AU2018233109B2 - Pharmaceutical combination comprising ponesimod - Google Patents

Pharmaceutical combination comprising ponesimod Download PDF

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Publication number
AU2018233109B2
AU2018233109B2 AU2018233109A AU2018233109A AU2018233109B2 AU 2018233109 B2 AU2018233109 B2 AU 2018233109B2 AU 2018233109 A AU2018233109 A AU 2018233109A AU 2018233109 A AU2018233109 A AU 2018233109A AU 2018233109 B2 AU2018233109 B2 AU 2018233109B2
Authority
AU
Australia
Prior art keywords
ponesimod
teriflunomide
active ingredient
treatment
disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2018233109A
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English (en)
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AU2018233109A1 (en
Inventor
Martine Clozel
Laetitia POUZOL
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Juvise Pharmaceuticals
Original Assignee
Laboratoires Juvise Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Juvise Pharmaceuticals filed Critical Laboratoires Juvise Pharmaceuticals
Publication of AU2018233109A1 publication Critical patent/AU2018233109A1/en
Application granted granted Critical
Publication of AU2018233109B2 publication Critical patent/AU2018233109B2/en
Priority to AU2023274118A priority Critical patent/AU2023274118B2/en
Assigned to LABORATOIRES JUVISE PHARMACEUTICALS reassignment LABORATOIRES JUVISE PHARMACEUTICALS Request for Assignment Assignors: ACTELION PHARMACEUTICALS LTD
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)
AU2018233109A 2017-03-14 2018-03-13 Pharmaceutical combination comprising ponesimod Active AU2018233109B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2023274118A AU2023274118B2 (en) 2017-03-14 2023-11-29 Pharmaceutical combination comprising ponesimod

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EPPCT/EP2017/055994 2017-03-14
EP2017055994 2017-03-14
PCT/EP2018/056185 WO2018167030A1 (en) 2017-03-14 2018-03-13 Pharmaceutical combination comprising ponesimod

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2023274118A Division AU2023274118B2 (en) 2017-03-14 2023-11-29 Pharmaceutical combination comprising ponesimod

Publications (2)

Publication Number Publication Date
AU2018233109A1 AU2018233109A1 (en) 2019-08-22
AU2018233109B2 true AU2018233109B2 (en) 2023-09-28

Family

ID=61655772

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2018233109A Active AU2018233109B2 (en) 2017-03-14 2018-03-13 Pharmaceutical combination comprising ponesimod
AU2023274118A Active AU2023274118B2 (en) 2017-03-14 2023-11-29 Pharmaceutical combination comprising ponesimod

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2023274118A Active AU2023274118B2 (en) 2017-03-14 2023-11-29 Pharmaceutical combination comprising ponesimod

Country Status (24)

Country Link
US (2) US11723896B2 (OSRAM)
EP (1) EP3595657A1 (OSRAM)
JP (3) JP7281406B2 (OSRAM)
KR (1) KR102574562B1 (OSRAM)
CN (1) CN110381942B (OSRAM)
AU (2) AU2018233109B2 (OSRAM)
BR (1) BR112019018894A2 (OSRAM)
CA (1) CA3056301C (OSRAM)
CL (1) CL2019002525A1 (OSRAM)
CO (1) CO2019008510A2 (OSRAM)
CR (1) CR20190464A (OSRAM)
DO (1) DOP2019000257A (OSRAM)
EA (1) EA201992117A1 (OSRAM)
EC (1) ECSP19073317A (OSRAM)
IL (1) IL269239B2 (OSRAM)
JO (1) JOP20190207A1 (OSRAM)
MA (1) MA49822A (OSRAM)
MX (1) MX390941B (OSRAM)
NI (1) NI201900092A (OSRAM)
PE (1) PE20191489A1 (OSRAM)
PH (1) PH12019502110A1 (OSRAM)
SG (1) SG11201907308UA (OSRAM)
UA (1) UA125756C2 (OSRAM)
WO (1) WO2018167030A1 (OSRAM)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20190207A1 (ar) * 2017-03-14 2019-09-10 Actelion Pharmaceuticals Ltd تركيبة صيدلانية تشتمل على بونيسيمود
US11013723B1 (en) 2018-10-16 2021-05-25 Celgene Corporation Solid forms of a thiazolidinone compound, compositions and methods of use thereof
US11014940B1 (en) 2018-10-16 2021-05-25 Celgene Corporation Thiazolidinone and oxazolidinone compounds and formulations
US11186556B1 (en) 2018-10-16 2021-11-30 Celgene Corporation Salts of a thiazolidinone compound, solid forms, compositions and methods of use thereof
US11014897B1 (en) 2018-10-16 2021-05-25 Celgene Corporation Solid forms comprising a thiazolidinone compound, compositions and methods of use thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006044741A1 (en) * 2004-10-19 2006-04-27 Aventis Pharmaceuticals Inc. Use of (z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating inflammatory bowel disease
WO2016091996A1 (en) * 2014-12-11 2016-06-16 Actelion Pharmaceuticals Ltd Dosing regimen for a selective s1p1 receptor agonist

