AU2015247833B2 - Bi-terminal PEGylated integrin-binding peptides and methods of use thereof - Google Patents

Bi-terminal PEGylated integrin-binding peptides and methods of use thereof Download PDF

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Publication number
AU2015247833B2
AU2015247833B2 AU2015247833A AU2015247833A AU2015247833B2 AU 2015247833 B2 AU2015247833 B2 AU 2015247833B2 AU 2015247833 A AU2015247833 A AU 2015247833A AU 2015247833 A AU2015247833 A AU 2015247833A AU 2015247833 B2 AU2015247833 B2 AU 2015247833B2
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conjugate
peg
peptide
integrin
imaging
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AU2015247833A1 (en
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Sven H. HAUSNER
Julie L. SUTCLIFFE
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University of California, San Diego
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University of California Berkeley
University of California, San Diego
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70546—Integrin superfamily
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32111—Aphthovirus, e.g. footandmouth disease virus
    • C12N2770/32122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU2015247833A 2014-04-15 2015-04-14 Bi-terminal PEGylated integrin-binding peptides and methods of use thereof Active AU2015247833B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2019232847A AU2019232847B2 (en) 2014-04-15 2019-09-18 Bi-terminal pegylated integrin-binding peptides and methods of use thereof

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461979997P 2014-04-15 2014-04-15
US61/979,997 2014-04-15
PCT/US2015/025700 WO2015160770A1 (en) 2014-04-15 2015-04-14 Bi-terminal pegylated integrin-binding peptides and methods of use thereof

Related Child Applications (1)

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AU2019232847A Division AU2019232847B2 (en) 2014-04-15 2019-09-18 Bi-terminal pegylated integrin-binding peptides and methods of use thereof

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AU2015247833A1 AU2015247833A1 (en) 2016-11-10
AU2015247833B2 true AU2015247833B2 (en) 2019-10-10

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AU2019232847A Active AU2019232847B2 (en) 2014-04-15 2019-09-18 Bi-terminal pegylated integrin-binding peptides and methods of use thereof

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US (3) US10919932B2 (enExample)
EP (1) EP3131566B1 (enExample)
JP (1) JP6789823B2 (enExample)
CN (1) CN106573031B (enExample)
AU (2) AU2015247833B2 (enExample)
CA (1) CA2945945C (enExample)
ES (1) ES2930029T3 (enExample)
WO (1) WO2015160770A1 (enExample)

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WO2015160770A1 (en) * 2014-04-15 2015-10-22 The Regents Of The University Of California Bi-terminal pegylated integrin-binding peptides and methods of use thereof
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CN109563135B (zh) 2016-06-13 2024-01-23 加利福尼亚大学董事会 α(V)β(6)整合素结合肽及其使用方法
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GB201613166D0 (en) 2016-07-29 2016-09-14 Vectura Ltd Polymer
US11613607B2 (en) * 2016-10-07 2023-03-28 Tokyo Institute Of Technology Branched type hetero monodispersed polyethylene glycol, production method thereof, and conjugate thereof
AU2017354041B2 (en) * 2016-11-01 2024-02-01 Arrowhead Pharmaceuticals, Inc. Alpha-V beta-6 integrin ligands and uses thereof
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WO2019154842A1 (en) * 2018-02-06 2019-08-15 Klinikum Rechts Der Isar Der Technischen Universität München Compound for intraoperative molecular bioimaging, method of making the same, use thereof in intraoperative molecular bioimaging and surgical method comprising intraoperative molecular bioimaging
EP3846858A4 (en) 2018-09-07 2022-10-19 The Regents of the University of California ALPHA-(V)BETA(6)INTEGRIN-BINDING PEPTIDES AND METHODS OF USE THEREOF
WO2020093055A2 (en) 2018-11-02 2020-05-07 Indi Molecular, Inc. Peptide libraries with non-canonical amino acids
CN114206906B (zh) * 2019-07-10 2024-02-20 香港大学 Peg化的合成kl4肽、其组合物和方法
CN110522923A (zh) * 2019-09-19 2019-12-03 四川大学 果糖和rgd肽共修饰的双重靶向三阴性乳腺癌的脂质材料
AU2020356931A1 (en) * 2019-10-02 2022-05-26 Sirnaomics, Inc. Oligonucleotides with nucleoside analogs
EP4048305A1 (en) * 2019-10-25 2022-08-31 University of Washington Computational design of alpha(v) beta (6) integrin binding proteins
WO2021226432A2 (en) * 2020-05-08 2021-11-11 The Regents Of The University Of California Methods of detecting and treating lung damage in respiratory-related viral infections
US20230277490A1 (en) * 2020-07-31 2023-09-07 Cedars-Sinai Medical Center Glutamine as an anticancer therapy in solid tumors
US20230405129A1 (en) * 2020-10-20 2023-12-21 The Boad Of Regents Of The University Of Taxas System Proinflammatory prodrugs
WO2022098745A1 (en) * 2020-11-03 2022-05-12 Indi Molecular, Inc. Compositions, delivery systems, and methods useful in tumor therapy
CN116829541A (zh) * 2020-12-04 2023-09-29 加利福尼亚大学董事会 肽受体放射性核素治疗
WO2022216920A1 (en) 2021-04-08 2022-10-13 Arrowhead Pharmaceuticals, Inc. Rnai agents for inhibiting expression of receptor for advanced glycation end-products, compositions thereof, and methods of use
EP4731270A1 (en) 2023-06-20 2026-04-29 The Regents of The University of California Combination therapy with peptide receptor radionuclide and dna repair inhibitor

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Also Published As

Publication number Publication date
ES2930029T3 (es) 2022-12-05
US20210206804A1 (en) 2021-07-08
US10919932B2 (en) 2021-02-16
AU2019232847B2 (en) 2020-08-27
JP2017513859A (ja) 2017-06-01
WO2015160770A1 (en) 2015-10-22
EP3131566A1 (en) 2017-02-22
CA2945945A1 (en) 2015-10-22
EP3131566A4 (en) 2017-11-08
US20170174723A1 (en) 2017-06-22
US20240101601A1 (en) 2024-03-28
CA2945945C (en) 2023-10-03
AU2015247833A1 (en) 2016-11-10
JP6789823B2 (ja) 2020-11-25
AU2019232847A1 (en) 2019-10-10
US11485758B2 (en) 2022-11-01
CN106573031B (zh) 2021-05-28
CN106573031A (zh) 2017-04-19
EP3131566B1 (en) 2022-10-05

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