AU2017332789B2 - Vaccine candidates for human respiratory syncytial virus (RSV) having attenuated phenotypes - Google Patents

Vaccine candidates for human respiratory syncytial virus (RSV) having attenuated phenotypes Download PDF

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Publication number
AU2017332789B2
AU2017332789B2 AU2017332789A AU2017332789A AU2017332789B2 AU 2017332789 B2 AU2017332789 B2 AU 2017332789B2 AU 2017332789 A AU2017332789 A AU 2017332789A AU 2017332789 A AU2017332789 A AU 2017332789A AU 2017332789 B2 AU2017332789 B2 AU 2017332789B2
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rsv
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ile
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asn
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AU2017332789A1 (en
Inventor
Ursula J. Buchholz
Peter L. Collins
Cyril LENOUEN
Steffen Mueller
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Codagenix Inc
US Department of Health and Human Services
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Usa As Represented By Secretary
Codagenix Inc
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Priority to AU2021218112A priority Critical patent/AU2021218112B2/en
Priority to AU2022256195A priority patent/AU2022256195B2/en
Priority to AU2024203948A priority patent/AU2024203948A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/00021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/00034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/00061—Methods of inactivation or attenuation
    • C12N2760/00062—Methods of inactivation or attenuation by genetic engineering

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
AU2017332789A 2016-09-23 2017-09-22 Vaccine candidates for human respiratory syncytial virus (RSV) having attenuated phenotypes Active AU2017332789B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2021218112A AU2021218112B2 (en) 2016-09-23 2021-08-19 Vaccine candidates for human respiratory syncytial virus (rsv) having attenuated phenotypes
AU2022256195A AU2022256195B2 (en) 2016-09-23 2022-10-21 Vaccine candidates for human respiratory syncytial virus (rsv) having attenuated phenotypes
AU2024203948A AU2024203948A1 (en) 2016-09-23 2024-06-11 Vaccine candidates for human respiratory syncytial virus (rsv) having attenuated phenotypes

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662399133P 2016-09-23 2016-09-23
US62/399,133 2016-09-23
US201662400476P 2016-09-27 2016-09-27
US62/400,476 2016-09-27
PCT/US2017/053047 WO2018057950A1 (en) 2016-09-23 2017-09-22 Vaccine candidates for human respiratory syncytial virus (rsv) having attenuated phenotypes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2021218112A Division AU2021218112B2 (en) 2016-09-23 2021-08-19 Vaccine candidates for human respiratory syncytial virus (rsv) having attenuated phenotypes

Publications (2)

Publication Number Publication Date
AU2017332789A1 AU2017332789A1 (en) 2019-05-09
AU2017332789B2 true AU2017332789B2 (en) 2021-05-27

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Family Applications (4)

Application Number Title Priority Date Filing Date
AU2017332789A Active AU2017332789B2 (en) 2016-09-23 2017-09-22 Vaccine candidates for human respiratory syncytial virus (RSV) having attenuated phenotypes
AU2021218112A Active AU2021218112B2 (en) 2016-09-23 2021-08-19 Vaccine candidates for human respiratory syncytial virus (rsv) having attenuated phenotypes
AU2022256195A Active AU2022256195B2 (en) 2016-09-23 2022-10-21 Vaccine candidates for human respiratory syncytial virus (rsv) having attenuated phenotypes
AU2024203948A Pending AU2024203948A1 (en) 2016-09-23 2024-06-11 Vaccine candidates for human respiratory syncytial virus (rsv) having attenuated phenotypes

Family Applications After (3)

Application Number Title Priority Date Filing Date
AU2021218112A Active AU2021218112B2 (en) 2016-09-23 2021-08-19 Vaccine candidates for human respiratory syncytial virus (rsv) having attenuated phenotypes
AU2022256195A Active AU2022256195B2 (en) 2016-09-23 2022-10-21 Vaccine candidates for human respiratory syncytial virus (rsv) having attenuated phenotypes
AU2024203948A Pending AU2024203948A1 (en) 2016-09-23 2024-06-11 Vaccine candidates for human respiratory syncytial virus (rsv) having attenuated phenotypes

Country Status (5)

