IES20180449A2 - Antistatic agent n-octyl-diaminoethyl glycine hydrochloride production plant - Google Patents
Antistatic agent n-octyl-diaminoethyl glycine hydrochloride production plantInfo
- Publication number
- IES20180449A2 IES20180449A2 IES20180449A2 IE S20180449 A2 IES20180449 A2 IE S20180449A2 IE S20180449 A2 IES20180449 A2 IE S20180449A2
- Authority
- IE
- Ireland
- Prior art keywords
- tank
- reactor
- connected respectively
- transfer pump
- production plant
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title claims description 21
- 239000002216 antistatic agent Substances 0.000 title claims description 13
- 229960001269 Glycine Hydrochloride Drugs 0.000 title claims description 12
- -1 n-octyl-diaminoethyl glycine hydrochloride Chemical compound 0.000 title description 2
- 238000009833 condensation Methods 0.000 claims description 16
- 230000005494 condensation Effects 0.000 claims description 16
- 238000004821 distillation Methods 0.000 claims description 16
- 239000002151 riboflavin Substances 0.000 claims description 16
- 239000004149 tartrazine Substances 0.000 claims description 16
- IVLXQGJVBGMLRR-UHFFFAOYSA-N 2-aminoacetic acid;hydron;chloride Chemical compound Cl.NCC(O)=O IVLXQGJVBGMLRR-UHFFFAOYSA-N 0.000 claims description 11
- RPNUMPOLZDHAAY-UHFFFAOYSA-N DETA Chemical compound NCCNCCN RPNUMPOLZDHAAY-UHFFFAOYSA-N 0.000 claims description 9
- CNDHHGUSRIZDSL-UHFFFAOYSA-N 1-chlorooctane Chemical compound CCCCCCCCCl CNDHHGUSRIZDSL-UHFFFAOYSA-N 0.000 claims description 6
- 239000000047 product Substances 0.000 description 9
- DBNYMXPUYZOHQN-UHFFFAOYSA-N N'-[2-(octadecylamino)ethyl]ethane-1,2-diamine Chemical compound CCCCCCCCCCCCCCCCCCNCCNCCN DBNYMXPUYZOHQN-UHFFFAOYSA-N 0.000 description 5
- FOCAUTSVDIKZOP-UHFFFAOYSA-N Chloroacetic acid Chemical compound OC(=O)CCl FOCAUTSVDIKZOP-UHFFFAOYSA-N 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- TVMXDCGIABBOFY-UHFFFAOYSA-N Octane Chemical class CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 238000002425 crystallisation Methods 0.000 description 3
- 230000005712 crystallization Effects 0.000 description 3
- 239000000706 filtrate Substances 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 239000002253 acid Substances 0.000 description 2
- 229940106681 chloroacetic acid Drugs 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- PDAOFKBIOKDCPC-UHFFFAOYSA-N N'-(2-aminoethyl)ethane-1,2-diamine;hydrochloride Chemical compound Cl.NCCNCCN PDAOFKBIOKDCPC-UHFFFAOYSA-N 0.000 description 1
- 210000003491 Skin Anatomy 0.000 description 1
- 230000000844 anti-bacterial Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000002194 synthesizing Effects 0.000 description 1
Description
FIELD OF THE INVENTION The present invention relates to a kind of pharmaceutical synthesis plant, more particularly, relates to antistatic agent N—octyl-diaminoethyl glycine hydrochloride production plant.
GENERAL BACKGROUND N—octy1—diaminoethylglycine hydrochloride has properties of rich foam, low toxicity, no irritation to skin and eyes, it also has good bactericidal property. Most of the existing production plant processes are complex. Thus, as an antistatic agent, the advantages and disadvantages of production N-octyl-diaminoethylglycine hydrochloride have a great economic significant for improving product quality and reducing the by-product contents.
