AU2017378324B2 - Bycyclic heteroaryl derivatives as CFTR potentiators - Google Patents

Bycyclic heteroaryl derivatives as CFTR potentiators Download PDF

Info

Publication number
AU2017378324B2
AU2017378324B2 AU2017378324A AU2017378324A AU2017378324B2 AU 2017378324 B2 AU2017378324 B2 AU 2017378324B2 AU 2017378324 A AU2017378324 A AU 2017378324A AU 2017378324 A AU2017378324 A AU 2017378324A AU 2017378324 B2 AU2017378324 B2 AU 2017378324B2
Authority
AU
Australia
Prior art keywords
pyrimidin
pyrrolo
trifluoromethyl
fluorophenyl
triazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2017378324A
Other languages
English (en)
Other versions
AU2017378324A1 (en
Inventor
Rajiah Aldrin DENNY
Ivan Viktorovich Efremov
David Christopher Limburg
John Paul Mathias
James John Mousseau
Joseph Walter Strohbach
Atli Thorarensen
Christoph Wolfgang ZAPF
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cystic Fibrosis Foundation
Original Assignee
Cystic Fibrosis Found
Cystic Fibrosis Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cystic Fibrosis Found, Cystic Fibrosis Foundation filed Critical Cystic Fibrosis Found
Publication of AU2017378324A1 publication Critical patent/AU2017378324A1/en
Assigned to CYSTIC FIBROSIS FOUNDATION reassignment CYSTIC FIBROSIS FOUNDATION Request for Assignment Assignors: CYSTIC FIBROSIS FOUNDATON THERAPEUTICS INC.
Application granted granted Critical
Publication of AU2017378324B2 publication Critical patent/AU2017378324B2/en
Priority to AU2021277702A priority Critical patent/AU2021277702B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2017378324A 2016-12-16 2017-12-14 Bycyclic heteroaryl derivatives as CFTR potentiators Active AU2017378324B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2021277702A AU2021277702B2 (en) 2016-12-16 2021-12-02 Bicyclic heteroaryl derivatives as CFTR potentiators

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662435253P 2016-12-16 2016-12-16
US62/435,253 2016-12-16
PCT/US2017/066317 WO2018112149A1 (en) 2016-12-16 2017-12-14 Bycyclic heteroaryl derivatives as cftr potentiators

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2021277702A Division AU2021277702B2 (en) 2016-12-16 2021-12-02 Bicyclic heteroaryl derivatives as CFTR potentiators

Publications (2)

Publication Number Publication Date
AU2017378324A1 AU2017378324A1 (en) 2019-06-27
AU2017378324B2 true AU2017378324B2 (en) 2021-09-02

Family

ID=62557188

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2017378324A Active AU2017378324B2 (en) 2016-12-16 2017-12-14 Bycyclic heteroaryl derivatives as CFTR potentiators
AU2021277702A Active AU2021277702B2 (en) 2016-12-16 2021-12-02 Bicyclic heteroaryl derivatives as CFTR potentiators

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2021277702A Active AU2021277702B2 (en) 2016-12-16 2021-12-02 Bicyclic heteroaryl derivatives as CFTR potentiators

Country Status (10)