Country Link
US (4) US10808012B2 (cg-RX-API-DMAC7.html)
EP (1) EP3515930A1 (cg-RX-API-DMAC7.html)
JP (3) JP7198759B2 (cg-RX-API-DMAC7.html)
AU (4) AU2017332789B2 (cg-RX-API-DMAC7.html)
WO (1) WO2018057950A1 (cg-RX-API-DMAC7.html)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2952387T3 (es) 2013-02-08 2023-10-31 Us Health Atenuación del virus respiratorio sincitial humano mediante la desoptimización de pares de codones a escala genómica
JP7198759B2 (ja) 2016-09-23 2023-01-04 ザ・ユナイテッド・ステイツ・オブ・アメリカ・アズ・リプリゼンテッド・バイ・ザ・セクレタリー・デパートメント・オブ・ヘルス・アンド・ヒューマン・サービシーズ 弱毒化表現型を有するヒト呼吸器多核体ウイルス（ｒｓｖ）のためのワクチン候補
WO2019126690A1 (en) 2017-12-22 2019-06-27 Codagenix Inc. Recombinant virus with codon-pair deoptimized region and uses thereof for the treatment of cancer
US12168049B2 (en) 2018-03-08 2024-12-17 Codagenix Inc. Attenuated flaviviruses
AU2021271702A1 (en) 2020-05-13 2023-01-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services RSV vaccine bearing one or more P gene mutations
EP4181956A4 (en) * 2020-07-16 2024-08-07 Griffith University VACCINE AGAINST A LIVE ATTENUATED VIRUS
CN117693360A (zh) * 2021-04-08 2024-03-12 科达金尼克斯有限公司 引发针对呼吸道合胞病毒的免疫应答的方法
WO2025054424A1 (en) * 2023-09-06 2025-03-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Human parainfluenza virus immunogenic molecules
WO2025128971A1 (en) * 2023-12-14 2025-06-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Rsv vaccine bearing a polynucleotide which is de-optimised and de-attenuated

Citations (1)

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Publication number Priority date Publication date Assignee Title
US20150368622A1 (en) * 2013-02-08 2015-12-24 The United Of America, As Represented By Secretary, Department Of Health And Human Services Attenuation of human respiratory syncytial virus by genome scale codon-pair deoptimization

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DE3224404A1 (de) 1982-06-30 1984-01-05 LuK Lamellen und Kupplungsbau GmbH, 7580 Bühl Reibungskupplung sowie verfahren zu deren montage
AU727923B2 (en) 1995-09-27 2001-01-04 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Production of infectious respiratory syncytial virus from cloned nucleotide sequences
JP4413999B2 (ja) 1996-07-15 2010-02-10 アメリカ合衆国 クローニングされたヌクレオチド配列からの弱毒化呼吸シンシチウムウィルスワクチンの製造
KR100702523B1 (ko) 1997-05-23 2007-04-04 더 가번먼트 오브 더 유나이티드 스테이츠 오브 아메리카, 에즈 레프리젠티드 바이 더 디파트먼트 오브 헬쓰 앤드 휴먼 서비시즈 클로닝된 뉴클레오타이드 서열로부터 약독화된파라인플루엔자 바이러스를 제조하는 방법
AU4065500A (en) 1999-04-13 2000-11-14 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Production of attenuated chimeric respiratory syncytial virus vaccines from cloned nucleotide sequences
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Patent Citations (1)

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C. LE NOUEN ET AL, "Attenuation of human respiratory syncytial virus by genome-scale codon-pair deoptimization", PROCEEDINGS NATIONAL ACADEMY OF SCIENCES PNAS, US, (2014-08-25), vol. 111, no. 36, pages 13169 - 13174 *

Also Published As

Publication number Publication date
AU2021218112B2 (en) 2022-07-21
AU2021218112A1 (en) 2021-09-09
AU2017332789A1 (en) 2019-05-09
US20190233476A1 (en) 2019-08-01
US20210188920A1 (en) 2021-06-24
JP2019534709A (ja) 2019-12-05
US11390651B2 (en) 2022-07-19
JP2022188047A (ja) 2022-12-20
JP7573001B2 (ja) 2024-10-24
AU2022256195A1 (en) 2023-02-02
WO2018057950A1 (en) 2018-03-29
US20240417431A1 (en) 2024-12-19
US12054519B2 (en) 2024-08-06
US20220340619A1 (en) 2022-10-27
EP3515930A1 (en) 2019-07-31
US10808012B2 (en) 2020-10-20
AU2024203948A1 (en) 2024-07-04
JP7198759B2 (ja) 2023-01-04
AU2022256195B2 (en) 2024-03-14
JP2025020142A (ja) 2025-02-12

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