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ES448386A1 (es) 1975-06-05 1978-04-16 Hoechst Ag Procedimiento para la preparacion de anilidas de acido 5-me-til-isoxazol-4-carboxilico.
DE2854439A1 (de) 1978-12-16 1980-07-03 Hoechst Ag Ein isoxazolderivat, verfahren zu seiner herstellung, diese verbindung enthaltende mittel und verwendung
DE3534440A1 (de) 1985-09-27 1987-04-02 Hoechst Ag Arzneimittel gegen chronische graft-versus-host-krankheiten sowie gegen autoimmunerkrankungen, insbesondere systemischen lupus erythematodes
US5268382A (en) 1985-09-27 1993-12-07 Hoechst Aktiengesellschaft Medicaments to combat autoimmune diseases, in particular systemic lupus erythematosus
DE60110043T2 (de) 2000-02-15 2006-03-02 Teva Pharmaceutical Industries Ltd. Methode zur synthetisierung von leflunomid
ES2305287T3 (es) 2001-04-05 2008-11-01 Aventis Pharmaceuticals Inc. Uso de (4'-trifluorometifenil)-amida del acido (z)-ciano-3-hidroxi-but-2-enoico para tratar la esclerosis multiple.
GB0123571D0 (en) * 2001-04-05 2001-11-21 Aventis Pharm Prod Inc Use of (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis
US6894184B2 (en) 2003-03-18 2005-05-17 Aventis Pharma Deutschland Gmbh Process for preparing 2-cyano-3-hydroxy-N-(phenyl)but-2-enamides
USRE43833E1 (en) 2003-11-21 2012-11-27 Actelion Pharmaceuticals Ltd. Thiazolidin-4-one derivatives
CN100567275C (zh) 2003-11-21 2009-12-09 埃科特莱茵药品有限公司 作为免疫抑制剂的5-(苯基-(z)-亚基)-噻唑烷-4-酮衍生物
DE102006017896A1 (de) 2006-04-13 2007-10-25 Tiefenbacher Pharmachemikalien Alfred E. Tiefenbacher Gmbh & Co. Kg Leflunomid enthaltende pharmazeutische Zusammensetzungen
US8912340B2 (en) 2006-11-23 2014-12-16 Actelion Pharmaceuticals Ltd. Process for the preparation of 2-imino-thiazolidin-4-one derivatives
US8263780B2 (en) 2006-11-23 2012-09-11 Actelion Pharmaceuticals Ltd. Process for the preparation of 2-imino-thiazolidin-4-one derivatives
AR070842A1 (es) 2008-03-17 2010-05-05 Actelion Pharmaceuticals Ltd Regimen de dosificacion para un agonista de receptor selectivo de s1p1
GB0819182D0 (en) 2008-10-20 2008-11-26 Actelion Pharmaceuticals Ltd Crystalline forms
CN104666272A (zh) 2009-09-18 2015-06-03 赛诺菲 稳定性提高的(z)-2-氰基-3-羟基-丁-2-烯酸-(4’-三氟甲基苯基)-酰胺片剂制剂
US8747844B2 (en) 2010-07-30 2014-06-10 Saint Louis University Methods of treating pain
WO2012018704A1 (en) 2010-08-02 2012-02-09 Sanofi-Aventis U.S. Llc Use of teriflunomide for treating multiple sclerosis
EP2692343A1 (en) 2012-08-03 2014-02-05 Forward Pharma A/S Combination therapy for treatment of multiple sclerosis
HRP20200883T1 (hr) 2012-08-17 2020-09-04 Actelion Pharmaceuticals Ltd. Postupak za pripremanje (2z,5z)-5-(3-kloro-4-((r)-2,3-dihidroksipropoksi)benziliden)-2-(propilimino)-3-(o-tolil)tiazolidin-4-ona i međuproizvodi koji se koriste u navedenom postupku
WO2016079687A1 (en) 2014-11-18 2016-05-26 Lupin Limited Oral pharmaceutical composition of teriflunomide
MA41139A (fr) 2014-12-11 2017-10-17 Actelion Pharmaceuticals Ltd Combinaison pharmaceutique comportant un agoniste sélectif du récepteur sip1
US20180185308A1 (en) 2015-06-18 2018-07-05 Matinas Biopharma Nanotechnologies, Inc. Compositions and methods for treating inflammatory disease or conditions
JOP20190207A1 (ar) * 2017-03-14 2019-09-10 Actelion Pharmaceuticals Ltd تركيبة صيدلانية تشتمل على بونيسيمود

