AU2016277126A1 - MCT4 inhibitors for treating disease - Google Patents

MCT4 inhibitors for treating disease Download PDF

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Publication number
AU2016277126A1
AU2016277126A1 AU2016277126A AU2016277126A AU2016277126A1 AU 2016277126 A1 AU2016277126 A1 AU 2016277126A1 AU 2016277126 A AU2016277126 A AU 2016277126A AU 2016277126 A AU2016277126 A AU 2016277126A AU 2016277126 A1 AU2016277126 A1 AU 2016277126A1
Authority
AU
Australia
Prior art keywords
chosen
recited
cancer
compound
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2016277126A
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English (en)
Inventor
John M. Mccall
Kenneth Mark Parnell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vettore LLC
Original Assignee
Vettore LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vettore LLC filed Critical Vettore LLC
Publication of AU2016277126A1 publication Critical patent/AU2016277126A1/en
Priority to AU2021200919A priority Critical patent/AU2021200919B2/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2016277126A 2015-06-12 2016-06-13 MCT4 inhibitors for treating disease Abandoned AU2016277126A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2021200919A AU2021200919B2 (en) 2015-06-12 2021-02-12 MCT4 inhibitors for treating disease

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562174685P 2015-06-12 2015-06-12
US62/174,685 2015-06-12
PCT/US2016/037213 WO2016201426A1 (en) 2015-06-12 2016-06-13 Mct4 inhibitors for treating disease

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2021200919A Division AU2021200919B2 (en) 2015-06-12 2021-02-12 MCT4 inhibitors for treating disease

Publications (1)

Publication Number Publication Date
AU2016277126A1 true AU2016277126A1 (en) 2017-12-14

Family

ID=57504734

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2016277126A Abandoned AU2016277126A1 (en) 2015-06-12 2016-06-13 MCT4 inhibitors for treating disease
AU2021200919A Active AU2021200919B2 (en) 2015-06-12 2021-02-12 MCT4 inhibitors for treating disease

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2021200919A Active AU2021200919B2 (en) 2015-06-12 2021-02-12 MCT4 inhibitors for treating disease

Country Status (11)

Country Link
US (6) US10202350B2 (enExample)
EP (2) EP3307068B1 (enExample)
JP (2) JP6944442B2 (enExample)
KR (1) KR102653599B1 (enExample)
CN (1) CN107635404B (enExample)
AU (2) AU2016277126A1 (enExample)
BR (1) BR112017026535B1 (enExample)
CA (1) CA2988983A1 (enExample)
ES (1) ES2894919T3 (enExample)
IL (2) IL256206A (enExample)
WO (1) WO2016201426A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102653599B1 (ko) * 2015-06-12 2024-04-01 베토어 엘엘씨 질환 치료용 mct4 저해제
KR102615828B1 (ko) 2016-12-12 2023-12-20 베토어 엘엘씨 Mct4 의 헤테로시클릭 저해제
WO2020033019A2 (en) 2018-04-25 2020-02-13 Charles R. Drew University Of Medicine And Science Novel mct4 inhibitors and uses thereof
TWI823932B (zh) * 2018-05-11 2023-12-01 中國大陸商迪哲（江蘇）醫藥有限公司 三唑并嘧啶化合物及其在治療癌症中之用途
US12351570B2 (en) 2018-12-21 2025-07-08 Merck Patent Gmbh Disubstituted alkyne derivatives
WO2020234454A1 (en) 2019-05-23 2020-11-26 Deutsches Krebsforschungszentrum Combination treatment of cancer targeting energy metabolism and intracellular ph
US20210214731A1 (en) * 2019-10-25 2021-07-15 President And Fellows Of Harvard College Methods for treating cancer
WO2022243574A1 (en) * 2021-05-21 2022-11-24 Cemm - Forschungszentrum Für Molekulare Medizin Gmbh 3-(phthalazin-1-yl)benzenesulfonamide-based slc16a3 inhibitors and their therapeutic use
CN113929627A (zh) * 2021-10-19 2022-01-14 吕梁学院 一种宾达利的合成方法
CN113845476B (zh) * 2021-11-08 2024-04-30 中国药科大学 一种喹诺酮衍生物及其制备方法和用途
EP4568953A1 (en) * 2022-08-10 2025-06-18 Vettore, LLC Methods and processes for the preparation of mct4 inhibitors

Family Cites Families (21)

