos para utilizarlas. |
| US20120202891A1 (en) * | 2009-04-29 | 2012-08-09 | University Of Kentucky Research Foundation | Cannabinoid-Containing Compositions and Methods for Their Use |
| SI2473475T1 (sl) * | 2009-08-31 | 2017-10-30 | Zynerba Pharmaceuticals, Inc. | Uporaba kanabidiolnih predzdravil pri topičnem in transdermalnem dajanju z mikroiglami |
| JP2015526065A (ja) * | 2012-06-26 | 2015-09-10 | アンバーデイル エンタープライゼズ プロプライエタリー リミテッド | 超音波キャビテーションによる脂肪組織からの幹細胞の単離および使用方法 |
| WO2016011451A1 (en) * | 2014-07-18 | 2016-01-21 | Medipath, Inc. | Compositions and methods for physiological delivery using cannabidiol |
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2018
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- 2018-08-13 WO PCT/IB2018/056090 patent/WO2019034985A1/en unknown
- 2018-08-13 MX MX2020001768A patent/MX2020001768A/es unknown
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- 2018-08-13 CA CA3072849A patent/CA3072849A1/en active Pending
- 2018-08-13 EP EP18846438.2A patent/EP3668500A4/en active Pending
- 2018-08-13 JO JOP/2020/0031A patent/JOP20200031A1/ar unknown
- 2018-08-13 KR KR1020207005446A patent/KR20200054171A/ko not_active Application Discontinuation
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2020
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| MX2020001768A (es) | 2020-12-03 |
| US20200170963A1 (en) | 2020-06-04 |
| BR112020003025A2 (pt) | 2020-08-04 |
| KR20200054171A (ko) | 2020-05-19 |
| JP2023109969A (ja) | 2023-08-08 |
| IL301622A (en) | 2023-05-01 |
| IL272593A (en) | 2020-03-31 |
| EP3668500A4 (en) | 2021-04-28 |
| US20240148669A1 (en) | 2024-05-09 |
| EP3668500A1 (en) | 2020-06-24 |
| AU2024205778A1 (en) | 2024-09-05 |
| CA3072849A1 (en) | 2019-02-21 |
| WO2019034985A1 (en) | 2019-02-21 |
| JOP20200031A1 (ar) | 2020-02-12 |
| US20240189255A1 (en) | 2024-06-13 |
| JP2020530857A (ja) | 2020-10-29 |
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