AU2018270295B2 - Pyrrolopyridine-aniline compounds for treatment of dermal disorders - Google Patents

Pyrrolopyridine-aniline compounds for treatment of dermal disorders Download PDF

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Publication number
AU2018270295B2
AU2018270295B2 AU2018270295A AU2018270295A AU2018270295B2 AU 2018270295 B2 AU2018270295 B2 AU 2018270295B2 AU 2018270295 A AU2018270295 A AU 2018270295A AU 2018270295 A AU2018270295 A AU 2018270295A AU 2018270295 B2 AU2018270295 B2 AU 2018270295B2
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AU
Australia
Prior art keywords
compound
alkyl
mek
disorder
disease
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AU2018270295A
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AU2018270295A1 (en
Inventor
Matthew Duncton
John Kincaid
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Nflection Therapeutics Inc
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Nflection Therapeutics Inc
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Publication of AU2018270295A1 publication Critical patent/AU2018270295A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2018270295A 2017-05-19 2018-05-18 Pyrrolopyridine-aniline compounds for treatment of dermal disorders Active AU2018270295B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762508997P 2017-05-19 2017-05-19
US62/508,997 2017-05-19
US201862663202P 2018-04-26 2018-04-26
US62/663,202 2018-04-26
PCT/US2018/033547 WO2018213810A1 (en) 2017-05-19 2018-05-18 Pyrrolopyridine-aniline compounds for treatment of dermal disorders

Publications (2)

Publication Number Publication Date
AU2018270295A1 AU2018270295A1 (en) 2019-12-05
AU2018270295B2 true AU2018270295B2 (en) 2022-03-03

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ID=62620966

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2018270295A Active AU2018270295B2 (en) 2017-05-19 2018-05-18 Pyrrolopyridine-aniline compounds for treatment of dermal disorders

Country Status (16)

Country Link
US (4) US11161845B2 (https=)
EP (1) EP3624796B1 (https=)
JP (1) JP7212956B2 (https=)
KR (1) KR102642411B1 (https=)
CN (1) CN111065393B (https=)
AU (1) AU2018270295B2 (https=)
CA (1) CA3063536A1 (https=)
DK (1) DK3624796T3 (https=)
ES (1) ES3030506T3 (https=)
FI (1) FI3624796T3 (https=)
IL (1) IL270752B (https=)
MA (1) MA49141A (https=)
MX (2) MX389965B (https=)
PL (1) PL3624796T3 (https=)
PT (1) PT3624796T (https=)
WO (1) WO2018213810A1 (https=)

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JP7237941B2 (ja) 2017-05-19 2023-03-13 エヌフレクション セラピューティクス インコーポレイテッド 皮膚障害の処置用の融合複素環式芳香族アニリン化合物
PT3624796T (pt) * 2017-05-19 2025-06-02 Nflection Therapeutics Inc Compostos de pirrolopiridina-anilina para tratamento de distúrbios dérmicos
WO2020106308A1 (en) 2018-11-20 2020-05-28 Nflection Therapeutics, Inc. Naphthyridinone-aniline compounds for treatment of dermal disorders
WO2020106306A1 (en) 2018-11-20 2020-05-28 Nflection Therapeutics, Inc. Cyanoaryl-aniline compounds for treatment of dermal disorders
EP4233834A3 (en) * 2018-11-20 2023-10-25 NFlection Therapeutics, Inc. Aryl-aniline and heteroaryl-aniline compounds for treatment of birthmarks
WO2020106305A1 (en) 2018-11-20 2020-05-28 Nflection Therapeutics, Inc. Thienyl-aniline compounds for treatment of dermal disorders
CA3120351A1 (en) * 2018-11-20 2020-05-28 Nflection Therapeutics, Inc. Aryl-aniline and heteroaryl-aniline compounds for treatment of skin cancers
IL301496A (en) * 2020-09-24 2023-05-01 Nflection Therapeutics Inc Treatment of cognitive dysfunction with pyrrolopyridine-aniline compounds
EP4281055A4 (en) * 2021-01-21 2025-06-18 NFlection Therapeutics, Inc. CRYSTALLINE FORMS OF A PYRROLOPYRIDINANILINE COMPOUND
JP2024503893A (ja) * 2021-01-21 2024-01-29 エヌフレクション セラピューティクス インコーポレイテッド ピロロピリジン－アニリン化合物を調製するための方法
IL312977A (en) 2021-11-23 2024-07-01 Nflection Therapeutics Inc Formulations of pyrrolopyridine-aniline compounds
WO2023096935A1 (en) * 2021-11-23 2023-06-01 Nflection Therapeutics, Inc. Formulations of pyrrolopyridine-aniline compounds
CA3254428A1 (en) * 2022-03-17 2023-09-21 SpringWorks Therapeutics Inc. TREATMENT OF PLEXIFORM NEUROFIBROMAS (NP) ASSOCIATED WITH TYPE 1 NEUROFIBROMATOSIS (NF1) IN PEDIATRIC PATIENTS WITH MIRDAMETINIB

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Also Published As

Publication number Publication date
IL270752A (en) 2020-01-30
US11161845B2 (en) 2021-11-02
CN111065393A (zh) 2020-04-24
ES3030506T3 (en) 2025-06-30
EP3624796A1 (en) 2020-03-25
JP2020520995A (ja) 2020-07-16
PT3624796T (pt) 2025-06-02
WO2018213810A1 (en) 2018-11-22
MX2019013561A (es) 2022-02-09
MX2022001697A (es) 2022-04-07
CN111065393B (zh) 2023-08-18
MA49141A (fr) 2020-03-25
US20250034137A1 (en) 2025-01-30
US20250388580A1 (en) 2025-12-25
US20200165243A1 (en) 2020-05-28
CA3063536A1 (en) 2018-11-22
PL3624796T3 (pl) 2025-06-30
US20220033399A1 (en) 2022-02-03
JP7212956B2 (ja) 2023-01-26
DK3624796T3 (da) 2025-06-02
EP3624796B1 (en) 2025-03-19
MX389965B (es) 2025-03-20
AU2018270295A1 (en) 2019-12-05
US12065439B2 (en) 2024-08-20
IL270752B (en) 2022-06-01
KR102642411B1 (ko) 2024-02-28
US12428418B2 (en) 2025-09-30
FI3624796T3 (fi) 2025-06-11
KR20200013239A (ko) 2020-02-06

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