AU2018101889A4 - Penicillin extractant high purity chloroform production plant - Google Patents
Penicillin extractant high purity chloroform production plant Download PDFInfo
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- AU2018101889A4 AU2018101889A4 AU2018101889A AU2018101889A AU2018101889A4 AU 2018101889 A4 AU2018101889 A4 AU 2018101889A4 AU 2018101889 A AU2018101889 A AU 2018101889A AU 2018101889 A AU2018101889 A AU 2018101889A AU 2018101889 A4 AU2018101889 A4 AU 2018101889A4
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- AU
- Australia
- Prior art keywords
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- high purity
- penicillin
- production plant
- extractant
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/38—Separation; Purification; Stabilisation; Use of additives
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Pencillin extractant high purity chloroform production plant Abstract 5 Penicillin extractant high purity chloroform production plant, including: filter (LIO), rectifying column (ElOl), filter (L102), tank (F101), pump (J101); among them, pump (JIO) is connected respectively to tank (FlOl) and filter (L1O), rectifying column (ElOl) is connected respectively to filter (LIO) and filter (L102); among them, microporous membrane diameter of filer (L102) is 0.12-0.15 [tm. Figure 1 Industrial chloroformn .1101:11- Figure 1
Description
Penicillin extractant high purity chloroform production plant
FIELD OF THE INVENTION
The present invention relates to a kind of pharmaceutical synthesis plant, more particularly, relates to penicillin extractant high purity chloroform production plant.
GENERAL BACKGROUND
High purity chloroform can be used as penicillin extractant. It can also be used in the pharmaceutical industry as solvent as well as extractant for essential oils and alkaloids. High purity chloroform is a good organic solvent. It can dissolve plexiglass, rubber and other polymer materials. It can be used as their adhesives. In the polymerization of olefins, it can be used as telogen. Under the peroxide initiated, olefin molecules can be hundreds of thousands of polymerization into a polymer, adding chloroform, the number of molecules of olefin polymerization can be controlled below 10 or above 50, making the polymerization carried out on request. It is also an important organic synthesis reagent. Under the action of alkali, it reacts with olefins to form halogenated three-membered ring compounds, which is an important method for synthesizing three-membered cyclic compounds. In analytical chemistry, it can be used as extractant in determination ofmercury, cobalt, manganese, lead, iodine, phosphorus and others. Most of the existing production plant processes are complex. Thus, as a penicillin extractant, the advantages and disadvantages of production equipment of high purity chloroform have a great economic significant for improving product quality and reducing the by-product contents.
SUMMARY
The purpose of the present invention is to provide penicillin extractant high purity chloroform production plant, including: filter (L101), rectifying column (E101), filter (LI02), tank (Fl01), pump (JI01); among them, pump (JI01) is connected respectively to tank (F101) and filter (L101), rectifying column (E101) is connected respectively to filter (LI01) and filter (LI02); among them, microporous membrane diameter of filer (L102) is 0.12-0.15 pm, nominal volume of tank (Fl 01) is 3.1-3.3 m3,
2018101889 30 Nov 2018 impeller diameter of pump (J101) is 145-150 mm.
Penicillin extractant high purity chloroform production plant, the production process is: processed the industrial chloroform raw material by Fl01 and J101, washed in filter L101, firstly washed with distilled water, with 30% the amount of 5 each volume of chloroform, washed for 7~9 times, washed with concentrated sulfuric acid with 10% the amount of chloroform each volume, washed for 4~6 times. Then washed with dilute caustic soda solution for 4-6 times, washed with distilled water for 2~5 times, and dehydrated by anhydrous calcium chloride. Rectified the dehydrated product in rectifying column E101, collected middle distillate of rectification. Filtered 10 the collected fraction through a microporous membrane in filter LI02, then subpackaged at ultra-clean workbench, obtained the finished product. The advantages of this invention are that the reaction time is reduced and the reaction rate is improved.
DESCRIPTION OF THE DRAWINGS
Figure 1 is penicillin extractant high purity chloroform production plant.
Include: filter (LI01), rectifying column (El01), filter (LI02), tank (Fl01), pump (J101);
DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS
The following examples with reference to specific embodiments of the present invention are further illustrated:
Embodiment 1
Raw materials and dosages
| Chloroform | Pure chemical | 45 | Water | Double distilled water | 200 |
| Sodium phenolate | Pure chemical | 70 | Concentrated sulfuric acid | Analytical purity, 98% | 30 |
| Anhydrous calcium | Pure chemical | 22 |
2018101889 30 Nov 2018
| chloride |
Penicillin extractant high purity chloroform production plant, including: filter (L101), rectifying column (E101), filter (L102), tank (F101), pump (J101); among them, pump (JI01) is connected respectively to tank (Fl01) and filter (LI01), rectifying column (E101) is connected respectively to filter (L101) and filter (L102);
among them, microporous membrane diameter of filer (L102) is 0.12 pm, nominal volume of tank (Fl 01) is 3.1 m3, impeller diameter of pump (JI 01) is 145 mm.
