AU2016305299B2 - DPEP-1 binding compositions and methods of use - Google Patents

DPEP-1 binding compositions and methods of use Download PDF

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Publication number
AU2016305299B2
AU2016305299B2 AU2016305299A AU2016305299A AU2016305299B2 AU 2016305299 B2 AU2016305299 B2 AU 2016305299B2 AU 2016305299 A AU2016305299 A AU 2016305299A AU 2016305299 A AU2016305299 A AU 2016305299A AU 2016305299 B2 AU2016305299 B2 AU 2016305299B2
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Australia
Prior art keywords
dpep
alkyl
peptide
inflammation
ischemia
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AU2016305299A
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AU2016305299A1 (en
Inventor
Saurav Roy Choudhury
Arthur Wing Sze Lau
Daniel Abraham Muruve
Jennifer Joy Rahn
Stephen Mark Robbins
Donna Lorraine Senger
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Arch Biopartners Inc
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Arch Biopartners Inc
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Priority to AU2021203872A priority Critical patent/AU2021203872B2/en
Priority to AU2023285759A priority patent/AU2023285759B2/en
Active legal-status Critical Current
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/664—Amides of phosphorus acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/302—Acyclic unsaturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/485—Exopeptidases (3.4.11-3.4.19)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/13—Dipeptidases (3.4.13)
    • C12Y304/13019—Membrane dipeptidase (3.4.13.19)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2016305299A 2015-08-11 2016-08-11 DPEP-1 binding compositions and methods of use Active AU2016305299B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2021203872A AU2021203872B2 (en) 2015-08-11 2021-06-10 DPEP-1 binding compositions and methods of use
AU2023285759A AU2023285759B2 (en) 2015-08-11 2023-12-19 DPEP-1 binding compositions and methods of use

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562203704P 2015-08-11 2015-08-11
US62/203,704 2015-08-11
US201562264032P 2015-12-07 2015-12-07
US62/264,032 2015-12-07
PCT/IB2016/001244 WO2017025802A1 (en) 2015-08-11 2016-08-11 Dpep-1 binding compositions and methods of use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2021203872A Division AU2021203872B2 (en) 2015-08-11 2021-06-10 DPEP-1 binding compositions and methods of use

Publications (2)

Publication Number Publication Date
AU2016305299A1 AU2016305299A1 (en) 2018-04-05
AU2016305299B2 true AU2016305299B2 (en) 2021-03-11

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AU2016305299A Active AU2016305299B2 (en) 2015-08-11 2016-08-11 DPEP-1 binding compositions and methods of use
AU2021203872A Active AU2021203872B2 (en) 2015-08-11 2021-06-10 DPEP-1 binding compositions and methods of use
AU2023285759A Active AU2023285759B2 (en) 2015-08-11 2023-12-19 DPEP-1 binding compositions and methods of use

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AU2021203872A Active AU2021203872B2 (en) 2015-08-11 2021-06-10 DPEP-1 binding compositions and methods of use
AU2023285759A Active AU2023285759B2 (en) 2015-08-11 2023-12-19 DPEP-1 binding compositions and methods of use

Country Status (8)

Country Link
US (3) US10493127B2 (https=)
EP (2) EP4643873A3 (https=)
JP (3) JP7054674B2 (https=)
AU (3) AU2016305299B2 (https=)
CA (2) CA2999800C (https=)
ES (1) ES3057215T3 (https=)
IL (2) IL305285A (https=)
WO (1) WO2017025802A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES3057215T3 (en) * 2015-08-11 2026-02-26 Arch Biopartners Inc Antagonist binding to dpep-1 for use in treating or preventing acute kidney injury or ischemia-reperfusion injury
AU2017281744B2 (en) * 2016-06-24 2022-10-27 Fundación Para La Investigación Biomédica Del Hospital Gregorio Marañón Cilastatin for use in the treatment of sepsis
JP7535514B2 (ja) * 2018-11-30 2024-08-16 アーチ バイオパートナーズ， インコーポレイテッド Ｄｐｅｐ－１結合剤および使用の方法
KR102730193B1 (ko) * 2020-07-24 2024-11-14 신규철 단일성분의 마이크로구조체 색전물질과 그 색전물질을 이용한 색전술로 시행되는 치료방법
KR102486996B1 (ko) * 2020-09-04 2023-01-10 서울대학교병원 펩타이드 및 이를 포함하는 피부 주름 개선용 조성물 및 대사성 질환 치료용 조성물
EP4320167A4 (en) * 2021-04-08 2025-08-06 Nat Res Council Canada DPEP-1 BINDING AGENTS AND METHODS OF USE THEREOF

