AU2017271189A1 - Cytosol-penetrating antibody and use thereof - Google Patents
Cytosol-penetrating antibody and use thereofInfo
- Publication number
- AU2017271189A1 AU2017271189A1 AU2017271189A AU2017271189A AU2017271189A1 AU 2017271189 A1 AU2017271189 A1 AU 2017271189A1 AU 2017271189 A AU2017271189 A AU 2017271189A AU 2017271189 A AU2017271189 A AU 2017271189A AU 2017271189 A1 AU2017271189 A1 AU 2017271189A1
- Authority
- AU
- Australia
- Prior art keywords
- cytosol
- penetrating antibody
- antibody
- penetrating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004965 antibodies Human genes 0.000 title 1
- 108090001123 antibodies Proteins 0.000 title 1
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020160065365A KR102000000B1 (en) | 2016-05-27 | 2016-05-27 | Endosomal escape motif enabling antibody to escape from endosomes and uses thereof |
KR1020160065379A KR20170133933A (en) | 2016-05-27 | 2016-05-27 | Method for inducing conformational changes in the complementarity determining regions of antibody |
KR10-2016-0065365 | 2016-05-27 | ||
KR10-2016-0065379 | 2016-05-27 | ||
PCT/KR2017/005559 WO2017204606A1 (en) | 2016-05-27 | 2017-05-26 | Cytosol-penetrating antibody and use thereof |
KR10-2017-0065670 | 2017-05-26 | ||
KR1020170065670A KR20180129514A (en) | 2017-05-26 | 2017-05-26 | Cytosol-Penetrating Antibodies and Uses Thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
AU2017271189A1 true AU2017271189A1 (en) | 2019-01-24 |
AU2017271189B2 AU2017271189B2 (en) | 2020-02-20 |
Family
ID=60412784
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2017271189A Ceased AU2017271189B2 (en) | 2016-05-27 | 2017-05-26 | Cytosol-penetrating antibody and use thereof |
Country Status (8)
Country | Link |
---|---|
US (1) | US11155641B2 (en) |
JP (1) | JP2019520086A (en) |
AU (1) | AU2017271189B2 (en) |
BR (1) | BR112018074275A2 (en) |
CA (1) | CA3025757A1 (en) |
IL (1) | IL263242A (en) |
MX (1) | MX2018014554A (en) |
WO (1) | WO2017204606A1 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101602876B1 (en) | 2014-07-22 | 2016-03-11 | 아주대학교산학협력단 | Method for inhibiting activated RAS using intact immunoglobulin antibody having Cell-penetrating ability and use thereof |
KR101602870B1 (en) | 2014-07-22 | 2016-03-21 | 아주대학교산학협력단 | Method for Cell-penetrating and cytosol-localizing of intact immunoglobulin antibody, and use thereof |
JP7165943B2 (en) * | 2017-11-01 | 2022-11-07 | 東洋紡株式会社 | Compounds having a π-electron conjugated unit and a carbazole group |
KR102118635B1 (en) * | 2017-12-28 | 2020-06-04 | 오름테라퓨틱 주식회사 | Immunotoxin comprising cytosol-penetrating antibody-fused RNase |
US10787487B2 (en) | 2018-06-21 | 2020-09-29 | Orum Therapeutics Inc. | Cell/tissue-specific cell-penetrating antibodies |
EP4267745A1 (en) * | 2020-12-23 | 2023-11-01 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecules with improved cytosol-penetrating activity |
WO2023003339A1 (en) | 2021-07-20 | 2023-01-26 | 아주대학교산학협력단 | Cell-penetrating degrading antibody that penetrates into cells to degrade and remove target protein and use thereof |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
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DE3785186T2 (en) | 1986-09-02 | 1993-07-15 | Enzon Lab Inc | BINDING MOLECULE WITH SINGLE POLYPEPTIDE CHAIN. |
WO1988006630A1 (en) | 1987-03-02 | 1988-09-07 | Genex Corporation | Method for the preparation of binding molecules |
WO1988007085A1 (en) | 1987-03-20 | 1988-09-22 | Creative Biomolecules, Inc. | Process for the purification of recombinant polypeptides |
AU601273B2 (en) | 1987-03-20 | 1990-09-06 | Creative Biomolecules, Inc. | Leader sequences for the production of recombinant proteins |
JPH02500329A (en) | 1987-05-21 | 1990-02-08 | クリエイテイブ・バイオマリキユールズ・インコーポレーテツド | Targeted multifunctional protein |
FR2706486B1 (en) | 1993-06-16 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nucleic sequences, vectors containing them, pharmaceutical compositions and therapeutic uses. |
CN1241574A (en) | 1998-07-02 | 2000-01-19 | 中国人民解放军第四军医大学 | Liver cancer-resisting monoclone antibody HAb25 and its single stranded antibody and bifunctional antibody |
WO2003077945A1 (en) | 2002-03-14 | 2003-09-25 | Medical Research Council | Intracellular antibodies |
GB0226727D0 (en) | 2002-11-15 | 2002-12-24 | Medical Res Council | Intrabodies |
