AU2015273217B2 - Pyrazolopyrimidine derivatives useful as inhibitors of Bruton's tyrosine kinase - Google Patents
Pyrazolopyrimidine derivatives useful as inhibitors of Bruton's tyrosine kinase Download PDFInfo
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- AU2015273217B2 AU2015273217B2 AU2015273217A AU2015273217A AU2015273217B2 AU 2015273217 B2 AU2015273217 B2 AU 2015273217B2 AU 2015273217 A AU2015273217 A AU 2015273217A AU 2015273217 A AU2015273217 A AU 2015273217A AU 2015273217 B2 AU2015273217 B2 AU 2015273217B2
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- amino
- phenyl
- methyl
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- pyrimidin
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Classifications
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Landscapes
- Health & Medical Sciences (AREA)
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- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| GB1410430.1 | 2014-06-11 | ||
| GBGB1410430.1A GB201410430D0 (en) | 2014-06-11 | 2014-06-11 | Compounds |
| PCT/GB2015/051719 WO2015189620A1 (en) | 2014-06-11 | 2015-06-11 | Pyrazolopyrimidine derivatives useful as inhibitors of bruton's tyrosine kinase |
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| AU2015273217A1 AU2015273217A1 (en) | 2017-01-05 |
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| ES (1) | ES2732897T3 (enExample) |
| GB (1) | GB201410430D0 (enExample) |
| WO (1) | WO2015189620A1 (enExample) |
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| GB201410430D0 (en) | 2014-06-11 | 2014-07-23 | Redx Pharma Ltd | Compounds |
| CN114685516A (zh) * | 2015-09-16 | 2022-07-01 | 洛克索肿瘤学股份有限公司 | 用于治疗癌症的作为btk抑制剂的吡唑并嘧啶衍生物 |
| UA127863C2 (uk) | 2015-12-16 | 2024-01-31 | Локсо Онколоджі, Інк. | Сполуки, які можна застосовувати як інгібітори кінази |
| US9630968B1 (en) | 2015-12-23 | 2017-04-25 | Arqule, Inc. | Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof |
| FI3882250T3 (fi) * | 2015-12-23 | 2023-04-27 | Arqule Inc | TETRAHYDROPYRANYYLIAMINO-PYRROLOPYRIMIDINONI KÄYTETTÄVÄKSI HOIDETTAESSA BTK-VÄLITTEISiÄ HÄIRIÖITÄ |
| KR102699906B1 (ko) * | 2016-01-21 | 2024-08-29 | 즈보 바이오폴라 창쉥 파마수티컬 컴퍼니 리미티드 | 브루톤 티로신 키나제 억제제 |
| ES2965081T3 (es) | 2016-07-07 | 2024-04-11 | Daewoong Pharmaceutical Co Ltd | Derivados 4-aminopirazolo[3,4-d]pirimidinil-azabiciclo y composición farmacéutica que comprende dichos derivados |
| SG11201901197PA (en) | 2016-08-24 | 2019-03-28 | Arqule Inc | Amino-pyrrolopyrimidinone compounds and methods of use thereof |
| WO2019130229A1 (en) * | 2017-12-28 | 2019-07-04 | Mylan Laboratories Ltd | Methods and intermediates for preparing rucaparib |
| WO2020043321A1 (en) | 2018-08-31 | 2020-03-05 | Stichting Katholieke Universiteit | Synergistic combinations of amino acid depletion agent sensitizers (aadas) and amino acid depletion agents (aada), and therapeutic methods of use thereof |
| WO2021110142A1 (en) * | 2019-12-04 | 2021-06-10 | Henan Normal University | Substituted imidazolecarboxamide as bruton's tyrosine kinase inhibitors |
| JP7011638B2 (ja) * | 2019-12-16 | 2022-02-10 | アークル インコーポレイテッド | テトラヒドロピラニルアミノ－ピロロピリミジノンおよびその使用の方法 |
| CN113214265B (zh) * | 2020-01-21 | 2023-07-07 | 江苏先声药业有限公司 | 嘧啶并五元环类化合物 |
| RU2747991C1 (ru) * | 2020-02-18 | 2021-05-18 | Аркьюл, Инк. | Тетрагидропиранил амино-пирролопиримидинон и способы его применения |
| JP2023518006A (ja) * | 2020-03-12 | 2023-04-27 | フォチョン・バイオサイエンシーズ・リミテッド | キナーゼ阻害剤としての化合物 |
| CN114075190A (zh) * | 2020-08-20 | 2022-02-22 | 北京诺诚健华医药科技有限公司 | 杂环类btk抑制剂 |
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| IL148718A0 (en) | 1999-09-17 | 2002-09-12 | Abbott Gmbh & Co Kg | Pyrazolopyrimidines as therapeutic agents |
| US6921763B2 (en) * | 1999-09-17 | 2005-07-26 | Abbott Laboratories | Pyrazolopyrimidines as therapeutic agents |
| US20030225098A1 (en) | 2002-03-21 | 2003-12-04 | Hirst Gavin C. | Kinase inhibitors |
| EA018573B1 (ru) | 2006-09-22 | 2013-09-30 | Фармасайкликс, Инк. | Ингибиторы тирозинкиназы брутона |
| WO2008054827A2 (en) | 2006-11-03 | 2008-05-08 | Pharmacyclics, Inc. | Bruton's tyrosine kinase activity probe and method of using |
| SG10201508035TA (en) * | 2007-03-28 | 2015-10-29 | Pharmacyclics Inc | Inhibitors of bruton's tyrosine kinase |
| SG10201510696RA (en) | 2008-06-27 | 2016-01-28 | Celgene Avilomics Res Inc | Heteroaryl compounds and uses thereof |
| US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
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| JP2017519754A (ja) | 2017-07-20 |
| US20190119281A1 (en) | 2019-04-25 |
| US10538524B2 (en) | 2020-01-21 |
| JP6721521B2 (ja) | 2020-07-15 |
| CA2951504C (en) | 2023-10-03 |
| CN106661035B (zh) | 2019-11-19 |
| US9975897B2 (en) | 2018-05-22 |
| US20170129897A1 (en) | 2017-05-11 |
| AU2015273217A1 (en) | 2017-01-05 |
| EP3154978A1 (en) | 2017-04-19 |
| GB201410430D0 (en) | 2014-07-23 |
| WO2015189620A1 (en) | 2015-12-17 |
| CN106661035A (zh) | 2017-05-10 |
| ES2732897T3 (es) | 2019-11-26 |
| EP3154978B1 (en) | 2019-04-03 |
| CA2951504A1 (en) | 2015-12-17 |
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