AU2017248817A1 - Compositions and methods of chimeric alloantigen receptor T cells - Google Patents

Compositions and methods of chimeric alloantigen receptor T cells Download PDF

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Publication number
AU2017248817A1
AU2017248817A1 AU2017248817A AU2017248817A AU2017248817A1 AU 2017248817 A1 AU2017248817 A1 AU 2017248817A1 AU 2017248817 A AU2017248817 A AU 2017248817A AU 2017248817 A AU2017248817 A AU 2017248817A AU 2017248817 A1 AU2017248817 A1 AU 2017248817A1
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Prior art keywords
acid sequence
nucleic acid
cell
cells
callar
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Abandoned
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AU2017248817A
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English (en)
Inventor
Valder Arruda
Michael C. Milone
Sarah RICHMAN
Benjamin SAMELSON-JONES
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Childrens Hospital of Philadelphia CHOP
University of Pennsylvania Penn
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Childrens Hospital of Philadelphia CHOP
University of Pennsylvania Penn
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Publication of AU2017248817A1 publication Critical patent/AU2017248817A1/en
Priority to AU2023222993A priority Critical patent/AU2023222993A1/en
Abandoned legal-status Critical Current

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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70532—B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the structure of the chimeric antigen receptor [CAR]
    • A61K2239/21—Transmembrane domain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the structure of the chimeric antigen receptor [CAR]
    • A61K2239/22—Intracellular domain
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
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    • C—CHEMISTRY; METALLURGY
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    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C—CHEMISTRY; METALLURGY
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AU2017248817A 2016-04-15 2017-04-14 Compositions and methods of chimeric alloantigen receptor T cells Abandoned AU2017248817A1 (en)

Priority Applications (1)

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AU2023222993A AU2023222993A1 (en) 2016-04-15 2023-09-01 Compositions and methods of chimeric alloantigen receptor T cells

Applications Claiming Priority (3)

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US201662322937P 2016-04-15 2016-04-15
US62/322,937 2016-04-15
PCT/US2017/027754 WO2017181101A1 (en) 2016-04-15 2017-04-14 Compositions and methods of chimeric alloantigen receptor t cells

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AU2023222993A Abandoned AU2023222993A1 (en) 2016-04-15 2023-09-01 Compositions and methods of chimeric alloantigen receptor T cells

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US (3) US20190153064A1 (https=)
EP (1) EP3443076A4 (https=)
JP (3) JP2019513394A (https=)
KR (1) KR20190003550A (https=)
CN (1) CN109328230A (https=)
AU (2) AU2017248817A1 (https=)
CA (1) CA3020599A1 (https=)
MX (1) MX2018012539A (https=)
RU (1) RU2018140056A (https=)
WO (1) WO2017181101A1 (https=)

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EP3443076A1 (en) 2019-02-20
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US20220220188A1 (en) 2022-07-14
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CN109328230A (zh) 2019-02-12
EP3443076A4 (en) 2020-04-15
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