Citations (5)

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WO1999046284A2 (en) * 1998-03-13 1999-09-16 The Burnham Institute Molecules that home to various selected organs or tissues
WO2004010846A2 (en) * 2002-07-27 2004-02-05 The Johns Hopkins School Of Medicine Design and synthesis of renal dipeptidase inhibitors
WO2006010496A1 (en) * 2004-07-28 2006-02-02 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with dipeptidase 1 (dpep1)
EP2143429A1 (en) * 2008-07-11 2010-01-13 Fundacion para la Investigacion Biomedica Del Hospital Gregorio Marañon Use of cilastatin to reduce the nephrotoxicity of different compounds
WO2015120536A1 (en) * 2014-02-13 2015-08-20 Arch Cancer Therapeutics, Inc. Peptides that block leukocyte recruitment and methods of use

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US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5629179A (en) 1995-03-17 1997-05-13 Novagen, Inc. Method and kit for making CDNA library
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US6344330B1 (en) 1998-03-27 2002-02-05 The Regents Of The University Of California Pharmacophore recombination for the identification of small molecule drug lead compounds
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US7544678B2 (en) * 2002-11-05 2009-06-09 The Trustees Of Columbia University In The City Of New York Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
EP3461499A1 (en) 2006-06-07 2019-04-03 The Board of Trustees of The Leland Stanford Junior University Anti-leukocyte recruitment therapy for the treatment of recurrence of epileptic seizures
EP2196212A4 (en) 2007-10-04 2012-01-25 Josai University Corp PREPARATION AND METHOD FOR THE ADMINISTRATION OF A VACCINE AND IONTOPHORESE DEVICE WITH THE PREPARATION
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EP4012714A1 (en) 2010-03-23 2022-06-15 Iogenetics, LLC. Bioinformatic processes for determination of peptide binding
ES3057215T3 (en) * 2015-08-11 2026-02-26 Arch Biopartners Inc Antagonist binding to dpep-1 for use in treating or preventing acute kidney injury or ischemia-reperfusion injury
AU2017281744B2 (en) 2016-06-24 2022-10-27 Fundación Para La Investigación Biomédica Del Hospital Gregorio Marañón Cilastatin for use in the treatment of sepsis

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999046284A2 (en) * 1998-03-13 1999-09-16 The Burnham Institute Molecules that home to various selected organs or tissues
WO2004010846A2 (en) * 2002-07-27 2004-02-05 The Johns Hopkins School Of Medicine Design and synthesis of renal dipeptidase inhibitors
WO2006010496A1 (en) * 2004-07-28 2006-02-02 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with dipeptidase 1 (dpep1)
EP2143429A1 (en) * 2008-07-11 2010-01-13 Fundacion para la Investigacion Biomedica Del Hospital Gregorio Marañon Use of cilastatin to reduce the nephrotoxicity of different compounds
WO2015120536A1 (en) * 2014-02-13 2015-08-20 Arch Cancer Therapeutics, Inc. Peptides that block leukocyte recruitment and methods of use

Also Published As

Publication number Publication date
JP2018528263A (ja) 2018-09-27
EP3334459C0 (en) 2025-12-17
CA2999800A1 (en) 2017-02-16
EP3334459A1 (en) 2018-06-20
ES3057215T3 (en) 2026-02-26
US12569538B2 (en) 2026-03-10
AU2021203872A1 (en) 2021-07-08
CA2999800C (en) 2025-12-09
EP4643873A2 (en) 2025-11-05
IL257458B1 (en) 2023-09-01
US20200078442A1 (en) 2020-03-12
US11666631B2 (en) 2023-06-06
JP2024050701A (ja) 2024-04-10
IL257458A (en) 2018-04-30
JP7054674B2 (ja) 2022-04-14
US10493127B2 (en) 2019-12-03
AU2021203872B2 (en) 2023-09-21
JP2022023215A (ja) 2022-02-07
EP3334459A4 (en) 2019-04-17
US20170258872A1 (en) 2017-09-14
EP4643873A3 (en) 2026-04-29
AU2023285759A1 (en) 2024-02-22
WO2017025802A1 (en) 2017-02-16
CA3279426A1 (en) 2026-03-02
AU2023285759B2 (en) 2025-11-13
IL305285A (en) 2023-10-01
EP3334459B1 (en) 2025-12-17
IL257458B2 (en) 2024-01-01
AU2016305299A1 (en) 2018-04-05
US20240108686A1 (en) 2024-04-04

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