Penicillin extractant high purity chloroform production plant, the production process is: processed the industrial chloroform raw material by Fl01 and J101, washed in filter L101, firstly washed with distilled water, with 30% the amount of 10 each volume of chloroform, washed for 7 times, washed with concentrated sulfuric acid with 10% the amount of chloroform each volume, washed for 4 times. Then washed with dilute caustic soda solution for 4 times, washed with distilled water for 2 times, and dehydrated by anhydrous calcium chloride. Rectified the dehydrated product in rectifying column E101, collected middle distillate of rectification. Filtered 15 the collected fraction through a microporous membrane in filter LI02, then subpackaged at ultra-clean workbench, obtained the finished product.
The qualities of the product are as follows:
| Exterior | Colorless liquid | transparent | Relative density (20 °C) | 1.482 |
| Constant boiling point (with water) (containing 97% CHC13) | 55 °C | Boiling point | 62 °C | |
| Solubility (100 mL water) | 0.83g | Refractive index (20 °C) | 1.4474 |
Embodiment 2
Raw materials and dosages
| Chloroform | Pure chemical | 50 | Water | Double | 230 |
2018101889 30 Nov 2018
| distilled water | |||||
| Sodium phenolate | Pure chemical | 80 | Concentrated sulfuric acid | Analytical purity, 98% | 40 |
| Anhydrous calcium chloride | Pure chemical | 28 |
Penicillin extractant high purity chloroform production plant, including: filter (L101), rectifying column (E101), filter (L102), tank (F101), pump (J101); among them, pump (JI01) is connected respectively to tank (Fl01) and filter (LI01), rectifying column (E101) is connected respectively to filter (L101) and filter (L102);
among them, microporous membrane diameter of filer (L102) is 0.15 pm, nominal volume of tank (Fl 01) is 3.3 m3, impeller diameter of pump (JI 01) is 150 mm.
Penicillin extractant high purity chloroform production plant, the production process is: processed the industrial chloroform raw material by Fl01 and J101, washed in filter L101, firstly washed with distilled water, with 30% the amount of 10 each volume of chloroform, washed for 9 times, washed with concentrated sulfuric acid with 10% the amount of chloroform each volume, washed for 6 times. Then washed with dilute caustic soda solution for 6 times, washed with distilled water for 5 times, and dehydrated by anhydrous calcium chloride. Rectified the dehydrated product in rectifying column E101, collected middle distillate of rectification. Filtered 15 the collected fraction through a microporous membrane in filter LI02, then subpackaged at ultra-clean workbench, obtained the finished product.
The qualities of the product are as follows:
| Exterior | Colorless transparent liquid | Relative density (20 °C) | 1.484 |
| Constant boiling point (with water) (containing 97% CHC13) | 56 °C | Boiling point | 63 °C |
2018101889 30 Nov 2018
| Solubility (100 mL water) | 0.84g | Refractive index (20 °C) | 1.4475 |
The embodiments of the present invention are merely preferred embodiments of the present invention, but the range of the present invention is not limited this, and any person who is familiar with those skilled in the arts, within the technical range of the present invention. It is intended that the technical solution and its inventive 5 concept be replaced or modified equivalently with reference to the range of the invention.
Claims (2)
1. Penicillin extractant high purity chloroform production plant, including: filter (L101), rectifying column (E101), filter (L102), tank (F101), pump (J101); among
5 them, pump (JI01) is connected respectively to tank (Fl01) and filter (LI01), rectifying column (E101) is connected respectively to filter (L101) and filter (L102); among them, microporous membrane diameter of filer (L102) is 0.12-0.15 pm.
2. Penicillin extractant high purity chloroform production plant according to claim 1 wherein nominal volume of tank (Fl 01) is 3.1-3.3 m3.
10 3. Penicillin extractant high purity chloroform production plant according to claim 1 wherein impeller diameter of pump (J101) is 145-150 mm.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711299631.8A CN108238843A (en) | 2017-12-09 | 2017-12-09 | The process units of the high-purity chloroform of penicillin g extract agent |
| CN2017112996318 | 2017-12-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2018101889A4 true AU2018101889A4 (en) | 2019-01-24 |
Family
ID=61158018
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2018101889A Ceased AU2018101889A4 (en) | 2017-12-09 | 2018-11-30 | Penicillin extractant high purity chloroform production plant |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN108238843A (en) |
| AU (1) | AU2018101889A4 (en) |
| GB (1) | GB201722031D0 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109134918A (en) * | 2018-08-20 | 2019-01-04 | 德清舒华泡沫座椅有限公司 | A kind of modification liquid and preparation method thereof to improve foamed plastics flame retardant property |
| CN109081940A (en) * | 2018-08-20 | 2018-12-25 | 德清舒华泡沫座椅有限公司 | A method of improving polyurethane foam plastics flame retardant property |
| CN109096533A (en) * | 2018-08-20 | 2018-12-28 | 德清舒华泡沫座椅有限公司 | A method of improving bacterial cellulose gel cavernous body flame retardant property |
-
2017
- 2017-12-09 CN CN201711299631.8A patent/CN108238843A/en not_active Withdrawn
- 2017-12-28 GB GBGB1722031.0A patent/GB201722031D0/en not_active Ceased
-
2018
- 2018-11-30 AU AU2018101889A patent/AU2018101889A4/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| GB201722031D0 (en) | 2018-02-14 |
| CN108238843A (en) | 2018-07-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGI | Letters patent sealed or granted (innovation patent) | ||
| MK22 | Patent ceased section 143a(d), or expired - non payment of renewal fee or expiry |