AU2015213844A1 - Molecular diagnostic test for predicting response to anti-angiogenic drugs and prognosis of cancer - Google Patents

Molecular diagnostic test for predicting response to anti-angiogenic drugs and prognosis of cancer

Info

Publication number
AU2015213844A1
AU2015213844A1 AU2015213844A AU2015213844A AU2015213844A1 AU 2015213844 A1 AU2015213844 A1 AU 2015213844A1 AU 2015213844 A AU2015213844 A AU 2015213844A AU 2015213844 A AU2015213844 A AU 2015213844A AU 2015213844 A1 AU2015213844 A1 AU 2015213844A1
Authority
AU
Australia
Prior art keywords
sample
expression
biomarkers
subject
biomarker
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2015213844A
Other languages
English (en)
Inventor
Timothy Davison
Steve Deharo
Sinead DONEGAN
Charlie GOURLEY
Denis Paul Harkin
Laura A HILL
Gera JELLEMA
Katherine E. Keating
Richard Kennedy
Andrena MCCAVIGAN
Fionnuala Patterson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Almac Diagnostics Ltd
Original Assignee
Almac Diagnostics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almac Diagnostics Ltd filed Critical Almac Diagnostics Ltd
Publication of AU2015213844A1 publication Critical patent/AU2015213844A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/118Prognosis of disease development
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU2015213844A 2014-02-07 2015-02-09 Molecular diagnostic test for predicting response to anti-angiogenic drugs and prognosis of cancer Abandoned AU2015213844A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461937224P 2014-02-07 2014-02-07
US61/937,224 2014-02-07
GBGB1409479.1A GB201409479D0 (en) 2014-05-28 2014-05-28 Molecular diagnostic test for cancer
GB1409479.1 2014-05-28
PCT/GB2015/050352 WO2015118353A1 (en) 2014-02-07 2015-02-09 Molecular diagnostic test for predicting response to anti-angiogenic drugs and prognosis of cancer

Publications (1)

Publication Number Publication Date
AU2015213844A1 true AU2015213844A1 (en) 2016-09-15

Family

ID=51177582

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2015213844A Abandoned AU2015213844A1 (en) 2014-02-07 2015-02-09 Molecular diagnostic test for predicting response to anti-angiogenic drugs and prognosis of cancer

Country Status (10)

Country Link
US (1) US10280468B2 (enExample)
EP (1) EP3102700A1 (enExample)
JP (1) JP2017506506A (enExample)
KR (1) KR20160117606A (enExample)
CN (1) CN106164296A (enExample)
AU (1) AU2015213844A1 (enExample)
BR (1) BR112016018044A2 (enExample)
CA (1) CA2938807A1 (enExample)
GB (1) GB201409479D0 (enExample)
WO (1) WO2015118353A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11568982B1 (en) 2014-02-17 2023-01-31 Health at Scale Corporation System to improve the logistics of clinical care by selectively matching patients to providers
US10650325B2 (en) * 2015-07-31 2020-05-12 Microsoft Technology Licensing, Llc Deterministic message distribution
US10496691B1 (en) 2015-09-08 2019-12-03 Google Llc Clustering search results
US11243206B2 (en) * 2016-09-28 2022-02-08 The Catholic University Of Korea Industry-Academic Cooperation Foundation Gender-specific markers for diagnosing prognosis and determining treatment strategy for renal cancer patients
JP6899848B2 (ja) * 2016-12-28 2021-07-07 公益財団法人がん研究会 抗vegfr−2抗体医薬品の治療効果を予測するバイオマーカー、検査方法、及び検査キット
CN107301328B (zh) * 2017-05-19 2021-04-06 浙江工业大学 基于数据流聚类的癌症亚型精准发现与演化分析方法
US10311967B2 (en) 2017-06-13 2019-06-04 Bostongene Corporation Systems and methods for generating, visualizing and classifying molecular functional profiles
JP6977965B2 (ja) * 2017-10-26 2021-12-08 公立大学法人福島県立医科大学 卵巣癌組織型鑑別方法
CN110880356A (zh) * 2018-09-05 2020-03-13 南京格致基因生物科技有限公司 对卵巢癌进行筛查、诊断或风险分级的方法和装置
EP3874274B1 (en) * 2018-10-31 2024-01-03 Regents of the University of Minnesota Methods for predicting a response to bevacizumab or platinum-based chemotherapy or both in patients with ovarian cancer
US11610679B1 (en) 2020-04-20 2023-03-21 Health at Scale Corporation Prediction and prevention of medical events using machine-learning algorithms
CN112164474B (zh) * 2020-07-14 2024-05-24 中国矿业大学 一种基于自表达模型的药物敏感性预测方法
US12094582B1 (en) 2020-08-11 2024-09-17 Health at Scale Corporation Intelligent healthcare data fabric system
US12080428B1 (en) 2020-09-10 2024-09-03 Health at Scale Corporation Machine intelligence-based prioritization of non-emergent procedures and visits
WO2022204438A1 (en) * 2021-03-25 2022-09-29 Oncxerna Therapeutics, Inc. Targeted therapies in cancer
EP4352265A4 (en) * 2021-06-04 2025-10-08 Cedars Sinai Medical Center USE OF CANCER CELL EXPRESSION OF CADHERIN 12 AND CADHERIN 18 TO TREAT BLADDER CANCERS
CN113667752A (zh) * 2021-09-09 2021-11-19 菲思特(上海)生物科技有限公司 一种用于柔红霉素代谢标志物的检测试剂盒及其检测方法和应用