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Publication number Priority date Publication date Assignee Title
IT1052111B (it) 1972-02-29 1981-06-20 Acraf Acidi i benzil i h indazol 3 carbossilici sostituiti e loro derivati
US5078780A (en) 1986-10-22 1992-01-07 Ciba-Geigy Corporation 1,5-diphenylpyrazole-3-carboxylic acid derivatives for the protection of cultivated plants
FR2742148B1 (fr) 1995-12-08 1999-10-22 Sanofi Sa Nouveaux derives du pyrazole-3-carboxamide, procede pour leur preparation et compositions pharmaceutiques les contenant
IT1293795B1 (it) 1997-07-28 1999-03-10 Angelini Ricerche Spa Farmaco attivo nel ridurre la produzione di proteina mcp-1
WO2005054852A1 (en) * 2003-11-21 2005-06-16 Astrazeneca Ab Screening method
EP1989185B8 (en) * 2006-02-28 2013-06-26 Dart NeuroScience LLC Therapeutic compounds
TWI339205B (en) 2006-10-02 2011-03-21 Nat Health Research Institutes Pyrazole compounds and pharmaceutical composition
US7919518B2 (en) * 2008-03-07 2011-04-05 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1, CX3CR1 and p40
CN102093341B (zh) 2009-12-10 2013-07-24 天津药物研究院 吲哚环取代的吡唑羧酸类内皮素受体拮抗剂及其制备方法和用途
AU2011291599B2 (en) * 2010-08-18 2015-09-10 Caris Life Sciences Switzerland Holdings Gmbh Circulating biomarkers for disease
US20130190324A1 (en) 2011-12-23 2013-07-25 The Regents Of The University Of Colorado, A Body Corporate Topical ocular drug delivery
US9296728B2 (en) * 2012-01-20 2016-03-29 Regents Of The University Of Minnesota Therapeutic compounds
WO2013112881A1 (en) 2012-01-27 2013-08-01 Thomas Jefferson University Mct protein inhibitor-related prognostic and therapeutic methods
KR20150010973A (ko) * 2012-05-18 2015-01-29 사노피 피라졸 유도체 및 lpar5 길항제로서의 그의 용도
PE20151140A1 (es) 2012-08-16 2015-08-07 Janssen Pharmaceutica Nv Pirazoles sustituidos como bloqueadores del canal de calcio tipo n
EP3004073A1 (en) * 2013-06-07 2016-04-13 Université catholique de Louvain 3-carboxy substituted coumarin derivatives with a potential utility for the treatment of cancer diseases
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DE202015003905U1 (de) 2015-06-05 2016-09-12 Rudolf King Methode zur Übermittlung und Differenzierung von Verfassungszuständen während und nach Auslösen eines persönlichen Notfallsystems oder Systems zur Mitteilung an ein soziales Notfallsystem oder Systems zur Mitteilung an ein soziales Notfall-Netzwerk
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KR102653599B1 (ko) 2015-06-12 2024-04-01 베토어 엘엘씨 질환 치료용 mct4 저해제
KR102615828B1 (ko) 2016-12-12 2023-12-20 베토어 엘엘씨 Mct4 의 헤테로시클릭 저해제

Also Published As

Publication number Publication date
ES2894919T3 (es) 2022-02-16
JP2018516994A (ja) 2018-06-28
EP3307068B1 (en) 2021-08-25
CN107635404B (zh) 2021-09-28
US12187682B2 (en) 2025-01-07
WO2016201426A1 (en) 2016-12-15
KR102653599B1 (ko) 2024-04-01
KR20180012852A (ko) 2018-02-06
US20240101518A1 (en) 2024-03-28
US20190112274A1 (en) 2019-04-18
BR112017026535B1 (pt) 2023-12-19
EP3307068A4 (en) 2018-12-26
IL256206A (en) 2018-02-28
US11155522B2 (en) 2021-10-26
US20250257039A1 (en) 2025-08-14
JP2021152056A (ja) 2021-09-30
US20160362378A1 (en) 2016-12-15
US10202350B2 (en) 2019-02-12
US20220251045A1 (en) 2022-08-11
AU2021200919A1 (en) 2021-03-04
NZ738078A (en) 2021-11-26
US20210009524A1 (en) 2021-01-14
EP3942934A1 (en) 2022-01-26
CA2988983A1 (en) 2016-12-15
CN107635404A (zh) 2018-01-26
EP3307068A1 (en) 2018-04-18
AU2021200919B2 (en) 2022-06-30
HK1253239A1 (en) 2019-06-14
US11724989B2 (en) 2023-08-15
IL278247B (en) 2021-12-01
JP6944442B2 (ja) 2021-10-06
BR112017026535A2 (pt) 2018-08-14

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MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted