AU2018101763A4 - Antistatic agent N-octyl-diaminoethyl glycine hydrochloride production plant - Google Patents
Antistatic agent N-octyl-diaminoethyl glycine hydrochloride production plant Download PDFInfo
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- AU2018101763A4 AU2018101763A4 AU2018101763A AU2018101763A AU2018101763A4 AU 2018101763 A4 AU2018101763 A4 AU 2018101763A4 AU 2018101763 A AU2018101763 A AU 2018101763A AU 2018101763 A AU2018101763 A AU 2018101763A AU 2018101763 A4 AU2018101763 A4 AU 2018101763A4
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- tank
- connected respectively
- reactor
- transfer pump
- pump
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
- C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/60—Preparation of compounds containing amino groups bound to a carbon skeleton by condensation or addition reactions, e.g. Mannich reaction, addition of ammonia or amines to alkenes or to alkynes or addition of compounds containing an active hydrogen atom to Schiff's bases, quinone imines, or aziranes
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Antistatic agent n-octyl-diaminoethyl glycine hydrochloride production plant Abstract Antistatic agent N-octyl-diaminoethyl glycine hydrochloride production plant, including: tank (F101), tank (F102), feedstock pump (Ji01), feedstock pump (J102), reactor (Di01), filter tower (ElOl), transfer pump (J103), transfer pump (J104), transfer pump (Ji05), distillation column (E102), condenser (ClOl), tank (F103), 10 condensation reactor (D102), filter (LiO), dryer (L102); among them, tank (FlOl) is used to store diethylenetriamine, tank (F102) is used to store chloroctane, tank (F103) is used to store intermediate products; the connection between the various components of the production plant is: feedstock pump (JiO) is connected respectively to tank (FlOl) and reactor (Di01), feedstock pump (J102) is connected respectively to tank 15 (F102) and reactor (Di01), transfer pump (J103) is connected respectively to reactor (Di01) and filter tower (ElOl), transfer pump (J104) is connected respectively to filter tower (ElOl) and distillation column (E102), condenser (ClOl) is connected respectively to distillation column (E102) and tank (F103), transfer pump (JI05) is connected respectively to tank (F103) and condensation reactor (D102), filter (LIO) 20 is connected respectively to condensation reactor (D102) and dryer (L102); among them, head thickness of tank (F101) is 9-10mm. Figure 1 FigureI
Description
Antistatic agent N-octyl-diaminoethyl glycine hydrochloride production plant
FIELD OF THE INVENTION
The present invention relates to a kind of pharmaceutical synthesis plant, more particularly, relates to antistatic agent N-octyl-diaminoethyl glycine hydrochloride production plant.
GENERAL BACKGROUND
N-octyl-diaminoethylglycine hydrochloride has properties of rich foam, low toxicity, no irritation to skin and eyes, it also has good bactericidal property. Most of 10 the existing production plant processes are complex. Thus, as an antistatic agent, the advantages and disadvantages of production equipment of N-octyl-diaminoethylglycine hydrochloride have a great economic significant for improving product quality and reducing the by-product contents.
SUMMARY
The purpose of the present invention is to provide antistatic agent
N-octyl-diaminoethyl glycine hydrochloride production plant, including: tank (Fl01), tank (Fl02), feedstock pump (JI01), feedstock pump (JI02), reactor (DI01), filter tower (El01), transfer pump (JI03), transfer pump (JI04), transfer pump (JI05), distillation column (E102), condenser (C101), tank (F103), condensation reactor 20 (DI02), filter (LI01), dryer (LI02); among them, tank (Fl01) is used to store diethylenetriamine, tank (Fl02) is used to store chloroctane, tank (Fl03) is used to store intermediate products; the connection between the various components of the production plant is: feedstock pump (JI01) is connected respectively to tank (Fl01) and reactor (DI01), feedstock pump (JI02) is connected respectively to tank (Fl02) 25 and reactor (DI01), transfer pump (JI03) is connected respectively to reactor (DI01) and filter tower (El01), transfer pump (JI04) is connected respectively to filter tower (El01) and distillation column (El02), condenser (Cl01) is connected respectively to distillation column (El02) and tank (Fl03), transfer pump (JI05) is connected respectively to tank (Fl03) and condensation reactor (DI02), filter (LI01) is connected respectively to condensation reactor (DI02) and dryer (LI02); among them, head thickness of tank (F101) is 9-10 mm, impeller diameter of transfer pump (J104) is 160-165 mm, heat exchanger tube diameter of condenser (C101) is 0.015-0.016 m.
