AU2015261775B2 - Novel compounds useful as S100-inhibitors - Google Patents
Novel compounds useful as S100-inhibitors Download PDFInfo
- Publication number
- AU2015261775B2 AU2015261775B2 AU2015261775A AU2015261775A AU2015261775B2 AU 2015261775 B2 AU2015261775 B2 AU 2015261775B2 AU 2015261775 A AU2015261775 A AU 2015261775A AU 2015261775 A AU2015261775 A AU 2015261775A AU 2015261775 B2 AU2015261775 B2 AU 2015261775B2
- Authority
- AU
- Australia
- Prior art keywords
- oxo
- trifluoromethyl
- tetraen
- dodeca
- triazatricyclo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 239000003112 inhibitor Substances 0.000 title abstract description 6
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- 150000003839 salts Chemical class 0.000 claims abstract description 34
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- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 186
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- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 122
- -1 4- cyclopentyl- Chemical group 0.000 claims description 120
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 106
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- 229910052736 halogen Inorganic materials 0.000 claims description 100
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- 125000000623 heterocyclic group Chemical group 0.000 claims description 85
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- COBFGLKMWGHNEK-UHFFFAOYSA-N tert-butyl 4-(2-amino-2-oxoethyl)piperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC(CC(N)=O)CC1 COBFGLKMWGHNEK-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| EP14169757.3 | 2014-05-23 | ||
| EP14169757 | 2014-05-23 | ||
| PCT/EP2015/061468 WO2015177367A1 (en) | 2014-05-23 | 2015-05-22 | Novel compounds useful as s100-inhibitors |
Publications (2)
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| AU2015261775A1 AU2015261775A1 (en) | 2016-12-08 |
| AU2015261775B2 true AU2015261775B2 (en) | 2019-07-11 |
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| AU2015261775A Ceased AU2015261775B2 (en) | 2014-05-23 | 2015-05-22 | Novel compounds useful as S100-inhibitors |
Country Status (12)
| Country | Link |
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| US (1) | US9771372B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2991990B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6580074B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20170005868A (cg-RX-API-DMAC7.html) |
| CN (1) | CN106414448B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2015261775B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112016024749A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2948436A1 (cg-RX-API-DMAC7.html) |
| EA (1) | EA030604B1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2620751T3 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2016014483A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015177367A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11858984B2 (en) | 2018-04-27 | 2024-01-02 | National University Corporation Okayama University | Anti-S100A8/A9 antibody and use thereof |
| US11197908B2 (en) | 2018-07-17 | 2021-12-14 | The Board Of Trustees Of The University Of Arkansas | Peptoids and methods for attenuating inflammatory response |
| US20230144545A1 (en) | 2019-10-30 | 2023-05-11 | National University Corporation Okayama University | Prophylactic and/or therapeutic agent for inflammatory pulmonary disease |
| WO2023209141A1 (en) | 2022-04-29 | 2023-11-02 | Westfälische Wilhelms-Universität Münster | Benzo[d]imidazo[1,2-a]imidazoles and their use in diagnosis |
| WO2025132458A1 (en) | 2023-12-18 | 2025-06-26 | Chiesi Farmaceutici S.P.A. | Pyridazinyl amino derivatives as alk5 inhibitors |
Citations (5)
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| WO2002069965A1 (en) * | 2001-03-05 | 2002-09-12 | Transtech Pharma, Inc. | Benzimidazole derivatives as therapeutic agents |
| EP1986009A1 (en) * | 2007-04-26 | 2008-10-29 | Active Biotech AB | Screening method |
