AU2017341825B2 - Biphenyl sulfonamide compounds for the treatment of kidney diseases or disorders - Google Patents

Biphenyl sulfonamide compounds for the treatment of kidney diseases or disorders Download PDF

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Publication number
AU2017341825B2
AU2017341825B2 AU2017341825A AU2017341825A AU2017341825B2 AU 2017341825 B2 AU2017341825 B2 AU 2017341825B2 AU 2017341825 A AU2017341825 A AU 2017341825A AU 2017341825 A AU2017341825 A AU 2017341825A AU 2017341825 B2 AU2017341825 B2 AU 2017341825B2
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Australia
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subject
compound
administration
pharmaceutically acceptable
day
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AU2017341825A
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AU2017341825A1 (en
Inventor
Radko KOMERS
Alvin SHIH
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Travere Therapeutics Inc
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Travere Therapeutics Inc
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Publication of AU2017341825A1 publication Critical patent/AU2017341825A1/en
Assigned to Travere Therapeutics, Inc. reassignment Travere Therapeutics, Inc. Amend patent request/document other than specification (104) Assignors: Retrophin, Inc.
Application granted granted Critical
Publication of AU2017341825B2 publication Critical patent/AU2017341825B2/en
Priority to AU2023219839A priority Critical patent/AU2023219839B2/en
Priority to AU2025271121A priority patent/AU2025271121A1/en
Active legal-status Critical Current
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2017341825A 2016-10-13 2017-10-13 Biphenyl sulfonamide compounds for the treatment of kidney diseases or disorders Active AU2017341825B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2023219839A AU2023219839B2 (en) 2016-10-13 2023-08-22 Biphenyl sulfonamide compounds for the treatment of kidney diseases or disorders
AU2025271121A AU2025271121A1 (en) 2016-10-13 2025-11-21 Biphenyl sulfonamide compounds for the treatment of kidney diseases or disorders

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662407860P 2016-10-13 2016-10-13
US62/407,860 2016-10-13
US201662423079P 2016-11-16 2016-11-16
US62/423,079 2016-11-16
PCT/US2017/056538 WO2018071784A1 (en) 2016-10-13 2017-10-13 Biphenyl sulfonamide compounds for the treatment of kidney diseases or disorders

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2023219839A Division AU2023219839B2 (en) 2016-10-13 2023-08-22 Biphenyl sulfonamide compounds for the treatment of kidney diseases or disorders

Publications (2)

Publication Number Publication Date
AU2017341825A1 AU2017341825A1 (en) 2019-04-11
AU2017341825B2 true AU2017341825B2 (en) 2023-06-01

Family

ID=60191503

Family Applications (3)

Application Number Title Priority Date Filing Date
AU2017341825A Active AU2017341825B2 (en) 2016-10-13 2017-10-13 Biphenyl sulfonamide compounds for the treatment of kidney diseases or disorders
AU2023219839A Active AU2023219839B2 (en) 2016-10-13 2023-08-22 Biphenyl sulfonamide compounds for the treatment of kidney diseases or disorders
AU2025271121A Pending AU2025271121A1 (en) 2016-10-13 2025-11-21 Biphenyl sulfonamide compounds for the treatment of kidney diseases or disorders

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2023219839A Active AU2023219839B2 (en) 2016-10-13 2023-08-22 Biphenyl sulfonamide compounds for the treatment of kidney diseases or disorders
AU2025271121A Pending AU2025271121A1 (en) 2016-10-13 2025-11-21 Biphenyl sulfonamide compounds for the treatment of kidney diseases or disorders

Country Status (10)

Country Link
US (5) US20190262317A1 (https=)
EP (1) EP3525784B1 (https=)
JP (4) JP2019530713A (https=)
KR (4) KR20240162167A (https=)
CN (5) CN110049764A (https=)
AU (3) AU2017341825B2 (https=)
BR (1) BR112019007576A2 (https=)
CA (1) CA3039819A1 (https=)
MA (1) MA46524A (https=)
WO (1) WO2018071784A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102902972B1 (ko) * 2018-10-04 2025-12-22 트래버르 테라퓨틱스, 인코포레이티드 Iv형 콜라겐 질환의 치료를 위한 비페닐 설폰아미드 화합물
CA3124127A1 (en) * 2018-12-21 2020-06-25 Travere Therapeutics, Inc. Amorphous sparsentan compositions
KR20230015874A (ko) * 2019-12-17 2023-01-31 치누크 세라퓨틱스, 인크. 아트라센탄에 의해 iga 신장병증을 치료하는 방법
US20220304979A1 (en) * 2019-12-17 2022-09-29 Chinook Therapeutics, Inc. Methods of reducing disease flares
JP2023521169A (ja) * 2020-04-10 2023-05-23 チヌーク セラピューティクス，インコーポレイテッド 糖尿病性腎疾患の処置方法
WO2022246200A1 (en) 2021-05-21 2022-11-24 Travere Therapeutics, Inc. Methods of treating kidney diseases or disorders
CN117836294A (zh) * 2021-08-26 2024-04-05 上海翰森生物医药科技有限公司 含芳环类生物拮抗剂、其制备方法和应用
IL312723A (en) * 2021-12-28 2024-07-01 Alchemedicine Inc Compound, angiotensin ii type 1 receptor antagonist, and pharmaceutical composition
WO2024073672A1 (en) 2022-09-30 2024-04-04 Travere Therapeutics, Inc. Combination therapy with sparsentan and a sglt2 inhibitor for treating kidney diseases or disorders
JP2025183466A (ja) * 2022-11-11 2025-12-17 株式会社アークメディスン 化合物、エンドセリンａ受容体拮抗剤、アンジオテンシンｉｉタイプ１受容体拮抗剤及び医薬組成物
WO2024249509A1 (en) 2023-05-31 2024-12-05 Travere Therapeutics, Inc. Sparsentan for use in a method of treating iga-mediated diseases
WO2025064688A1 (en) 2023-09-20 2025-03-27 Travere Therapeutics, Inc. Sparsentan for treating immunoglobulin a nephropathy (igan)
CN118666826A (zh) * 2024-08-23 2024-09-20 成都臻拓医药科技有限公司 一种司帕生坦原料药的重结晶纯化方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150164865A1 (en) * 2009-03-31 2015-06-18 Ligand Pharmaceuticals Inc. Oral formulations of diphenylsulfonamide endothelin and angiotensin ii receptor agonists to treat elevated blood pressure and diabetic nephropathy