Antistatic agent N-octyl-diaminoethyl glycine hydrochloride production plant, the production process is: added the measured diethylenetriamine into reactor D101, raised the temperature to 160-170 °C, added chlorinated octane under continuous stirring, maintained the temperature to react for 1-2 h, rested for 3-4 h until diethylenetriamine hydrochloride precipitated completely, removed sediments by filtration through E101, distilled the filtrate in distillation still El02 under reduced pressure, collected the fraction of 160-170°C (1.5 kPa) and stored in F103, got the light yellow viscous liquid, which is octadecyldiethylenetriamine. Added the measured octadecyldiethylenetriamine and chloroacetic acid aqueous solution into condensation reactor DI02, reacted at 80-90 °C for 30-50 min, introduced into crystallization tank while it is hot, obtained the colorless crystalline flakes, suction filtered by L101, dried by L102 and got the finished product. The advantages of this invention are that the reaction time is reduced and the reaction rate is improved.
DESCRIPTION OF THE DRAWINGS
Figure 1 antistatic agent N-octyl-diaminoethyl glycine hydrochloride production plant.
Include: tank (Fl01), tank (Fl02), feedstock pump (JI01), feedstock pump (J102), reactor (D101), filter tower (E101), transfer pump (J103), transfer pump (JI04), transfer pump (JI05), distillation column (El02), condenser (Cl01), tank (Fl03), condensation reactor (DI02), filter (LI01), dryer (LI02);
DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS
The following examples with reference to specific embodiments of the present invention are further illustrated:
Embodiment 1
Raw materials and dosages
2018101763 18 Nov 2018
| D iethy lenetr iamine | Industrial grade | 200 kg | Chloroacetic acid | Industrial grade | 200kg |
| Chlorooctane | Industrial grade | 300kg |
Antistatic agent N-octyl-diaminoethyl glycine hydrochloride production plant, including: tank (Fl01), tank (Fl02), feedstock pump (JI01), feedstock pump (JI02), reactor (D101), filter tower (E101), transfer pump (J103), transfer pump (J104), transfer pump (J105), distillation column (E102), condenser (C101), tank (F103), 5 condensation reactor (DI02), filter (LI01), dryer (LI02); among them, tank (Fl01) is used to store diethylenetriamine, tank (Fl02) is used to store chloroctane, tank (Fl03) is used to store intermediate products; the connection between the various components of the production plant is: feedstock pump (JI01) is connected respectively to tank (Fl01) and reactor (DI01), feedstock pump (JI02) is connected respectively to tank 10 (Fl02) and reactor (DI01), transfer pump (JI03) is connected respectively to reactor (D101) and filter tower (E101), transfer pump (J104) is connected respectively to filter tower (E101) and distillation column (E102), condenser (C101) is connected respectively to distillation column (E102) and tank (F103), transfer pump (J105) is connected respectively to tank (Fl03) and condensation reactor (DI02), filter (LI01) 15 is connected respectively to condensation reactor (DI02) and dryer (LI02); among them, head thickness of tank (Fl01) is 9 mm, impeller diameter of transfer pump (J104) is 160 mm, heat exchanger tube diameter of condenser (C101) is 0.015 m.
Antistatic agent N-octyl-diaminoethyl glycine hydrochloride production plant, the production process is: added the measured diethylenetriamine into reactor D101, 20 raised the temperature to 160 °C, added chlorinated octane under continuous stirring, maintained the temperature to react for 1 h, rested for 3 h until diethylenetriamine hydrochloride precipitated completely, removed sediments by filtration through E101, distilled the filtrate in distillation still El02 under reduced pressure, collected the fraction of 160°C (1.5 kPa) and stored in F103, got the light yellow viscous liquid, 25 which is octadecyldiethylenetriamine. Added the measured
2018101763 18 Nov 2018 octadecyldiethylenetriamine and chloroacetic acid aqueous solution into condensation reactor DI02, reacted at 80 °C for 30 min, introduced into crystallization tank while it is hot, obtained the colorless crystalline flakes, suction filtered by L101, dried by LI02 and got the finished product.
The qualities of the product are as follows:
| Exterior | Flake crystal | pH value | 9.3 |
| Actives | >33% |
Embodiment 2
Raw materials and dosages
| D iethy lenetr iamine | Industrial grade | 210 kg | Chloroacetic acid | Industrial grade | 220kg |
| Chlorooctane | Industrial grade | 320kg |
Antistatic agent N-octyl-diaminoethyl glycine hydrochloride production plant, including: tank (Fl01), tank (Fl02), feedstock pump (JI01), feedstock pump (JI02), reactor (D101), filter tower (E101), transfer pump (J103), transfer pump (J104), transfer pump (J105), distillation column (E102), condenser (C101), tank (F103), condensation reactor (DI02), filter (LI01), dryer (LI02); among them, tank (Fl01) is used to store diethylenetriamine, tank (Fl02) is used to store chloroctane, tank (Fl03) is used to store intermediate products; the connection between the various components of the production plant is: feedstock pump (JI01) is connected respectively to tank (Fl01) and reactor (DI01), feedstock pump (JI02) is connected respectively to tank (Fl02) and reactor (DI01), transfer pump (JI03) is connected respectively to reactor (D101) and filter tower (E101), transfer pump (J104) is connected respectively to filter tower (E101) and distillation column (E102), condenser (C101) is connected respectively to distillation column (E102) and tank (F103), transfer pump (J105) is connected respectively to tank (Fl03) and condensation reactor (DI02), filter (LI01) is connected respectively to condensation reactor (DI02) and dryer (LI02); among them, head thickness of tank (Fl01) is 10 mm, impeller diameter of transfer pump (J104) is 165 mm, heat exchanger tube diameter of condenser (C101) is 0.016 m.