| US20090186879A1 (en) * | 2008-01-22 | 2009-07-23 | Takeda Pharmaceutical Company Limited | Tricyclic compounds and use thereof |
| CN101597262A (zh) * | 2002-03-05 | 2009-12-09 | 特兰斯泰克制药公司 | 抑制配体与高级糖化终产物受体相互作用的单和双环吡咯衍生物 |
| WO2015086525A1 (en) * | 2013-12-09 | 2015-06-18 | Ucb Biopharma Sprl | Fused tricyclic benzimidazoles derivatives as modulators of tnf activity |
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| US6248755B1 (en) | 1999-04-06 | 2001-06-19 | Merck & Co., Inc. | Pyrrolidine modulators of chemokine receptor activity |
| AR029489A1 (es) | 2000-03-10 | 2003-07-02 | Euro Celtique Sa | Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento |
| EP1305308B1 (en) | 2000-07-26 | 2006-12-20 | Smithkline Beecham Plc | Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity |
| GB0117506D0 (en) | 2001-07-18 | 2001-09-12 | Bayer Ag | Imidazopyridinones |
| SE0104331D0 (sv) | 2001-12-19 | 2001-12-19 | Astrazeneca Ab | Novel compounds |
| US20060111416A1 (en) | 2004-11-24 | 2006-05-25 | Lane Charlotte A L | Octahydropyrrolo[3,4-C]pyrrole derivatives |
| CA2663856A1 (en) | 2006-09-28 | 2008-04-10 | Exelixis, Inc. | Jak-2 modulators and methods of use |
| AU2008231384B2 (en) | 2007-03-23 | 2011-09-15 | Amgen Inc. | Heterocyclic compounds and their use |
| AU2008266154A1 (en) | 2007-06-13 | 2008-12-24 | Claxosmithkltne Llc | Farnesoid X receptor agonists |
| TW201004941A (en) | 2008-07-16 | 2010-02-01 | Wyeth Corp | Alpha7 nicotinic acetylcholine receptor inhibitors |
| MX2011009213A (es) | 2009-03-02 | 2011-12-14 | Sirtris Pharmaceuticals Inc | Quinolinas 8-sustituidas y analogos relacionados como moduladores de sirtuina. |
| WO2013067260A1 (en) | 2011-11-03 | 2013-05-10 | Genentech, Inc. | Bicyclic piperazine compounds |
-
2015
- 2015-05-22 JP JP2016568812A patent/JP6580074B2/ja not_active Expired - Fee Related
- 2015-05-22 US US15/312,762 patent/US9771372B2/en not_active Expired - Fee Related
- 2015-05-22 MX MX2016014483A patent/MX2016014483A/es unknown
- 2015-05-22 WO PCT/EP2015/061468 patent/WO2015177367A1/en not_active Ceased
- 2015-05-22 ES ES15724640.6T patent/ES2620751T3/es active Active
- 2015-05-22 CA CA2948436A patent/CA2948436A1/en not_active Abandoned
- 2015-05-22 EP EP15724640.6A patent/EP2991990B1/en active Active
- 2015-05-22 CN CN201580026356.5A patent/CN106414448B/zh not_active Expired - Fee Related
- 2015-05-22 AU AU2015261775A patent/AU2015261775B2/en not_active Ceased
- 2015-05-22 EA EA201692405A patent/EA030604B1/ru not_active IP Right Cessation
- 2015-05-22 KR KR1020167035803A patent/KR20170005868A/ko not_active Withdrawn
- 2015-05-22 BR BR112016024749A patent/BR112016024749A2/pt not_active IP Right Cessation
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| CN101597262A (zh) * | 2002-03-05 | 2009-12-09 | 特兰斯泰克制药公司 | 抑制配体与高级糖化终产物受体相互作用的单和双环吡咯衍生物 |
| EP1986009A1 (en) * | 2007-04-26 | 2008-10-29 | Active Biotech AB | Screening method |
| US20090186879A1 (en) * | 2008-01-22 | 2009-07-23 | Takeda Pharmaceutical Company Limited | Tricyclic compounds and use thereof |
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| WO2015086525A1 (en) * | 2013-12-09 | 2015-06-18 | Ucb Biopharma Sprl | Fused tricyclic benzimidazoles derivatives as modulators of tnf activity |
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2015177367A1 (en) | 2015-11-26 |
| BR112016024749A2 (pt) | 2017-08-15 |
| EA201692405A1 (ru) | 2017-06-30 |
| US9771372B2 (en) | 2017-09-26 |
| HK1221463A1 (en) | 2017-06-02 |
| EA030604B1 (ru) | 2018-08-31 |
| MX2016014483A (es) | 2017-01-23 |
| US20170204098A1 (en) | 2017-07-20 |
| KR20170005868A (ko) | 2017-01-16 |
| EP2991990B1 (en) | 2017-02-01 |
| CN106414448A (zh) | 2017-02-15 |
| CA2948436A1 (en) | 2015-11-26 |
| JP2017516772A (ja) | 2017-06-22 |
| ES2620751T3 (es) | 2017-06-29 |
| EP2991990A1 (en) | 2016-03-09 |
| JP6580074B2 (ja) | 2019-09-25 |
| AU2015261775A1 (en) | 2016-12-08 |
| CN106414448B (zh) | 2019-04-19 |
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