Country Link
US (4) US10131670B2 (enExample)
EP (1) EP3554506B1 (enExample)
JP (1) JP7150721B2 (enExample)
CN (1) CN110300589B (enExample)
AU (2) AU2017378324B2 (enExample)
CA (1) CA3046968A1 (enExample)
MX (1) MX391651B (enExample)
RU (1) RU2753056C2 (enExample)
SG (2) SG10201911076QA (enExample)
WO (1) WO2018112149A1 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201913603QA (en) 2014-10-06 2020-02-27 Vertex Pharma Modulators of cystic fibrosis transmembrane conductance regulator
EP3379933B1 (en) 2015-11-25 2023-02-15 Gilead Apollo, LLC Fungicidal compositions containing derivatives of 2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidine
MX2018006286A (es) 2015-11-25 2018-09-07 Gilead Apollo Llc Inhibidores de acc pirazolicos y usos de los mismos.
JP2018536660A (ja) 2015-11-25 2018-12-13 ギリアド アポロ， エルエルシー エステルａｃｃ阻害剤およびその使用
AU2016361428A1 (en) 2015-11-25 2018-05-24 Gilead Apollo, Llc Triazole ACC inhibitors and uses thereof
US10570115B2 (en) 2016-09-30 2020-02-25 Vertex Pharmaceuticals Incorporated Modulator of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
HRP20201946T1 (hr) 2016-12-09 2021-01-22 Vertex Pharmaceuticals Incorporated Modulator regulatora transmembranske provodljivosti cistične fibroze, farmaceutski sastavi, postupci liječenja, i postupak za dobivanje modulatora
MA54105A (fr) 2017-06-08 2021-09-15 Vertex Pharma Méthodes de traitement de la fibrose kystique
US11517564B2 (en) 2017-07-17 2022-12-06 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
ES2912657T3 (es) 2017-08-02 2022-05-26 Vertex Pharma Procesos para preparar compuestos de pirrolidina
WO2019079760A1 (en) 2017-10-19 2019-04-25 Vertex Pharmaceuticals Incorporated CRYSTALLINE FORMS AND COMPOSITIONS OF CFTR MODULATORS
MA51039A (fr) 2017-12-08 2020-10-14 Vertex Pharma Procédés pour préparer des modulateurs du régulateur de la conductance transmembranaire de la mucoviscidose
TWI810243B (zh) 2018-02-05 2023-08-01 美商維泰克斯製藥公司 用於治療囊腫纖化症之醫藥組合物
MD3752510T2 (ro) 2018-02-15 2023-06-30 Vertex Pharma Macrociclii ca modulatori ai regulatorului conductanței transmembranare în fibroza chistică, compoziții farmaceutice ale acestora, utilizarea lor în tratamentul fibrozei chistice, și procedeu pentru fabricarea acestora
EP3774825A1 (en) 2018-04-13 2021-02-17 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
AR118555A1 (es) * 2019-04-03 2021-10-20 Vertex Pharma Agentes moduladores del regulador de la conductancia transmembrana de la fibrosis quística
AU2020290094B2 (en) * 2019-06-10 2024-01-18 Novartis Ag Pyridine and pyrazine derivative for the treatment of CF, COPD, and bronchiectasis
KR20220035421A (ko) 2019-07-15 2022-03-22 노파르티스 아게 (s)-3-아미노-6-메톡시-n-(3,3,3-트리플루오로-2-히드록시-2-메틸프로필)-5-(트리플루오로메틸)피콜린아미드의 제형
TWI899097B (zh) 2019-08-14 2025-10-01 美商維泰克斯製藥公司 製備cftr調節劑之方法
CA3150162A1 (en) 2019-08-14 2021-02-18 Vertex Pharmaceuticals Incorporated Crystalline forms of cftr modulators
TWI867024B (zh) 2019-08-14 2024-12-21 美商維泰克斯製藥公司 囊腫纖維化跨膜傳導調節蛋白之調節劑
JP2023538125A (ja) 2020-08-20 2023-09-06 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 粘液過剰分泌を特徴とする呼吸器疾患を処置するための方法
KR20230118123A (ko) 2020-12-10 2023-08-10 버텍스 파마슈티칼스 인코포레이티드 낭성 섬유증 치료 방법
CN112876524B (zh) * 2021-01-26 2022-10-28 上海法默生物科技有限公司 一种瑞德西韦中间体的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004100868A2 (en) * 2003-04-23 2004-11-25 Abbott Laboratories Method of treating transplant rejection
WO2007114926A2 (en) * 2006-04-04 2007-10-11 The Regents Of The University Of California Kinase antagonists

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10135815A1 (de) 2001-07-23 2003-02-06 Bayer Ag Verwendung von 2-Alkoxyphenyl-substituierten Imidazotriazinonen
TWI329112B (en) 2002-07-19 2010-08-21 Bristol Myers Squibb Co Novel inhibitors of kinases
US7429596B2 (en) * 2003-06-20 2008-09-30 The Regents Of The University Of California 1H-pyrrolo [2,3-D] pyrimidine derivatives and methods of use thereof
JP5249776B2 (ja) 2005-12-02 2013-07-31 バイエル・ヘルスケア・エルエルシー 過剰増殖性疾患および血管新生と関連する疾患を処置するために有用な置換された４−アミノ−ピロロトリアジン誘導体
JP5512975B2 (ja) 2005-12-29 2014-06-04 アッヴィ・インコーポレイテッド タンパク質キナーゼ阻害薬
WO2009062118A2 (en) * 2007-11-07 2009-05-14 Foldrx Pharmaceuticals, Inc. Modulation of protein trafficking
DK2531187T3 (en) * 2010-02-05 2015-11-09 Adverio Pharma Gmbh sGC stimulators OR sGC activators alone and in combination with PDE5 inhibitors for the treatment of cystic fibrosis
UY34484A (es) 2011-12-15 2013-07-31 Bayer Ip Gmbh Benzotienilo-pirrolotriazinas disustituidas y sus usos
JP6371838B2 (ja) 2013-07-02 2018-08-08 ライゼン・ファーマシューティカルズ・エスアー Ｐｉ３ｋタンパク質キナーゼ阻害剤、特に、デルタ及び／またはガンマ阻害剤
AU2017362350B2 (en) * 2016-11-18 2021-12-23 Cystic Fibrosis Foundation Pyrrolopyrimidines as CFTR potentiators