Antistatic agent N-octyl-diaminoethyl glycine hydrochloride production plant, the production process is: added the measured diethylenetriamine into reactor D101, raised the temperature to 170 °C, added chlorinated octane under continuous stirring, maintained the temperature to react for 2 h, rested for 4 h until diethylenetriamine hydrochloride precipitated completely, removed sediments by filtration through E101, distilled the filtrate in distillation still El02 under reduced pressure, collected the fraction of 170°C (1.5 kPa) and stored in F103, got the light yellow viscous liquid, which is octadecyldiethylenetriamine. Added the measured octadecyldiethylenetriamine and chloroacetic acid aqueous solution into condensation reactor D102, reacted at 90 °C for 50 min, introduced into crystallization tank while it is hot, obtained the colorless crystalline flakes, suction filtered by L101, dried by LI02 and got the finished product.
The qualities of the product are as follows:
| Exterior | Flake crystal | pH value | 9.6 |
| Actives | >35% |
The embodiments of the present invention are merely preferred embodiments of the present invention, but the range of the present invention is not limited this, and any person who is familiar with those skilled in the arts, within the technical range of the present invention. It is intended that the technical solution and its inventive concept be replaced or modified equivalently with reference to the range of the invention.
Claims (3)
1. Antistatic agent N-octyl-diaminoethyl glycine hydrochloride production plant, including: tank (Fl01), tank (Fl02), feedstock pump (JI01), feedstock pump (JI02), reactor (D101), filter tower (E101), transfer pump (J103), transfer pump (J104), transfer pump (J105), distillation column (E102), condenser (C101), tank (F103), condensation reactor (DI02), filter (L101), dryer (L102); among them, tank (Fl01) is used to store diethylenetriamine, tank (Fl02) is used to store chloroctane, tank (Fl03) is used to store intermediate products; the connection between the various components of the production plant is: feedstock pump (JI01) is connected respectively to tank (Fl01) and reactor (DI01), feedstock pump (JI02) is connected respectively to tank (Fl02) and reactor (DI01), transfer pump (JI03) is connected respectively to reactor (D101) and filter tower (E101), transfer pump (J104) is connected respectively to filter tower (El01) and distillation column (El02), condenser (Cl01) is connected respectively to distillation column (E102) and tank (F103), transfer pump (J105) is connected respectively to tank (Fl03) and condensation reactor (DI02), filter (L101) is connected respectively to condensation reactor (DI02) and dryer (L102); among them, head thickness of tank (Fl 01) is 9-10mm.
2. Antistatic agent N-octyl-diaminoethyl glycine hydrochloride production plant,according to claim 1 wherein impeller diameter of transfer pump (JI04) is 160-165 mm.
3. Antistatic agent N-octyl-diaminoethyl glycine hydrochloride production plant,according to claim 1 wherein heat exchanger tube diameter of condenser (C101) is 0.015-0.016 m.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711237534.6A CN108238964A (en) | 2017-11-30 | 2017-11-30 | The process units of antistatic agent N- octyl groups-diaminoethyl glycine hydrochloride |
| CN2017112375346 | 2017-11-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2018101763A4 true AU2018101763A4 (en) | 2019-01-17 |
Family
ID=61131772
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2018101763A Ceased AU2018101763A4 (en) | 2017-11-30 | 2018-11-18 | Antistatic agent N-octyl-diaminoethyl glycine hydrochloride production plant |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN108238964A (en) |
| AU (1) | AU2018101763A4 (en) |
| GB (1) | GB201721980D0 (en) |
-
2017
- 2017-11-30 CN CN201711237534.6A patent/CN108238964A/en not_active Withdrawn
- 2017-12-27 GB GBGB1721980.9A patent/GB201721980D0/en not_active Ceased
-
2018
- 2018-11-18 AU AU2018101763A patent/AU2018101763A4/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| GB201721980D0 (en) | 2018-02-07 |
| CN108238964A (en) | 2018-07-03 |
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| Date | Code | Title | Description |
|---|---|---|---|
| FGI | Letters patent sealed or granted (innovation patent) | ||
| MK22 | Patent ceased section 143a(d), or expired - non payment of renewal fee or expiry |