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5525464A (en) 1987-04-01 1996-06-11 Hyseq, Inc. Method of sequencing by hybridization of oligonucleotide probes
US5202231A (en) 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
GB8810400D0 (en) 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
EP0430881A3 (en) 1989-11-29 1991-10-23 Ciba-Geigy Ag Photochromic compounds, process for their preparation and their use
US5288644A (en) 1990-04-04 1994-02-22 The Rockefeller University Instrument and method for the sequencing of genome
US5324633A (en) 1991-11-22 1994-06-28 Affymax Technologies N.V. Method and apparatus for measuring binding affinity
WO1993020236A1 (en) 1992-04-03 1993-10-14 Applied Biosystems, Inc. Probe composition and method
US5503980A (en) 1992-11-06 1996-04-02 Trustees Of Boston University Positional sequencing by hybridization
US5858659A (en) 1995-11-29 1999-01-12 Affymetrix, Inc. Polymorphism detection
US5470710A (en) 1993-10-22 1995-11-28 University Of Utah Automated hybridization/imaging device for fluorescent multiplex DNA sequencing
GB9401833D0 (en) 1994-02-01 1994-03-30 Isis Innovation Method for discovering ligands
GB9507238D0 (en) 1995-04-07 1995-05-31 Isis Innovation Detecting dna sequence variations
US5661028A (en) 1995-09-29 1997-08-26 Lockheed Martin Energy Systems, Inc. Large scale DNA microsequencing device
JP2002515738A (ja) 1996-01-23 2002-05-28 アフィメトリックス,インコーポレイティド 核酸分析法
US6998234B2 (en) 2000-11-03 2006-02-14 Oncotech, Inc. Methods for cancer prognosis and diagnosis relating to tumor vascular endothelial cells
KR20160014775A (ko) 2003-05-30 2016-02-11 제넨테크, 인크. 항-vegf 항체를 사용한 치료
WO2004108896A2 (en) 2003-06-03 2004-12-16 The Board Of Trustees Of The University Of Arkansas Gene expression profiling of uterine serous papillary carcinomas and ovarian serous papillary tumors
EP1704250B1 (en) 2003-12-31 2012-09-19 The Penn State Research Foundation Methods for predicting and overcoming resistance to chemotherapy in ovarian cancer
US20080113874A1 (en) 2004-01-23 2008-05-15 The Regents Of The University Of Colorado Gefitinib sensitivity-related gene expression and products and methods related thereto
EP1737980A2 (en) 2004-04-09 2007-01-03 Fondazione IRCCS Istituto Nazionale dei Tumori Gene expression markers for predicting response to chemotherapy
EP1756306A2 (en) 2004-05-14 2007-02-28 Ludwig Institute For Cancer Research Identification and characterization of a subset of glioblastomas sensitive to treatment with imatinib
MX2007000944A (es) 2004-07-23 2007-04-13 Astrazeneca Ab Metodo para pronosticar la sensibilidad de un tumor a farmacos del receptor erbb.
US20060134663A1 (en) 2004-11-03 2006-06-22 Paul Harkin Transcriptome microarray technology and methods of using the same
US7862995B2 (en) 2004-12-10 2011-01-04 Targeted Molecular Diagnostics Methods and materials for predicting responsiveness to treatment with dual tyrosine kinase inhibitor
WO2007015947A2 (en) 2005-07-29 2007-02-08 Bayer Healthcare Llc Methods and kits for the prediction of therapeutic success, recurrence free and overall survival in cancer therapies
US8445198B2 (en) 2005-12-01 2013-05-21 Medical Prognosis Institute Methods, kits and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy
EP1963862A4 (en) 2005-12-05 2010-03-03 Merck & Co Inc METHOD FOR PREDICTING THE APPLICATION FOR TREATMENT BASED ON THE EXPRESSION PROFILES OF PROTEIN AND TRANSCRIPTION BIOMARKERS
AU2007211085A1 (en) 2006-01-27 2007-08-09 Tripath Imaging, Inc. Methods for identifying patients with an increased likelihood of having ovarian cancer and compositions therefor
US8768629B2 (en) 2009-02-11 2014-07-01 Caris Mpi, Inc. Molecular profiling of tumors
CN101541977A (zh) 2006-09-19 2009-09-23 诺瓦提斯公司 用于raf抑制剂的靶向调节、效力、诊断和/或预后的生物标志物
NZ582941A (en) 2007-08-13 2012-05-25 Almac Diagnostics Ltd A 3' -based sequencing approach for microarray manufacture
MX2010005057A (es) 2007-11-09 2010-05-19 Genentech Inc Metodos y composiciones para uso de diagnostico en pacientes de cancer.
JP2011525106A (ja) 2008-06-04 2011-09-15 ジ・アリゾナ・ボード・オブ・リージェンツ・オン・ビハーフ・オブ・ザ・ユニバーシティ・オブ・アリゾナ 瀰漫性b大細胞型リンパ腫のマーカーおよびその使用方法
EP2294420B8 (en) 2008-06-06 2015-10-21 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Survival predictor for diffuse large B cell lymphoma
AU2009270851A1 (en) 2008-07-16 2010-01-21 Dana-Farber Cancer Institute, Inc. Signatures and PCDETERMINANTS associated with prostate cancer and methods of use thereof
JP5606438B2 (ja) 2008-07-23 2014-10-15 エフ.ホフマン−ラ ロシュ アーゲー 抗血管新生療法を受容可能な被験体の同定
EP2706358A3 (en) 2008-12-23 2014-05-07 Merck Patent GmbH Biomarkers for inhibitors with anti-angiogenic activity
WO2010088688A2 (en) 2009-02-02 2010-08-05 Biotheranostics, Inc. Diagnosis of in situ and invasive breast cancer
SG10201401722XA (en) 2009-05-01 2014-08-28 Genomic Health Inc Gene expression profile algorithm and test for likelihood of recurrence of colorectal cancer andresponse to chemotherapy
US7615353B1 (en) 2009-07-06 2009-11-10 Aveo Pharmaceuticals, Inc. Tivozanib response prediction
JP5606537B2 (ja) 2009-09-17 2014-10-15 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 癌患者における診断使用のための方法及び組成物
MY166040A (en) 2010-09-15 2018-05-21 Almac Diagnostics Ltd Molecular diagnostic test for cancer
US20150024952A1 (en) 2010-12-28 2015-01-22 Arlet Alarcon Molecular profiling for cancer
EA025926B1 (ru) 2011-06-02 2017-02-28 Олмак Дайэгностикс Лимитед Молекулярно-диагностический тест на рак
BR112014017320A2 (en) 2012-01-13 2018-05-29 Genentech, Inc method for determining whether a patient is prone to respond to treatment with a vegf antagonist, method for optimizing the therapeutic efficacy of a vegf antagonist, method for selecting a therapy, method for identifying a biomarker, and method for diagnosing an angiogenic disorder
AU2013353839A1 (en) * 2012-12-03 2015-06-18 Almac Diagnostics Limited Molecular diagnostic test for cancer