CA2506128A1 (en) | 2002-11-15 | 2004-06-03 | Medical Research Council | Anti-activated ras antibodies |
TW200806789A (en) | 2006-03-27 | 2008-02-01 | Globeimmune Inc | RAS mutation and compositions and methods related thereto |
KR101658247B1 (en) | 2008-01-03 | 2016-09-22 | 더 스크립스 리서치 인스티튜트 | Antibody targeting through a modular recognition domain |
KR100849941B1 (en) | 2008-04-29 | 2008-08-01 | 원우이에프엔지니어링주식회사 | Tester for heat and smoke fire sensing device |
WO2009134027A2 (en) | 2008-04-30 | 2009-11-05 | Ajou University Industry-Academic Cooperation Foundation | Anti-nucleic acid antibody inducing cell death of cancer cells and composition for preventing or treating cancers comprising the same |
KR101075123B1 (en) | 2008-10-24 | 2011-10-19 | 아주대학교산학협력단 | Humanized antibody with nucleic nucleic acid-hydrolyzing activity and tumor cell-penetrating ability and uses thereof |
US20110263829A1 (en) | 2008-11-11 | 2011-10-27 | Ajou University Industry Academic Cooperation Foundation | Cell-penetrating, sequence-specific and nucleic acid-hydrolyzing antibody, method for preparing the same and pharmaceutical composition comprising the same |
CN101402675B (en) | 2008-11-28 | 2012-05-30 | 中国人民解放军第三军医大学第三附属医院 | Target restraint alpha Nu beta3 positive cell proliferation cyclic peptides |
US20110053829A1 (en) | 2009-09-03 | 2011-03-03 | Curevac Gmbh | Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids |
WO2011140151A1 (en) | 2010-05-04 | 2011-11-10 | Dyax Corp. | Antibodies against epidermal growth factor receptor (egfr) |
GB201103631D0 (en) | 2011-03-03 | 2011-04-13 | Univ Leeds | Identification of candidate therapeutics |
US9701740B2 (en) | 2011-04-01 | 2017-07-11 | Yale University | Cell-penetrating anti-DNA antibodies and uses thereof inhibit DNA repair |
US9283272B2 (en) | 2012-03-30 | 2016-03-15 | The United States Of America As Represented By The Department Of Veterans Affairs | Targeting intracellular target-binding determinants with intracellular antibodies |
WO2014042209A1 (en) | 2012-09-14 | 2014-03-20 | 公益財団法人がん研究会 | Peptides that bind to epithelial cell adhesion molecule |
US10011635B2 (en) | 2013-09-27 | 2018-07-03 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Cyclic peptide conjugates and methods of use |
KR101602870B1 (en) * | 2014-07-22 | 2016-03-21 | 아주대학교산학협력단 | Method for Cell-penetrating and cytosol-localizing of intact immunoglobulin antibody, and use thereof |
WO2016013870A1 (en) * | 2014-07-22 | 2016-01-28 | 아주대학교산학협력단 | Method for positioning, in cytoplasm, antibody having complete immunoglobulin form by penetrating antibody through cell membrane, and use for same |
KR101602876B1 (en) * | 2014-07-22 | 2016-03-11 | 아주대학교산학협력단 | Method for inhibiting activated RAS using intact immunoglobulin antibody having Cell-penetrating ability and use thereof |
WO2016013871A1 (en) * | 2014-07-22 | 2016-01-28 | 아주대학교산학협력단 | Method for suppressing ras activated in cell by using antibody having cytoplasm penetration capacity and complete immunoglobulin form, and use for same |
AU2016243026B2 (en) | 2015-04-03 | 2022-03-31 | Eureka Therapeutics, Inc. | Constructs targeting AFP peptide/MHC complexes and uses thereof |
KR101790669B1 (en) | 2015-10-14 | 2017-10-26 | 아주대학교산학협력단 | Enhanced split-GFP complementation system, and use thereof |
KR101836392B1 (en) | 2016-08-17 | 2018-03-08 | 한림대학교 산학협력단 | A vaccine composition comprising cyclic peptide, an antibody against the cyclic peptide and an anticancer compositions comprising the same |
EP3712180A4 (en) | 2017-11-16 | 2021-08-11 | Orum Therapeutics Inc. | Antibody inhibiting activated ras in cell by internalizing into cytosol of cell, and use thereof |
US10787487B2 (en) | 2018-06-21 | 2020-09-29 | Orum Therapeutics Inc. | Cell/tissue-specific cell-penetrating antibodies |
-
2017
- 2017-05-26 JP JP2019514699A patent/JP2019520086A/en not_active Ceased
- 2017-05-26 MX MX2018014554A patent/MX2018014554A/en unknown
- 2017-05-26 BR BR112018074275A patent/BR112018074275A2/en not_active IP Right Cessation
- 2017-05-26 CA CA3025757A patent/CA3025757A1/en not_active Abandoned
- 2017-05-26 US US16/304,444 patent/US11155641B2/en active Active
- 2017-05-26 AU AU2017271189A patent/AU2017271189B2/en not_active Ceased
- 2017-05-26 WO PCT/KR2017/005559 patent/WO2017204606A1/en unknown
-
2018
- 2018-11-22 IL IL263242A patent/IL263242A/en unknown
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