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6638937B2 (en) 1998-07-06 2003-10-28 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
WO2000001389A1 (en) * 1998-07-06 2000-01-13 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
DE60030764T2 (de) 1999-12-15 2007-09-13 Bristol-Myers Squibb Co. Biphenyl - sulfonamide als duale angiotensin - endothelin - rezeptor - antagonisten
GB0513553D0 (en) * 2005-07-01 2005-08-10 Fond D Amico Per La Ricerca Su Rab3a
WO2010135350A2 (en) 2009-05-20 2010-11-25 Pharmacopeia, Llc Biphenyl intermediate compounds and methods for the preparation of a dual angiotensin ii and endothelin a receptor antagonist
US9719981B2 (en) * 2012-08-17 2017-08-01 Father Flanagan's Boys' Home RAC1 inhibitors for the treatment of alport glomerular disease
MA39838B1 (fr) * 2014-04-04 2019-05-31 Pfizer Composés bicycliques hétéroaryle ou aryle fusionnés et leur utilisation en tant qu'inhibiteurs irak4
KR102902972B1 (ko) 2018-10-04 2025-12-22 트래버르 테라퓨틱스, 인코포레이티드 Iv형 콜라겐 질환의 치료를 위한 비페닐 설폰아미드 화합물

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150164865A1 (en) * 2009-03-31 2015-06-18 Ligand Pharmaceuticals Inc. Oral formulations of diphenylsulfonamide endothelin and angiotensin ii receptor agonists to treat elevated blood pressure and diabetic nephropathy

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
RADKO KOMERS, HORACIO PLOTKIN: "Dual inhibition of renin-angiotensin-aldosterone system and endothelin-1 in treatment of chronic kidney disease", AMERICAN JOURNAL OF PHYSIOLOGY - REGULATORY , INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, AMERICAN PHYSIOLOGICAL SOCIETY., US, vol. 310, no. 10, 15 May 2016 (2016-05-15), US , pages R877 - R884, XP055436443, ISSN: 0363-6119, DOI: 10.1152/ajpregu.00425.2015 *
YUICHI IKEDA, HIDETOSHI KUMAGAI, YOSHIHIRO MOTOZAWA, JUN-ICHI SUZUKI, ISSEI KOMURO: "Next Generation ARBs. Going Beyond Modulation of the Renin-Angiotensin System", INTERNATIONAL HEART JOURNAL, JAPAN, 1 January 2015 (2015-01-01), Japan , pages 585, XP055436552, Retrieved from the Internet <URL:https://www.jstage.jst.go.jp/article/ihj/56/6/56_15-295/_pdf/-char/en> *

Also Published As

Publication number Publication date
KR102528435B1 (ko) 2023-05-03
US20200281901A1 (en) 2020-09-10
CN117085013A (zh) 2023-11-21
KR20220132030A (ko) 2022-09-29
KR20230066644A (ko) 2023-05-16
CN114788823A (zh) 2022-07-26
US20250325522A1 (en) 2025-10-23
JP2022141802A (ja) 2022-09-29
WO2018071784A1 (en) 2018-04-19
EP3525784A1 (en) 2019-08-21
EP3525784B1 (en) 2026-01-28
KR20190077348A (ko) 2019-07-03
AU2017341825A1 (en) 2019-04-11
JP2019530713A (ja) 2019-10-24
CN117017985A (zh) 2023-11-10
AU2025271121A1 (en) 2025-12-18
US20250325523A1 (en) 2025-10-23
US20210196688A1 (en) 2021-07-01
CN110049764A (zh) 2019-07-23
CA3039819A1 (en) 2018-04-19
US10864197B2 (en) 2020-12-15
CN116983302A (zh) 2023-11-03
BR112019007576A2 (pt) 2019-07-02
AU2023219839A1 (en) 2023-09-07
JP2025060754A (ja) 2025-04-10
MA46524A (fr) 2019-08-21
KR20240162167A (ko) 2024-11-14
AU2023219839B2 (en) 2025-08-21
US20190262317A1 (en) 2019-08-29
JP2022137245A (ja) 2022-09-21

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Owner name: TRAVERE THERAPEUTICS, INC.

Free format text: FORMER NAME(S): RETROPHIN, INC.

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