Also Published As

Publication number Publication date
CA2938807A1 (en) 2015-08-13
BR112016018044A2 (pt) 2018-02-20
GB201409479D0 (en) 2014-07-09
JP2017506506A (ja) 2017-03-09
CN106164296A (zh) 2016-11-23
EP3102700A1 (en) 2016-12-14
KR20160117606A (ko) 2016-10-10
US10280468B2 (en) 2019-05-07
US20170073761A1 (en) 2017-03-16
WO2015118353A1 (en) 2015-08-13

Similar Documents

Publication Publication Date Title
US10280468B2 (en) Molecular diagnostic test for predicting response to anti-angiogenic drugs and prognosis of cancer
US11091809B2 (en) Molecular diagnostic test for cancer
AU2012261820B2 (en) Molecular diagnostic test for cancer
US11254986B2 (en) Gene signature for immune therapies in cancer
US10378066B2 (en) Molecular diagnostic test for cancer
AU2012261820A1 (en) Molecular diagnostic test for cancer
US20160222459A1 (en) Molecular diagnostic test for lung cancer
US20160222460A1 (en) Molecular diagnostic test for oesophageal cancer
WO2017216559A1 (en) Predicting responsiveness to therapy in prostate cancer
US20170088902A1 (en) Expression profiling for cancers treated with anti-angiogenic therapy

Legal Events

Date Code Title Description
MK1 Application lapsed section 142(2)(a) - no request for examination in relevant period