SUMMARY The purpose of the present invention is to provide antistatic agent N-octyl-diaminoethyl glycine hydrochloride production plant, including: tank (F 101), tank (F102), feedstock pump (J101), feedstock pump (.1102), reactor (D101), filter tower (E101), transfer pump (J 103), transfer pump (J104), transfer pump (1105), distillation column (E102), condenser (C101), tank (F103), condensation reactor (D102), filter (L101), dryer (L102); among them, tank (F101) is used to store diethylenetriamine, tank (F102) is used to store chloroctane, tank (F103) is used to store intermediate products; the connection between the various components of the production plant is: feedstock pump (J 101) is connected respectively to tank (F101) and reactor (D101), feedstock pump (Jl02) is connected respectively to tank (F102) and reactor (D101), transfer pump (J 103) is connected respectively to reactor (D101) and filter tower (E101), transfer pump (J 104) is connected respectively to filter tower (E101) and distillation column (E102), condenser (C101) is connected respectively to distillation column (E102) and tank (F103), transfer pump (J105) is connected respectively to tank (F103) and condensation reactor (D102), filter (L101) is equipment of connected respectively to condensation reactor (D102) and dryer (L102); among them, head thickness of tank (F101) is 9-10 mm, impeller diameter of transfer pump (1 104) is 160-165 mm, heat exchanger tube diameter of condenser (C101) is 0015-0016 m.
Antistatic agent N-octyl-diaminoethyl glycine hydrochloride production plant, the production process is: added the measured diethylenetriamine into reactor D101, raised the temperature to 160-170 "C, added chlorinated octane under continuous stirring, maintained the temperature to react for 1-2 h, rested for 3-4 h until dietliylenetriamine hydrochloride precipitated completely, removed sediments by filtration through E101, distilled the filtrate in distillation still E102 under reduced pressure, collected the fraction of 160—170°C (1.5 kPa) and stored in F103, got the light yellow viscous liquid, which is octadecyldiethylenetriamine. Added the measured octadecyldiethylenetriamine and chloroacetic acid aqueous solution into condensation reactor D102, reacted at 80-90 "C for 30-50 min, introduced into crystallization tank while it is hot, obtained the colorless crystalline flakes, suction filtered by L101, dried by L102 and got the finished product. The advantages of this invention are that the reaction time is reduced and the reaction rate is improved.
DESCRIPTION OF THE DRAWINGS Figure 1 antistatic agent N-octyl-diaminoethyl glycine hydrochloride production plant. lnclude: tank (F101), tank (F102), feedstock pump (J101), feedstock pump (1102), reactor (D101), filter tower (E101), transfer pump (.1103), transfer pump (J 104), transfer pump (J105), distillation column (E102), condenser (C101), tank (F103), condensation reactor (D102), filter (L101), dryer (L102); DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS The following examples with reference to specific embodiments of the present invention are further illustrated: Embodiment 1 Raw materials and dosages Diethylenetriamine Industrial 200 kg Chloroacetic Industrial 200kg grade id grade Chlorooctane Industrial 300kg grade Antistatic agent N—octy1-diaminoetliyl glycine hydrochloride production plant, including: tank (F101), tank (F102), feedstock pump (J101), feedstock pump (J102), reactor (D101), filter tower (E101), transfer pump (J103), transfer pump (J104), transfer pump (1105), distillation column (E102), condenser (C101), tank (F103), condensation reactor (D102), filter (L101), dryer (L102); among them, tank (F101) is used to store diethylenetriamine, tank (F102) is used to store chloroctane, tank (F103) is used to store intermediate products; the connection between the various components of the production plant is: feedstock pump (J 101) is connected respectively to tank (F101) and reactor (D101), feedstock pump (J 102) is connected respectively to tank (F102) and reactor (D101), transfer pump (J 103) is connected respectively to reactor (D101) and filter tower (E101), transfer pump (J 104) is connected respectively to filter tower (E101) and distillation column (E102), condenser (C101) is connected respectively to distillation column (E102) and tank (F103), transfer pump (.1105) is connected respectively to tank (F 103) and condensation reactor (D102), filter (L101) is connected respectively to condensation reactor (D102) and dryer (L102); among them, head thickness of tank (F101) is 9 mm, impeller diameter of transfer pump (J 104) is 160 mm, heat exchanger tube diameter of condenser (C101) is 0.015 m.
Antistatic agent N—octyl-diaminoethyl glycine hydrochloride production plant, the production process is: added the measured diethylenetriamine into reactor D101, raised the temperature to 160 °C, added chlorinated octane under continuous stirring, maintained the temperature to react for 1 h, rested for 3 11 until diethylenetriamine hydrochloride precipitated completely, removed sediments by filtration through E101 , distilled the filtrate in distillation still E102 under reduced pressure, collected the fraction of 160°C (1.5 kPa) and stored in F103, got the light yellow viscous liquid, which is Added the octadecyldiethylenetriamine. measured octadecyldiethylenetriamine and chloroacetic acid aqueous solution into condensation reactor D102, reacted at 80 °C for 30 min, introduced into crystallization tank while it is hot, obtained the colorless crystalline flakes, suction filtered by L101, dried by L102 and got the finished product.