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006044741A1 (en) * 2004-10-19 2006-04-27 Aventis Pharmaceuticals Inc. Use of (z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating inflammatory bowel disease
WO2016091996A1 (en) * 2014-12-11 2016-06-16 Actelion Pharmaceuticals Ltd Dosing regimen for a selective s1p1 receptor agonist

Also Published As

Publication number Publication date
MX390941B (es) 2025-03-21
JOP20190207A1 (ar) 2019-09-10
US20240139161A1 (en) 2024-05-02
DOP2019000257A (es) 2020-09-15
US11723896B2 (en) 2023-08-15
CO2019008510A2 (es) 2019-10-21
AU2023274118B2 (en) 2024-12-12
IL269239B2 (en) 2023-07-01
NI201900092A (es) 2020-03-11
PE20191489A1 (es) 2019-10-21
CN110381942B (zh) 2022-12-27
AU2023274118A1 (en) 2023-12-21
ECSP19073317A (es) 2019-11-30
SG11201907308UA (en) 2019-09-27
CL2019002525A1 (es) 2020-02-07
JP2024096962A (ja) 2024-07-17
EP3595657A1 (en) 2020-01-22
AU2018233109A1 (en) 2019-08-22
JP2020510045A (ja) 2020-04-02
JP2023030091A (ja) 2023-03-07
CA3056301C (en) 2024-10-01
PH12019502110A1 (en) 2020-03-16
KR20190122716A (ko) 2019-10-30
EA201992117A1 (ru) 2020-02-17
IL269239A (en) 2019-11-28
MX2019010874A (es) 2019-12-11
JP7281406B2 (ja) 2023-05-25
CA3056301A1 (en) 2018-09-20
CR20190464A (es) 2019-11-26
KR102574562B1 (ko) 2023-09-04
CN110381942A (zh) 2019-10-25
BR112019018894A2 (pt) 2020-04-14
US20200069655A1 (en) 2020-03-05
MA49822A (fr) 2020-06-17
UA125756C2 (uk) 2022-06-01
IL269239B1 (en) 2023-03-01
WO2018167030A1 (en) 2018-09-20

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PC Assignment registered

Owner name: LABORATOIRES JUVISE PHARMACEUTICALS

Free format text: FORMER OWNER(S): ACTELION PHARMACEUTICALS LTD