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004100868A2 (en) * 2003-04-23 2004-11-25 Abbott Laboratories Method of treating transplant rejection
WO2007114926A2 (en) * 2006-04-04 2007-10-11 The Regents Of The University Of California Kinase antagonists

Also Published As

Publication number Publication date
US20180170938A1 (en) 2018-06-21
CN110300589B (zh) 2023-03-10
RU2019120990A (ru) 2021-01-18
RU2019120990A3 (enExample) 2021-01-18
US20190330219A1 (en) 2019-10-31
AU2021277702B2 (en) 2023-11-30
CN110300589A (zh) 2019-10-01
EP3554506A1 (en) 2019-10-23
WO2018112149A1 (en) 2018-06-21
US20190016728A1 (en) 2019-01-17
RU2753056C2 (ru) 2021-08-11
SG10201911076QA (en) 2020-01-30
MX2019007135A (es) 2019-11-18
AU2021277702A1 (en) 2021-12-23
JP2020502103A (ja) 2020-01-23
JP7150721B2 (ja) 2022-10-11
AU2017378324A1 (en) 2019-06-27
EP3554506B1 (en) 2021-04-28
BR112019012335A2 (pt) 2020-03-03
US10377762B2 (en) 2019-08-13
MX391651B (es) 2025-03-21
US10131670B2 (en) 2018-11-20
US10766904B2 (en) 2020-09-08
CA3046968A1 (en) 2018-06-21
US10208053B2 (en) 2019-02-19
SG10201911221RA (en) 2020-02-27
US20190016727A1 (en) 2019-01-17
EP3554506A4 (en) 2020-06-10

Similar Documents

Publication Publication Date Title
AU2021277702B2 (en) Bicyclic heteroaryl derivatives as CFTR potentiators
AU2022201816B2 (en) Pyrrolopyrimidines as CFTR potentiators
HK40015891B (en) Bycyclic heteroaryl derivatives as cftr potentiators
HK40015891A (en) Bycyclic heteroaryl derivatives as cftr potentiators
BR122024011694A2 (pt) Compostos derivados de heteroarila bicíclica como potenciadores de cftr, composição farmacêutica que compreende os mesmos e uso dos ditos compostos para tratar fibrose cística, asma, bronquiectasia, doença pulmonar obstrutiva crônica, constipação, diabetes mellitus, doença do olho seco, pancreatite, rinossinusite ou síndrome de sjogren
BR112019012335B1 (pt) Compostos derivados de heteroarila bicíclica como potenciadores de cftr, composição farmacêutica que compreende os mesmos e uso dos ditos compostos para tratar fibrose cística, asma, bronquiectasia, doença pulmonar obstrutiva crônica, constipação, diabetes mellitus, doença do olho seco, pancreatite, rinossinusite ou síndrome de sjogren
BR122024011694B1 (pt) Compostos derivados de heteroarila bicíclica como potenciadores de cftr, composição farmacêutica que compreende os mesmos e uso dos ditos compostos para tratar fibrose cística, asma, bronquiectasia, doença pulmonar obstrutiva crônica, constipação, diabetes mellitus, doença do olho seco, pancreatite, rinossinusite ou síndrome de sjogren
HK40014108A (en) Pyrrolopyrimidines as cftr potentiators
HK40014108B (en) Pyrrolopyrimidines as cftr potentiators
BR122022008825B1 (pt) Compostos pirrolopirimidinas potenciadores de cftr, composição farmacêutica que compreende os mesmos e usos terapêuticos dos ditos compostos e composição
BR112019010167B1 (pt) Compostos pirrolopirimidinas potenciadores de cftr

Legal Events

Date Code Title Description
PC1 Assignment before grant (sect. 113)

Owner name: CYSTIC FIBROSIS FOUNDATION

Free format text: FORMER APPLICANT(S): CYSTIC FIBROSIS FOUNDATON THERAPEUTICS INC.

FGA Letters patent sealed or granted (standard patent)