AU2015273217B2 - Pyrazolopyrimidine derivatives useful as inhibitors of Bruton's tyrosine kinase - Google Patents
Pyrazolopyrimidine derivatives useful as inhibitors of Bruton's tyrosine kinase Download PDFInfo
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- AU2015273217B2 AU2015273217B2 AU2015273217A AU2015273217A AU2015273217B2 AU 2015273217 B2 AU2015273217 B2 AU 2015273217B2 AU 2015273217 A AU2015273217 A AU 2015273217A AU 2015273217 A AU2015273217 A AU 2015273217A AU 2015273217 B2 AU2015273217 B2 AU 2015273217B2
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- amino
- phenyl
- methyl
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- pyrimidin
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Classifications
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Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| GB1410430.1 | 2014-06-11 | ||
| GBGB1410430.1A GB201410430D0 (en) | 2014-06-11 | 2014-06-11 | Compounds |
| PCT/GB2015/051719 WO2015189620A1 (en) | 2014-06-11 | 2015-06-11 | Pyrazolopyrimidine derivatives useful as inhibitors of bruton's tyrosine kinase |
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| GB (1) | GB201410430D0 (enExample) |
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| GB201410430D0 (en) | 2014-06-11 | 2014-07-23 | Redx Pharma Ltd | Compounds |
| CN114685516A (zh) * | 2015-09-16 | 2022-07-01 | 洛克索肿瘤学股份有限公司 | 用于治疗癌症的作为btk抑制剂的吡唑并嘧啶衍生物 |
| PT3390395T (pt) | 2015-12-16 | 2020-11-03 | Loxo Oncology Inc | Compostos úteis como inibidores de quinase |
| US9630968B1 (en) | 2015-12-23 | 2017-04-25 | Arqule, Inc. | Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof |
| PH12018501390B1 (en) * | 2015-12-23 | 2022-06-10 | Arqule Inc | Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof |
| IL260691B (en) * | 2016-01-21 | 2022-07-01 | Zibo Biopolar Changsheng Pharmaceutical Co Ltd | Bruton's tyrosine kinase inhibitors |
| KR102327917B1 (ko) * | 2016-07-07 | 2021-11-17 | 주식회사 대웅제약 | 신규한 4-아미노피라졸로[3,4-d]피리미디닐아자바이사이클로 유도체 및 이를 포함하는 약학 조성물 |
| BR112019003504A2 (pt) | 2016-08-24 | 2019-05-21 | Arqule, Inc. | compostos de amino-pirrolopirimidinona e métodos de uso dos mesmos |
| WO2019130229A1 (en) * | 2017-12-28 | 2019-07-04 | Mylan Laboratories Ltd | Methods and intermediates for preparing rucaparib |
| US20220362357A1 (en) | 2018-08-31 | 2022-11-17 | Stichting Radboud Universitair Medisch Centrum | Synergistic Combinations of Amino Acid Depletion Agent Sensitizers (AADAS) and Amino Acid Depletion Agents (AADA), and Therapeutic Methods of Use Thereof |
| EP4069689A4 (en) * | 2019-12-04 | 2023-12-20 | Henan Zhiwei Biomedicine Co., Ltd. | SUBSTITUTED IMIDAZOLECARBOXAMIDE AS BRUTON TYROSINKINASE INHIBITORS |
| JP7011638B2 (ja) * | 2019-12-16 | 2022-02-10 | アークル インコーポレイテッド | テトラヒドロピラニルアミノ－ピロロピリミジノンおよびその使用の方法 |
| CN113214265B (zh) * | 2020-01-21 | 2023-07-07 | 江苏先声药业有限公司 | 嘧啶并五元环类化合物 |
| RU2747991C1 (ru) * | 2020-02-18 | 2021-05-18 | Аркьюл, Инк. | Тетрагидропиранил амино-пирролопиримидинон и способы его применения |
| EP4118086A1 (en) * | 2020-03-12 | 2023-01-18 | Fochon Biosciences, Ltd. | Compounds useful as kinase inhibitors |
| CN114075190A (zh) * | 2020-08-20 | 2022-02-22 | 北京诺诚健华医药科技有限公司 | 杂环类btk抑制剂 |
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| TR200201505T2 (tr) | 1999-09-17 | 2003-01-21 | Abbott Gmbh & Co.Kg | Terapötik maddeler olarak pirazolopirimidinler |
| US6921763B2 (en) | 1999-09-17 | 2005-07-26 | Abbott Laboratories | Pyrazolopyrimidines as therapeutic agents |
| US20030225098A1 (en) | 2002-03-21 | 2003-12-04 | Hirst Gavin C. | Kinase inhibitors |
| SG166093A1 (en) * | 2006-09-22 | 2010-11-29 | Pharmacyclics Inc | Inhibitors of brutonæs tyrosine kinase |
| US8987233B2 (en) | 2006-11-03 | 2015-03-24 | Pharmacyclics, Inc. | Bruton's tyrosine kinase activity probe and method of using |
| CN101674834B (zh) * | 2007-03-28 | 2013-06-12 | 环状药物公司 | 布鲁顿氏酪氨酸激酶(Bruton's tyrosine kinase)抑制剂 |
| US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| NZ624345A (en) | 2008-06-27 | 2016-07-29 | Celgene Avilomics Res Inc | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| CA2730930C (en) * | 2008-07-16 | 2015-01-13 | Pharmacyclics, Inc. | Inhibitors of bruton's tyrosine kinase for the treatment of solid tumors |
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2015
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| CA2951504C (en) | 2023-10-03 |
| CN106661035A (zh) | 2017-05-10 |
| US20170129897A1 (en) | 2017-05-11 |
| JP2017519754A (ja) | 2017-07-20 |
| EP3154978A1 (en) | 2017-04-19 |
| US10538524B2 (en) | 2020-01-21 |
| US9975897B2 (en) | 2018-05-22 |
| CN106661035B (zh) | 2019-11-19 |
| US20190119281A1 (en) | 2019-04-25 |
| CA2951504A1 (en) | 2015-12-17 |
| AU2015273217A1 (en) | 2017-01-05 |
| GB201410430D0 (en) | 2014-07-23 |
| WO2015189620A1 (en) | 2015-12-17 |
| ES2732897T3 (es) | 2019-11-26 |
| EP3154978B1 (en) | 2019-04-03 |
| JP6721521B2 (ja) | 2020-07-15 |
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