The qualities of the product are as follows: Exterior Flake crystal pH value 9.3 Actives Z3 3% Embodiment 2 Raw materials and dosages Diethylenetriamine Industrial 210 kg Chloroacetic Industrial 220kg grade acid grade Chlorooctane Industrial 320kg grade Antistatic agent N-octyl-diaminoethyl glycine hydrochloride production plant, including: tank (F101), tank (F102), feedstock pump (J10l), feedstock pump (Jl02), reactor (D101), filter tower (E101), transfer pump (Jl03), transfer pump (J104), transfer pump (1105), distillation column (E102), condenser (C101), tank (F103), condensation reactor (D102), filter (L101), dryer (L102); among them tank (F101) is used to store diethylenetriamine, tank (F102) is used to store chloroctane, tank (F103) is used to store intermediate products; the connection between the various components of the production plant is: feedstock pump (.1101) is connected respectively to tank (F101) and reactor (D101), feedstock pump (1102) is connected respectively to tank (F102) and reactor (D101), transfer pump (J 103) is connected respectively to reactor (D101) and filter tower (E101), transfer pump (J104) is connected respectively to filter tower (E101) and distillation column (E102), condenser (C101) is connected respectively to distillation column (E102) and tank (F103), transfer pump (J 105) is connected respectively to tank (F103) and condensation reactor (D102), filter (L101) is connected respectively to condensation reactor (D102) and dryer (L102); among them, head thickness of tank (F 101) is 10 mm, impeller diameter of transfer pump (JIO4) is l65 mm, heat exchanger tube diameter of condenser (C101) is 0.016 m.
Antistatic agent N—octyl-diaminoethyl glycine hydrochloride production plant, the production process is: added the measured diethylenetriamine into reactor D101, raised the temperature to 170 "C, added chlorinated octane under continuous stirring, maintained the temperature to react for 2 h, rested for 4 h until diethylenetriainine hydrochloride precipitated completely, removed sediments by filtration through E101, distilled the filtrate in distillation still E102 under reduced pressure, collected the fiaction of 170C (1.5 kPa) and stored in F103, got the light yellow viscous liquid, which is Added the 0ctadecyldiethylenetriamine. measured octadecyldiethylenetriamine and cliloroacetic acid aqueous solution into condensation reactor D102, reacted at 90 "C for 50 min, introduced into crystallization tank while it is hot, obtained the colorless crystalline flakes, suction filtered by Ll0l, dried by L102 and got the finished product.
The qualities of the product are as follows: Exterior Flake crystal pH value 9.6 Actives 235% The embodiments of the present invention are merely preferred embodiments of the present invention, but the range of the present invention is not limited this, and any person who is familiar with those skilled in the arts, within the technical range of the present invention. It is intended that the technical solution and its inventive concept be replaced or modified equivalently with reference to the range of the invention.
Claims (3)
1. Antistatic agent N-octyl—diaminoethyl glycine hydrochloride production plant, including: tank (F101), tank (F102), feedstock pump (Jl01), feedstock pump (Jl02), reactor (D101), filter tower (E101), transfer pump (J103), transfer pump (J104), transfer pump (1105), distillation column (E102), condenser (C101), tank (F103), condensation reactor (D102), filter (L101), dryer (L102); among them, tank (F101) is used to store diethylenetriamine, tank (F102) is used to store chloroctane, tank (F103) is used to store intermediate products; the connection between the various components of the production plant is: feedstock pump (1101) is connected respectively to tank (F 101) and reactor (D101), feedstock pump (1102) is connected respectively to tank (F102) and reactor (D101), transfer pump (J103) is connected respectively to reactor (D101) and filter tower (E101), transfer pump (J104) is connected respectively to filter tower (E101) and distillation column (E102), condenser (C101) is connected respectively to distillation column (E102) and tank (F103), transfer pump (J105) is connected respectively to tank (F103) and condensation reactor (D102), filter (L101) is connected respectively to condensation reactor (D102) and dryer (L102); among them, head thickness of tank (F101) is 9-1 Omm. '
2. Antistatic agent N—octyl-diaminoethyl glycine hydrochloride production plant,according to claim 1 wherein impeller diameter of transfer pump (1104) is 160-165 mm.
3. Antistatic agent N-octy1—diaminoethyl glycine hydrochloride production plant,according to claim 1 wherein heat exchanger tube diameter of condenser (C101) is 0015-0016 m.
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