AU2015342324B2 - Drug for inhibiting adipose cell differentiation and insulin resistance - Google Patents

Drug for inhibiting adipose cell differentiation and insulin resistance Download PDF

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Publication number
AU2015342324B2
AU2015342324B2 AU2015342324A AU2015342324A AU2015342324B2 AU 2015342324 B2 AU2015342324 B2 AU 2015342324B2 AU 2015342324 A AU2015342324 A AU 2015342324A AU 2015342324 A AU2015342324 A AU 2015342324A AU 2015342324 B2 AU2015342324 B2 AU 2015342324B2
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Australia
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peg
modified
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mice
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AU2015342324A1 (en
Inventor
Yan Fu
Hui Li
Xinan Lu
Yongzhang Luo
Hui Wang
Shunli ZHAN
Daifu ZHOU
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Tsinghua University
Protgen Ltd
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Tsinghua University
Protgen Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU2015342324A 2014-11-03 2015-11-03 Drug for inhibiting adipose cell differentiation and insulin resistance Active AU2015342324B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201410610777 2014-11-03
CN201410610777.X 2014-11-03
CN201510021469 2015-01-15
CN201510021469.8 2015-01-15
PCT/CN2015/093726 WO2016070798A1 (zh) 2014-11-03 2015-11-03 一种抑制脂肪细胞分化和胰岛素耐受的药物

Publications (2)

Publication Number Publication Date
AU2015342324A1 AU2015342324A1 (en) 2017-06-29
AU2015342324B2 true AU2015342324B2 (en) 2021-08-19

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2015342324A Active AU2015342324B2 (en) 2014-11-03 2015-11-03 Drug for inhibiting adipose cell differentiation and insulin resistance

Country Status (7)

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US (2) US20180015148A1 (enExample)
EP (1) EP3246043A4 (enExample)
JP (2) JP2018501195A (enExample)
CN (2) CN107148277B (enExample)
AU (1) AU2015342324B2 (enExample)
CA (1) CA3003760A1 (enExample)
WO (1) WO2016070798A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016127948A1 (zh) * 2015-02-13 2016-08-18 清华大学 一种重组蛋白质药物的分子设计
WO2018086603A1 (zh) 2016-11-10 2018-05-17 北京普罗吉生物科技发展有限公司 聚乙二醇化血管内皮抑制素类似物及其应用
US10276161B2 (en) 2016-12-27 2019-04-30 Google Llc Contextual hotwords

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101596320A (zh) * 2006-01-20 2009-12-09 清华大学 一种治疗肿瘤的药物及其应用
WO2012130141A1 (zh) * 2011-03-28 2012-10-04 清华大学 一种增强靶细胞摄取治疗剂的方法和药物组合物
CN103703140A (zh) * 2011-03-30 2014-04-02 德克萨斯大学系统董事会 用于靶向哺乳动物中的脂肪细胞的方法和组合物
EP2754718A1 (en) * 2011-09-09 2014-07-16 Tsinghua University Vascular endothelial myostatin mutant that mutates at atp binding sites

Family Cites Families (6)

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DE69824750T2 (de) * 1997-10-31 2005-07-07 Children's Medical Center Corp., Boston Methoden zur regulierung der grösse und des wachstums von durchblutetem normalem gewebe
CA2458047A1 (en) * 2001-09-07 2003-03-20 Board Of Regents, The University Of Texas System Compositions and methods of use of targeting peptides against placenta and adipose tissues
US7524811B2 (en) * 2003-08-29 2009-04-28 Children's Medical Center Corporation Anti-angiogenic peptides from the N-terminus of endostatin
CN103083681A (zh) * 2006-01-20 2013-05-08 清华大学 一种治疗肿瘤的药物及其应用
EP2214709A4 (en) * 2007-11-08 2011-05-11 Univ Utah Res Found USE OF ANGIOGENESIS ANTAGONISTS IN DISEASES WITH ANOMAL VENEER PREPARATION
CN101219206A (zh) * 2008-02-01 2008-07-16 山东先声麦得津生物制药有限公司 重组人血管内皮抑制素在制药中的应用

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101596320A (zh) * 2006-01-20 2009-12-09 清华大学 一种治疗肿瘤的药物及其应用
WO2012130141A1 (zh) * 2011-03-28 2012-10-04 清华大学 一种增强靶细胞摄取治疗剂的方法和药物组合物
CN103703140A (zh) * 2011-03-30 2014-04-02 德克萨斯大学系统董事会 用于靶向哺乳动物中的脂肪细胞的方法和组合物
EP2754718A1 (en) * 2011-09-09 2014-07-16 Tsinghua University Vascular endothelial myostatin mutant that mutates at atp binding sites

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Coulon, S., et al., "Angiogenesis in chronic liver disease and its complications," (2010). Liver international, pp146 - 162, DOI:10.1111/j.1478-3231.2010.02369.x *
HUI WANG ET AL, "Endostatin Prevents Dietary-Induced Obesity by Inhibiting Adipogenesis and Angiogenesis", DIABETES, US, (2015-01-20), vol. 64, no. 7, doi:10.2337/db14-0528, ISSN 0012-1797, pages 2442 - 2456 *
Rupnick, M., et al., "Adipose tissue mass can be regulated through the vasculature," (2002). PNAS (99) no 15, pp10730 - 10735. doi/10.1073/pnas. 162349799 *
VIRTUE S ET AL, "Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome An allostatic perspective", BIOCHIMICA ET BIOPHYSICA ACTA (2010) vol. 1801, no. 3, doi:10.1016/J.BBALIP.2009.12.006, pages 338 - 349 *
Yihai Cao, "Angiogenesis modulates adipogenesis and obesity", The Journal of Clinical Investigation. (2007); vol 117(9): pages 2362-2368. https://doi.org/10.1172/JCI32239 *

Also Published As

Publication number Publication date
EP3246043A1 (en) 2017-11-22
CN107148277B (zh) 2022-03-22
JP7227197B2 (ja) 2023-02-21
JP2020172546A (ja) 2020-10-22
CN114558111A (zh) 2022-05-31
EP3246043A4 (en) 2018-09-05
JP2018501195A (ja) 2018-01-18
WO2016070798A1 (zh) 2016-05-12
AU2015342324A1 (en) 2017-06-29
CN107148277A (zh) 2017-09-08
US20220409703A1 (en) 2022-12-29
US20180015148A1 (en) 2018-01-18
EP3246043A9 (en) 2018-03-14
CA3003760A1 (en) 2016-05-12

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