AU2016342375B2 - Analogs of celastrol - Google Patents

Analogs of celastrol Download PDF

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Publication number
AU2016342375B2
AU2016342375B2 AU2016342375A AU2016342375A AU2016342375B2 AU 2016342375 B2 AU2016342375 B2 AU 2016342375B2 AU 2016342375 A AU2016342375 A AU 2016342375A AU 2016342375 A AU2016342375 A AU 2016342375A AU 2016342375 B2 AU2016342375 B2 AU 2016342375B2
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AU
Australia
Prior art keywords
administration
mmol
solution
vacuo
obesity
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Active
Application number
AU2016342375A
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English (en)
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AU2016342375A1 (en
Inventor
Yanbing Ding
Ralph Mazitschek
Kaisheng SHEN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Erx Pharmaceuticals Inc
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Erx Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Erx Pharmaceuticals Inc filed Critical Erx Pharmaceuticals Inc
Publication of AU2016342375A1 publication Critical patent/AU2016342375A1/en
Assigned to ERX PHARMACEUTICALS INC reassignment ERX PHARMACEUTICALS INC Amend patent request/document other than specification (104) Assignors: ERX PHARMACEUTICALS, INC.
Application granted granted Critical
Publication of AU2016342375B2 publication Critical patent/AU2016342375B2/en
Priority to AU2022204238A priority Critical patent/AU2022204238B2/en
Priority to AU2024201504A priority patent/AU2024201504A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Liquid Crystal (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Optical Filters (AREA)
AU2016342375A 2015-10-23 2016-10-21 Analogs of celastrol Active AU2016342375B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2022204238A AU2022204238B2 (en) 2015-10-23 2022-06-17 Analogs of celastrol
AU2024201504A AU2024201504A1 (en) 2015-10-23 2024-03-07 Analogs of celastrol

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562245356P 2015-10-23 2015-10-23
US62/245,356 2015-10-23
PCT/US2016/058313 WO2017070615A1 (en) 2015-10-23 2016-10-21 Analogs of celastrol

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2022204238A Division AU2022204238B2 (en) 2015-10-23 2022-06-17 Analogs of celastrol

Publications (2)

Publication Number Publication Date
AU2016342375A1 AU2016342375A1 (en) 2018-05-17
AU2016342375B2 true AU2016342375B2 (en) 2022-03-17

Family

ID=58558149

Family Applications (3)

Application Number Title Priority Date Filing Date
AU2016342375A Active AU2016342375B2 (en) 2015-10-23 2016-10-21 Analogs of celastrol
AU2022204238A Active AU2022204238B2 (en) 2015-10-23 2022-06-17 Analogs of celastrol
AU2024201504A Abandoned AU2024201504A1 (en) 2015-10-23 2024-03-07 Analogs of celastrol

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2022204238A Active AU2022204238B2 (en) 2015-10-23 2022-06-17 Analogs of celastrol
AU2024201504A Abandoned AU2024201504A1 (en) 2015-10-23 2024-03-07 Analogs of celastrol

Country Status (8)

Country Link
US (3) US10662218B2 (enExample)
EP (1) EP3364956A4 (enExample)
JP (3) JP7034078B2 (enExample)
CN (2) CN119241632A (enExample)
AU (3) AU2016342375B2 (enExample)
BR (1) BR112018008103A2 (enExample)
MA (1) MA45430A (enExample)
WO (1) WO2017070615A1 (enExample)

Families Citing this family (17)

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Publication number Priority date Publication date Assignee Title
CN119241632A (zh) * 2015-10-23 2025-01-03 Erx制药股份有限公司 雷公藤红素的类似物
WO2017180998A2 (en) 2016-04-15 2017-10-19 Beckman Coulter, Inc. Photoactive macromolecules and uses thereof
WO2017214709A1 (en) * 2016-06-15 2017-12-21 NOISEUX, Nicolas Reagents, compositions and methods for improving viability and function of cells, tissues and organs
CN108026142B (zh) * 2016-07-04 2022-07-08 艾凯奇（厦门）生物科技有限公司 孤儿核受体Nur77的配体及其用途
CN109705187B (zh) * 2019-01-29 2021-08-20 石家庄学院 一种雷公藤红素衍生物及其制备方法与应用
CN112094313B (zh) * 2019-06-17 2023-07-04 中国科学院上海药物研究所 一类氨基取代的雷公藤红素衍生物以及其制备方法和用途
CN112110977B (zh) * 2019-06-21 2022-02-25 中国科学院上海药物研究所 一类雷公藤红素衍生物、其制备方法及用途
CA3163593A1 (en) 2020-01-15 2021-07-22 Guangrong Zheng Therapeutic agents and methods of treatment
CN111202737B (zh) * 2020-03-20 2022-08-05 中国药科大学 雷公藤红素酰胺衍生物在制备治疗自身性免疫疾病药物的应用
US12673106B2 (en) 2020-08-28 2026-07-07 University Of Florida Research Foundation, Incorporated Modulators of nuclear receptor subfamily 4 group A member 1 (NR4A1) and uses thereof
CN115677812B (zh) * 2022-01-18 2023-12-15 聊城大学 一类雷公藤红素衍生物及其制备方法与应用
US20250375401A1 (en) * 2022-06-21 2025-12-11 Seoul National University R&Db Foundation Pharmaceutical composition containing demethylzeylasteral for prevention or treatment of diseases caused by muscle loss
IL317983A (en) * 2022-07-15 2025-02-01 Celloram Inc History of Celestrol
EP4618998A1 (en) * 2022-11-17 2025-09-24 ERX Pharmaceuticals Inc. Celastrol salts, crystalline forms, and uses thereof
US20260191807A1 (en) * 2022-11-17 2026-07-09 Erx Pharmaceuticals Inc. Compositions and methods for treatment of prader-willi syndrome
WO2025106760A1 (en) * 2023-11-16 2025-05-22 Erx Pharmaceuticals Corporation Intranasal formulations of celastrol
CN119431489A (zh) * 2024-11-13 2025-02-14 肇源县总医院 一种雷公藤红素衍生物及其制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007117466A2 (en) * 2006-03-31 2007-10-18 Massachusetts Institute Of Technology Celastrol, gedunin, and derivatives thereof as hsp90 inhibitors
US20110166216A1 (en) * 2007-08-17 2011-07-07 Burnham Institute For Medical Research Compositions and Methods for Inhibiting Growth and Metastasis of Melanoma
WO2012024893A1 (en) * 2010-08-23 2012-03-01 Suzhou Neupharma Co., Ltd. Certain chemical entities, compositions, and methods
WO2014052583A1 (en) * 2012-09-27 2014-04-03 The Children's Medical Center Corporation Compounds for the treatment of obesity and methods of use thereof
US20150274634A1 (en) * 2014-03-26 2015-10-01 The Children's Medical Center Corporation Compounds for the treatment of obesity and methods of use thereof

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US4911920A (en) 1986-07-30 1990-03-27 Alcon Laboratories, Inc. Sustained release, comfort formulation for glaucoma therapy
FR2588189B1 (fr) 1985-10-03 1988-12-02 Merck Sharp & Dohme Composition pharmaceutique de type a transition de phase liquide-gel
DK0495421T3 (da) 1991-01-15 1996-12-09 Alcon Lab Inc Anvendelse af carragenaner i topiske ophthalmiske sammensætninger
US5212162A (en) 1991-03-27 1993-05-18 Alcon Laboratories, Inc. Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
US6309853B1 (en) 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
US20030027786A1 (en) 2001-06-06 2003-02-06 Karsten Maeder Lipase inhibiting composition
FR2875913A1 (fr) 2004-09-29 2006-03-31 Sea On Line Sa Systeme d'alerte anti-collision installe a bord d'un vehicule marin et procede d'analyse anti-collision
ES2277568B1 (es) 2005-12-30 2008-04-01 Consejo Superior De Investigaciones Cientificas Derivados de triterpenoquinona y triterpenofenoles y su aplicacion para el tratamiento de tumores y enfermedades parasitarias.
CN101686951A (zh) 2006-11-13 2010-03-31 纽约市哥伦比亚大学托管会 治疗糖尿病的选择性蛋白酶体抑制物
EA201492184A1 (ru) 2012-05-25 2015-07-30 Берг Ллк Способы лечения метаболического синдрома путем модулирования белка теплового шока (hsp) 90-бета
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CN119241632A (zh) * 2015-10-23 2025-01-03 Erx制药股份有限公司 雷公藤红素的类似物
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Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007117466A2 (en) * 2006-03-31 2007-10-18 Massachusetts Institute Of Technology Celastrol, gedunin, and derivatives thereof as hsp90 inhibitors
US20110166216A1 (en) * 2007-08-17 2011-07-07 Burnham Institute For Medical Research Compositions and Methods for Inhibiting Growth and Metastasis of Melanoma
WO2012024893A1 (en) * 2010-08-23 2012-03-01 Suzhou Neupharma Co., Ltd. Certain chemical entities, compositions, and methods
WO2014052583A1 (en) * 2012-09-27 2014-04-03 The Children's Medical Center Corporation Compounds for the treatment of obesity and methods of use thereof
US20150274634A1 (en) * 2014-03-26 2015-10-01 The Children's Medical Center Corporation Compounds for the treatment of obesity and methods of use thereof

Non-Patent Citations (2)

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Title
GONZALEZ, A. G. ET AL, "Iguesterin, a new quinonoid triterpene from Catha cassinoides ", Phytochemistry, 1975, vol. 14, no. 4, pages 1067 - 1070 *
LADA KLAIC ET AL, "Celastrol Analogues as Inducers of the Heat Shock Response. Design and Synthesis of Affinity Probes for the Identification of Protein Targets", ACS CHEMICAL BIOLOGY, (2012-03-14), vol. 7, no. 5, pages 928 - 937 *

Also Published As

Publication number Publication date
RU2018118633A (ru) 2019-11-25
BR112018008103A2 (pt) 2018-11-06
US20240190911A1 (en) 2024-06-13
JP2022017473A (ja) 2022-01-25
MA45430A (fr) 2019-05-01
JP7339992B2 (ja) 2023-09-06
CN108601751A (zh) 2018-09-28
US20210061851A1 (en) 2021-03-04
AU2024201504A1 (en) 2024-03-28
AU2022204238A1 (en) 2022-07-07
JP7034078B2 (ja) 2022-03-11
JP2023164877A (ja) 2023-11-14
EP3364956A4 (en) 2019-05-01
JP2018531289A (ja) 2018-10-25
US10662218B2 (en) 2020-05-26
WO2017070615A1 (en) 2017-04-27
AU2022204238B2 (en) 2023-12-14
US20180362575A1 (en) 2018-12-20
CA3002924A1 (en) 2017-04-27
RU2018118633A3 (enExample) 2020-02-17
CN119241632A (zh) 2025-01-03
EP3364956A1 (en) 2018-08-29
US11753436B2 (en) 2023-09-12
AU2016342375A1 (en) 2018-05-17

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Owner name: ERX PHARMACEUTICALS INC

Free format text: FORMER NAME(S): ERX PHARMACEUTICALS, INC.

FGA Letters patent sealed or granted (standard patent)